Details for: MEA1

Gene ID: 4201

Symbol: MEA1

Ensembl ID: ENSG00000124733

Description: male-enhanced antigen 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 198.9775
    Cell Significance Index: -30.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 115.3194
    Cell Significance Index: -29.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 87.0014
    Cell Significance Index: -35.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 78.7309
    Cell Significance Index: -31.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 75.7430
    Cell Significance Index: -35.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 69.8309
    Cell Significance Index: -35.9200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.4856
    Cell Significance Index: -35.8900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 34.0249
    Cell Significance Index: -32.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.2143
    Cell Significance Index: -36.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5285
    Cell Significance Index: -37.6000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.4255
    Cell Significance Index: -28.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.1859
    Cell Significance Index: -19.2500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.4930
    Cell Significance Index: 31.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.1048
    Cell Significance Index: 17.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.5637
    Cell Significance Index: 32.7300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.5283
    Cell Significance Index: 11.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3560
    Cell Significance Index: 36.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2898
    Cell Significance Index: 209.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2321
    Cell Significance Index: 64.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2191
    Cell Significance Index: 143.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1060
    Cell Significance Index: 10.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0419
    Cell Significance Index: 48.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8886
    Cell Significance Index: 160.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8527
    Cell Significance Index: 9.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8129
    Cell Significance Index: 99.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7935
    Cell Significance Index: 27.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7929
    Cell Significance Index: 20.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7721
    Cell Significance Index: 106.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7548
    Cell Significance Index: 412.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7267
    Cell Significance Index: 54.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7076
    Cell Significance Index: 5.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6341
    Cell Significance Index: 33.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6240
    Cell Significance Index: 18.3300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.6080
    Cell Significance Index: 6.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5905
    Cell Significance Index: 261.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4736
    Cell Significance Index: 60.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4458
    Cell Significance Index: 20.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4287
    Cell Significance Index: 4.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3732
    Cell Significance Index: 48.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3506
    Cell Significance Index: 18.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3401
    Cell Significance Index: 24.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3215
    Cell Significance Index: 20.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2791
    Cell Significance Index: 12.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2558
    Cell Significance Index: 7.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2312
    Cell Significance Index: 14.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2029
    Cell Significance Index: 20.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1736
    Cell Significance Index: 4.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1728
    Cell Significance Index: 34.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1659
    Cell Significance Index: 149.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1411
    Cell Significance Index: 26.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1017
    Cell Significance Index: 2.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0885
    Cell Significance Index: 17.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0466
    Cell Significance Index: 0.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0381
    Cell Significance Index: 28.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0333
    Cell Significance Index: 0.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0324
    Cell Significance Index: 1.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0013
    Cell Significance Index: -0.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0044
    Cell Significance Index: -0.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0112
    Cell Significance Index: -4.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0146
    Cell Significance Index: -27.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0223
    Cell Significance Index: -41.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0265
    Cell Significance Index: -40.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0310
    Cell Significance Index: -42.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0363
    Cell Significance Index: -25.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0390
    Cell Significance Index: -28.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0502
    Cell Significance Index: -31.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0522
    Cell Significance Index: -8.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0531
    Cell Significance Index: -29.9700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0542
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0665
    Cell Significance Index: -41.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0781
    Cell Significance Index: -35.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0992
    Cell Significance Index: -28.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1140
    Cell Significance Index: -0.9300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1249
    Cell Significance Index: -3.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1339
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1573
    Cell Significance Index: -18.0200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1633
    Cell Significance Index: -1.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1823
    Cell Significance Index: -5.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1954
    Cell Significance Index: -41.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2000
    Cell Significance Index: -5.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2075
    Cell Significance Index: -24.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2105
    Cell Significance Index: -4.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2155
    Cell Significance Index: -5.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2229
    Cell Significance Index: -32.4000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2624
    Cell Significance Index: -3.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2873
    Cell Significance Index: -3.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3347
    Cell Significance Index: -26.5100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.3594
    Cell Significance Index: -2.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3600
    Cell Significance Index: -37.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3606
    Cell Significance Index: -22.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4001
    Cell Significance Index: -11.7900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4123
    Cell Significance Index: -4.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4654
    Cell Significance Index: -8.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4852
    Cell Significance Index: -32.6300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4880
    Cell Significance Index: -37.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4893
    Cell Significance Index: -5.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5223
    Cell Significance Index: -29.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5526
    Cell Significance Index: -15.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5812
    Cell Significance Index: -35.6300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6691
    Cell Significance Index: -14.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MEA1 is a gene that exhibits a wide range of expression profiles across various cell types, including CD14-low, CD16-positive monocytes, erythroid progenitor cells, oogonial cells, interstitial cells of the ovary, basal cells of the epithelium of the trachea, granulosa cells, ovarian surface epithelial cells, pancreatic acinar cells, mesodermal cells, and cortical thymic epithelial cells. This diverse expression pattern underscores the gene's multifaceted role in cellular development and differentiation. Notably, MEA1 is significantly expressed in cells involved in immune responses, suggesting its potential involvement in modulating immune cell function. **Pathways and Functions:** MEA1 is integrated into several critical cellular pathways, including cell differentiation, cytoplasm, male gonad development, protein binding, and spermatogenesis. The gene's involvement in these pathways highlights its essential role in regulating cellular processes that are crucial for reproductive health and immune system function. Specifically, MEA1's involvement in spermatogenesis underscores its potential as a therapeutic target for male infertility disorders. Additionally, the gene's expression in immune cells suggests its role in modulating immune responses and maintaining immune homeostasis. **Clinical Significance:** The clinical significance of MEA1 lies in its potential applications in the diagnosis and treatment of immune system disorders and reproductive health issues. For instance, MEA1's expression in granulosa cells and ovarian surface epithelial cells raises the possibility of its involvement in ovarian function and fertility. Furthermore, the gene's role in spermatogenesis makes it an attractive target for the development of novel therapeutic strategies for male infertility. Moreover, MEA1's expression in immune cells suggests its potential as a biomarker for immune system disorders, such as autoimmune diseases and immunodeficiency syndromes. In conclusion, MEA1 is a gene that plays a critical role in regulating cellular processes that are essential for reproductive health and immune system function. Its involvement in spermatogenesis, immune cell development, and protein binding highlights its multifaceted role in cellular differentiation and development. As research into MEA1 continues to uncover its molecular mechanisms, it is likely that this gene will emerge as a key player in the development of novel therapeutic strategies for a range of clinical applications.

Genular Protein ID: 1551358245

Symbol: MEA1_HUMAN

Name: Male-enhanced antigen 1

UniProtKB Accession Codes:

Q16626 Q5TC36 Q9BV01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2813404

Title: Male-enhanced antigen gene is phylogenetically conserved and expressed at late stages of spermatogenesis.

PubMed ID: 2813404

DOI: 10.1073/pnas.86.21.8462

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 185
  • Mass: 19905
  • Checksum: F50E6892FBA7435C
  • Sequence:
    • MGPERHLSGA PARMATVVLG GDTMGPERIF PNQTEELGHQ GPSEGTGDWS SEEPEEEQEE 
TGSGPAGYSY QPLNQDPEQE EVELAPVGDG DVVADIQDRI QALGLHLPDP PLESEDEDEE 
GATALNNHSS IPMDPEHVEL VKRTMAGVSL PAPGVPAWAR EISDAQWEDV VQKALQARQA 
SPAWK

Genular Protein ID: 378929941

Symbol: A0A2R8Y7W8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2R8Y7W8

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 5 GO 1 GeneTree 1 HGNC 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 172
  • Mass: 18544
  • Checksum: 9342AFAD2C96FF25
  • Sequence:
    • MATVVLGGDT MGPERIFPNQ TEELGHQGPS EGTGDWSSEE PEEEQEETGS GPAGYSYQPL 
NQDPEQEEVE LAPVGDGDVV ADIQDRIQAL GLHLPDPPLE SEDEDEEGAT ALNNHSSIPM 
DPEHVELVKR TMAGVSLPAP GVPAWAREIS DAQWEDVVQK ALQARQASPA WK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.