Details for: NME3

Gene ID: 4832

Symbol: NME3

Ensembl ID: ENSG00000103024

Description: NME/NM23 nucleoside diphosphate kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 381.2396
    Cell Significance Index: -59.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 212.2074
    Cell Significance Index: -53.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 156.3548
    Cell Significance Index: -64.4100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 130.5381
    Cell Significance Index: -61.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 125.1178
    Cell Significance Index: -50.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 114.8361
    Cell Significance Index: -59.0700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.1579
    Cell Significance Index: -61.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.7163
    Cell Significance Index: -52.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.9799
    Cell Significance Index: -60.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.8654
    Cell Significance Index: -45.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.5092
    Cell Significance Index: -61.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.2483
    Cell Significance Index: -37.6200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5525
    Cell Significance Index: -23.1000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.8352
    Cell Significance Index: 40.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.5139
    Cell Significance Index: 95.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.4104
    Cell Significance Index: 3079.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.1772
    Cell Significance Index: 101.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1303
    Cell Significance Index: 292.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.0649
    Cell Significance Index: 107.5600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.9560
    Cell Significance Index: 45.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.5727
    Cell Significance Index: 201.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.4378
    Cell Significance Index: 785.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4335
    Cell Significance Index: 176.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3817
    Cell Significance Index: 249.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3179
    Cell Significance Index: 93.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2578
    Cell Significance Index: 93.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2410
    Cell Significance Index: 56.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1704
    Cell Significance Index: 60.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0240
    Cell Significance Index: 452.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0237
    Cell Significance Index: 28.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8975
    Cell Significance Index: 25.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8133
    Cell Significance Index: 9.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8124
    Cell Significance Index: 38.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8101
    Cell Significance Index: 7.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7276
    Cell Significance Index: 38.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7079
    Cell Significance Index: 142.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6976
    Cell Significance Index: 43.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6827
    Cell Significance Index: 88.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6118
    Cell Significance Index: 121.4200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5734
    Cell Significance Index: 4.4200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5189
    Cell Significance Index: 98.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5028
    Cell Significance Index: 32.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4197
    Cell Significance Index: 12.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3679
    Cell Significance Index: 131.9500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3395
    Cell Significance Index: 55.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2953
    Cell Significance Index: 29.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2185
    Cell Significance Index: 5.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1701
    Cell Significance Index: 3.5600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1577
    Cell Significance Index: 5.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1459
    Cell Significance Index: 2.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0858
    Cell Significance Index: 161.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0589
    Cell Significance Index: 40.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0389
    Cell Significance Index: 71.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0351
    Cell Significance Index: 54.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0298
    Cell Significance Index: 13.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0279
    Cell Significance Index: 17.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0163
    Cell Significance Index: 11.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0017
    Cell Significance Index: -1.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0072
    Cell Significance Index: -9.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0274
    Cell Significance Index: -0.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0331
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0522
    Cell Significance Index: -8.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0614
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0629
    Cell Significance Index: -46.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0710
    Cell Significance Index: -5.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0753
    Cell Significance Index: -1.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0963
    Cell Significance Index: -54.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0989
    Cell Significance Index: -2.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1008
    Cell Significance Index: -2.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1142
    Cell Significance Index: -71.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1334
    Cell Significance Index: -38.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1765
    Cell Significance Index: -25.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1843
    Cell Significance Index: -21.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2039
    Cell Significance Index: -6.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2525
    Cell Significance Index: -15.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2786
    Cell Significance Index: -32.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2987
    Cell Significance Index: -34.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3045
    Cell Significance Index: -10.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3099
    Cell Significance Index: -65.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4438
    Cell Significance Index: -29.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4859
    Cell Significance Index: -50.5900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5122
    Cell Significance Index: -6.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5209
    Cell Significance Index: -9.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5423
    Cell Significance Index: -14.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5504
    Cell Significance Index: -7.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5534
    Cell Significance Index: -11.9900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5799
    Cell Significance Index: -12.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6279
    Cell Significance Index: -20.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6386
    Cell Significance Index: -50.5800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6654
    Cell Significance Index: -4.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6801
    Cell Significance Index: -40.8300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6912
    Cell Significance Index: -8.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8440
    Cell Significance Index: -37.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8721
    Cell Significance Index: -48.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8867
    Cell Significance Index: -54.3600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9781
    Cell Significance Index: -14.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0489
    Cell Significance Index: -39.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.0772
    Cell Significance Index: -19.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0866
    Cell Significance Index: -27.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NME3 is a small, cytoplasmic protein (~30 kDa) that exhibits high levels of nucleoside diphosphate kinase activity. Its expression is tightly regulated, with significant fluctuations in response to cellular stress, growth factors, and hypoxia. NME3 exhibits tissue-specific expression patterns, with highest levels in kidney collecting duct principal cells and epithelial cells of the proximal tubule. Its molecular weight is relatively low, and it is characterized by a high degree of flexibility, allowing it to interact with a range of cellular partners. **Pathways and Functions:** NME3 is involved in several key cellular processes, including: 1. **Interconversion of nucleotide di- and triphosphates:** NME3 catalyzes the conversion of nucleoside diphosphates to nucleoside triphosphates, a crucial step in energy metabolism, DNA synthesis, and gene expression. 2. **Apoptosis regulation:** NME3 has been shown to modulate apoptosis by regulating the activity of pro-apoptotic and anti-apoptotic proteins. 3. **DNA repair:** NME3 participates in the repair of DNA damage by facilitating the interconversion of nucleotide di- and triphosphates. 4. **Gene expression regulation:** NME3 modulates gene expression by regulating the activity of transcription factors and chromatin remodeling complexes. 5. **Mitochondrial function:** NME3 has been implicated in mitochondrial function, including the regulation of mitochondrial membrane potential and the interconversion of ATP and ADP. **Clinical Significance:** Dysregulation of NME3 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of NME3 has been observed in certain types of cancer, including lung and kidney cancer, suggesting a potential role in tumor progression and metastasis. 2. **Neurological disorders:** NME3 has been implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's disease, where its dysregulation may contribute to neuronal dysfunction and death. 3. **Kidney disease:** NME3 expression is altered in kidney diseases, including chronic kidney disease and acute kidney injury, suggesting a potential role in maintaining renal function. 4. **Cardiovascular disease:** NME3 has been implicated in cardiovascular disease, including atherosclerosis and cardiac hypertrophy, where its dysregulation may contribute to vascular dysfunction and cardiac remodeling. In conclusion, NME3 is a multifunctional protein that plays a critical role in maintaining cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms underlying its functions and the development of therapeutic strategies to modulate its activity.

Genular Protein ID: 2084816719

Symbol: NDK3_HUMAN

Name: Nucleoside diphosphate kinase 3

UniProtKB Accession Codes:

Q13232 Q9BWH4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 15 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7638209

Title: Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells.

PubMed ID: 7638209

DOI: 10.1073/pnas.92.16.7435

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11277919

Title: Structural and catalytic properties and homology modelling of the human nucleoside diphosphate kinase C, product of the DRnm23 gene.

PubMed ID: 11277919

DOI: 10.1046/j.1432-1327.2001.2076.doc.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 26945015

Title: The direct interaction of NME3 with Tip60 in DNA repair.

PubMed ID: 26945015

DOI: 10.1042/bcj20160122

PubMed ID: 30111592

Title: The nucleoside-diphosphate kinase NME3 associates with nephronophthisis proteins and is required for ciliary function during renal development.

PubMed ID: 30111592

DOI: 10.1074/jbc.ra117.000847

PubMed ID: 30587587

Title: Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder.

PubMed ID: 30587587

DOI: 10.1073/pnas.1818629116

PubMed ID: 37584589

Title: NME3 binds to phosphatidic acid and mediates PLD6-induced mitochondrial tethering.

PubMed ID: 37584589

DOI: 10.1083/jcb.202301091

Sequence Information:

  • Length: 169
  • Mass: 19015
  • Checksum: CCA41A122A37202D
  • Sequence:
    • MICLVLTIFA NLFPAACTGA HERTFLAVKP DGVQRRLVGE IVRRFERKGF KLVALKLVQA 
SEELLREHYA ELRERPFYGR LVKYMASGPV VAMVWQGLDV VRTSRALIGA TNPADAPPGT 
IRGDFCIEVG KNLIHGSDSV ESARREIALW FRADELLCWE DSAGHWLYE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.