Details for: MGMT
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 276.5112
Cell Significance Index: -43.0100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 140.9853
Cell Significance Index: -35.7600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 96.6137
Cell Significance Index: -39.2500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 93.5562
Cell Significance Index: -44.1700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 84.7225
Cell Significance Index: -43.5800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 66.2720
Cell Significance Index: -44.4700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 41.2991
Cell Significance Index: -39.4300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 36.5625
Cell Significance Index: -45.0800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 12.3824
Cell Significance Index: -27.1000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.3373
Cell Significance Index: -33.0500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.1864
Cell Significance Index: -37.4300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.6927
Cell Significance Index: -46.1400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.9540
Cell Significance Index: 586.2400 - Cell Name: peg cell (CL4033014)
Fold Change: 2.4754
Cell Significance Index: 57.1900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 2.2800
Cell Significance Index: 136.8800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.1295
Cell Significance Index: 110.6200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.8874
Cell Significance Index: 219.9500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.8072
Cell Significance Index: 49.1900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.7744
Cell Significance Index: 29.8900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.6757
Cell Significance Index: 915.1500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.6752
Cell Significance Index: 108.0800 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4365
Cell Significance Index: 176.6300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.4259
Cell Significance Index: 27.8300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3720
Cell Significance Index: 247.3200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.3534
Cell Significance Index: 63.1000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2622
Cell Significance Index: 253.1900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.0198
Cell Significance Index: 27.2800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.9425
Cell Significance Index: 52.8900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7821
Cell Significance Index: 107.4000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7169
Cell Significance Index: 316.9700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.6802
Cell Significance Index: 87.8800 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.6721
Cell Significance Index: 86.1600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6310
Cell Significance Index: 18.1800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.6269
Cell Significance Index: 46.7200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.5889
Cell Significance Index: 41.6500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5742
Cell Significance Index: 67.7200 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5480
Cell Significance Index: 104.2900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5068
Cell Significance Index: 22.9700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4865
Cell Significance Index: 10.5400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4510
Cell Significance Index: 21.2000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.3871
Cell Significance Index: 11.3700 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.2945
Cell Significance Index: 7.7500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2871
Cell Significance Index: 22.0400 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.2667
Cell Significance Index: 3.4100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2467
Cell Significance Index: 15.5500 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2369
Cell Significance Index: 6.6200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2291
Cell Significance Index: 82.1600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2149
Cell Significance Index: 10.8600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2068
Cell Significance Index: 35.3100 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.1717
Cell Significance Index: 1.4200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1356
Cell Significance Index: 250.1600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1255
Cell Significance Index: 5.5500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1193
Cell Significance Index: 224.6500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0977
Cell Significance Index: 150.4200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0798
Cell Significance Index: 50.6700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0781
Cell Significance Index: 4.0700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0779
Cell Significance Index: 1.6300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0657
Cell Significance Index: 29.8300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0570
Cell Significance Index: 0.5300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0501
Cell Significance Index: 45.2800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0473
Cell Significance Index: 1.7900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0458
Cell Significance Index: 4.5300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0219
Cell Significance Index: 29.8400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0167
Cell Significance Index: 12.2800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0093
Cell Significance Index: 1.5100 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.0013
Cell Significance Index: -0.0100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0021
Cell Significance Index: -0.0400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0155
Cell Significance Index: -0.5400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0206
Cell Significance Index: -15.5800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0310
Cell Significance Index: -4.5000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0333
Cell Significance Index: -3.4000 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0485
Cell Significance Index: -35.8900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0678
Cell Significance Index: -38.2300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.0681
Cell Significance Index: -0.9800 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0747
Cell Significance Index: -1.1200 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0784
Cell Significance Index: -48.9800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0974
Cell Significance Index: -3.1200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1260
Cell Significance Index: -36.2600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1379
Cell Significance Index: -7.2400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1471
Cell Significance Index: -9.8900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1787
Cell Significance Index: -2.1300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1985
Cell Significance Index: -5.3000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1992
Cell Significance Index: -5.0900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2309
Cell Significance Index: -48.6400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2729
Cell Significance Index: -31.2700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.2788
Cell Significance Index: -4.1200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2968
Cell Significance Index: -4.0500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3055
Cell Significance Index: -18.7800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3479
Cell Significance Index: -27.5500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3540
Cell Significance Index: -9.1000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3701
Cell Significance Index: -38.5400 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.3709
Cell Significance Index: -6.5500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.4783
Cell Significance Index: -13.6500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5235
Cell Significance Index: -11.1500 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.5898
Cell Significance Index: -3.8500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.6086
Cell Significance Index: -13.0100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.6339
Cell Significance Index: -13.8800 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.6638
Cell Significance Index: -9.4500 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.7048
Cell Significance Index: -5.9200 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.7124
Cell Significance Index: -10.2300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3330689506
Symbol: MGMT_HUMAN
Name: Methylated-DNA--protein-cysteine methyltransferase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2405387
Title: Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine.
PubMed ID: 2405387
PubMed ID: 2188979
Title: cDNA cloning and chromosomal assignment of the human O6-methylguanine-DNA methyltransferase. cDNA expression in Escherichia coli and gene expression in human cells.
PubMed ID: 2188979
PubMed ID: 2394694
Title: Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase.
PubMed ID: 2394694
PubMed ID: 2359121
Title: Expression and cloning of complementary DNA for a human enzyme that repairs O6-methylguanine in DNA.
PubMed ID: 2359121
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1985934
Title: Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA.
PubMed ID: 1985934
PubMed ID: 8202360
Title: Specificities of human, rat and E. coli O6-methylguanine-DNA methyltransferases towards the repair of O6-methyl and O6-ethylguanine in DNA.
PubMed ID: 8202360
PubMed ID: 7954470
Title: Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.
PubMed ID: 7954470
PubMed ID: 7766621
Title: Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine.
PubMed ID: 7766621
DOI: 10.1021/bi00021a024
PubMed ID: 7614699
Title: The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity.
PubMed ID: 7614699
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 10747039
Title: Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.
PubMed ID: 10747039
PubMed ID: 10606635
Title: Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase.
PubMed ID: 10606635
DOI: 10.1093/nar/28.2.393
PubMed ID: 15964013
Title: The structure of the human AGT protein bound to DNA and its implications for damage detection.
PubMed ID: 15964013
Sequence Information:
- Length: 207
- Mass: 21646
- Checksum: 76BBF19DFC4512D6
- Sequence:
MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM QCTAWLNAYF HQPEAIEEFP VPALHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG LGGSSGLAGA WLKGAGATSG SPPAGRN
Genular Protein ID: 799171085
Symbol: B4DEE8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15164054
Title: The DNA sequence and comparative analysis of human chromosome 10.
PubMed ID: 15164054
DOI: 10.1038/nature02462
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
Sequence Information:
- Length: 238
- Mass: 25050
- Checksum: 9A1774B6637A0788
- Sequence:
MLGQPAPLER FASRRPQVLA VRTVCDLVLG KMDKDCEMKR TTLDSPLGKL ELSGCEQGLH EIKLLGKGTS AADAVEVPAP AAVLGGPEPL MQCTAWLNAY FHQPEAIEEF PVPALHHPVF QQESFTRQVL WKLLKVVKFG EVISYQQLAA LAGNPKAARA VGGAMRGNPV PILIPCHRVV CSSGAVGNYS GGLAVKEWLL AHEGHRLGKP GLGGSSGLAG AWLKGAGATS GSPPAGRN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.