Details for: NKTR

Gene ID: 4820

Symbol: NKTR

Ensembl ID: ENSG00000114857

Description: natural killer cell triggering receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 682.7275
    Cell Significance Index: -106.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 391.5537
    Cell Significance Index: -99.3200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 275.5205
    Cell Significance Index: -113.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 242.0769
    Cell Significance Index: -114.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 231.0113
    Cell Significance Index: -93.8500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 210.8148
    Cell Significance Index: -108.4400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 170.3968
    Cell Significance Index: -114.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 98.8434
    Cell Significance Index: -94.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 90.7940
    Cell Significance Index: -111.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 37.5085
    Cell Significance Index: -100.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.0532
    Cell Significance Index: -98.4500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.7477
    Cell Significance Index: -113.4400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 25.7198
    Cell Significance Index: -56.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.8589
    Cell Significance Index: 216.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.2241
    Cell Significance Index: 62.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5467
    Cell Significance Index: 505.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4722
    Cell Significance Index: 495.9200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.4342
    Cell Significance Index: 35.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2476
    Cell Significance Index: 145.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.2081
    Cell Significance Index: 61.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0996
    Cell Significance Index: 753.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.9111
    Cell Significance Index: 117.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8047
    Cell Significance Index: 247.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7533
    Cell Significance Index: 190.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.6447
    Cell Significance Index: 74.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5982
    Cell Significance Index: 83.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4026
    Cell Significance Index: 107.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2986
    Cell Significance Index: 15.4800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2395
    Cell Significance Index: 857.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2353
    Cell Significance Index: 222.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1897
    Cell Significance Index: 649.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1632
    Cell Significance Index: 51.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1612
    Cell Significance Index: 78.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1540
    Cell Significance Index: 33.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1122
    Cell Significance Index: 136.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0092
    Cell Significance Index: 119.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9906
    Cell Significance Index: 37.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9472
    Cell Significance Index: 121.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.8912
    Cell Significance Index: 565.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8615
    Cell Significance Index: 45.2300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7986
    Cell Significance Index: 9.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7851
    Cell Significance Index: 347.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6920
    Cell Significance Index: 1302.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6275
    Cell Significance Index: 566.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5552
    Cell Significance Index: 13.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4853
    Cell Significance Index: 22.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4171
    Cell Significance Index: 769.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3878
    Cell Significance Index: 597.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3469
    Cell Significance Index: 7.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2986
    Cell Significance Index: 135.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1958
    Cell Significance Index: 266.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1042
    Cell Significance Index: 3.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0709
    Cell Significance Index: 2.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0367
    Cell Significance Index: 3.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0298
    Cell Significance Index: 0.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0223
    Cell Significance Index: 1.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0041
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0352
    Cell Significance Index: -26.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0380
    Cell Significance Index: -7.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0474
    Cell Significance Index: -8.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0833
    Cell Significance Index: -63.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1040
    Cell Significance Index: -64.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1259
    Cell Significance Index: -9.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1587
    Cell Significance Index: -89.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1629
    Cell Significance Index: -4.3500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1664
    Cell Significance Index: -1.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1683
    Cell Significance Index: -11.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2030
    Cell Significance Index: -33.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2352
    Cell Significance Index: -30.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2505
    Cell Significance Index: -4.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2955
    Cell Significance Index: -4.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2976
    Cell Significance Index: -62.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2990
    Cell Significance Index: -15.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3007
    Cell Significance Index: -30.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3172
    Cell Significance Index: -8.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3231
    Cell Significance Index: -46.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3521
    Cell Significance Index: -101.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3645
    Cell Significance Index: -25.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4420
    Cell Significance Index: -27.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5468
    Cell Significance Index: -63.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6561
    Cell Significance Index: -75.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6881
    Cell Significance Index: -71.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6977
    Cell Significance Index: -18.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7757
    Cell Significance Index: -46.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7993
    Cell Significance Index: -19.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8331
    Cell Significance Index: -23.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8800
    Cell Significance Index: -100.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.1750
    Cell Significance Index: -33.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2851
    Cell Significance Index: -101.7800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.3584
    Cell Significance Index: -20.0500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.3860
    Cell Significance Index: -21.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.5154
    Cell Significance Index: -31.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.6975
    Cell Significance Index: -45.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.8121
    Cell Significance Index: -111.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.8275
    Cell Significance Index: -38.9200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.8414
    Cell Significance Index: -39.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.8542
    Cell Significance Index: -47.3700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.8622
    Cell Significance Index: -28.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.9257
    Cell Significance Index: -44.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.0099
    Cell Significance Index: -44.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The NKTR gene is a single-copy gene with an Ensembl ID of ENSG00000114857. It is primarily expressed in cells of the immune system, including NK cells, T cells, and dendritic cells, as well as in neuronal cells, such as GABAergic neurons and Purkinje cells. The NKTR protein is a type II transmembrane protein that interacts with other proteins to modulate cellular signaling pathways. It is also involved in the regulation of protein folding and peptidyl-prolyl cis-trans isomerization, which is essential for maintaining protein structure and function. **Pathways and Functions:** The NKTR gene is involved in several cellular pathways, including: 1. **Cyclosporin a binding:** NKTR interacts with cyclosporin A, a potent immunosuppressant, to modulate its activity and prevent excessive immune suppression. 2. **Cytoplasmic and nuclear signaling:** NKTR regulates cytoplasmic and nuclear signaling pathways, including the activation of transcription factors and the modulation of gene expression. 3. **Mitochondrial function:** NKTR interacts with mitochondrial proteins to regulate mitochondrial function and biogenesis. 4. **Protein folding and peptidyl-prolyl cis-trans isomerization:** NKTR regulates protein folding and peptidyl-prolyl cis-trans isomerization, which is essential for maintaining protein structure and function. **Clinical Significance:** The NKTR gene has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Dysregulation of NKTR expression and function has been implicated in several diseases, including: 1. **Autoimmune diseases:** NKTR dysregulation has been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes. 2. **Cancer:** NKTR has been shown to regulate tumor growth and metastasis, and its dysregulation has been implicated in various types of cancer. 3. **Neurological disorders:** NKTR is involved in the regulation of neuronal function and development, and its dysregulation has been linked to neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, the NKTR gene plays a critical role in regulating natural killer cell function and cellular homeostasis. Its dysregulation has significant clinical implications, particularly in the context of autoimmune diseases and cancer. Further research is needed to fully understand the mechanisms of NKTR regulation and its clinical significance.

Genular Protein ID: 3746892291

Symbol: NKTR_HUMAN

Name: Natural-killer cells cyclophilin-related protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8421688

Title: A cyclophilin-related protein involved in the function of natural killer cells.

PubMed ID: 8421688

DOI: 10.1073/pnas.90.2.542

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20676357

Title: Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.

PubMed ID: 20676357

DOI: 10.1371/journal.pbio.1000439

Sequence Information:

  • Length: 1462
  • Mass: 165677
  • Checksum: D98A1147763EF527
  • Sequence:
  • MGAQDRPQCH FDIEINREPV GRIMFQLFSD ICPKTCKNFL CLCSGEKGLG KTTGKKLCYK 
    GSTFHRVVKN FMIQGGDFSE GNGKGGESIY GGYFKDENFI LKHDRAFLLS MANRGKHTNG 
    SQFFITTKPA PHLDGVHVVF GLVISGFEVI EQIENLKTDA ASRPYADVRV IDCGVLATKS 
    IKDVFEKKRK KPTHSEGSDS SSNSSSSSES SSESELEHER SRRRKHKRRP KVKRSKKRRK 
    EASSSEEPRN KHAMNPKGHS ERSDTNEKRS VDSSAKREKP VVRPEEIPPV PENRFLLRRD 
    MPVVTAEPEP KIPDVAPIVS DQKPSVSKSG RKIKGRGTIR YHTPPRSRSC SESDDDDSSE 
    TPPHWKEEMQ RLRAYRPPSG EKWSKGDKLS DPCSSRWDER SLSQRSRSWS YNGYYSDLST 
    ARHSGHHKKR RKEKKVKHKK KGKKQKHCRR HKQTKKRRIL IPSDIESSKS STRRMKSSCD 
    RERSSRSSSL SSHHSSKRDW SKSDKDVQSS LTHSSRDSYR SKSHSQSYSR GSSRSRTASK 
    SSSHSRSRSK SRSSSKSGHR KRASKSPRKT ASQLSENKPV KTEPLRATMA QNENVVVQPV 
    VAENIPVIPL SDSPPPSRWK PGQKPWKPSY ERIQEMKAKT THLLPIQSTY SLANIKETGS 
    SSSYHKREKN SESDQSTYSK YSDRSSESSP RSRSRSSRSR SYSRSYTRSR SLASSHSRSR 
    SPSSRSHSRN KYSDHSQCSR SSSYTSISSD DGRRAKRRLR SSGKKNSVSH KKHSSSSEKT 
    LHSKYVKGRD RSSCVRKYSE SRSSLDYSSD SEQSSVQATQ SAQEKEKQGQ MERTHNKQEK 
    NRGEEKSKSE RECPHSKKRT LKENLSDHLR NGSKPKRKNY AGSKWDSESN SERDVTKNSK 
    NDSHPSSDKE EGEATSDSES EVSEIHIKVK PTTKSSTNTS LPDDNGAWKS SKQRTSTSDS 
    EGSCSNSENN RGKPQKHKHG SKENLKREHT KKVKEKLKGK KDKKHKAPKR KQAFHWQPPL 
    EFGEEEEEEI DDKQVTQESK EKKVSENNET IKDNILKTEK SSEEDLSGKH DTVTVSSDLD 
    QFTKDDSKLS ISPTALNTEE NVACLQNIQH VEESVPNGVE DVLQTDDNME ICTPDRSSPA 
    KVEETSPLGN ARLDTPDINI VLKQDMATEH PQAEVVKQES SMSESKVLGE VGKQDSSSAS 
    LASAGESTGK KEVAEKSQIN LIDKKWKPLQ GVGNLAAPNA ATSSAVEVKV LTTVPEMKPQ 
    GLRIEIKSKN KVRPGSLFDE VRKTARLNRR PRNQESSSDE QTPSRDDDSQ SRSPSRSRSK 
    SETKSRHRTR SVSYSHSRSR SRSSTSSYRS RSYSRSRSRG WYSRGRTRSR SSSYRSYKSH 
    RTSSRSRSRS SSYDPHSRSR SYTYDSYYSR SRSRSRSQRS DSYHRGRSYN RRSRSCRSYG 
    SDSESDRSYS HHRSPSESSR YS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.