Details for: NOS3

Gene ID: 4846

Symbol: NOS3

Ensembl ID: ENSG00000164867

Description: nitric oxide synthase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 24.8159
    Cell Significance Index: -3.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.2182
    Cell Significance Index: -3.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.8125
    Cell Significance Index: -3.6400
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.3113
    Cell Significance Index: 19.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.1388
    Cell Significance Index: -3.8700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.1749
    Cell Significance Index: 15.6200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.7945
    Cell Significance Index: 25.8100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.6370
    Cell Significance Index: 5.7000
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.2818
    Cell Significance Index: 9.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8386
    Cell Significance Index: 43.6800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.6732
    Cell Significance Index: 5.3200
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.4807
    Cell Significance Index: 3.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4510
    Cell Significance Index: 7.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4225
    Cell Significance Index: 4.8000
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.3640
    Cell Significance Index: 3.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3051
    Cell Significance Index: 8.9600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2983
    Cell Significance Index: 3.0900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2830
    Cell Significance Index: 2.6900
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.1500
    Cell Significance Index: 1.0300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1485
    Cell Significance Index: 1.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1210
    Cell Significance Index: 14.1000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1124
    Cell Significance Index: 1.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0540
    Cell Significance Index: 37.3200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0159
    Cell Significance Index: 8.6800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.0029
    Cell Significance Index: 0.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0004
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0012
    Cell Significance Index: -0.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -5.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0035
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0043
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0055
    Cell Significance Index: -4.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0061
    Cell Significance Index: -3.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0069
    Cell Significance Index: -2.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0070
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0074
    Cell Significance Index: -1.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0077
    Cell Significance Index: -1.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0086
    Cell Significance Index: -1.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0087
    Cell Significance Index: -3.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0089
    Cell Significance Index: -2.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0097
    Cell Significance Index: -0.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0119
    Cell Significance Index: -0.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0120
    Cell Significance Index: -2.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0141
    Cell Significance Index: -0.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0154
    Cell Significance Index: -1.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0154
    Cell Significance Index: -0.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0181
    Cell Significance Index: -2.4900
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.0205
    Cell Significance Index: -0.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0228
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0285
    Cell Significance Index: -3.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0298
    Cell Significance Index: -3.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0300
    Cell Significance Index: -3.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0309
    Cell Significance Index: -3.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0310
    Cell Significance Index: -2.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0373
    Cell Significance Index: -3.8800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0382
    Cell Significance Index: -0.4700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0480
    Cell Significance Index: -0.6200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0513
    Cell Significance Index: -0.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0522
    Cell Significance Index: -0.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0541
    Cell Significance Index: -1.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0561
    Cell Significance Index: -4.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0589
    Cell Significance Index: -0.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0592
    Cell Significance Index: -3.9800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0598
    Cell Significance Index: -0.6500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0598
    Cell Significance Index: -0.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0606
    Cell Significance Index: -3.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0613
    Cell Significance Index: -3.7700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0648
    Cell Significance Index: -0.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0699
    Cell Significance Index: -3.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0701
    Cell Significance Index: -3.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0731
    Cell Significance Index: -4.1000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0747
    Cell Significance Index: -3.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0760
    Cell Significance Index: -3.5700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0809
    Cell Significance Index: -1.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0847
    Cell Significance Index: -3.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0866
    Cell Significance Index: -3.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0886
    Cell Significance Index: -2.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0977
    Cell Significance Index: -3.7000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1028
    Cell Significance Index: -1.3700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1048
    Cell Significance Index: -3.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1049
    Cell Significance Index: -5.3000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1081
    Cell Significance Index: -1.4800
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1097
    Cell Significance Index: -1.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1110
    Cell Significance Index: -3.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1117
    Cell Significance Index: -3.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1155
    Cell Significance Index: -3.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1162
    Cell Significance Index: -3.8100
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1177
    Cell Significance Index: -1.2400
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1199
    Cell Significance Index: -1.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1223
    Cell Significance Index: -4.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1239
    Cell Significance Index: -4.3600
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: -0.1302
    Cell Significance Index: -0.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1359
    Cell Significance Index: -3.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1361
    Cell Significance Index: -3.9000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1393
    Cell Significance Index: -1.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Constitutive Expression**: NOS3 is constitutively expressed in endothelial cells, meaning it is always active and produces NO at a basal level. 2. **High Affinity for L-Arginine**: NOS3 has a high affinity for L-arginine, the amino acid substrate necessary for NO production. 3. **Unique Substrate Specificity**: NOS3 is the only isoform of nitric oxide synthase that produces NO in response to L-arginine, whereas other isoforms produce NO in response to L-citrulline. 4. **Regulation by Tetrahydrobiopterin (BH4)**: NOS3 requires BH4 as a cofactor for NO production, and its dysregulation can lead to decreased BH4 levels and reduced NO production. 5. **Involvement in Angiogenesis**: NOS3 plays a crucial role in angiogenesis, the process of new blood vessel formation, by promoting endothelial cell migration and proliferation. **Pathways and Functions** 1. **Nitric Oxide Biosynthesis**: NOS3 produces NO in response to various stimuli, including shear stress, hormones, and neurotransmitters. 2. **Vasodilation**: NO produced by NOS3 causes smooth muscle relaxation, leading to vasodilation and decreased blood pressure. 3. **Endothelial Function**: NOS3 regulates endothelial function by maintaining vascular homeostasis, promoting angiogenesis, and inhibiting platelet activation and smooth muscle cell proliferation. 4. **Blood Pressure Regulation**: NOS3 plays a crucial role in regulating blood pressure by promoting vasodilation and inhibiting vasoconstriction. 5. **Inflammation and Immune Response**: NOS3 is involved in the regulation of inflammation and immune response by producing NO in response to LPS and other inflammatory stimuli. **Clinical Significance** 1. **Hypertension**: Dysregulation of NOS3 has been implicated in the development of hypertension, highlighting the importance of NOS3 in blood pressure regulation. 2. **Atherosclerosis**: NOS3 has been shown to play a role in atherosclerosis, a condition characterized by the buildup of plaque in blood vessels. 3. **Heart Failure**: NOS3 dysregulation has been linked to heart failure, highlighting the importance of NOS3 in maintaining cardiovascular function. 4. **Angiogenesis**: NOS3 plays a crucial role in angiogenesis, making it a potential target for the treatment of cardiovascular diseases. 5. **Inflammation and Immune Response**: NOS3 is involved in the regulation of inflammation and immune response, making it a potential target for the treatment of inflammatory and immune-related diseases. In conclusion, NOS3 is a critical enzyme involved in the production of nitric oxide in the vascular endothelium, playing a vital role in maintaining vascular homeostasis, regulating blood pressure, and promoting vasodilation. Its dysregulation has been implicated in various cardiovascular diseases, highlighting the importance of NOS3 in cardiovascular health.

Genular Protein ID: 2770121937

Symbol: NOS3_HUMAN

Name: Constitutive NOS

UniProtKB Accession Codes:

P29474 A0S0A7 A0S0A8 A8KA63 B2RCQ1 E9PFR2 Q13662 Q14251 Q14434 Q548C1 Q6GSL5 Q9UDC6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 55 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 43 DrugCentral 1 EC 1 EMBL 49 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 67 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 69 PDBsum 69 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 8 RefSeq 5 Rhea 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1378832

Title: Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

PubMed ID: 1378832

DOI: 10.1016/s0021-9258(18)42066-2

PubMed ID: 1379542

Title: Molecular cloning and characterization of human endothelial nitric oxide synthase.

PubMed ID: 1379542

DOI: 10.1016/0014-5793(92)80697-f

PubMed ID: 7688726

Title: Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene.

PubMed ID: 7688726

DOI: 10.1016/s0021-9258(19)85359-0

PubMed ID: 7509596

Title: Gene structure, polymorphism and mapping of the human endothelial nitric oxide synthase gene.

PubMed ID: 7509596

DOI: 10.1006/bbrc.1994.1146

PubMed ID: 7519987

Title: Cloning and structural characterization of the human endothelial nitric-oxide-synthase gene.

PubMed ID: 7519987

DOI: 10.1111/j.1432-1033.1994.tb19045.x

PubMed ID: 17264164

Title: Alternative splicing in intron 13 of the human eNOS gene: a potential mechanism for regulating eNOS activity.

PubMed ID: 17264164

DOI: 10.1096/fj.06-7434com

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7514568

Title: Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene.

PubMed ID: 7514568

DOI: 10.1006/geno.1994.1068

PubMed ID: 7475956

Title: Expression of constitutive endothelial nitric oxide synthase in human blood platelets.

PubMed ID: 7475956

DOI: 10.1016/0024-3205(95)02191-k

PubMed ID: 7515611

Title: Purification and characterization of the constitutive nitric oxide synthase from human placenta.

PubMed ID: 7515611

DOI: 10.1006/abbi.1994.1232

PubMed ID: 11149895

Title: NOSIP, a novel modulator of endothelial nitric oxide synthase activity.

PubMed ID: 11149895

DOI: 10.1096/fj.00-0078com

PubMed ID: 12446846

Title: NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase.

PubMed ID: 12446846

DOI: 10.1073/pnas.252345399

PubMed ID: 16126727

Title: Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II.

PubMed ID: 16126727

DOI: 10.1074/jbc.m506374200

PubMed ID: 16234328

Title: NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS.

PubMed ID: 16234328

DOI: 10.1242/jcs.02620

PubMed ID: 16135813

Title: Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.

PubMed ID: 16135813

DOI: 10.1128/mcb.25.18.8251-8258.2005

PubMed ID: 20213743

Title: CDK5 phosphorylates eNOS at Ser-113 and regulates NO production.

PubMed ID: 20213743

DOI: 10.1002/jcb.22515

PubMed ID: 23585225

Title: LPS induces pp60c-src-mediated tyrosine phosphorylation of Hsp90 in lung vascular endothelial cells and mouse lung.

PubMed ID: 23585225

DOI: 10.1152/ajplung.00419.2012

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 35772285

Title: 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.

PubMed ID: 35772285

DOI: 10.1016/j.bmc.2022.116878

PubMed ID: 10074942

Title: Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation.

PubMed ID: 10074942

DOI: 10.1038/6675

PubMed ID: 12437348

Title: Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.

PubMed ID: 12437348

DOI: 10.1021/bi026313j

PubMed ID: 18849972

Title: Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

PubMed ID: 18849972

DOI: 10.1038/nchembio.115

PubMed ID: 25286850

Title: Structures of human constitutive nitric oxide synthases.

PubMed ID: 25286850

DOI: 10.1107/s1399004714017064

PubMed ID: 9737779

Title: A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese.

PubMed ID: 9737779

DOI: 10.1007/s004390050785

PubMed ID: 11740345

Title: In-vivo effects of Glu298Asp endothelial nitric oxide synthase polymorphism.

PubMed ID: 11740345

DOI: 10.1097/00008571-200112000-00009

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1203
  • Mass: 133275
  • Checksum: B761A6D40B1A5649
  • Sequence:
    • MGNLKSVAQE PGPPCGLGLG LGLGLCGKQG PATPAPEPSR APASLLPPAP EHSPPSSPLT 
QPPEGPKFPR VKNWEVGSIT YDTLSAQAQQ DGPCTPRRCL GSLVFPRKLQ GRPSPGPPAP 
EQLLSQARDF INQYYSSIKR SGSQAHEQRL QEVEAEVAAT GTYQLRESEL VFGAKQAWRN 
APRCVGRIQW GKLQVFDARD CRSAQEMFTY ICNHIKYATN RGNLRSAITV FPQRCPGRGD 
FRIWNSQLVR YAGYRQQDGS VRGDPANVEI TELCIQHGWT PGNGRFDVLP LLLQAPDDPP 
ELFLLPPELV LEVPLEHPTL EWFAALGLRW YALPAVSNML LEIGGLEFPA APFSGWYMST 
EIGTRNLCDP HRYNILEDVA VCMDLDTRTT SSLWKDKAAV EINVAVLHSY QLAKVTIVDH 
HAATASFMKH LENEQKARGG CPADWAWIVP PISGSLTPVF HQEMVNYFLS PAFRYQPDPW 
KGSAAKGTGI TRKKTFKEVA NAVKISASLM GTVMAKRVKA TILYGSETGR AQSYAQQLGR 
LFRKAFDPRV LCMDEYDVVS LEHETLVLVV TSTFGNGDPP ENGESFAAAL MEMSGPYNSS 
PRPEQHKSYK IRFNSISCSD PLVSSWRRKR KESSNTDSAG ALGTLRFCVF GLGSRAYPHF 
CAFARAVDTR LEELGGERLL QLGQGDELCG QEEAFRGWAQ AAFQAACETF CVGEDAKAAA 
RDIFSPKRSW KRQRYRLSAQ AEGLQLLPGL IHVHRRKMFQ ATIRSVENLQ SSKSTRATIL 
VRLDTGGQEG LQYQPGDHIG VCPPNRPGLV EALLSRVEDP PAPTEPVAVE QLEKGSPGGP 
PPGWVRDPRL PPCTLRQALT FFLDITSPPS PQLLRLLSTL AEEPREQQEL EALSQDPRRY 
EEWKWFRCPT LLEVLEQFPS VALPAPLLLT QLPLLQPRYY SVSSAPSTHP GEIHLTVAVL 
AYRTQDGLGP LHYGVCSTWL SQLKPGDPVP CFIRGAPSFR LPPDPSLPCI LVGPGTGIAP 
FRGFWQERLH DIESKGLQPT PMTLVFGCRC SQLDHLYRDE VQNAQQRGVF GRVLTAFSRE 
PDNPKTYVQD ILRTELAAEV HRVLCLERGH MFVCGDVTMA TNVLQTVQRI LATEGDMELD 
EAGDVIGVLR DQQRYHEDIF GLTLRTQEVT SRIRTQSFSL QERQLRGAVP WAFDPPGSDT 
NSP

Genular Protein ID: 267244175

Symbol: A0S0A6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0S0A6

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 12 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 4 Gene3D 2 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 2 SAM 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 17264164

Title: Alternative splicing in intron 13 of the human eNOS gene: a potential mechanism for regulating eNOS activity.

PubMed ID: 17264164

DOI: 10.1096/fj.06-7434com

Sequence Information:

  • Length: 596
  • Mass: 65584
  • Checksum: 8503AC7A8B4E9C06
  • Sequence:
    • MGNLKSVAQE PGPPCGLGLG LGLGLCGKQG PATPAPEPSR APASLLPPAP EHSPPSSPLT 
QPPEGPKFPR VKNWEVGSIT YDTLSAQAQQ DGPCTPRRCL GSLVFPRKLQ GRPSPGPPAP 
EQLLSQARDF INQYYSSIKR SGSQAHEQRL QEVEAEVAAT GTYQLRESEL VFGAKQAWRN 
APRCVGRIQW GKLQVFDARD CRSAQEMFTY ICNHIKYATN RGNLRSAITV FPQRCPGRGD 
FRIWNSQLVR YAGYRQQDGS VRGDPANVEI TELCIQHGWT PGNGRFDVLP LLLQAPDEPP 
ELFLLPPELV LEVPLEHPTL EWFAALGLRW YALPAVSNML LEIGGLEFPA APFSGWYMST 
EIGTRNLCDP HRYNILEDVA VCMDLDTRTT SSLWKDKAAV EINVAVLHSY QLAKVTIVDH 
HAATASFMKH LENEQKARGG CPADWAWIVP PISGSLTPVF HQEMVNYFLS PAFRYQPDPW 
KGSAAKGTGI TRKKTFKEVA NAVKISASLM GTVMAKRVKA TILYGSETGR AQSYAQQLGR 
LFRKAFDPRV LCMDEYDVVS LEHETLVLVV TSTFGNGDPP ENGESVSLPE VSVTTE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.