Details for: NME3
Gene ID: 4832
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: NME3
Ensembl ID: ENSG00000103024
Description: NME/NM23 nucleoside diphosphate kinase 3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 43.3rCSI 41.68%PRS 26.01
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CSI 34.98rCSI 36.64%PRS 26.65
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CSI 22.71rCSI 27.11%PRS 42.63
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CSI 19.89rCSI 27.1%PRS 21.83
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CSI 18.54rCSI 19.37%PRS 25.97
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CSI 18.52rCSI 16.29%PRS 18.36
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CSI 16.59rCSI 48.03%PRS 28.03
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CSI 14.68rCSI 13.25%PRS 22.91
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CSI 14.01rCSI 38.48%PRS 39.99
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CSI 13.62rCSI 24.75%PRS 37.92
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CSI 13.43rCSI 19.04%PRS 23.25
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CSI 11.76rCSI 20.74%PRS 32.16
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CSI 10.59rCSI 18.1%PRS 48.99
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CSI 10.5rCSI 14.36%PRS 28.28
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CSI 10.23rCSI 13.19%PRS 15.76
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CSI 9.94rCSI 9.78%PRS 26.88
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CSI 9.58rCSI 13.8%PRS 38.56
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CSI 9.5rCSI 33.33%PRS 41.85
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CSI 9.26rCSI 11.27%PRS 31.14
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CSI 8.48rCSI 18.78%PRS 23.17
-
CSI 8.26rCSI 44.98%PRS 52.35
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CSI 8.04rCSI 16.32%PRS 13.69
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CSI 8.01rCSI 10.19%PRS 28.87
-
CSI 7.68rCSI 10.27%PRS 32.09
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CSI 7.64rCSI 5.68%PRS 36.52
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CSI 7.35rCSI 20.26%PRS 23.36
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CSI 7.26rCSI 23.22%PRS 21.05
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CSI 6.9rCSI 11.3%PRS 19.37
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CSI 6.59rCSI 26.22%PRS 41.09
-
CSI 6.2rCSI 8.47%PRS 27.73
-
CSI 6.17rCSI 5.12%PRS 23.85
-
CSI 6.1rCSI 6.21%PRS 35.54
-
CSI 5.91rCSI 16.95%PRS 37.58
-
CSI 5.71rCSI 5.99%PRS 23.45
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CSI 5.61rCSI 26.16%PRS 50.59
-
CSI 5.52rCSI 3.87%PRS 53.29
-
CSI 5.35rCSI 8.67%PRS 25.16
-
CSI 5.23rCSI 10.81%PRS 35.49
-
CSI 5.05rCSI 25.32%PRS 33.15
-
CSI 4.92rCSI 7.02%PRS 27.87
-
CSI 4.88rCSI 34.41%PRS 58.75
-
CSI 4.66rCSI 3.24%PRS 30.32
-
CSI 4.52rCSI 21.67%PRS 21.22
-
CSI 4.46rCSI 8.36%PRS 18.29
-
CSI 4.4rCSI 4.24%PRS 18.55
-
CSI 4.38rCSI 6.28%PRS 19.56
-
CSI 4.33rCSI 5.44%PRS 74.5
-
CSI 4.28rCSI 64.27%PRS 58.82
-
CSI 4.25rCSI 3.66%PRS 36.72
-
CSI 4.25rCSI 8.43%PRS 25.98
-
CSI 4.12rCSI 7.23%PRS 19.37
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CSI 4.05rCSI 9.5%PRS 34.87
-
CSI 3.78rCSI 4.71%PRS 34.46
-
CSI 3.74rCSI 17.53%PRS 55.26
-
CSI 3.72rCSI 5.8%PRS 52.89
-
CSI 3.7rCSI 16.3%PRS 22.7
-
CSI 3.66rCSI 8.69%PRS 36.65
-
CSI 3.51rCSI 6.95%PRS 57.65
-
CSI 3.49rCSI 4.75%PRS 54.12
-
CSI 3.42rCSI 9.62%PRS 31.14
-
CSI 3.41rCSI 5.22%PRS 39.89
-
CSI 3.41rCSI 3.65%PRS 23.14
-
CSI 3.4rCSI 2.58%PRS 33.27
-
CSI 3.35rCSI 4.81%PRS 33.05
-
CSI 3.33rCSI 14.62%PRS 44.32
-
CSI 3.33rCSI 13.99%PRS 54.14
-
CSI 3.3rCSI 2.65%PRS 43.55
-
CSI 3.28rCSI 6.74%PRS 23.9
-
CSI 3.26rCSI 10.47%PRS 34.2
-
CSI 3.2rCSI 5.05%PRS 25.22
-
CSI 3.12rCSI 3.66%PRS 35.26
-
CSI 3.08rCSI 4.51%PRS 26.64
-
CSI 3.03rCSI 6.67%PRS 37.17
-
CSI 3.01rCSI 18.81%PRS 19.84
-
CSI 2.9rCSI 2.57%PRS 25.38
-
CSI 2.85rCSI 2.14%PRS 61.7
-
CSI 2.85rCSI 2.11%PRS 21.54
-
CSI 2.81rCSI 6.42%PRS 24.56
-
CSI 2.79rCSI 4.26%PRS 42.45
-
CSI 2.76rCSI 2.88%PRS 25.71
-
CSI 2.76rCSI 3.43%PRS 26.8
-
CSI 2.71rCSI 2.1%PRS 24.37
-
CSI 2.68rCSI 1.86%PRS 35.23
-
CSI 2.66rCSI 5.88%PRS 17.97
-
CSI 2.65rCSI 10.31%PRS 33.54
-
CSI 2.64rCSI 4.24%PRS 59.16
-
CSI 2.64rCSI 10.21%PRS 45.52
-
CSI 2.63rCSI 2.43%PRS 26.24
-
CSI 2.56rCSI 1.94%PRS 34.29
-
CSI 2.52rCSI 2.38%PRS 26.31
-
CSI 2.46rCSI 24.22%PRS 56.91
-
CSI 2.43rCSI 1.92%PRS 17.27
-
CSI 2.34rCSI 3.25%PRS 33.48
-
CSI 2.34rCSI 10.1%PRS 43.4
-
CSI 2.33rCSI 9.31%PRS 48.98
-
CSI 2.32rCSI 2.47%PRS 40.94
-
CSI 2.31rCSI 3.73%PRS 36.52
-
CSI 2.3rCSI 2.09%PRS 37.79
-
CSI 2.27rCSI 3.66%PRS 16.48
-
CSI 2.27rCSI 2.33%PRS 39.64
-
CSI 0.0rCSI 0.3%PRS 42.5%
-
CSI 0.1rCSI 3.8%PRS 50.4%
-
CSI 0.2rCSI 2.3%PRS 52.6%
-
CSI 0.2rCSI 4.6%PRS 73.3%
-
CSI 0.2rCSI 4.6%PRS 58.7%
-
CSI 0.2rCSI 3.4%PRS 70.3%
-
CSI 0.2rCSI 2.1%PRS 30.7%
-
CSI 0.2rCSI 1.7%PRS 24.0%
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CSI 0.2rCSI 2.2%PRS 56.4%
-
CSI 0.2rCSI 1.7%PRS 45.8%
-
CSI 0.2rCSI 2.6%PRS 71.7%
-
CSI 0.2rCSI 5.4%PRS 13.9%
-
CSI 0.2rCSI 5.5%PRS 14.8%
-
CSI 0.2rCSI 4.6%PRS 58.6%
-
CSI 0.3rCSI 0.4%PRS 34.7%
-
CSI 0.3rCSI 1.6%PRS 64.2%
-
CSI 0.3rCSI 1.6%PRS 68.0%
-
CSI 0.3rCSI 2.5%PRS 68.8%
-
CSI 0.3rCSI 0.5%PRS 25.7%
-
CSI 0.3rCSI 2.0%PRS 51.7%
-
CSI 0.4rCSI 0.4%PRS 29.5%
-
CSI 0.4rCSI 2.1%PRS 47.2%
-
CSI 0.4rCSI 1.1%PRS 32.3%
-
CSI 0.4rCSI 1.7%PRS 15.7%
-
CSI 0.5rCSI 1.3%PRS 19.6%
-
CSI 0.5rCSI 2.3%PRS 33.7%
-
CSI 0.5rCSI 10.8%PRS 71.4%
-
CSI 0.5rCSI 2.8%PRS 36.3%
-
CSI 0.5rCSI 0.6%PRS 28.7%
-
CSI 0.5rCSI 1.3%PRS 23.2%
-
CSI 0.5rCSI 1.3%PRS 30.9%
-
CSI 0.5rCSI 0.5%PRS 31.7%
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CSI 0.5rCSI 1.2%PRS 25.6%
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CSI 0.6rCSI 1.4%PRS 39.1%
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CSI 0.6rCSI 2.0%PRS 16.0%
-
CSI 0.6rCSI 1.8%PRS 43.6%
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CSI 0.6rCSI 2.3%PRS 14.3%
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CSI 0.7rCSI 15.2%PRS 45.4%
-
CSI 0.7rCSI 1.1%PRS 29.5%
-
CSI 0.7rCSI 2.3%PRS 59.5%
-
CSI 0.7rCSI 2.7%PRS 23.4%
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CSI 0.7rCSI 1.8%PRS 25.0%
-
CSI 0.7rCSI 1.8%PRS 19.1%
-
CSI 0.7rCSI 1.8%PRS 24.7%
-
CSI 0.7rCSI 1.7%PRS 46.0%
-
CSI 0.7rCSI 3.3%PRS 63.2%
-
CSI 0.7rCSI 5.5%PRS 44.2%
-
CSI 0.7rCSI 2.0%PRS 20.8%
-
CSI 0.8rCSI 1.2%PRS 30.2%
-
CSI 0.8rCSI 1.6%PRS 41.1%
-
CSI 0.8rCSI 1.0%PRS 37.6%
-
CSI 0.8rCSI 2.4%PRS 42.3%
-
CSI 0.9rCSI 0.7%PRS 28.2%
-
CSI 0.9rCSI 2.2%PRS 55.7%
-
CSI 0.9rCSI 2.5%PRS 48.2%
-
CSI 0.9rCSI 4.0%PRS 67.3%
-
CSI 0.9rCSI 3.0%PRS 18.1%
-
CSI 0.9rCSI 2.4%PRS 46.6%
-
CSI 0.9rCSI 2.5%PRS 38.2%
-
CSI 0.9rCSI 1.2%PRS 32.5%
-
CSI 0.9rCSI 1.6%PRS 19.0%
-
CSI 0.9rCSI 6.8%PRS 58.2%
-
CSI 0.9rCSI 1.4%PRS 38.7%
-
CSI 1.0rCSI 1.1%PRS 47.9%
-
CSI 1.0rCSI 1.5%PRS 28.7%
-
CSI 1.0rCSI 1.5%PRS 23.1%
-
CSI 1.0rCSI 1.8%PRS 61.1%
-
CSI 1.0rCSI 1.5%PRS 32.4%
-
CSI 1.0rCSI 2.9%PRS 23.7%
-
CSI 1.0rCSI 3.5%PRS 39.4%
-
CSI 1.0rCSI 5.6%PRS 36.5%
-
CSI 1.0rCSI 6.6%PRS 49.3%
-
CSI 1.0rCSI 2.3%PRS 15.7%
-
CSI 1.0rCSI 1.7%PRS 19.2%
-
CSI 1.1rCSI 1.7%PRS 21.1%
-
CSI 1.1rCSI 1.1%PRS 21.5%
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CSI 1.1rCSI 0.9%PRS 25.3%
-
CSI 1.1rCSI 1.3%PRS 14.9%
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CSI 1.1rCSI 1.9%PRS 24.5%
-
CSI 1.1rCSI 2.4%PRS 28.7%
-
CSI 1.1rCSI 2.7%PRS 14.8%
-
CSI 1.1rCSI 2.1%PRS 46.4%
-
CSI 1.1rCSI 2.7%PRS 35.8%
-
CSI 1.1rCSI 0.9%PRS 36.8%
-
CSI 1.1rCSI 3.7%PRS 29.6%
-
CSI 1.2rCSI 4.6%PRS 23.3%
-
CSI 1.2rCSI 2.0%PRS 15.1%
-
CSI 1.2rCSI 2.3%PRS 25.8%
-
CSI 1.2rCSI 2.2%PRS 55.0%
-
CSI 1.2rCSI 3.0%PRS 23.3%
-
CSI 1.2rCSI 3.1%PRS 30.8%
-
CSI 1.2rCSI 2.4%PRS 53.9%
-
CSI 1.2rCSI 2.2%PRS 19.2%
-
CSI 1.3rCSI 2.1%PRS 45.9%
-
CSI 1.3rCSI 6.9%PRS 41.8%
-
CSI 1.3rCSI 2.5%PRS 54.9%
-
CSI 1.3rCSI 2.8%PRS 46.0%
-
CSI 1.3rCSI 1.2%PRS 44.0%
-
CSI 1.3rCSI 2.3%PRS 14.9%
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CSI 1.3rCSI 3.1%PRS 53.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2084816719
Symbol: NDK3_HUMAN
Name: Nucleoside diphosphate kinase 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7638209
Title: Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells.
PubMed ID: 7638209
PubMed ID: 11157797
Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
PubMed ID: 11157797
DOI: 10.1093/hmg/10.4.339
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11277919
Title: Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene.
PubMed ID: 11277919
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 26945015
Title: The direct interaction of NME3 with Tip60 in DNA repair.
PubMed ID: 26945015
DOI: 10.1042/bcj20160122
PubMed ID: 30111592
Title: The nucleoside-diphosphate kinase NME3 associates with nephronophthisis proteins and is required for ciliary function during renal development.
PubMed ID: 30111592
PubMed ID: 30587587
Title: Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.
PubMed ID: 30587587
PubMed ID: 37584589
Title: NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering.
PubMed ID: 37584589
Sequence Information:
- Length: 169
- Mass: 19015
- Checksum: CCA41A122A37202D
- Sequence:
MICLVLTIFA NLFPAACTGA HERTFLAVKP DGVQRRLVGE IVRRFERKGF KLVALKLVQA SEELLREHYA ELRERPFYGR LVKYMASGPV VAMVWQGLDV VRTSRALIGA TNPADAPPGT IRGDFCIEVG KNLIHGSDSV ESARREIALW FRADELLCWE DSAGHWLYE