Details for: NEDD8
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 539.5858
Cell Significance Index: -83.9300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 321.5933
Cell Significance Index: -81.5700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 253.6973
Cell Significance Index: -104.5100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 231.0417
Cell Significance Index: -109.0800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 197.4590
Cell Significance Index: -101.5700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 163.5415
Cell Significance Index: -109.7400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 81.5966
Cell Significance Index: -100.6100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 27.5212
Cell Significance Index: -108.6000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 26.1830
Cell Significance Index: -80.4200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.8173
Cell Significance Index: -47.7300 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 9.6411
Cell Significance Index: 240.4200 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.5669
Cell Significance Index: 74.6600 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.3702
Cell Significance Index: 98.9800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.0702
Cell Significance Index: 421.6300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.0239
Cell Significance Index: 140.9900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.9876
Cell Significance Index: 33.9400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.9537
Cell Significance Index: 363.1800 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.9439
Cell Significance Index: 77.4100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.9286
Cell Significance Index: 137.6400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.8220
Cell Significance Index: 508.7100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.7591
Cell Significance Index: 1506.8100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.6607
Cell Significance Index: 139.7000 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.6126
Cell Significance Index: 20.8600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.2099
Cell Significance Index: 20.3500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.1684
Cell Significance Index: 139.9000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.9938
Cell Significance Index: 881.5000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.9203
Cell Significance Index: 52.2700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.8877
Cell Significance Index: 140.6900 - Cell Name: odontoblast (CL0000060)
Fold Change: 1.8442
Cell Significance Index: 236.4200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.6004
Cell Significance Index: 113.1900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.5947
Cell Significance Index: 188.0600 - Cell Name: peg cell (CL4033014)
Fold Change: 1.5621
Cell Significance Index: 36.0900 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.4959
Cell Significance Index: 193.2600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.2751
Cell Significance Index: 66.2400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9587
Cell Significance Index: 192.3100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.9488
Cell Significance Index: 32.9700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9071
Cell Significance Index: 89.7300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.8792
Cell Significance Index: 16.2500 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.8693
Cell Significance Index: 9.4500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.7682
Cell Significance Index: 13.5800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.5248
Cell Significance Index: 151.0100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4491
Cell Significance Index: 76.6800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4027
Cell Significance Index: 8.7300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3406
Cell Significance Index: 122.1600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2542
Cell Significance Index: 192.4100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2377
Cell Significance Index: 45.2400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1332
Cell Significance Index: 2.2300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1307
Cell Significance Index: 3.4900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.1071
Cell Significance Index: 5.4100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0963
Cell Significance Index: 70.5900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0083
Cell Significance Index: -6.1200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0509
Cell Significance Index: -5.2000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0565
Cell Significance Index: -106.2900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0578
Cell Significance Index: -36.0800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0704
Cell Significance Index: -129.9000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0843
Cell Significance Index: -129.7600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0960
Cell Significance Index: -130.5300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1150
Cell Significance Index: -64.8600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1492
Cell Significance Index: -94.7300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1605
Cell Significance Index: -4.6300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1674
Cell Significance Index: -4.8000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1944
Cell Significance Index: -40.9400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2108
Cell Significance Index: -24.1500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2368
Cell Significance Index: -107.4600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2640
Cell Significance Index: -30.7700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.3655
Cell Significance Index: -59.4400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.4149
Cell Significance Index: -14.5800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4393
Cell Significance Index: -27.6900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4427
Cell Significance Index: -11.3100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.4839
Cell Significance Index: -96.0300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.5442
Cell Significance Index: -22.3000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6768
Cell Significance Index: -53.6000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7309
Cell Significance Index: -106.2400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.7937
Cell Significance Index: -54.8900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.8581
Cell Significance Index: -18.2800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.8741
Cell Significance Index: -39.6200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8889
Cell Significance Index: -28.4700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.8901
Cell Significance Index: -101.6000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.9746
Cell Significance Index: -74.7900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.0193
Cell Significance Index: -57.2000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0533
Cell Significance Index: -109.6700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.1941
Cell Significance Index: -33.3700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.3183
Cell Significance Index: -7.9700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.4282
Cell Significance Index: -21.4000 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -1.5619
Cell Significance Index: -9.6100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.7201
Cell Significance Index: -46.0900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.7392
Cell Significance Index: -106.6300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.7413
Cell Significance Index: -51.2900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.8762
Cell Significance Index: -82.9900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.9401
Cell Significance Index: -26.4700 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.1167
Cell Significance Index: -17.7800 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -2.1336
Cell Significance Index: -44.5300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.2325
Cell Significance Index: -84.5400 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -2.2813
Cell Significance Index: -46.4200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.3132
Cell Significance Index: -81.0400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.3488
Cell Significance Index: -76.9000 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.3929
Cell Significance Index: -41.2500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.4250
Cell Significance Index: -89.0200 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -2.4745
Cell Significance Index: -31.6900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.6356
Cell Significance Index: -83.9400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 954541440
Symbol: NEDD8_HUMAN
Name: NEDD8
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9694792
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10318914
Title: Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function.
PubMed ID: 10318914
PubMed ID: 9353319
Title: Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein.
PubMed ID: 9353319
PubMed ID: 9790970
Title: Cleavage of the C-terminus of NEDD8 by UCH-L3.
PubMed ID: 9790970
PubMed ID: 10597293
Title: Covalent modification of all members of human cullin family proteins by NEDD8.
PubMed ID: 10597293
PubMed ID: 11259415
Title: NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression.
PubMed ID: 11259415
PubMed ID: 11953428
Title: The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105.
PubMed ID: 11953428
PubMed ID: 12215427
Title: Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor.
PubMed ID: 12215427
PubMed ID: 12730221
Title: NEDP1, a highly conserved cysteine protease that deneddylates cullins.
PubMed ID: 12730221
PubMed ID: 12759363
Title: DEN1 is a dual function protease capable of processing the C-terminus of Nedd8 and deconjugating hyper-neddylated CUL1.
PubMed ID: 12759363
PubMed ID: 15242646
Title: Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.
PubMed ID: 15242646
PubMed ID: 20850415
Title: The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1.
PubMed ID: 20850415
PubMed ID: 20688984
Title: Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family.
PubMed ID: 20688984
PubMed ID: 21903097
Title: Inhibition of cullin RING ligases by cycle inhibiting factor: evidence for interference with Nedd8-induced conformational control.
PubMed ID: 21903097
PubMed ID: 23589306
Title: The cyclomodulin cycle inhibiting factor (CIF) alters cullin neddylation dynamics.
PubMed ID: 23589306
PubMed ID: 26632597
Title: Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8.
PubMed ID: 26632597
DOI: 10.1038/ncomms10053
PubMed ID: 9857030
Title: Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes.
PubMed ID: 9857030
PubMed ID: 14690597
Title: The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
PubMed ID: 14690597
PubMed ID: 15567417
Title: Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1.
PubMed ID: 15567417
PubMed ID: 22691497
Title: The molecular basis of ubiquitin-like protein NEDD8 deamidation by the bacterial effector protein Cif.
PubMed ID: 22691497
PubMed ID: 23175788
Title: Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis.
PubMed ID: 23175788
Sequence Information:
- Length: 81
- Mass: 9072
- Checksum: DC2FE102BE4725D2
- Sequence:
MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK ILGGSVLHLV LALRGGGGLR Q
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.