Details for: METTL1

Gene ID: 4234

Symbol: METTL1

Ensembl ID: ENSG00000037897

Description: methyltransferase 1, tRNA methylguanosine

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 60.7540
    Cell Significance Index: -9.4500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.2069
    Cell Significance Index: -8.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.9056
    Cell Significance Index: -9.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.3073
    Cell Significance Index: -8.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 14.6940
    Cell Significance Index: -9.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.7144
    Cell Significance Index: -8.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.5972
    Cell Significance Index: -10.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4343
    Cell Significance Index: -9.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7661
    Cell Significance Index: -10.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3627
    Cell Significance Index: 259.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9425
    Cell Significance Index: 56.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9292
    Cell Significance Index: 91.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7050
    Cell Significance Index: 18.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6190
    Cell Significance Index: 17.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5038
    Cell Significance Index: 454.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4877
    Cell Significance Index: 79.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3850
    Cell Significance Index: 28.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3783
    Cell Significance Index: 48.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3566
    Cell Significance Index: 18.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3537
    Cell Significance Index: 6.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3263
    Cell Significance Index: 22.5700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3224
    Cell Significance Index: 4.6200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.3065
    Cell Significance Index: 3.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2873
    Cell Significance Index: 7.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2861
    Cell Significance Index: 18.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2687
    Cell Significance Index: 12.1800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2262
    Cell Significance Index: 16.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2155
    Cell Significance Index: 95.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2042
    Cell Significance Index: 2.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2040
    Cell Significance Index: 23.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1890
    Cell Significance Index: 8.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1649
    Cell Significance Index: 4.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1597
    Cell Significance Index: 3.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1437
    Cell Significance Index: 78.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1378
    Cell Significance Index: 18.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1268
    Cell Significance Index: 2.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1242
    Cell Significance Index: 22.3900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1118
    Cell Significance Index: 1.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1092
    Cell Significance Index: 2.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1034
    Cell Significance Index: 12.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0981
    Cell Significance Index: 4.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0768
    Cell Significance Index: 2.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0639
    Cell Significance Index: 12.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0478
    Cell Significance Index: 1.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0415
    Cell Significance Index: 1.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0372
    Cell Significance Index: 0.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0344
    Cell Significance Index: 0.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0295
    Cell Significance Index: 1.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0127
    Cell Significance Index: 9.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0105
    Cell Significance Index: 0.6800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0096
    Cell Significance Index: 0.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0018
    Cell Significance Index: -0.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0045
    Cell Significance Index: -0.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0053
    Cell Significance Index: -9.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0075
    Cell Significance Index: -1.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0075
    Cell Significance Index: -0.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0079
    Cell Significance Index: -5.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0085
    Cell Significance Index: -15.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0086
    Cell Significance Index: -0.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0089
    Cell Significance Index: -6.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0097
    Cell Significance Index: -1.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0102
    Cell Significance Index: -15.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0104
    Cell Significance Index: -1.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0112
    Cell Significance Index: -15.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0134
    Cell Significance Index: -8.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0173
    Cell Significance Index: -6.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0184
    Cell Significance Index: -10.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0189
    Cell Significance Index: -5.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0202
    Cell Significance Index: -0.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0209
    Cell Significance Index: -1.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0225
    Cell Significance Index: -1.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0239
    Cell Significance Index: -10.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0257
    Cell Significance Index: -16.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0268
    Cell Significance Index: -3.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0381
    Cell Significance Index: -1.0700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0423
    Cell Significance Index: -1.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0577
    Cell Significance Index: -12.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0650
    Cell Significance Index: -9.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0863
    Cell Significance Index: -5.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0951
    Cell Significance Index: -7.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0984
    Cell Significance Index: -1.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1030
    Cell Significance Index: -2.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1117
    Cell Significance Index: -1.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1217
    Cell Significance Index: -9.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1399
    Cell Significance Index: -4.1100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1476
    Cell Significance Index: -1.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1526
    Cell Significance Index: -9.3800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1575
    Cell Significance Index: -1.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1581
    Cell Significance Index: -10.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1606
    Cell Significance Index: -4.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1644
    Cell Significance Index: -9.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1857
    Cell Significance Index: -9.7500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2023
    Cell Significance Index: -1.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2171
    Cell Significance Index: -5.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2186
    Cell Significance Index: -9.6700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2341
    Cell Significance Index: -1.9900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2358
    Cell Significance Index: -3.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2411
    Cell Significance Index: -8.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** METTL1 is a cytosolic enzyme that specifically methylates the guanosine nucleotide at position 7 (N7) of tRNA molecules. This modification is crucial for the proper folding and stability of tRNAs, as well as their interaction with ribosomes and aminoacyl-tRNA synthetases. METTL1 is highly expressed in various cell types, including respiratory basal cells, germ cells, and intestinal epithelial cells. Its expression is also elevated in immune cells, such as GABAergic interneurons and forebrain radial glial cells, suggesting a role in immune regulation. **Pathways and Functions:** METTL1 plays a crucial role in several cellular pathways, including: 1. **RNA metabolism:** METTL1 is involved in the processing and maturation of tRNAs, which is essential for protein synthesis. 2. **Protein binding:** The methylated tRNA molecules interact with ribosomes and aminoacyl-tRNA synthetases, ensuring the accurate translation of genetic information. 3. **Immune regulation:** METTL1 has been implicated in the regulation of immune responses, particularly in the context of tRNA-mediated immune recognition. 4. **Cellular stress response:** METTL1 has been shown to be upregulated in response to cellular stress, suggesting a role in the regulation of cellular stress responses. **Clinical Significance:** Dysregulation of METTL1 has been linked to several diseases, including: 1. **Neurological disorders:** METTL1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** METTL1 has been shown to be overexpressed in various types of cancer, including colorectal cancer and leukemia. 3. **Immune-mediated disorders:** METTL1 has been implicated in the regulation of immune responses, and its dysregulation has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, METTL1 is a critical enzyme involved in RNA modification and immune regulation. Its dysregulation has been linked to several diseases, highlighting its importance as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which METTL1 regulates cellular processes and to develop effective therapeutic strategies for its dysregulation.

Genular Protein ID: 2397854373

Symbol: TRMB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UBP6 B2RBX1 H7BXF2 Q14105 Q53FS9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 29 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EMDB 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 11 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10329009

Title: Molecular analysis of METTL1, a novel human methyltransferase-like gene with a high degree of phylogenetic conservation.

PubMed ID: 10329009

DOI: 10.1006/geno.1999.5780

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12403464

Title: Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.

PubMed ID: 12403464

DOI: 10.1017/s1355838202024019

PubMed ID: 15861136

Title: The tRNA methylase METTL1 is phosphorylated and inactivated by PKB and RSK in vitro and in cells.

PubMed ID: 15861136

DOI: 10.1038/sj.emboj.7600648

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26751069

Title: Wuho is a new member in maintaining genome stability through its interaction with flap endonuclease 1.

PubMed ID: 26751069

DOI: 10.1371/journal.pbio.1002349

PubMed ID: 31031084

Title: Transcriptome-wide mapping of internal N7-methylguanosine methylome in mammalian mRNA.

PubMed ID: 31031084

DOI: 10.1016/j.molcel.2019.03.036

PubMed ID: 31031083

Title: METTL1 promotes let-7 microRNA processing via m7G methylation.

PubMed ID: 31031083

DOI: 10.1016/j.molcel.2019.03.040

PubMed ID: 34352207

Title: METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.

PubMed ID: 34352207

DOI: 10.1016/j.molcel.2021.06.031

PubMed ID: 34352206

Title: N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.

PubMed ID: 34352206

DOI: 10.1016/j.molcel.2021.07.003

PubMed ID: 34371184

Title: METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression.

PubMed ID: 34371184

DOI: 10.1016/j.ymthe.2021.08.005

PubMed ID: 37379838

Title: QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism.

PubMed ID: 37379838

DOI: 10.1016/j.cell.2023.05.047

PubMed ID: 37369656

Title: Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1.

PubMed ID: 37369656

DOI: 10.1038/s41421-023-00562-y

PubMed ID: 36599982

Title: Structures and mechanisms of tRNA methylation by METTL1-WDR4.

PubMed ID: 36599982

DOI: 10.1038/s41586-022-05565-5

PubMed ID: 36599985

Title: Structural basis of regulated m7G tRNA modification by METTL1-WDR4.

PubMed ID: 36599985

DOI: 10.1038/s41586-022-05566-4

Sequence Information:

  • Length: 276
  • Mass: 31471
  • Checksum: 715AE85A18632892
  • Sequence:
    • MAAETRNVAG AEAPPPQKRY YRQRAHSNPM ADHTLRYPVK PEEMDWSELY PEFFAPLTQN 
QSHDDPKDKK EKRAQAQVEF ADIGCGYGGL LVELSPLFPD TLILGLEIRV KVSDYVQDRI 
RALRAAPAGG FQNIACLRSN AMKHLPNFFY KGQLTKMFFL FPDPHFKRTK HKWRIISPTL 
LAEYAYVLRV GGLVYTITDV LELHDWMCTH FEEHPLFERV PLEDLSEDPV VGHLGTSTEE 
GKKVLRNGGK NFPAIFRRIQ DPVLQAVTSQ TSLPGH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.