Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 181.6835
Cell Significance Index: -28.2600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 99.7858
Cell Significance Index: -25.3100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 69.1471
Cell Significance Index: -28.4900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 64.4006
Cell Significance Index: -30.4100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 64.0112
Cell Significance Index: -26.0100 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 56.7474
Cell Significance Index: -29.1900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 45.4679
Cell Significance Index: -30.5100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 27.5153
Cell Significance Index: -26.2700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 24.8752
Cell Significance Index: -30.6700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.3253
Cell Significance Index: -27.6600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.6767
Cell Significance Index: -26.6500 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.8737
Cell Significance Index: -31.0700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.4379
Cell Significance Index: -14.0900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4673
Cell Significance Index: 294.3400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.1323
Cell Significance Index: 58.9800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.0045
Cell Significance Index: 44.4300 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9744
Cell Significance Index: 158.4800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.9710
Cell Significance Index: 36.7700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9425
Cell Significance Index: 169.9000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.9111
Cell Significance Index: 8.3900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.8454
Cell Significance Index: 16.5000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.8359
Cell Significance Index: 97.4200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.7973
Cell Significance Index: 41.4200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7494
Cell Significance Index: 92.1500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.7369
Cell Significance Index: 34.3600 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6985
Cell Significance Index: 9.5300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6522
Cell Significance Index: 89.5600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6159
Cell Significance Index: 60.9300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5729
Cell Significance Index: 113.6900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5399
Cell Significance Index: 193.6700 - Cell Name: peg cell (CL4033014)
Fold Change: 0.5324
Cell Significance Index: 12.3000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.5283
Cell Significance Index: 35.5300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4967
Cell Significance Index: 34.3500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4954
Cell Significance Index: 58.4200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4861
Cell Significance Index: 27.2800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4525
Cell Significance Index: 247.1000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.3820
Cell Significance Index: 7.0600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.3015
Cell Significance Index: 19.4500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3015
Cell Significance Index: 133.2900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2886
Cell Significance Index: 22.1500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2875
Cell Significance Index: 54.7100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2793
Cell Significance Index: 19.7500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2668
Cell Significance Index: 5.7800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2602
Cell Significance Index: 234.9200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2449
Cell Significance Index: 7.0200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2420
Cell Significance Index: 6.4900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2334
Cell Significance Index: 10.9700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2131
Cell Significance Index: 27.3200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.1687
Cell Significance Index: 4.8200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0930
Cell Significance Index: 2.6800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0817
Cell Significance Index: 5.0200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.0732
Cell Significance Index: 1.5700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0623
Cell Significance Index: 95.8700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0529
Cell Significance Index: 2.4000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0342
Cell Significance Index: 63.0800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0234
Cell Significance Index: 0.6300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0162
Cell Significance Index: 11.8800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0160
Cell Significance Index: 0.8400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0128
Cell Significance Index: 24.0500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0082
Cell Significance Index: 5.2100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0032
Cell Significance Index: -4.3700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0132
Cell Significance Index: -6.0000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0169
Cell Significance Index: -12.7800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0193
Cell Significance Index: -0.5200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0309
Cell Significance Index: -3.1600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0349
Cell Significance Index: -4.5100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0393
Cell Significance Index: -29.1300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0469
Cell Significance Index: -1.3100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0484
Cell Significance Index: -8.2600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0497
Cell Significance Index: -3.1300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0512
Cell Significance Index: -28.8900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0550
Cell Significance Index: -34.3300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0725
Cell Significance Index: -5.4000 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0771
Cell Significance Index: -1.2900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0890
Cell Significance Index: -25.6100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1065
Cell Significance Index: -3.4100 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.1099
Cell Significance Index: -2.3400 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1120
Cell Significance Index: -1.9200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1130
Cell Significance Index: -16.4300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1160
Cell Significance Index: -2.5400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1517
Cell Significance Index: -5.3300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1552
Cell Significance Index: -17.7800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1618
Cell Significance Index: -4.2600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1650
Cell Significance Index: -34.7500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2463
Cell Significance Index: -6.3300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2553
Cell Significance Index: -20.2200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2656
Cell Significance Index: -7.2300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2701
Cell Significance Index: -28.1200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3148
Cell Significance Index: -10.9400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3269
Cell Significance Index: -7.8400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3644
Cell Significance Index: -18.4200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3681
Cell Significance Index: -9.4100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3919
Cell Significance Index: -11.5100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.4244
Cell Significance Index: -10.6100 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4470
Cell Significance Index: -6.6000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4923
Cell Significance Index: -30.1800 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.5633
Cell Significance Index: -11.7900 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.5738
Cell Significance Index: -4.8200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.5957
Cell Significance Index: -10.0400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.6530
Cell Significance Index: -6.7600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3251719241
Symbol: NBN_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9590180
Title: Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome.
PubMed ID: 9590180
PubMed ID: 9590181
Title: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
PubMed ID: 9590181
PubMed ID: 9620777
Title: Positional cloning of the gene for Nijmegen breakage syndrome.
PubMed ID: 9620777
DOI: 10.1038/549
PubMed ID: 9933573
Title: Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1.
PubMed ID: 9933573
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 9705271
Title: Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
PubMed ID: 9705271
PubMed ID: 10783165
Title: BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
PubMed ID: 10783165
PubMed ID: 10802669
Title: ATM-dependent phosphorylation of nibrin in response to radiation exposure.
PubMed ID: 10802669
DOI: 10.1038/75508
PubMed ID: 10839544
Title: Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products.
PubMed ID: 10839544
DOI: 10.1038/35013083
PubMed ID: 10766245
Title: ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway.
PubMed ID: 10766245
DOI: 10.1038/35007091
PubMed ID: 10839545
Title: ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response.
PubMed ID: 10839545
DOI: 10.1038/35013089
PubMed ID: 10888888
Title: Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres.
PubMed ID: 10888888
DOI: 10.1038/77139
PubMed ID: 11238951
Title: Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization.
PubMed ID: 11238951
PubMed ID: 12470659
Title: Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein.
PubMed ID: 12470659
PubMed ID: 12419185
Title: NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain.
PubMed ID: 12419185
PubMed ID: 15064416
Title: Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
PubMed ID: 15064416
PubMed ID: 16188882
Title: Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1.
PubMed ID: 16188882
PubMed ID: 15916964
Title: ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.
PubMed ID: 15916964
PubMed ID: 15758953
Title: Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
PubMed ID: 15758953
DOI: 10.1038/nature03442
PubMed ID: 15616588
Title: Nbs1 is required for ATR-dependent phosphorylation events.
PubMed ID: 15616588
PubMed ID: 15790808
Title: ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex.
PubMed ID: 15790808
PubMed ID: 16467875
Title: The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control.
PubMed ID: 16467875
PubMed ID: 16622404
Title: Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex.
PubMed ID: 16622404
DOI: 10.1038/nsmb1090
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17823411
Title: Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.
PubMed ID: 17823411
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18583988
Title: Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage.
PubMed ID: 18583988
PubMed ID: 18411307
Title: Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin.
PubMed ID: 18411307
PubMed ID: 18582474
Title: Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites.
PubMed ID: 18582474
PubMed ID: 18678890
Title: MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks.
PubMed ID: 18678890
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19338747
Title: Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1.
PubMed ID: 19338747
PubMed ID: 19804756
Title: A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.
PubMed ID: 19804756
PubMed ID: 19759395
Title: N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair.
PubMed ID: 19759395
PubMed ID: 19683501
Title: SOSS complexes participate in the maintenance of genomic stability.
PubMed ID: 19683501
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20943970
Title: Physical interaction between the herpes simplex virus type 1 exonuclease, UL12, and the DNA double-strand break-sensing MRN complex.
PubMed ID: 20943970
DOI: 10.1128/jvi.01506-10
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23115235
Title: The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination.
PubMed ID: 23115235
PubMed ID: 22464731
Title: Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.
PubMed ID: 22464731
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23762398
Title: Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.
PubMed ID: 23762398
PubMed ID: 24534091
Title: Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.
PubMed ID: 24534091
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26438602
Title: Acetylation of histone H2AX at Lys 5 by the TIP60 histone acetyltransferase complex is essential for the dynamic binding of NBS1 to damaged chromatin.
PubMed ID: 26438602
DOI: 10.1128/mcb.00757-15
PubMed ID: 26215093
Title: MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex.
PubMed ID: 26215093
DOI: 10.1038/ncomms8744
PubMed ID: 27568553
Title: MRNIP/C5orf45 interacts with the MRN complex and contributes to the DNA damage response.
PubMed ID: 27568553
PubMed ID: 27814491
Title: Nbs1 converts the human Mre11/Rad50 nuclease complex into an endo/exonuclease machine specific for protein-DNA adducts.
PubMed ID: 27814491
PubMed ID: 27889449
Title: Phosphorylated CtIP functions as a co-factor of the MRE11-RAD50-NBS1 endonuclease in DNA end resection.
PubMed ID: 27889449
PubMed ID: 28867292
Title: Single-molecule imaging reveals how Mre11-Rad50-Nbs1 initiates DNA break repair.
PubMed ID: 28867292
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30886146
Title: UFL1 promotes histone H4 ufmylation and ATM activation.
PubMed ID: 30886146
PubMed ID: 30787182
Title: NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation.
PubMed ID: 30787182
PubMed ID: 30952868
Title: Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks.
PubMed ID: 30952868
PubMed ID: 31537797
Title: MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts.
PubMed ID: 31537797
PubMed ID: 33836577
Title: A conserved Ctp1/CtIP C-terminal peptide stimulates Mre11 endonuclease activity.
PubMed ID: 33836577
PubMed ID: 28216226
Title: NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres.
PubMed ID: 28216226
PubMed ID: 35076389
Title: Structure of the human ATM kinase and mechanism of Nbs1 binding.
PubMed ID: 35076389
DOI: 10.7554/elife.74218
PubMed ID: 36577401
Title: Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions.
PubMed ID: 36577401
PubMed ID: 11325820
Title: Mutations in the Nijmegen breakage syndrome gene (NBS1) in childhood acute lymphoblastic leukemia (ALL).
PubMed ID: 11325820
PubMed ID: 14684699
Title: Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility.
PubMed ID: 14684699
PubMed ID: 14688016
Title: Polymorphisms in DNA repair and metabolic genes in bladder cancer.
PubMed ID: 14688016
PubMed ID: 15338273
Title: First case of aplastic anemia in a Japanese child with a homozygous missense mutation in the NBS1 gene (I171V) associated with genomic instability.
PubMed ID: 15338273
PubMed ID: 21248752
Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.
PubMed ID: 21248752
DOI: 10.1038/nature09639
Sequence Information:
- Length: 754
- Mass: 84959
- Checksum: CD602F09BA73DAB6
- Sequence:
MWKLLPAAGP AGGEPYRLLT GVEYVVGRKN CAILIENDQS ISRNHAVLTA NFSVTNLSQT DEIPVLTLKD NSKYGTFVNE EKMQNGFSRT LKSGDGITFG VFGSKFRIEY EPLVACSSCL DVSGKTALNQ AILQLGGFTV NNWTEECTHL VMVSVKVTIK TICALICGRP IVKPEYFTEF LKAVESKKQP PQIESFYPPL DEPSIGSKNV DLSGRQERKQ IFKGKTFIFL NAKQHKKLSS AVVFGGGEAR LITEENEEEH NFFLAPGTCV VDTGITNSQT LIPDCQKKWI QSIMDMLQRQ GLRPIPEAEI GLAVIFMTTK NYCDPQGHPS TGLKTTTPGP SLSQGVSVDE KLMPSAPVNT TTYVADTESE QADTWDLSER PKEIKVSKME QKFRMLSQDA PTVKESCKTS SNNNSMVSNT LAKMRIPNYQ LSPTKLPSIN KSKDRASQQQ QTNSIRNYFQ PSTKKRERDE ENQEMSSCKS ARIETSCSLL EQTQPATPSL WKNKEQHLSE NEPVDTNSDN NLFTDTDLKS IVKNSASKSH AAEKLRSNKK REMDDVAIED EVLEQLFKDT KPELEIDVKV QKQEEDVNVR KRPRMDIETN DTFSDEAVPE SSKISQENEI GKKRELKEDS LWSAKEISNN DKLQDDSEML PKKLLLTEFR SLVIKNSTSR NPSGINDDYG QLKNFKKFKK VTYPGAGKLP HIIGGSDLIA HHARKNTELE EWLRQEMEVQ NQHAKEESLA DDLFRYNPYL KRRR
Genular Protein ID: 4101678250
Symbol: A0A0C4DG07_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
Sequence Information:
- Length: 672
- Mass: 75969
- Checksum: 261AFBB31A0D3030
- Sequence:
MQNGFSRTLK SGDGITFGVF GSKFRIEYEP LVACSSCLDV SGKTALNQAI LQLGGFTVNN WTEECTHLVM VSVKVTIKTI CALICGRPIV KPEYFTEFLK AVESKKQPPQ IESFYPPLDE PSIGSKNVDL SGRQERKQIF KGKTFIFLNA KQHKKLSSAV VFGGGEARLI TEENEEEHNF FLAPGTCVVD TGITNSQTLI PDCQKKWIQS IMDMLQRQGL RPIPEAEIGL AVIFMTTKNY CDPQGHPSTG LKTTTPGPSL SQGVSVDEKL MPSAPVNTTT YVADTESEQA DTWDLSERPK EIKVSKMEQK FRMLSQDAPT VKESCKTSSN NNSMVSNTLA KMRIPNYQLS PTKLPSINKS KDRASQQQQT NSIRNYFQPS TKKRERDEEN QEMSSCKSAR IETSCSLLEQ TQPATPSLWK NKEQHLSENE PVDTNSDNNL FTDTDLKSIV KNSASKSHAA EKLRSNKKRE MDDVAIEDEV LEQLFKDTKP ELEIDVKVQK QEEDVNVRKR PRMDIETNDT FSDEAVPESS KISQENEIGK KRELKEDSLW SAKEISNNDK LQDDSEMLPK KLLLTEFRSL VIKNSTSRNP SGINDDYGQL KNFKKFKKVT YPGAGKLPHI IGGSDLIAHH ARKNTELEEW LRQEMEVQNQ HAKEESLADD LFRYNPYLKR RR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.