Details for: NDUFV3

Gene ID: 4731

Symbol: NDUFV3

Ensembl ID: ENSG00000160194

Description: NADH:ubiquinone oxidoreductase subunit V3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 268.6035
    Cell Significance Index: -41.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 180.8050
    Cell Significance Index: -45.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 134.1918
    Cell Significance Index: -55.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 109.3784
    Cell Significance Index: -51.6400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.0442
    Cell Significance Index: -44.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 95.6870
    Cell Significance Index: -49.2200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 76.9721
    Cell Significance Index: -51.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.8608
    Cell Significance Index: -44.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.6121
    Cell Significance Index: -48.8400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.1864
    Cell Significance Index: -46.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.2563
    Cell Significance Index: -52.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.7073
    Cell Significance Index: -39.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.8230
    Cell Significance Index: -19.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3518
    Cell Significance Index: 109.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.0692
    Cell Significance Index: 93.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8903
    Cell Significance Index: 25.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7477
    Cell Significance Index: 315.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6360
    Cell Significance Index: 15.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5941
    Cell Significance Index: 43.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5922
    Cell Significance Index: 195.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4307
    Cell Significance Index: 41.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4095
    Cell Significance Index: 769.7500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.2072
    Cell Significance Index: 10.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1996
    Cell Significance Index: 240.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1950
    Cell Significance Index: 75.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1527
    Cell Significance Index: 60.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1288
    Cell Significance Index: 224.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1013
    Cell Significance Index: 23.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0172
    Cell Significance Index: 52.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0042
    Cell Significance Index: 137.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8593
    Cell Significance Index: 308.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8527
    Cell Significance Index: 58.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8347
    Cell Significance Index: 64.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7462
    Cell Significance Index: 329.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7416
    Cell Significance Index: 52.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6505
    Cell Significance Index: 17.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6324
    Cell Significance Index: 29.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6048
    Cell Significance Index: 7.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6006
    Cell Significance Index: 102.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5554
    Cell Significance Index: 41.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5318
    Cell Significance Index: 68.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4813
    Cell Significance Index: 11.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4517
    Cell Significance Index: 23.5300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3712
    Cell Significance Index: 5.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3444
    Cell Significance Index: 44.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3198
    Cell Significance Index: 52.0200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2573
    Cell Significance Index: 3.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1634
    Cell Significance Index: 147.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1622
    Cell Significance Index: 9.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1147
    Cell Significance Index: 2.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1018
    Cell Significance Index: 19.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0787
    Cell Significance Index: 5.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0744
    Cell Significance Index: 8.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0692
    Cell Significance Index: 1.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0677
    Cell Significance Index: 49.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0621
    Cell Significance Index: 116.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0517
    Cell Significance Index: 39.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0291
    Cell Significance Index: 1.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0274
    Cell Significance Index: 50.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0227
    Cell Significance Index: 34.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0056
    Cell Significance Index: 3.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0032
    Cell Significance Index: 1.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0003
    Cell Significance Index: 0.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0037
    Cell Significance Index: -2.7400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0269
    Cell Significance Index: -18.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0323
    Cell Significance Index: -20.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0473
    Cell Significance Index: -4.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0593
    Cell Significance Index: -33.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0655
    Cell Significance Index: -2.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0941
    Cell Significance Index: -9.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1129
    Cell Significance Index: -1.8900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1139
    Cell Significance Index: -23.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1481
    Cell Significance Index: -42.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1558
    Cell Significance Index: -2.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1822
    Cell Significance Index: -26.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2066
    Cell Significance Index: -23.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2204
    Cell Significance Index: -1.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2484
    Cell Significance Index: -28.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2867
    Cell Significance Index: -32.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3184
    Cell Significance Index: -21.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3354
    Cell Significance Index: -26.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3425
    Cell Significance Index: -10.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3435
    Cell Significance Index: -8.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4385
    Cell Significance Index: -11.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4420
    Cell Significance Index: -15.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4500
    Cell Significance Index: -46.8600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5103
    Cell Significance Index: -12.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5662
    Cell Significance Index: -16.2300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5901
    Cell Significance Index: -36.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5914
    Cell Significance Index: -17.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6626
    Cell Significance Index: -13.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7083
    Cell Significance Index: -18.9800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.7616
    Cell Significance Index: -5.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7745
    Cell Significance Index: -19.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8118
    Cell Significance Index: -23.1700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8433
    Cell Significance Index: -8.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8503
    Cell Significance Index: -22.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9953
    Cell Significance Index: -23.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.0113
    Cell Significance Index: -17.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NDUFV3 is a mitochondrial protein encoded by the ENSG00000160194 gene. It belongs to the NADH dehydrogenase (ubiquinone) family and is a subunit of the respiratory chain complex I. NDUV3 is a flavoprotein, containing a FAD cofactor essential for its enzymatic activity. The protein is highly conserved across species, suggesting its fundamental importance in mitochondrial function. NDUV3 is primarily expressed in cells with high energy requirements, such as myeloid leukocytes, erythroid progenitor cells, and kidney collecting duct intercalated cells. **Pathways and Functions** NDUFV3 is integral to several key pathways, including: 1. **Aerobic Respiration**: NDUV3 facilitates the transfer of electrons from NADH to ubiquinone, generating a proton gradient across the mitochondrial inner membrane. 2. **Mitochondrial Electron Transport**: NDUV3 is a critical component of the respiratory chain complex I, responsible for the transfer of electrons and the production of ATP through oxidative phosphorylation. 3. **Protein Binding**: NDUV3 interacts with other mitochondrial proteins, including cytochrome c oxidase and ATP synthase, to regulate the electron transport chain. 4. **Heat Production**: NDUV3 is involved in the regulation of heat production by uncoupling proteins, which can affect cellular metabolism and energy homeostasis. **Clinical Significance** Dysregulation of NDUV3 has been implicated in various diseases, including: 1. **Neurodegenerative Disorders**: Mutations in the NDUFA1 gene, which encodes a related subunit, have been associated with neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 2. **Metabolic Disorders**: Abnormalities in NDUV3 expression or function have been linked to metabolic disorders, such as diabetes and obesity. 3. **Cancer**: NDUV3 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma. 4. **Mitochondrial Myopathies**: Mutations in the NDUFA1 gene have also been associated with mitochondrial myopathies, such as Kearns-Sayre syndrome and MERRF syndrome. In conclusion, NDUV3 is a critical component of the mitochondrial respiratory chain complex I, playing a vital role in maintaining cellular energy homeostasis. Abnormalities in NDUV3 expression or function have been linked to various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the mechanisms underlying NDUV3 dysfunction and to develop therapeutic strategies to mitigate its effects.

Genular Protein ID: 27027218

Symbol: NDUV3_HUMAN

Name: NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

UniProtKB Accession Codes:

P56181 A8K0M1 J3KNX7 Q6FGD3 Q8WU60 Q9HCR5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 13 Ensembl 2 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9344673

Title: Molecular cloning and characterization of the human mitochondrial NADH:oxidoreductase 10-kDa gene (NDUFV3).

PubMed ID: 9344673

DOI: 10.1006/geno.1997.4930

PubMed ID: 10950923

Title: Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region.

PubMed ID: 10950923

DOI: 10.1006/geno.2000.6253

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27626371

Title: Accessory subunits are integral for assembly and function of human mitochondrial complex I.

PubMed ID: 27626371

DOI: 10.1038/nature19754

Sequence Information:

  • Length: 108
  • Mass: 11941
  • Checksum: BD7375474AB0B1EC
  • Sequence:
    • MAAPCLLRQG RAGALKTMLQ EAQVFRGLAS TVSLSAESGK SEKGQPQNSK KQSPPKKPAP 
VPAEPFDNTT YKNLQHHDYS TYTFLDLNLE LSKFRMPQPS SGRESPRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.