Details for: NFYB

Gene ID: 4801

Symbol: NFYB

Ensembl ID: ENSG00000120837

Description: nuclear transcription factor Y subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 126.9084
    Cell Significance Index: -19.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.8182
    Cell Significance Index: -24.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.0319
    Cell Significance Index: -24.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.7649
    Cell Significance Index: -26.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.2113
    Cell Significance Index: -22.4300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.7341
    Cell Significance Index: -22.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.3714
    Cell Significance Index: -26.3500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7757
    Cell Significance Index: -20.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8917
    Cell Significance Index: -27.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8860
    Cell Significance Index: -21.1500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.3443
    Cell Significance Index: 91.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.1269
    Cell Significance Index: 147.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.6059
    Cell Significance Index: 1449.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5095
    Cell Significance Index: 175.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3956
    Cell Significance Index: 151.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2373
    Cell Significance Index: 201.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2313
    Cell Significance Index: 16.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8577
    Cell Significance Index: 29.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6872
    Cell Significance Index: 18.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6602
    Cell Significance Index: 90.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5691
    Cell Significance Index: 251.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5591
    Cell Significance Index: 35.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5582
    Cell Significance Index: 16.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5391
    Cell Significance Index: 294.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5319
    Cell Significance Index: 37.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5133
    Cell Significance Index: 63.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5127
    Cell Significance Index: 60.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4939
    Cell Significance Index: 99.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4314
    Cell Significance Index: 9.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4298
    Cell Significance Index: 20.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4253
    Cell Significance Index: 76.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3914
    Cell Significance Index: 20.5500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3845
    Cell Significance Index: 3.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3311
    Cell Significance Index: 7.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3272
    Cell Significance Index: 15.3800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2774
    Cell Significance Index: 35.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2577
    Cell Significance Index: 51.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2525
    Cell Significance Index: 24.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2019
    Cell Significance Index: 72.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1802
    Cell Significance Index: 8.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1721
    Cell Significance Index: 11.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1715
    Cell Significance Index: 4.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1660
    Cell Significance Index: 10.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1653
    Cell Significance Index: 8.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1102
    Cell Significance Index: 8.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0766
    Cell Significance Index: 4.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0737
    Cell Significance Index: 9.5200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0340
    Cell Significance Index: 0.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0327
    Cell Significance Index: 6.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0275
    Cell Significance Index: 1.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0216
    Cell Significance Index: 1.6600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0182
    Cell Significance Index: 0.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0073
    Cell Significance Index: 5.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0050
    Cell Significance Index: 9.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0046
    Cell Significance Index: 0.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0033
    Cell Significance Index: 0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0072
    Cell Significance Index: -13.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0078
    Cell Significance Index: -11.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0176
    Cell Significance Index: -23.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0177
    Cell Significance Index: -13.4100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0210
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0236
    Cell Significance Index: -4.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0288
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0327
    Cell Significance Index: -24.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0357
    Cell Significance Index: -5.2000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0438
    Cell Significance Index: -0.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0451
    Cell Significance Index: -25.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0476
    Cell Significance Index: -29.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0545
    Cell Significance Index: -5.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0657
    Cell Significance Index: -1.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0774
    Cell Significance Index: -22.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1364
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1489
    Cell Significance Index: -31.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1580
    Cell Significance Index: -18.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1774
    Cell Significance Index: -4.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1805
    Cell Significance Index: -12.1400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1925
    Cell Significance Index: -5.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2107
    Cell Significance Index: -16.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2325
    Cell Significance Index: -5.0400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2449
    Cell Significance Index: -25.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2568
    Cell Significance Index: -4.4000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2944
    Cell Significance Index: -7.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3084
    Cell Significance Index: -13.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3378
    Cell Significance Index: -8.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3608
    Cell Significance Index: -22.1200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3632
    Cell Significance Index: -3.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3762
    Cell Significance Index: -11.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3985
    Cell Significance Index: -15.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4058
    Cell Significance Index: -10.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4139
    Cell Significance Index: -12.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4669
    Cell Significance Index: -11.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5009
    Cell Significance Index: -5.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5042
    Cell Significance Index: -13.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5540
    Cell Significance Index: -15.8100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5769
    Cell Significance Index: -11.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5775
    Cell Significance Index: -12.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5784
    Cell Significance Index: -18.4200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5862
    Cell Significance Index: -4.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5896
    Cell Significance Index: -19.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The NFYB gene is a relatively small gene, with a length of approximately 1.5 kilobases. It is located on chromosome 9q34.3 and is highly conserved across species, suggesting its importance in fundamental biological processes. The NFYB protein is a subunit of the NFY complex, which is composed of three subunits: NFYB, NFYC, and NFYA. The NFYB subunit is responsible for binding to DNA and recruiting the NFY complex to specific transcriptional enhancers. **Pathways and Functions** The NFYB gene is involved in several key cellular pathways, including: 1. **Activation of gene expression by SREBF**: The NFYB subunit interacts with SREBF (Sterol Regulatory Element Binding Factor) to activate the expression of genes involved in lipid metabolism. 2. **Unfolded Protein Response (UPR)**: The NFYB subunit is involved in the UPR, a stress response pathway that regulates the expression of genes involved in protein folding and degradation. 3. **Chromatin Remodeling**: The NFYB subunit interacts with chromatin-modifying enzymes to regulate chromatin structure and gene expression. 4. **Metabolism**: The NFYB subunit is involved in regulating the expression of genes involved in lipid and steroid metabolism. **Clinical Significance** Dysregulation of the NFYB gene has been implicated in various diseases, including: 1. **Metabolic disorders**: Mutations in the NFYB gene have been associated with metabolic disorders, such as obesity and insulin resistance. 2. **Cancer**: The NFYB subunit is overexpressed in several types of cancer, including breast and lung cancer. 3. **Neurodegenerative diseases**: The NFYB subunit has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. In summary, the NFYB gene plays a crucial role in regulating gene expression in various cell types, and its dysregulation has been implicated in several diseases. Further studies are needed to fully understand the mechanisms by which the NFYB gene regulates gene expression and its role in disease pathogenesis.

Genular Protein ID: 282070003

Symbol: NFYB_HUMAN

Name: Nuclear transcription factor Y subunit beta

UniProtKB Accession Codes:

P25208 A8K7B9 Q96IY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1577736

Title: Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain.

PubMed ID: 1577736

DOI: 10.1016/s0021-9258(19)50377-5

PubMed ID: 1549471

Title: Evolutionary variation of the CCAAT-binding transcription factor NF-Y.

PubMed ID: 1549471

DOI: 10.1093/nar/20.5.1087

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15243141

Title: Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro.

PubMed ID: 15243141

DOI: 10.1093/nar/gkh692

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 12401788

Title: The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y.

PubMed ID: 12401788

DOI: 10.1074/jbc.m209635200

PubMed ID: 23332751

Title: Sequence-specific transcription factor NF-Y displays histone-like DNA binding and H2B-like ubiquitination.

PubMed ID: 23332751

DOI: 10.1016/j.cell.2012.11.047

Sequence Information:

  • Length: 207
  • Mass: 22831
  • Checksum: 1ADFA0E45F3CF972
  • Sequence:
    • MTMDGDSSTT DASQLGISAD YIGGSHYVIQ PHDDTEDSMN DHEDTNGSKE SFREQDIYLP 
IANVARIMKN AIPQTGKIAK DAKECVQECV SEFISFITSE ASERCHQEKR KTINGEDILF 
AMSTLGFDSY VEPLKLYLQK FREAMKGEKG IGGAVTATDG LSEELTEEAF TNQLPAGLIT 
TDGQQQNVMV YTTSYQQISG VQQIQFS

Genular Protein ID: 2355300300

Symbol: F8VSL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

F8VSL3

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 3 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 208
  • Mass: 22957
  • Checksum: E7A948B284D35126
  • Sequence:
    • MNLMDGDSST TDASQLGISA DYIGGSHYVI QPHDDTEDSM NDHEDTNGSK ESFREQDIYL 
PIANVARIMK NAIPQTGKIA KDAKECVQEC VSEFISFITS EASERCHQEK RKTINGEDIL 
FAMSTLGFDS YVEPLKLYLQ KFREAMKGEK GIGGAVTATD GLSEELTEEA FTNQLPAGLI 
TTDGQQQNVM VYTTSYQQIS GVQQIQFS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.