MNAT1 | ENSG00000020426 | NCBI 4331

Details for: MNAT1

Gene ID: 4331

Symbol: MNAT1

Ensembl ID: ENSG00000020426

Description: MNAT1 component of CDK activating kinase

Associated with

Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cyclin a/b1/b2 associated events during g2/m transition
(R-HSA-69273)
Cyclin a:cdk2-associated events at s phase entry
(R-HSA-69656)
Cyclin d associated events in g1
(R-HSA-69231)
Cyclin e associated events during g1/s transition
(R-HSA-69202)
Disease
(R-HSA-1643685)
Dual incision in tc-ner
(R-HSA-6782135)
Epigenetic regulation of gene expression
(R-HSA-212165)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of incision complex in gg-ner
(R-HSA-5696395)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Formation of tc-ner pre-incision complex
(R-HSA-6781823)
Formation of the early elongation complex
(R-HSA-113418)
Formation of the hiv-1 early elongation complex
(R-HSA-167158)
G1 phase
(R-HSA-69236)
G1/s transition
(R-HSA-69206)
G2/m transition
(R-HSA-69275)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Hiv transcription initiation
(R-HSA-167161)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mrna capping
(R-HSA-72086)
Negative epigenetic regulation of rrna expression
(R-HSA-5250941)
Norc negatively regulates rrna expression
(R-HSA-427413)
Nucleotide excision repair
(R-HSA-5696398)
Rna pol ii ctd phosphorylation and interaction with ce
(R-HSA-77075)
Rna pol ii ctd phosphorylation and interaction with ce during hiv infection
(R-HSA-167160)
Rna polymerase ii hiv promoter escape
(R-HSA-167162)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii promoter escape
(R-HSA-73776)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rna polymerase ii transcription initiation
(R-HSA-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-HSA-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-HSA-73779)
Rna polymerase i promoter clearance
(R-HSA-73854)
Rna polymerase i promoter escape
(R-HSA-73772)
Rna polymerase i transcription
(R-HSA-73864)
Rna polymerase i transcription initiation
(R-HSA-73762)
Rna polymerase i transcription termination
(R-HSA-73863)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-HSA-8939236)
S phase
(R-HSA-69242)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Transcriptional regulation by runx1
(R-HSA-8878171)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Viral infection pathways
(R-HSA-9824446)
Adult heart development
(GO:0007512)
Cak-ercc2 complex
(GO:0070516)
Cyclin-dependent protein kinase holoenzyme complex
(GO:0000307)
Cyclin-dependent protein serine/threonine kinase activator activity
(GO:0061575)
Dna repair
(GO:0006281)
G1/s transition of mitotic cell cycle
(GO:0000082)
Negative regulation of apoptotic process
(GO:0043066)
Nucleoplasm
(GO:0005654)
Nucleotide-excision repair
(GO:0006289)
Positive regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0045737)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein binding
(GO:0005515)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to calcium ion
(GO:0051592)
Transcription factor tfiih core complex
(GO:0000439)
Transcription factor tfiih holo complex
(GO:0005675)
Transcription factor tfiik complex
(GO:0070985)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)
Ventricular system development
(GO:0021591)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 426.8855
Cell Significance Index: -66.4000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 254.5306
Cell Significance Index: -64.5600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 143.2890
Cell Significance Index: -67.6500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 133.1177
Cell Significance Index: -54.0800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 56.8425
Cell Significance Index: -54.2700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 55.4927
Cell Significance Index: -68.4200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 21.8227
Cell Significance Index: -58.4600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 20.8045
Cell Significance Index: -63.9000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.4858
Cell Significance Index: -69.0000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.2186
Cell Significance Index: -28.9300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 5.3870
Cell Significance Index: 138.4700
Cell Name: type I muscle cell (CL0002211)
Fold Change: 4.3878
Cell Significance Index: 107.0600
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 3.4225
Cell Significance Index: 42.4500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.3455
Cell Significance Index: 187.7300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.0398
Cell Significance Index: 609.7800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.0158
Cell Significance Index: 114.2000
Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.9317
Cell Significance Index: 70.3100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.8922
Cell Significance Index: 127.9300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.6716
Cell Significance Index: 164.2100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.5433
Cell Significance Index: 912.2300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.5150
Cell Significance Index: 499.1200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.4165
Cell Significance Index: 281.6200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.3487
Cell Significance Index: 157.9300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.2069
Cell Significance Index: 30.1100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.8594
Cell Significance Index: 142.6900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.5457
Cell Significance Index: 44.1100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.4924
Cell Significance Index: 147.6400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.3258
Cell Significance Index: 916.9700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.2776
Cell Significance Index: 207.8000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.0101
Cell Significance Index: 28.2300
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.9814
Cell Significance Index: 20.9800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8876
Cell Significance Index: 484.7400
Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.8485
Cell Significance Index: 13.6900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8287
Cell Significance Index: 149.3800
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8164
Cell Significance Index: 100.3800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7267
Cell Significance Index: 79.0400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6044
Cell Significance Index: 545.7300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4500
Cell Significance Index: 12.0200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4362
Cell Significance Index: 192.8400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.4207
Cell Significance Index: 7.2100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3090
Cell Significance Index: 42.4400
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2875
Cell Significance Index: 14.9400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2741
Cell Significance Index: 12.7800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2279
Cell Significance Index: 6.5700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2206
Cell Significance Index: 10.3700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1856
Cell Significance Index: 349.4300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1682
Cell Significance Index: 11.6400
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1442
Cell Significance Index: 2.8200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1314
Cell Significance Index: 9.2900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1149
Cell Significance Index: 5.2100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1002
Cell Significance Index: 12.8500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0820
Cell Significance Index: 52.0700
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0815
Cell Significance Index: 36.9700
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.0614
Cell Significance Index: 0.5400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0611
Cell Significance Index: 112.6600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0595
Cell Significance Index: 91.6300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0510
Cell Significance Index: 9.7000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0364
Cell Significance Index: 4.3000
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0055
Cell Significance Index: -0.1500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0091
Cell Significance Index: -12.3800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0239
Cell Significance Index: -0.8400
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0374
Cell Significance Index: -27.4000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0615
Cell Significance Index: -45.5400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0669
Cell Significance Index: -50.6200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0925
Cell Significance Index: -15.7900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1109
Cell Significance Index: -62.5300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1211
Cell Significance Index: -75.6500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1260
Cell Significance Index: -7.9400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1266
Cell Significance Index: -16.3600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1321
Cell Significance Index: -1.5800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2070
Cell Significance Index: -59.5500
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2223
Cell Significance Index: -3.2800
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2244
Cell Significance Index: -32.6200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2247
Cell Significance Index: -7.8100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2489
Cell Significance Index: -25.4300
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.2502
Cell Significance Index: -3.1200
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2907
Cell Significance Index: -6.3700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3309
Cell Significance Index: -69.6900
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.3545
Cell Significance Index: -5.0900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3743
Cell Significance Index: -19.6500
Cell Name: adipocyte of breast (CL0002617)
Fold Change: -0.3852
Cell Significance Index: -4.8500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3895
Cell Significance Index: -29.0300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.3961
Cell Significance Index: -20.6300
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4461
Cell Significance Index: -28.7800
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.4637
Cell Significance Index: -4.8300
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4853
Cell Significance Index: -13.0100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4879
Cell Significance Index: -55.9000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5479
Cell Significance Index: -57.0500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5997
Cell Significance Index: -14.9900
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.6185
Cell Significance Index: -12.2300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.6199
Cell Significance Index: -13.4300
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.6346
Cell Significance Index: -8.0100
Cell Name: peg cell (CL4033014)
Fold Change: -0.6568
Cell Significance Index: -15.1800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6607
Cell Significance Index: -52.3300
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.7955
Cell Significance Index: -5.3900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.8161
Cell Significance Index: -26.7200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8361
Cell Significance Index: -26.6300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8413
Cell Significance Index: -51.5800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.8453
Cell Significance Index: -17.9400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.0038
Cell Significance Index: -16.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** MNAT1 is a component of the CDK-activating kinase complex, which is a crucial regulator of cell cycle progression. The protein is involved in the assembly of this complex, which in turn activates cyclin-dependent kinases (CDKs). CDKs are essential for the progression of cells through the cell cycle, and their dysregulation can lead to various diseases. **Pathways and Functions** MNAT1 is involved in several cellular pathways, including: 1. **Cell Cycle Regulation**: MNAT1 plays a crucial role in the regulation of cell cycle progression, particularly during the G1/S transition and G2/M phases. 2. **DNA Repair**: MNAT1 is involved in the regulation of DNA repair pathways, including nucleotide excision repair (NER) and global genome NER (GG-NER). 3. **Transcription Regulation**: MNAT1 regulates transcription by interacting with RNA polymerase II (RNAPII) and other transcription factors. 4. **Apoptosis Regulation**: MNAT1 negatively regulates the apoptotic process by interacting with pro-apoptotic proteins. **Clinical Significance** Dysregulation of MNAT1 has been implicated in various diseases, including: 1. **Cancer**: MNAT1 is overexpressed in various types of cancer, including breast, lung, and colorectal cancer. 2. **Cardiovascular Disorders**: MNAT1 is involved in the regulation of smooth muscle cell proliferation, which is essential for cardiovascular health. 3. **Neurological Conditions**: MNAT1 is involved in the regulation of neuronal differentiation and survival, which is essential for neurological health. **Implications for Immunology** MNAT1 has implications for immunology due to its involvement in various immune-related pathways, including: 1. **Antigen Presentation**: MNAT1 regulates the presentation of antigens by antigen-presenting cells (APCs). 2. **Immune Response**: MNAT1 modulates the immune response by regulating the activity of immune cells, including T cells and B cells. In conclusion, MNAT1 is a critical gene involved in various cellular processes, including cell cycle regulation, DNA repair, transcription regulation, and apoptosis regulation. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions. Further research is needed to fully understand the immunological significance of MNAT1 and its role in disease pathology.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

CDK-activating kinase assembly factor MAT1

Genular Protein ID: 4245035717

Symbol: MAT1_HUMAN

Name: CDK-activating kinase assembly factor MAT1

UniProtKB Accession Codes:

P51948 G3V1U8 Q15817 Q6ICQ7

Database IDs:

Citations:

PubMed ID: 8521818

Title: In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.

PubMed ID: 8521818

DOI: 10.1002/j.1460-2075.1995.tb00248.x

PubMed ID: 8521393

Title: Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor.

PubMed ID: 8521393

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9852112

Title: Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.

PubMed ID: 9852112

DOI: 10.1074/jbc.273.51.34444

PubMed ID: 10024882

Title: Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.

PubMed ID: 10024882

DOI: 10.1016/s1097-2765(00)80177-x

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11056162

Title: Solution structure of the N-terminal domain of the human TFIIH MAT1 subunit: new insights into the RING finger family.

PubMed ID: 11056162

DOI: 10.1074/jbc.m007963200

Sequence Information:

Length: 309
Mass: 35823
Checksum: 6818DDE230E81A97
Sequence:

MDDQGCPRCK TTKYRNPSLK LMVNVCGHTL CESCVDLLFV RGAGNCPECG TPLRKSNFRV 
QLFEDPTVDK EVEIRKKVLK IYNKREEDFP SLREYNDFLE EVEEIVFNLT NNVDLDNTKK 
KMEIYQKENK DVIQKNKLKL TREQEELEEA LEVERQENEQ RRLFIQKEEQ LQQILKRKNK 
QAFLDELESS DLPVALLLAQ HKDRSTQLEM QLEKPKPVKP VTFSTGIKMG QHISLAPIHK 
LEEALYEYQP LQIETYGPHV PELEMLGRLG YLNHVRAASP QDLAGGYTSS LACHRALQDA 
FSGLFWQPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: MNAT1

Associated with

Cells (max top 100)

Other Information

In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. PubMed ID: 8521818

Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor. PubMed ID: 8521393

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. PubMed ID: 9852112

Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7. PubMed ID: 10024882

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Solution structure of the N-terminal domain of the human TFIIH MAT1 subunit: new insights into the RING finger family. PubMed ID: 11056162