Details for: NOVA1

Gene ID: 4857

Symbol: NOVA1

Ensembl ID: ENSG00000139910

Description: NOVA alternative splicing regulator 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 412.1929
    Cell Significance Index: -104.5500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 266.7633
    Cell Significance Index: -109.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 212.5083
    Cell Significance Index: -100.3300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 212.0332
    Cell Significance Index: -86.1400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 90.5270
    Cell Significance Index: -86.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 25.2994
    Cell Significance Index: -55.3700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 15.4601
    Cell Significance Index: 104.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 7.6138
    Cell Significance Index: 148.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 5.2856
    Cell Significance Index: 90.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.2402
    Cell Significance Index: 237.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.1531
    Cell Significance Index: 164.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9851
    Cell Significance Index: 598.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4244
    Cell Significance Index: 869.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.2945
    Cell Significance Index: 1586.9400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.1110
    Cell Significance Index: 110.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.1025
    Cell Significance Index: 141.3700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.9720
    Cell Significance Index: 15.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8929
    Cell Significance Index: 71.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7373
    Cell Significance Index: 76.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.6739
    Cell Significance Index: 305.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6168
    Cell Significance Index: 17.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5769
    Cell Significance Index: 520.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3441
    Cell Significance Index: 68.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2970
    Cell Significance Index: 29.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1314
    Cell Significance Index: 6.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1256
    Cell Significance Index: 193.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1058
    Cell Significance Index: 199.2500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0953
    Cell Significance Index: 15.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0930
    Cell Significance Index: 126.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0810
    Cell Significance Index: 149.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0621
    Cell Significance Index: 11.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0484
    Cell Significance Index: 30.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0330
    Cell Significance Index: -4.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0396
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0593
    Cell Significance Index: -43.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0942
    Cell Significance Index: -58.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1117
    Cell Significance Index: -81.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1126
    Cell Significance Index: -49.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1492
    Cell Significance Index: -112.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1551
    Cell Significance Index: -4.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1622
    Cell Significance Index: -91.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1684
    Cell Significance Index: -19.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1898
    Cell Significance Index: -103.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2718
    Cell Significance Index: -12.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3219
    Cell Significance Index: -92.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3496
    Cell Significance Index: -73.6400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3502
    Cell Significance Index: -50.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.4256
    Cell Significance Index: -76.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4541
    Cell Significance Index: -12.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5325
    Cell Significance Index: -39.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5760
    Cell Significance Index: -73.8400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.5799
    Cell Significance Index: -99.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5954
    Cell Significance Index: -60.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.6809
    Cell Significance Index: -83.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.7435
    Cell Significance Index: -96.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7754
    Cell Significance Index: -80.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8173
    Cell Significance Index: -93.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.8540
    Cell Significance Index: -59.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.8762
    Cell Significance Index: -103.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9542
    Cell Significance Index: -15.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9933
    Cell Significance Index: -113.8000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0021
    Cell Significance Index: -21.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.0586
    Cell Significance Index: -63.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1979
    Cell Significance Index: -24.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1994
    Cell Significance Index: -94.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1995
    Cell Significance Index: -73.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2384
    Cell Significance Index: -95.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2753
    Cell Significance Index: -27.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.3298
    Cell Significance Index: -94.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3309
    Cell Significance Index: -39.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4133
    Cell Significance Index: -46.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.4147
    Cell Significance Index: -66.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4691
    Cell Significance Index: -51.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5658
    Cell Significance Index: -50.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.5724
    Cell Significance Index: -50.0800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.5734
    Cell Significance Index: -19.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.6979
    Cell Significance Index: -104.3600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.7594
    Cell Significance Index: -25.2700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -1.8797
    Cell Significance Index: -23.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.9146
    Cell Significance Index: -120.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.9153
    Cell Significance Index: -22.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.9597
    Cell Significance Index: -38.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -2.0151
    Cell Significance Index: -104.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.0975
    Cell Significance Index: -73.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.1198
    Cell Significance Index: -59.2400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -2.2256
    Cell Significance Index: -28.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.3255
    Cell Significance Index: -50.9200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -2.3637
    Cell Significance Index: -17.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -2.4580
    Cell Significance Index: -23.3000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -2.5020
    Cell Significance Index: -50.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -2.5085
    Cell Significance Index: -53.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.5589
    Cell Significance Index: -63.8300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -2.6083
    Cell Significance Index: -27.1700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.6917
    Cell Significance Index: -46.5400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -2.7490
    Cell Significance Index: -29.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.7940
    Cell Significance Index: -130.2700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -2.7980
    Cell Significance Index: -17.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.9794
    Cell Significance Index: -64.3700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -3.0231
    Cell Significance Index: -36.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -3.0514
    Cell Significance Index: -63.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Alternative Splicing Regulator:** NOVA1 acts as a regulator of alternative splicing, ensuring the precise joining of exons to generate mature mRNA transcripts. 2. **Spliceosome Involvement:** NOVA1 interacts with the spliceosome to regulate alternative splicing, highlighting its importance in this post-transcriptional process. 3. **Widespread Expression:** NOVA1 is expressed in various cell types, including skeletal muscle fibroblasts, neurons, and glial cells, underscoring its potential role in maintaining cellular homeostasis and tissue development. 4. **Sequence-Specific Binding:** NOVA1 exhibits sequence-specific binding to mRNA, enabling it to regulate alternative splicing with precision. **Pathways and Functions:** 1. **Cytoplasmic and Nuclear Processes:** NOVA1 is involved in cytoplasmic and nuclear processes, including mRNA binding, processing, and splicing. 2. **Regulation of Alternative Splicing:** NOVA1 regulates alternative splicing via the spliceosome, ensuring the precise joining of exons to generate mature mRNA transcripts. 3. **Negative Regulation of Cold-Induced Thermogenesis:** NOVA1 has been implicated in the negative regulation of cold-induced thermogenesis, a process essential for maintaining thermoregulation in mammals. 4. **Nervous System Development:** NOVA1 is involved in nervous system development, highlighting its potential role in the regulation of alternative splicing during neural differentiation. **Clinical Significance:** 1. **Cancer Association:** NOVA1 has been associated with various cancers, including neuro-oncological ventral antigen 1-positive tumors, suggesting its potential role in tumorigenesis. 2. **Neurological Disorders:** NOVA1's involvement in nervous system development and alternative splicing regulation may contribute to the pathogenesis of neurological disorders, such as neurodegenerative diseases and autism spectrum disorder. 3. **Thermoregulation:** NOVA1's negative regulation of cold-induced thermogenesis may have implications for the treatment of hypothermia-related disorders. 4. **Alternative Splicing Dysregulation:** Dysregulation of alternative splicing, mediated by NOVA1, may contribute to various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and tissue development. In conclusion, NOVA1 plays a critical role in regulating alternative splicing via the spliceosome, ensuring the precise joining of exons to generate mature mRNA transcripts. Its widespread expression across various cell types and involvement in cytoplasmic and nuclear processes underscore its importance in maintaining cellular homeostasis and tissue development. Further research is necessary to fully elucidate the clinical significance of NOVA1 and its implications in human disease.

Genular Protein ID: 1838467768

Symbol: NOVA1_HUMAN

Name: Neuro-oncological ventral antigen 1

UniProtKB Accession Codes:

P51513 A8K0S4 A8K4Q7 D3DS81 D3DS82 Q6B004

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 13 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8398153

Title: Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system.

PubMed ID: 8398153

DOI: 10.1016/0896-6273(93)90077-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8558240

Title: The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies.

PubMed ID: 8558240

DOI: 10.1523/jneurosci.16-03-01114.1996

PubMed ID: 10811881

Title: The tetranucleotide UCAY directs the specific recognition of RNA by the Nova K-homology 3 domain.

PubMed ID: 10811881

DOI: 10.1073/pnas.090553997

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 10368286

Title: Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains.

PubMed ID: 10368286

DOI: 10.1016/s0969-2126(99)80025-2

Sequence Information:

  • Length: 507
  • Mass: 51727
  • Checksum: DBF455477988CDCA
  • Sequence:
    • MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY FLKVLIPSYA 
AGSIIGKGGQ TIVQLQKETG ATIKLSKSKD FYPGTTERVC LIQGTVEALN AVHGFIAEKI 
REMPQNVAKT EPVSILQPQT TVNPDRIKQT LPSSPTTTKS SPSDPMTTSR ANQVKIIVPN 
STAGLIIGKG GATVKAVMEQ SGAWVQLSQK PDGINLQERV VTVSGEPEQN RKAVELIIQK 
IQEDPQSGSC LNISYANVTG PVANSNPTGS PYANTAEVLP TAAAAAGLLG HANLAGVAAF 
PAVLSGFTGN DLVAITSALN TLASYGYNLN TLGLGLSQAA ATGALAAAAA SANPAAAAAN 
LLATYASEAS ASGSTAGGTA GTFALGSLAA ATAATNGYFG AASPLAASAI LGTEKSTDGS 
KDVVEIAVPE NLVGAILGKG GKTLVEYQEL TGARIQISKK GEFVPGTRNR KVTITGTPAA 
TQAAQYLITQ RITYEQGVRA ANPQKVG

Genular Protein ID: 3365338740

Symbol: B7Z770_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z770

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 5 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 385
  • Mass: 38711
  • Checksum: 1D41A3A7D0ED31F3
  • Sequence:
    • MPQNVAKTEP VSILQPQTTV NPDRIKQTLP SSPTTTKSSP SDPMTTSRAN QVKIIVPNST 
AGLIIGKGGA TVKAVMEQSG AWVQLSQKPD GINLQERVVT VSGEPEQNRK AVELIIQKIQ 
EDPQSGSCLN ISYANVTGPV ANSNPTGSPY ANTAEVLPTA AAAAGLLGHA NLAGVAAFPA 
VLSGFTGNDL VAITSALNTL ASYGYNLNTL GLGLSQAAAT GALAAAAASA NPAAAAANLL 
ATYASEASAS GSTAGGTAGT FALGSLAAAT AATNGYFGAA SPLAASAILG TEKSTDGSKD 
VVEIAVPENL VGAILGKGGK TLVEYQELTG ARIQISKKGE FVPGTRNRKV TITGTPAATQ 
AAQYLITQRI TYEQGVRAAN PQKVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.