Details for: NUCB2

Gene ID: 4925

Symbol: NUCB2

Ensembl ID: ENSG00000070081

Description: nucleobindin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 284.6118
    Cell Significance Index: -44.2700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 151.3542
    Cell Significance Index: -62.3500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 140.0589
    Cell Significance Index: -66.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 133.7207
    Cell Significance Index: -54.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 122.9429
    Cell Significance Index: -63.2400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 98.9461
    Cell Significance Index: -66.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.9227
    Cell Significance Index: -18.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 56.8216
    Cell Significance Index: -54.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 47.5686
    Cell Significance Index: -58.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5975
    Cell Significance Index: -49.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.6612
    Cell Significance Index: -61.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.6710
    Cell Significance Index: -41.9900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 10.7733
    Cell Significance Index: 288.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.0841
    Cell Significance Index: -22.0700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 7.2834
    Cell Significance Index: 151.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.5092
    Cell Significance Index: 150.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.0132
    Cell Significance Index: 233.7400
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.9940
    Cell Significance Index: 31.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.3844
    Cell Significance Index: 510.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.3953
    Cell Significance Index: 219.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.4996
    Cell Significance Index: 426.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1503
    Cell Significance Index: 349.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8160
    Cell Significance Index: 48.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7584
    Cell Significance Index: 131.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5865
    Cell Significance Index: 217.8700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.5241
    Cell Significance Index: 9.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3936
    Cell Significance Index: 151.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3281
    Cell Significance Index: 79.7300
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.1546
    Cell Significance Index: 7.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1067
    Cell Significance Index: 222.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.0965
    Cell Significance Index: 48.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9927
    Cell Significance Index: 356.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.9296
    Cell Significance Index: 35.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8858
    Cell Significance Index: 24.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8820
    Cell Significance Index: 481.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8603
    Cell Significance Index: 776.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8232
    Cell Significance Index: 42.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7086
    Cell Significance Index: 140.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7037
    Cell Significance Index: 14.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6118
    Cell Significance Index: 78.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5603
    Cell Significance Index: 38.7500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4675
    Cell Significance Index: 88.9700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4471
    Cell Significance Index: 5.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4293
    Cell Significance Index: 55.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3374
    Cell Significance Index: 20.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3323
    Cell Significance Index: 15.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3217
    Cell Significance Index: 142.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2921
    Cell Significance Index: 202.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2245
    Cell Significance Index: 2.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2224
    Cell Significance Index: 27.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1948
    Cell Significance Index: 12.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1648
    Cell Significance Index: 9.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1200
    Cell Significance Index: 225.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1198
    Cell Significance Index: 21.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1179
    Cell Significance Index: 3.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1036
    Cell Significance Index: 5.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0829
    Cell Significance Index: 62.7500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0425
    Cell Significance Index: 0.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0403
    Cell Significance Index: 62.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0339
    Cell Significance Index: 62.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0065
    Cell Significance Index: 4.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0112
    Cell Significance Index: -15.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0177
    Cell Significance Index: -13.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0248
    Cell Significance Index: -18.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0485
    Cell Significance Index: -30.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0557
    Cell Significance Index: -25.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0565
    Cell Significance Index: -5.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0607
    Cell Significance Index: -4.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0613
    Cell Significance Index: -34.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0704
    Cell Significance Index: -0.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0837
    Cell Significance Index: -8.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1031
    Cell Significance Index: -21.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1231
    Cell Significance Index: -2.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1435
    Cell Significance Index: -2.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1486
    Cell Significance Index: -17.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1595
    Cell Significance Index: -11.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1631
    Cell Significance Index: -10.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1652
    Cell Significance Index: -4.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1694
    Cell Significance Index: -48.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1782
    Cell Significance Index: -5.1400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1989
    Cell Significance Index: -6.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2122
    Cell Significance Index: -5.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2326
    Cell Significance Index: -33.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2799
    Cell Significance Index: -31.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3196
    Cell Significance Index: -36.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4422
    Cell Significance Index: -20.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5357
    Cell Significance Index: -55.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5608
    Cell Significance Index: -29.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5867
    Cell Significance Index: -15.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5901
    Cell Significance Index: -18.9000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.7068
    Cell Significance Index: -4.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7138
    Cell Significance Index: -43.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7225
    Cell Significance Index: -57.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8589
    Cell Significance Index: -24.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8694
    Cell Significance Index: -20.8500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8976
    Cell Significance Index: -7.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0983
    Cell Significance Index: -23.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.1226
    Cell Significance Index: -32.9700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1460
    Cell Significance Index: -42.0700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1679
    Cell Significance Index: -31.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NUCB2 is a DNA-binding protein that exhibits a unique ability to interact with nucleic acids, thereby influencing gene expression and cellular behavior. Its expression is widespread across various cell types, including salivary gland acinar cells, tracheobronchial tree ciliated columnar cells, hematopoietic stem cells, and natural killer cells. This broad expression pattern suggests that NUCB2 plays a critical role in maintaining cellular homeostasis and regulating the immune response. **Pathways and Functions:** NUCB2's involvement in various signaling pathways highlights its multifaceted role in cellular regulation. Some of the key pathways and functions associated with NUCB2 include: * Calcium ion binding: NUCB2 interacts with calcium ions, which are essential for signaling events in cells. * DNA binding: As a DNA-binding protein, NUCB2 regulates gene expression by interacting with specific DNA sequences. * Guanyl-nucleotide exchange factor activity: NUCB2 facilitates the exchange of guanine nucleotides, which is crucial for G-protein-mediated signal transduction. * Protein binding: NUCB2 interacts with various proteins, including G-protein alpha-subunits, to modulate signaling events. **Clinical Significance:** The clinical significance of NUCB2 lies in its potential role in modulating immune responses and regulating cellular homeostasis. Dysregulation of NUCB2 expression has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. For instance: * Cancer: NUCB2's role in regulating cell growth and differentiation makes it a potential therapeutic target for cancer treatment. * Autoimmune disorders: NUCB2's involvement in immune regulation suggests that it may play a critical role in autoimmune diseases, such as rheumatoid arthritis and lupus. * Inflammatory conditions: NUCB2's expression in natural killer cells and its role in regulating immune responses make it a potential target for treating inflammatory conditions, such as asthma and chronic obstructive pulmonary disease (COPD). **Conclusion:** In conclusion, NUCB2 is a gene of emerging significance in immunology, with its unique ability to interact with nucleic acids and modulate various signaling pathways. Further research is necessary to fully elucidate the clinical significance of NUCB2 and its potential role in regulating immune responses and cellular homeostasis. As an expert immunologist, I believe that NUCB2 holds great promise for the development of novel therapeutic strategies for various diseases, including cancer, autoimmune disorders, and inflammatory conditions.

Genular Protein ID: 1148242881

Symbol: NUCB2_HUMAN

Name: DNA-binding protein NEFA

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7811391

Title: Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein.

PubMed ID: 7811391

DOI: 10.1515/bchm3.1994.375.8.497

PubMed ID: 9639681

Title: Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene.

PubMed ID: 9639681

DOI: 10.1016/s0925-4439(98)00025-8

PubMed ID: 12087473

Title: Serological identification and expression analysis of gastric cancer-associated genes.

PubMed ID: 12087473

DOI: 10.1038/sj.bjc.6600321

PubMed ID: 20427483

Title: Troglitazone, a ligand of peroxisome proliferator-activated receptor-gamma, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene.

PubMed ID: 20427483

DOI: 10.1210/en.2009-1169

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 11749975

Title: Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region.

PubMed ID: 11749975

DOI: 10.1016/s0014-5793(01)03187-8

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30194280

Title: A biochemical and genetic discovery pipeline identifies PLCdelta4b as a nonreceptor activator of heterotrimeric G-proteins.

PubMed ID: 30194280

DOI: 10.1074/jbc.ra118.003580

Sequence Information:

  • Length: 420
  • Mass: 50223
  • Checksum: ABA74587B72C33FE
  • Sequence:
  • MRWRTILLQY CFLLITCLLT ALEAVPIDID KTKVQNIHPV ESAKIEPPDT GLYYDEYLKQ 
    VIDVLETDKH FREKLQKADI EEIKSGRLSK ELDLVSHHVR TKLDELKRQE VGRLRMLIKA 
    KLDSLQDIGM DHQALLKQFD HLNHLNPDKF ESTDLDMLIK AATSDLEHYD KTRHEEFKKY 
    EMMKEHERRE YLKTLNEEKR KEEESKFEEM KKKHENHPKV NHPGSKDQLK EVWEETDGLD 
    PNDFDPKTFF KLHDVNSDGF LDEQELEALF TKELEKVYDP KNEEDDMVEM EEERLRMREH 
    VMNEVDTNKD RLVTLEEFLK ATEKKEFLEP DSWETLDQQQ FFTEEELKEY ENIIALQENE 
    LKKKADELQK QKEELQRQHD QLEAQKLEYH QVIQQMEQKK LQQGIPPSGP AGELKFEPHI

Genular Protein ID: 3885277042

Symbol: Q2L696_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 390
  • Mass: 46630
  • Checksum: DB4FA8B2882C4BA6
  • Sequence:
  • MRWRTILLQY CFLLITCLLT ALEAVPIDID KTKVQNIHPV ESAKIEPPDT GLYYDEYLKQ 
    VIDVLETDKH FREKLQKADI EEIKSGRLSK ELDLVSHHVR TKLDELKRQE VGRLRMLIKA 
    KLDSLQDIGM DHQALLKQFD HLNHLNPDKF ESTDLDMLIK AATSDLEHYD KTRHEEFKKY 
    EMMKEHERRE YLKTLNEEKR KEEESKFEEM KKKHENHPKV NHPGSKDQLK EVWEETDGLD 
    PNDFDPKTFF KLHDVNSDGF LDEQELEALF TKELEKVYDP KNEEDDMVEM EEERLRMREH 
    VMNETLDQQQ FFTEEELKEY ENIIALQENE LKKKADELQK QKEELQRQHD QLEAQKLEYH 
    QVIQQMEQKK LQQGIPPSGP AGELKFEPHI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.