Details for: OAZ2

Gene ID: 4947

Symbol: OAZ2

Ensembl ID: ENSG00000180304

Description: ornithine decarboxylase antizyme 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 317.5282
    Cell Significance Index: -49.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.6223
    Cell Significance Index: -45.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 139.3381
    Cell Significance Index: -57.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 114.0170
    Cell Significance Index: -53.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.5427
    Cell Significance Index: -43.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.4367
    Cell Significance Index: -50.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.8710
    Cell Significance Index: -43.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.7882
    Cell Significance Index: -50.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.0334
    Cell Significance Index: -45.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.6478
    Cell Significance Index: -53.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.6459
    Cell Significance Index: -35.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6853
    Cell Significance Index: -16.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0305
    Cell Significance Index: 353.1700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.0478
    Cell Significance Index: 16.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.0325
    Cell Significance Index: 70.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.9237
    Cell Significance Index: 34.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7637
    Cell Significance Index: 92.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3210
    Cell Significance Index: 83.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2253
    Cell Significance Index: 63.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1299
    Cell Significance Index: 23.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0632
    Cell Significance Index: 172.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9210
    Cell Significance Index: 118.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9069
    Cell Significance Index: 67.5900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.8621
    Cell Significance Index: 9.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7580
    Cell Significance Index: 104.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7269
    Cell Significance Index: 145.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7243
    Cell Significance Index: 71.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7102
    Cell Significance Index: 19.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6546
    Cell Significance Index: 357.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6308
    Cell Significance Index: 37.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6235
    Cell Significance Index: 80.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5769
    Cell Significance Index: 26.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5003
    Cell Significance Index: 221.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4578
    Cell Significance Index: 56.3000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4268
    Cell Significance Index: 29.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4107
    Cell Significance Index: 10.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3966
    Cell Significance Index: 71.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3549
    Cell Significance Index: 16.6800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3420
    Cell Significance Index: 236.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3033
    Cell Significance Index: 60.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2978
    Cell Significance Index: 106.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1497
    Cell Significance Index: 11.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1487
    Cell Significance Index: 3.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1371
    Cell Significance Index: 9.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1185
    Cell Significance Index: 13.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1120
    Cell Significance Index: 19.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0959
    Cell Significance Index: 1.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0811
    Cell Significance Index: 15.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0488
    Cell Significance Index: 0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0131
    Cell Significance Index: 9.9000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0098
    Cell Significance Index: 18.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0040
    Cell Significance Index: -0.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0227
    Cell Significance Index: -41.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0254
    Cell Significance Index: -39.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0292
    Cell Significance Index: -21.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0310
    Cell Significance Index: -42.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0419
    Cell Significance Index: -26.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0434
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0455
    Cell Significance Index: -28.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0466
    Cell Significance Index: -21.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0561
    Cell Significance Index: -31.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0700
    Cell Significance Index: -1.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0752
    Cell Significance Index: -7.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0931
    Cell Significance Index: -3.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0938
    Cell Significance Index: -4.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1202
    Cell Significance Index: -25.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1362
    Cell Significance Index: -39.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1546
    Cell Significance Index: -3.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1551
    Cell Significance Index: -17.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1757
    Cell Significance Index: -9.8600
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.1991
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2230
    Cell Significance Index: -25.4600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2273
    Cell Significance Index: -2.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2639
    Cell Significance Index: -38.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2699
    Cell Significance Index: -14.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2855
    Cell Significance Index: -7.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3150
    Cell Significance Index: -21.1800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3723
    Cell Significance Index: -4.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4190
    Cell Significance Index: -7.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4235
    Cell Significance Index: -9.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4523
    Cell Significance Index: -9.8000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4572
    Cell Significance Index: -3.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4684
    Cell Significance Index: -48.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4993
    Cell Significance Index: -39.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5700
    Cell Significance Index: -18.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6105
    Cell Significance Index: -17.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7467
    Cell Significance Index: -33.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8359
    Cell Significance Index: -24.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8479
    Cell Significance Index: -14.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8639
    Cell Significance Index: -52.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9035
    Cell Significance Index: -55.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9214
    Cell Significance Index: -34.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9522
    Cell Significance Index: -25.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9691
    Cell Significance Index: -24.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9808
    Cell Significance Index: -22.6600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0246
    Cell Significance Index: -29.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1543
    Cell Significance Index: -42.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.1587
    Cell Significance Index: -34.0300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2489
    Cell Significance Index: -40.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Inhibitory function:** OAZ2 acts as an antizyme, inhibiting the activity of ODC, thereby regulating polyamine biosynthesis. 2. **Cell-type specificity:** OAZ2 is highly expressed in specific cell types, including retinal rod cells, peripheral nervous system neurons, and kidney cells, suggesting a cell-type-specific role in polyamine metabolism. 3. **Regulation of polyamine biosynthesis:** OAZ2 modulates the levels of polyamines, which are essential for various cellular processes, including cell growth, differentiation, and survival. 4. **Negative regulation:** OAZ2 exerts negative regulation on polyamine transmembrane transport, suggesting a complex interplay between polyamine biosynthesis and transport. **Pathways and Functions:** 1. **Polyamine biosynthesis:** OAZ2 inhibits ODC, thereby regulating the synthesis of polyamines, such as putrescine, spermidine, and spermine. 2. **Negative regulation of polyamine transmembrane transport:** OAZ2 exerts negative regulation on polyamine transmembrane transport, suggesting a complex interplay between polyamine biosynthesis and transport. 3. **Regulation of intracellular protein transport:** OAZ2 positively regulates intracellular protein transport, suggesting a role in protein trafficking and cellular homeostasis. 4. **Regulation of protein catabolic process:** OAZ2 positively regulates protein catabolic process, suggesting a role in protein degradation and cellular homeostasis. **Clinical Significance:** 1. **Polyamine-related disorders:** Alterations in polyamine metabolism, including changes in OAZ2 expression, have been implicated in various disorders, such as cancer, neurodegenerative diseases, and metabolic disorders. 2. **Cancer therapy:** OAZ2 has been identified as a potential target for cancer therapy, as alterations in polyamine metabolism have been linked to cancer progression and metastasis. 3. **Neurodegenerative diseases:** Changes in OAZ2 expression have been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting a potential role in disease pathogenesis. 4. **Metabolic disorders:** OAZ2 has been implicated in metabolic disorders, such as obesity and diabetes, highlighting the importance of polyamine metabolism in maintaining metabolic homeostasis. In conclusion, the OAZ2 gene plays a critical role in regulating polyamine metabolism and cellular regulation, with implications for various diseases, including cancer, neurodegenerative diseases, and metabolic disorders. Further research is needed to fully elucidate the functions of OAZ2 and its role in human disease.

Genular Protein ID: 3445407530

Symbol: OAZ2_HUMAN

Name: Ornithine decarboxylase antizyme 2

UniProtKB Accession Codes:

O95190

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9782076

Title: A second mammalian antizyme: conservation of programmed ribosomal frameshifting.

PubMed ID: 9782076

DOI: 10.1006/geno.1998.5434

PubMed ID: 10352227

Title: Structure of human ornithine decarboxylase antizyme 2 gene.

PubMed ID: 10352227

DOI: 10.1016/s0378-1119(99)00128-6

PubMed ID: 17900240

Title: Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.

PubMed ID: 17900240

DOI: 10.1042/bj20071004

Sequence Information:

  • Length: 189
  • Mass: 21011
  • Checksum: 66390D87EB30CB8F
  • Sequence:
    • MINTQDSSIL PLSNCPQLQC CRHIVPGPLW CSDAPHPLSK IPGGRGGGRD PSLSALIYKD 
EKLTVTQDLP VNDGKPHIVH FQYEVTEVKV SSWDAVLSSQ SLFVEIPDGL LADGSKEGLL 
ALLEFAEEKM KVNYVFICFR KGREDRAPLL KTFSFLGFEI VRPGHPCVPS RPDVMFMVYP 
LDQNLSDED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.