Details for: NDUFS8

Gene ID: 4728

Symbol: NDUFS8

Ensembl ID: ENSG00000110717

Description: NADH:ubiquinone oxidoreductase core subunit S8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 287.7298
    Cell Significance Index: -44.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 195.7473
    Cell Significance Index: -49.6500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 157.0952
    Cell Significance Index: -64.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 147.5666
    Cell Significance Index: -59.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 140.0907
    Cell Significance Index: -66.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 128.7751
    Cell Significance Index: -66.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 98.8641
    Cell Significance Index: -66.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 63.7240
    Cell Significance Index: -60.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 50.3668
    Cell Significance Index: -62.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.7712
    Cell Significance Index: -66.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.8329
    Cell Significance Index: -48.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.8645
    Cell Significance Index: -39.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.2343
    Cell Significance Index: -20.2100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.1989
    Cell Significance Index: 35.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.7845
    Cell Significance Index: 176.4500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.4042
    Cell Significance Index: 27.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.7442
    Cell Significance Index: 63.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.7000
    Cell Significance Index: 2437.9300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.5521
    Cell Significance Index: 34.8200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.5373
    Cell Significance Index: 23.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3333
    Cell Significance Index: 48.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2386
    Cell Significance Index: 275.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1966
    Cell Significance Index: 395.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1665
    Cell Significance Index: 98.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9764
    Cell Significance Index: 51.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.9270
    Cell Significance Index: 133.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9188
    Cell Significance Index: 1047.9200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.9069
    Cell Significance Index: 20.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.8438
    Cell Significance Index: 54.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.8058
    Cell Significance Index: 94.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6805
    Cell Significance Index: 100.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6086
    Cell Significance Index: 113.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5344
    Cell Significance Index: 72.1200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5173
    Cell Significance Index: 113.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4869
    Cell Significance Index: 204.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3475
    Cell Significance Index: 70.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3235
    Cell Significance Index: 585.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.2092
    Cell Significance Index: 42.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1085
    Cell Significance Index: 143.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0956
    Cell Significance Index: 29.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0667
    Cell Significance Index: 125.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0017
    Cell Significance Index: 64.6300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9237
    Cell Significance Index: 11.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9110
    Cell Significance Index: 57.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5873
    Cell Significance Index: 111.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5362
    Cell Significance Index: 68.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5180
    Cell Significance Index: 103.9200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4841
    Cell Significance Index: 5.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4366
    Cell Significance Index: 74.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4267
    Cell Significance Index: 69.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3288
    Cell Significance Index: 8.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2377
    Cell Significance Index: 47.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2295
    Cell Significance Index: 168.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2227
    Cell Significance Index: 11.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2092
    Cell Significance Index: 75.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1927
    Cell Significance Index: 145.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1813
    Cell Significance Index: 4.8400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1675
    Cell Significance Index: 4.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1510
    Cell Significance Index: 14.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1357
    Cell Significance Index: 4.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1299
    Cell Significance Index: 4.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0332
    Cell Significance Index: 0.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0292
    Cell Significance Index: 2.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0034
    Cell Significance Index: 6.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0201
    Cell Significance Index: -37.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0271
    Cell Significance Index: -2.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0322
    Cell Significance Index: -49.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0398
    Cell Significance Index: -24.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0482
    Cell Significance Index: -65.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0536
    Cell Significance Index: -0.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0545
    Cell Significance Index: -34.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0749
    Cell Significance Index: -42.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0839
    Cell Significance Index: -38.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1269
    Cell Significance Index: -2.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1458
    Cell Significance Index: -16.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1662
    Cell Significance Index: -19.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1713
    Cell Significance Index: -13.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1869
    Cell Significance Index: -53.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1882
    Cell Significance Index: -39.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2407
    Cell Significance Index: -6.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2976
    Cell Significance Index: -4.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3213
    Cell Significance Index: -46.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4219
    Cell Significance Index: -9.1400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4370
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4856
    Cell Significance Index: -55.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5818
    Cell Significance Index: -8.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6092
    Cell Significance Index: -63.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6116
    Cell Significance Index: -37.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6183
    Cell Significance Index: -16.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7345
    Cell Significance Index: -49.3900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7374
    Cell Significance Index: -8.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7809
    Cell Significance Index: -43.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8655
    Cell Significance Index: -24.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.8853
    Cell Significance Index: -21.6000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.9562
    Cell Significance Index: -7.3700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0143
    Cell Significance Index: -10.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0329
    Cell Significance Index: -63.3300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0496
    Cell Significance Index: -30.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1343
    Cell Significance Index: -33.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NDUFS8 is a mitochondrial protein that belongs to the NADH dehydrogenase (ubiquinone) family. It is a core subunit of the respiratory chain complex I, which is responsible for the transfer of electrons from NADH to ubiquinone. This process is essential for the production of ATP through the chemiosmotic coupling mechanism. NDUFS8 is characterized by its high degree of sequence conservation across species, indicating its critical role in mitochondrial function. The gene is also highly expressed in tissues that require high energy production, such as the kidney and erythroid progenitor cells. **Pathways and Functions:** NDUFS8 is involved in the following pathways: 1. **Aerobic Respiration:** NDUFS8 is a critical component of the respiratory chain complex I, which is essential for the transfer of electrons from NADH to ubiquinone, resulting in the production of ATP. 2. **Mitochondrial Electron Transport:** NDUFS8 is involved in the electron transport chain, which generates a proton motive force that drives ATP synthesis. 3. **Metabolism:** NDUFS8 is involved in the metabolism of fatty acids, amino acids, and glucose, which are essential for energy production. 4. **Response to Oxidative Stress:** NDUFS8 is involved in the response to oxidative stress, which is a condition characterized by an imbalance between the production of reactive oxygen species (ROS) and the ability of cells to detoxify them. **Clinical Significance:** Dysregulation of NDUFS8 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders:** NDUFS8 mutations have been associated with neurodegenerative disorders, such as Parkinson's disease and Huntington's disease. 2. **Metabolic Disorders:** NDUFS8 mutations have been associated with metabolic disorders, such as mitochondrial myopathies and diabetic cardiomyopathy. 3. **Cancer:** NDUFS8 mutations have been associated with an increased risk of cancer, particularly in the context of mitochondrial dysfunction. 4. **Mitochondrial Diseases:** NDUFS8 mutations have been associated with mitochondrial diseases, such as Kearns-Sayre syndrome and MELAS syndrome. In conclusion, NDUFS8 is a critical component of the mitochondrial respiratory chain complex I, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of NDUFS8 in mitochondrial function and disease, and to develop effective therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 2635616237

Symbol: NDUS8_HUMAN

Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

UniProtKB Accession Codes:

O00217 B2RB86 Q0VDA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9116042

Title: cDNA sequence and chromosomal localization of the NDUFS8 human gene coding for the 23 kDa subunit of the mitochondrial complex I.

PubMed ID: 9116042

DOI: 10.1016/s0167-4781(97)00020-1

PubMed ID: 9666055

Title: Genomic structure of the human NDUFS8 gene coding for the iron-sulfur TYKY subunit of the mitochondrial NADH:ubiquinone oxidoreductase.

PubMed ID: 9666055

DOI: 10.1016/s0378-1119(98)00275-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

PubMed ID: 9837812

Title: The first nuclear-encoded complex I mutation in a patient with Leigh syndrome.

PubMed ID: 9837812

DOI: 10.1086/302154

PubMed ID: 15159508

Title: Late-onset Leigh syndrome in a patient with mitochondrial complex I NDUFS8 mutations.

PubMed ID: 15159508

DOI: 10.1212/01.wnl.0000125251.56131.65

PubMed ID: 16142472

Title: Sequence analysis of nuclear genes encoding functionally important complex I subunits in children with encephalomyopathy.

PubMed ID: 16142472

DOI: 10.1007/s00109-005-0712-y

PubMed ID: 22499348

Title: Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing.

PubMed ID: 22499348

DOI: 10.1136/jmedgenet-2012-100846

Sequence Information:

  • Length: 210
  • Mass: 23705
  • Checksum: 8C3EBD205BFA0112
  • Sequence:
    • MRCLTTPMLL RALAQAARAG PPGGRSLHSS AVAATYKYVN MQDPEMDMKS VTDRAARTLL 
WTELFRGLGM TLSYLFREPA TINYPFEKGP LSPRFRGEHA LRRYPSGEER CIACKLCEAI 
CPAQAITIEA EPRADGSRRT TRYDIDMTKC IYCGFCQEAC PVDAIVEGPN FEFSTETHEE 
LLYNKEKLLN NGDKWEAEIA ANIQADYLYR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.