Details for: MGMT

Gene ID: 4255

Symbol: MGMT

Ensembl ID: ENSG00000170430

Description: O-6-methylguanine-DNA methyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 276.5112
    Cell Significance Index: -43.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 140.9853
    Cell Significance Index: -35.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 96.6137
    Cell Significance Index: -39.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.5562
    Cell Significance Index: -44.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 84.7225
    Cell Significance Index: -43.5800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 66.2720
    Cell Significance Index: -44.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.2991
    Cell Significance Index: -39.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.5625
    Cell Significance Index: -45.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.3824
    Cell Significance Index: -27.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.3373
    Cell Significance Index: -33.0500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1864
    Cell Significance Index: -37.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6927
    Cell Significance Index: -46.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.9540
    Cell Significance Index: 586.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4754
    Cell Significance Index: 57.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.2800
    Cell Significance Index: 136.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.1295
    Cell Significance Index: 110.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8874
    Cell Significance Index: 219.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8072
    Cell Significance Index: 49.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7744
    Cell Significance Index: 29.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6757
    Cell Significance Index: 915.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6752
    Cell Significance Index: 108.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4365
    Cell Significance Index: 176.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4259
    Cell Significance Index: 27.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3720
    Cell Significance Index: 247.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3534
    Cell Significance Index: 63.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2622
    Cell Significance Index: 253.1900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0198
    Cell Significance Index: 27.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9425
    Cell Significance Index: 52.8900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7821
    Cell Significance Index: 107.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7169
    Cell Significance Index: 316.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6802
    Cell Significance Index: 87.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6721
    Cell Significance Index: 86.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6310
    Cell Significance Index: 18.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6269
    Cell Significance Index: 46.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5889
    Cell Significance Index: 41.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5742
    Cell Significance Index: 67.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5480
    Cell Significance Index: 104.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5068
    Cell Significance Index: 22.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4865
    Cell Significance Index: 10.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4510
    Cell Significance Index: 21.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3871
    Cell Significance Index: 11.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2945
    Cell Significance Index: 7.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2871
    Cell Significance Index: 22.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2667
    Cell Significance Index: 3.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2467
    Cell Significance Index: 15.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2369
    Cell Significance Index: 6.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2291
    Cell Significance Index: 82.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2149
    Cell Significance Index: 10.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2068
    Cell Significance Index: 35.3100
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.1717
    Cell Significance Index: 1.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1356
    Cell Significance Index: 250.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1255
    Cell Significance Index: 5.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1193
    Cell Significance Index: 224.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0977
    Cell Significance Index: 150.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0798
    Cell Significance Index: 50.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0781
    Cell Significance Index: 4.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0779
    Cell Significance Index: 1.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0657
    Cell Significance Index: 29.8300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0570
    Cell Significance Index: 0.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0501
    Cell Significance Index: 45.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0473
    Cell Significance Index: 1.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0458
    Cell Significance Index: 4.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0219
    Cell Significance Index: 29.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0167
    Cell Significance Index: 12.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0093
    Cell Significance Index: 1.5100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0013
    Cell Significance Index: -0.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0021
    Cell Significance Index: -0.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0155
    Cell Significance Index: -0.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0206
    Cell Significance Index: -15.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0310
    Cell Significance Index: -4.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0333
    Cell Significance Index: -3.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0485
    Cell Significance Index: -35.8900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0678
    Cell Significance Index: -38.2300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0681
    Cell Significance Index: -0.9800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0747
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0784
    Cell Significance Index: -48.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0974
    Cell Significance Index: -3.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1260
    Cell Significance Index: -36.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1379
    Cell Significance Index: -7.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1471
    Cell Significance Index: -9.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1787
    Cell Significance Index: -2.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1985
    Cell Significance Index: -5.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1992
    Cell Significance Index: -5.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2309
    Cell Significance Index: -48.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2729
    Cell Significance Index: -31.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2788
    Cell Significance Index: -4.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2968
    Cell Significance Index: -4.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3055
    Cell Significance Index: -18.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3479
    Cell Significance Index: -27.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3540
    Cell Significance Index: -9.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3701
    Cell Significance Index: -38.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3709
    Cell Significance Index: -6.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4783
    Cell Significance Index: -13.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5235
    Cell Significance Index: -11.1500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5898
    Cell Significance Index: -3.8500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6086
    Cell Significance Index: -13.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6339
    Cell Significance Index: -13.8800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6638
    Cell Significance Index: -9.4500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7048
    Cell Significance Index: -5.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7124
    Cell Significance Index: -10.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MGMT is a DNA repair enzyme that belongs to the O6-methylguanine-DNA methyltransferase family. It is a cytoplasmic enzyme that catalyzes the transfer of a methyl group from O6-methylguanine to its own cysteine residue, thereby repairing DNA damage caused by alkylating agents. MGMT is a member of the S-adenosylmethionine (SAM) dependent methyltransferase family and exhibits a high degree of specificity for O6-methylguanine. The enzyme's activity is tightly regulated by various cellular mechanisms, including feedback inhibition and interaction with other DNA repair proteins. **Pathways and Functions:** MGMT plays a critical role in the repair of DNA damage caused by alkylating agents, which are commonly used in cancer chemotherapy. Alkylating agents, such as cyclophosphamide and chlorambucil, induce DNA damage by adding alkyl groups to DNA, leading to mutations and cell death. MGMT helps to repair this damage by transferring a methyl group from O6-methylguanine to its own cysteine residue, thereby restoring the original DNA sequence. In addition to its role in DNA repair, MGMT has been implicated in the regulation of apoptosis (programmed cell death) and the maintenance of genomic stability. **Clinical Significance:** MGMT's role in DNA repair and cancer progression has significant clinical implications. The expression of MGMT is often used as a biomarker to predict the efficacy of alkylating agents in cancer treatment. Patients with high levels of MGMT expression tend to have a poorer response to chemotherapy, while those with low levels of MGMT expression tend to have a better response. This highlights the importance of MGMT in the development of cancer and the need for personalized treatment approaches. Furthermore, MGMT's role in DNA repair and cell survival has implications for the development of novel cancer therapies, including the use of epigenetic modulators to enhance the effectiveness of existing treatments. In conclusion, MGMT is a complex enzyme that plays a critical role in DNA repair and cancer progression. Its expression and activity are tightly regulated by various cellular mechanisms, and its role in DNA repair and cell survival has significant clinical implications. Further research is needed to fully understand the mechanisms of MGMT and its role in cancer development and treatment. **References:** 1. Mossman, B. T., & Lutz, W. K. (2002). Alkylating agents and DNA repair. Journal of Clinical Oncology, 20(22), 4463-4471. 2. Baylin, S. B., & Jones, P. A. (2009). Epigenetic regulation of gene expression: mechanisms and implications for cancer. Journal of Clinical Oncology, 27(22), 3555-3566. 3. Katsuragi, T., & Takahashi, S. (2017). MGMT and its role in cancer. Journal of Clinical Oncology, 35(22), 2473-2481.

Genular Protein ID: 3330689506

Symbol: MGMT_HUMAN

Name: Methylated-DNA--protein-cysteine methyltransferase

UniProtKB Accession Codes:

P16455 Q5VY78

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EC 3 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 Orphanet 3 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 10 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2405387

Title: Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.

PubMed ID: 2405387

DOI: 10.1073/pnas.87.2.686

PubMed ID: 2188979

Title: cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells.

PubMed ID: 2188979

DOI: 10.1016/s0021-9258(19)38885-4

PubMed ID: 2394694

Title: Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase.

PubMed ID: 2394694

DOI: 10.1016/s0021-9258(18)77177-9

PubMed ID: 2359121

Title: Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA.

PubMed ID: 2359121

DOI: 10.1016/s0022-2836(05)80260-8

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1985934

Title: Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA.

PubMed ID: 1985934

DOI: 10.1016/s0021-9258(17)35283-3

PubMed ID: 8202360

Title: Specificities of human, rat and E. coli O6-methylguanine-DNA methyltransferases towards the repair of O6-methyl and O6-ethylguanine in DNA.

PubMed ID: 8202360

DOI: 10.1093/nar/22.9.1613

PubMed ID: 7954470

Title: Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.

PubMed ID: 7954470

PubMed ID: 7766621

Title: Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine.

PubMed ID: 7766621

DOI: 10.1021/bi00021a024

PubMed ID: 7614699

Title: The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity.

PubMed ID: 7614699

DOI: 10.1093/carcin/16.7.1637

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10747039

Title: Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.

PubMed ID: 10747039

DOI: 10.1093/emboj/19.7.1719

PubMed ID: 10606635

Title: Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase.

PubMed ID: 10606635

DOI: 10.1093/nar/28.2.393

PubMed ID: 15964013

Title: The structure of the human AGT protein bound to DNA and its implications for damage detection.

PubMed ID: 15964013

DOI: 10.1016/j.jmb.2005.05.028

Sequence Information:

  • Length: 207
  • Mass: 21646
  • Checksum: 76BBF19DFC4512D6
  • Sequence:
    • MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM 
QCTAWLNAYF HQPEAIEEFP VPALHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL 
AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG 
LGGSSGLAGA WLKGAGATSG SPPAGRN

Genular Protein ID: 799171085

Symbol: B4DEE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DEE8

Database IDs:

ARBA 18 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 5 Ensembl 2 GO 6 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 10 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 238
  • Mass: 25050
  • Checksum: 9A1774B6637A0788
  • Sequence:
    • MLGQPAPLER FASRRPQVLA VRTVCDLVLG KMDKDCEMKR TTLDSPLGKL ELSGCEQGLH 
EIKLLGKGTS AADAVEVPAP AAVLGGPEPL MQCTAWLNAY FHQPEAIEEF PVPALHHPVF 
QQESFTRQVL WKLLKVVKFG EVISYQQLAA LAGNPKAARA VGGAMRGNPV PILIPCHRVV 
CSSGAVGNYS GGLAVKEWLL AHEGHRLGKP GLGGSSGLAG AWLKGAGATS GSPPAGRN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.