Details for: MLF1

Gene ID: 4291

Symbol: MLF1

Ensembl ID: ENSG00000178053

Description: myeloid leukemia factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 221.8647
    Cell Significance Index: -34.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 133.5339
    Cell Significance Index: -33.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.1268
    Cell Significance Index: -33.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.0620
    Cell Significance Index: -33.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 68.2080
    Cell Significance Index: -27.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.7093
    Cell Significance Index: -27.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.0626
    Cell Significance Index: -34.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.0872
    Cell Significance Index: -32.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7138
    Cell Significance Index: -34.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.2633
    Cell Significance Index: 173.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.1848
    Cell Significance Index: 137.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5037
    Cell Significance Index: 112.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4718
    Cell Significance Index: 42.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3492
    Cell Significance Index: 59.6800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.2788
    Cell Significance Index: 18.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2227
    Cell Significance Index: 46.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2188
    Cell Significance Index: 665.5900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.2045
    Cell Significance Index: 9.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1199
    Cell Significance Index: 13.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0182
    Cell Significance Index: 46.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0085
    Cell Significance Index: 52.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9880
    Cell Significance Index: 13.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9712
    Cell Significance Index: 125.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9385
    Cell Significance Index: 109.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7762
    Cell Significance Index: 155.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7603
    Cell Significance Index: 686.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6353
    Cell Significance Index: 62.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6330
    Cell Significance Index: 13.2500
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.6141
    Cell Significance Index: 1.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4866
    Cell Significance Index: 79.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4014
    Cell Significance Index: 51.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3995
    Cell Significance Index: 54.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3891
    Cell Significance Index: 10.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3640
    Cell Significance Index: 160.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3480
    Cell Significance Index: 16.3600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3370
    Cell Significance Index: 20.2300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3277
    Cell Significance Index: 5.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.2705
    Cell Significance Index: 1.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2695
    Cell Significance Index: 18.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2310
    Cell Significance Index: 41.6400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2305
    Cell Significance Index: 1.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2286
    Cell Significance Index: 7.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2168
    Cell Significance Index: 5.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2020
    Cell Significance Index: 24.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1718
    Cell Significance Index: 61.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1693
    Cell Significance Index: 11.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0980
    Cell Significance Index: 1.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0846
    Cell Significance Index: 58.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0835
    Cell Significance Index: 15.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0613
    Cell Significance Index: 2.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0531
    Cell Significance Index: 1.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0072
    Cell Significance Index: 13.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0042
    Cell Significance Index: 0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0037
    Cell Significance Index: 0.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0072
    Cell Significance Index: -0.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0106
    Cell Significance Index: -19.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0110
    Cell Significance Index: -8.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0129
    Cell Significance Index: -19.9100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0132
    Cell Significance Index: -6.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0146
    Cell Significance Index: -19.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0281
    Cell Significance Index: -21.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0314
    Cell Significance Index: -23.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0315
    Cell Significance Index: -20.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0469
    Cell Significance Index: -2.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0477
    Cell Significance Index: -4.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0506
    Cell Significance Index: -1.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0523
    Cell Significance Index: -29.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0602
    Cell Significance Index: -37.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0636
    Cell Significance Index: -12.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0955
    Cell Significance Index: -27.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1059
    Cell Significance Index: -6.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1120
    Cell Significance Index: -16.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1156
    Cell Significance Index: -3.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1232
    Cell Significance Index: -1.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1287
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1321
    Cell Significance Index: -22.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1480
    Cell Significance Index: -16.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1636
    Cell Significance Index: -34.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1639
    Cell Significance Index: -4.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1909
    Cell Significance Index: -10.7100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2103
    Cell Significance Index: -4.8600
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.2136
    Cell Significance Index: -1.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2172
    Cell Significance Index: -4.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2342
    Cell Significance Index: -3.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2548
    Cell Significance Index: -6.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2587
    Cell Significance Index: -30.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2684
    Cell Significance Index: -13.9800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2803
    Cell Significance Index: -1.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2983
    Cell Significance Index: -6.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3052
    Cell Significance Index: -24.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3191
    Cell Significance Index: -33.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3663
    Cell Significance Index: -22.4600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4243
    Cell Significance Index: -6.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4471
    Cell Significance Index: -13.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4599
    Cell Significance Index: -10.0700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.4692
    Cell Significance Index: -7.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5152
    Cell Significance Index: -33.2400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5744
    Cell Significance Index: -7.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5832
    Cell Significance Index: -6.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5907
    Cell Significance Index: -15.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MLF1 is a gene that exhibits a wide range of characteristics, including: 1. **Cellular specificity**: MLF1 is expressed in various cell types, such as ciliated columnar cells of the tracheobronchial tree, pancreatic A cells, fetal cardiomyocytes, and fibroblasts of the mammary gland. 2. **Regulation of cell cycle**: MLF1 is involved in regulating the G1/S phase transition, a critical checkpoint in the cell cycle that ensures proper DNA replication and cell division. 3. **DNA-templated transcription**: MLF1 regulates DNA-templated transcription, a process essential for gene expression and cellular differentiation. 4. **Protein binding**: MLF1 interacts with various proteins, including those involved in signal transduction by p53 class mediators. 5. **Multifunctional nature**: MLF1's functions are not limited to a single cellular process, but rather involve a complex interplay between multiple pathways. **Pathways and Functions:** MLF1's involvement in various cellular processes can be attributed to its participation in the following pathways: 1. **Cell cycle regulation**: MLF1 regulates the G1/S phase transition, ensuring proper DNA replication and cell division. 2. **DNA-templated transcription**: MLF1 regulates transcriptional activity, influencing gene expression and cellular differentiation. 3. **Signal transduction**: MLF1 interacts with proteins involved in signal transduction by p53 class mediators, modulating cellular responses to external stimuli. 4. **Ciliary function**: MLF1's expression in ciliated cells suggests its involvement in regulating ciliary function and motility. **Clinical Significance:** The study of MLF1 and its functions has significant implications for our understanding of various diseases, including: 1. **Cancer**: Dysregulation of MLF1's functions may contribute to cancer development and progression. 2. **Neurological disorders**: MLF1's involvement in ciliary function and signal transduction pathways may be relevant to neurological disorders, such as ciliopathy and neurodegenerative diseases. 3. **Cardiovascular disease**: MLF1's expression in cardiomyocytes and fibroblasts may be linked to cardiovascular disease, particularly in the context of cardiac remodeling and fibrosis. In conclusion, MLF1 is a multifaceted gene with far-reaching implications for our understanding of cellular regulation and disease. Further research is necessary to fully elucidate MLF1's functions and its role in various diseases, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 240054257

Symbol: MLF1_HUMAN

Name: Myeloid leukemia factor 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8570204

Title: The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.

PubMed ID: 8570204

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15116101

Title: cDNA cloning and characterization of a novel gene encoding the MLF1-interacting protein MLF1IP.

PubMed ID: 15116101

DOI: 10.1038/sj.onc.1207448

PubMed ID: 15861129

Title: Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3.

PubMed ID: 15861129

DOI: 10.1038/sj.emboj.7600656

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22151054

Title: Structural insights of the MLF1/14-3-3 interaction.

PubMed ID: 22151054

DOI: 10.1111/j.1742-4658.2011.08445.x

Sequence Information:

  • Length: 268
  • Mass: 30627
  • Checksum: 08774217329F737A
  • Sequence:
  • MFRMLNSSFE DDPFFSESIL AHRENMRQMI RSFSEPFGRD LLSISDGRGR AHNRRGHNDG 
    EDSLTHTDVS SFQTMDQMVS NMRNYMQKLE RNFGQLSVDP NGHSFCSSSV MTYSKIGDEP 
    PKVFQASTQT RRAPGGIKET RKAMRDSDSG LEKMAIGHHI HDRAHVIKKS KNKKTGDEEV 
    NQEFINMNES DAHAFDEEWQ SEVLKYKPGR HNLGNTRMRS VGHENPGSRE LKRREKPQQS 
    PAIEHGRRSN VLGDKLHIKG SSVKSNKK

Genular Protein ID: 2277235006

Symbol: Q5HYH4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 256
  • Mass: 28808
  • Checksum: 63B188D3DFA82062
  • Sequence:
  • MRQMIRSFSE PFGRDLLSIS DGRGRAHNRR GHNDGEDSLT ATSCSLVPFG DFGHTDVSSF 
    QTMDQMVSNM RNYMQKLERN FGQLSVDPNG HSFCSSSVMT YSKIGDEPPK VFQASTQTRR 
    APGGIKETRK AMRDSDSGLE KMAIGHHIHD RAHVIKKSKN KKTGDEEVNQ EFINMNESDA 
    HAFDEEWQSE VLKYKPGRHN LGNTRMRSVG HENPGSRELK RGEKPQQSPA IEHGRRSNVL 
    GDKLHIKGSS VKSNKK

Genular Protein ID: 3199779746

Symbol: A0A140VKD2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 243
  • Mass: 27625
  • Checksum: 061E87A385C3E063
  • Sequence:
  • MRQMIRSFSE PFGRDLLSIS DGRGRAHNRR GHNDGEDSLT HTDVSSFQTM DQMVSNMRNY 
    MQKLERNFGQ LSVDPNGHSF CSSSVMTYSK IGDEPPKVFQ ASTQTRRAPG GIKETRKAMR 
    DSDSGLEKMA IGHHIHDRAH VIKKSKNKKT GDEEVNQEFI NMNESDAHAF DEEWQSEVLK 
    YKPGRHNLGN TRMRSVGHEN PGSRELKRRE KPQQSPAIEH GRRSNVLGDK LHIKGSSVKS 
    NKK

Genular Protein ID: 517724634

Symbol: B2RD48_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 268
  • Mass: 30615
  • Checksum: 08706B173293837A
  • Sequence:
  • MFRMLNSSFE DDPFFSESTL AHRENMRQMI RSFSEPFGRD LLSISDGRGR AHNRRGHNDG 
    EDSLTHTDVS SFQTMDQMVS NMRNYMQKLE RNFGQLSVDP NGHSFCSSSV MTYSKIGDEP 
    PKVFQASTQT RRAPGGIKET RKAMRDSDSG LEKMAIGHHI HDRAHVIKKS KNKKTGDEEV 
    NQEFINMNES DAHAFDEEWQ SEVLKYKPGR HNLGNTRMRS VGHENPGSRE LKRREKPQQS 
    PAIEHGRRSN VLGDKLHIKG SSVKSNKK

Genular Protein ID: 2042308157

Symbol: Q2TLE4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 243
  • Mass: 27615
  • Checksum: 05D187A3860CE17C
  • Sequence:
  • MRQMIRSFSE PFGRDLLSIS DGRGRAHNRR GHNDGEDSLT HTDVSSFQTM DQMVSNMRNY 
    MQKLERNFGQ LSVDPNGHSF CSSSVMTYSK IGDEPPKVFQ ASTQTRRASG GIKETRKAMR 
    DSDSGLEKMA IGHHIHDRAH VIKKSKNKKT GDEEVNQEFI NMNESDAHAF DEEWQSEVLK 
    YKPGRHNLGN TRMRSVGHEN PGSRELKRRE KPQQSPAIEH GRRSNVLGDK LHIKGSSVKS 
    NKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.