Details for: OGDH

Gene ID: 4967

Symbol: OGDH

Ensembl ID: ENSG00000105953

Description: oxoglutarate dehydrogenase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 270.5322
    Cell Significance Index: -42.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 168.6620
    Cell Significance Index: -42.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 111.3491
    Cell Significance Index: -45.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 95.5260
    Cell Significance Index: -45.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 94.2507
    Cell Significance Index: -38.2900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.1284
    Cell Significance Index: -42.7600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 67.1364
    Cell Significance Index: -45.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 40.2517
    Cell Significance Index: -38.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.2648
    Cell Significance Index: -43.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.6671
    Cell Significance Index: -41.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.9650
    Cell Significance Index: -36.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.2163
    Cell Significance Index: -44.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5822
    Cell Significance Index: -23.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.2585
    Cell Significance Index: 250.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.6260
    Cell Significance Index: 67.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7091
    Cell Significance Index: 342.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4483
    Cell Significance Index: 168.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1785
    Cell Significance Index: 233.8700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1644
    Cell Significance Index: 28.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0792
    Cell Significance Index: 30.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0589
    Cell Significance Index: 379.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9668
    Cell Significance Index: 157.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9165
    Cell Significance Index: 22.9100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.7403
    Cell Significance Index: 10.9300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7380
    Cell Significance Index: 19.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7211
    Cell Significance Index: 19.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6856
    Cell Significance Index: 38.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6709
    Cell Significance Index: 30.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6110
    Cell Significance Index: 422.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5895
    Cell Significance Index: 16.9900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5185
    Cell Significance Index: 10.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4352
    Cell Significance Index: 19.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4319
    Cell Significance Index: 53.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4274
    Cell Significance Index: 77.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4114
    Cell Significance Index: 15.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3394
    Cell Significance Index: 17.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2503
    Cell Significance Index: 136.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2001
    Cell Significance Index: 7.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1994
    Cell Significance Index: 375.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1840
    Cell Significance Index: 116.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1570
    Cell Significance Index: 15.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1490
    Cell Significance Index: 65.8600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1454
    Cell Significance Index: 8.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1447
    Cell Significance Index: 9.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1437
    Cell Significance Index: 27.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1361
    Cell Significance Index: 61.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1029
    Cell Significance Index: 189.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0939
    Cell Significance Index: 144.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0729
    Cell Significance Index: 1.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0309
    Cell Significance Index: 3.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0257
    Cell Significance Index: 34.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0126
    Cell Significance Index: 0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0080
    Cell Significance Index: 1.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0023
    Cell Significance Index: 1.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0007
    Cell Significance Index: 0.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0168
    Cell Significance Index: -10.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0225
    Cell Significance Index: -16.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0277
    Cell Significance Index: -1.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0284
    Cell Significance Index: -21.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0439
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0511
    Cell Significance Index: -8.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0584
    Cell Significance Index: -32.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0671
    Cell Significance Index: -6.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0929
    Cell Significance Index: -4.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0931
    Cell Significance Index: -1.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1063
    Cell Significance Index: -13.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1246
    Cell Significance Index: -18.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1263
    Cell Significance Index: -2.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1338
    Cell Significance Index: -38.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1414
    Cell Significance Index: -29.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1458
    Cell Significance Index: -18.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1822
    Cell Significance Index: -11.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2009
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2185
    Cell Significance Index: -25.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2573
    Cell Significance Index: -3.5100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2672
    Cell Significance Index: -5.8500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2688
    Cell Significance Index: -5.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2812
    Cell Significance Index: -29.2800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2902
    Cell Significance Index: -8.2800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3360
    Cell Significance Index: -2.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3402
    Cell Significance Index: -24.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3409
    Cell Significance Index: -17.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3425
    Cell Significance Index: -39.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3526
    Cell Significance Index: -7.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4047
    Cell Significance Index: -32.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4084
    Cell Significance Index: -30.4400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4103
    Cell Significance Index: -9.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4585
    Cell Significance Index: -12.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4588
    Cell Significance Index: -8.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5072
    Cell Significance Index: -10.7700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5381
    Cell Significance Index: -6.7100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6291
    Cell Significance Index: -38.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6591
    Cell Significance Index: -9.4800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7028
    Cell Significance Index: -8.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7234
    Cell Significance Index: -10.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7534
    Cell Significance Index: -24.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7752
    Cell Significance Index: -25.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7781
    Cell Significance Index: -9.2800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8056
    Cell Significance Index: -8.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8079
    Cell Significance Index: -28.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **OGDH Complex:** OGDH is a part of the OGDH complex, a multi-enzyme system that includes dihydrolipoyl transacetylase, dihydrolipoyl dehydrogenase, and dihydrolipoyl transacetylase (E1, E2, and E3 components, respectively). 2. **Metabolic Pathways:** OGDH is involved in multiple metabolic pathways, including the TCA cycle, glycolysis, amino acid metabolism, and precursor metabolite generation. 3. **Subcellular Localization:** OGDH is primarily localized in the mitochondrial matrix, with some expression detected in the nucleus and cytosol. 4. **Regulatory Mechanisms:** OGDH activity is regulated by various mechanisms, including allosteric control, substrate availability, and post-translational modifications. **Pathways and Functions:** 1. **Citric Acid Cycle (TCA Cycle):** OGDH is a critical component of the TCA cycle, facilitating the conversion of oxoglutarate to succinyl-CoA, which is then converted to succinate and subsequently enters the electron transport chain. 2. **Glycolysis:** OGDH is involved in glycolysis, where it helps to generate energy from glucose through the conversion of pyruvate to acetyl-CoA. 3. **Amino Acid Metabolism:** OGDH plays a role in amino acid metabolism, particularly in the degradation of lysine and the generation of precursor metabolites. 4. **Precursor Metabolite Generation:** OGDH contributes to the generation of precursor metabolites, including succinyl-CoA, which is used in various biosynthetic pathways. **Clinical Significance:** 1. **Metabolic Disorders:** OGDH dysfunction has been implicated in various metabolic disorders, including mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS syndrome). 2. **Cancer:** Aberrant OGDH expression has been observed in certain types of cancer, suggesting a potential role in tumorigenesis. 3. **Neurological Disorders:** OGDH has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 4. **Cardiovascular Disease:** OGDH dysfunction has been linked to cardiovascular disease, particularly in the context of ischemic stroke. In conclusion, OGDH is a multifunctional enzyme that plays a critical role in various metabolic pathways and cellular development. Its dysregulation has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis and overall health. Further research is needed to fully elucidate the complex relationships between OGDH and its downstream targets, ultimately shedding light on the molecular mechanisms underlying these diseases.

Genular Protein ID: 2380533276

Symbol: ODO1_HUMAN

Name: 2-oxoglutarate dehydrogenase, mitochondrial

UniProtKB Accession Codes:

Q02218 B4E2U9 D3DVL0 E9PBM1 Q96DD3 Q9UDX0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 1 EMBL 12 EMDB 2 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 3 RefSeq 3 Rhea 4 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1542694

Title: Cloning and nucleotide sequence of the cDNA encoding human 2-oxoglutarate dehydrogenase (lipoamide).

PubMed ID: 1542694

DOI: 10.1073/pnas.89.5.1963

PubMed ID: 7622061

Title: The gene encoding human 2-oxoglutarate dehydrogenase: structural organization and mapping to chromosome 7p13-p14.

PubMed ID: 7622061

DOI: 10.1016/0378-1119(95)00086-l

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17370265

Title: Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry.

PubMed ID: 17370265

DOI: 10.1002/pmic.200600410

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24495017

Title: Studies on the regulation of the human E1 subunit of the 2-oxoglutarate dehydrogenase complex, including the identification of a novel calcium-binding site.

PubMed ID: 24495017

DOI: 10.1042/bj20131664

PubMed ID: 25210035

Title: Human 2-oxoglutarate dehydrogenase complex E1 component forms a thiamin-derived radical by aerobic oxidation of the enamine intermediate.

PubMed ID: 25210035

DOI: 10.1074/jbc.m114.591073

PubMed ID: 28435050

Title: The human Krebs cycle 2-oxoglutarate dehydrogenase complex creates an additional source of superoxide/hydrogen peroxide from 2-oxoadipate as alternative substrate.

PubMed ID: 28435050

DOI: 10.1016/j.freeradbiomed.2017.04.017

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29211711

Title: KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase.

PubMed ID: 29211711

DOI: 10.1038/nature25003

PubMed ID: 32792488

Title: ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex.

PubMed ID: 32792488

DOI: 10.1038/s41467-020-17862-6

PubMed ID: 18973345

Title: Different thermodynamic binding mechanisms and peptide fine specificities associated with a panel of structurally similar high-affinity T cell receptors.

PubMed ID: 18973345

DOI: 10.1021/bi801349g

PubMed ID: 35272141

Title: Structural basis for the activity and regulation of human alpha-ketoglutarate dehydrogenase revealed by Cryo-EM.

PubMed ID: 35272141

DOI: 10.1016/j.bbrc.2022.02.093

Sequence Information:

  • Length: 1023
  • Mass: 115935
  • Checksum: F428DD342F232E7C
  • Sequence:
    • MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL SGTSSNYVEE 
MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS RGSLAAVAHA QSLVEAQPNV 
DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL GILDADLDSS VPADIISSTD KLGFYGLDES 
DLDKVFHLPT TTFIGGQESA LPLREIIRRL EMAYCQHIGV EFMFINDLEQ CQWIRQKFET 
PGIMQFTNEE KRTLLARLVR STRFEEFLQR KWSSEKRFGL EGCEVLIPAL KTIIDKSSEN 
GVDYVIMGMP HRGRLNVLAN VIRKELEQIF CQFDSKLEAA DEGSGDVKYH LGMYHRRINR 
VTDRNITLSL VANPSHLEAA DPVVMGKTKA EQFYCGDTEG KKVMSILLHG DAAFAGQGIV 
YETFHLSDLP SYTTHGTVHV VVNNQIGFTT DPRMARSSPY PTDVARVVNA PIFHVNSDDP 
EAVMYVCKVA AEWRSTFHKD VVVDLVCYRR NGHNEMDEPM FTQPLMYKQI RKQKPVLQKY 
AELLVSQGVV NQPEYEEEIS KYDKICEEAF ARSKDEKILH IKHWLDSPWP GFFTLDGQPR 
SMSCPSTGLT EDILTHIGNV ASSVPVENFT IHGGLSRILK TRGEMVKNRT VDWALAEYMA 
FGSLLKEGIH IRLSGQDVER GTFSHRHHVL HDQNVDKRTC IPMNHLWPNQ APYTVCNSSL 
SEYGVLGFEL GFAMASPNAL VLWEAQFGDF HNTAQCIIDQ FICPGQAKWV RQNGIVLLLP 
HGMEGMGPEH SSARPERFLQ MCNDDPDVLP DLKEANFDIN QLYDCNWVVV NCSTPGNFFH 
VLRRQILLPF RKPLIIFTPK SLLRHPEARS SFDEMLPGTH FQRVIPEDGP AAQNPENVKR 
LLFCTGKVYY DLTRERKARD MVGQVAITRI EQLSPFPFDL LLKEVQKYPN AELAWCQEEH 
KNQGYYDYVK PRLRTTISRA KPVWYAGRDP AAAPATGNKK THLTELQRLL DTAFDLDVFK 
NFS

Genular Protein ID: 1687857340

Symbol: E9PCR7_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PCR7

Database IDs:

ARBA 16 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 4 GeneTree 1 HGNC 1 IntAct 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 2 Pfam 4 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 4 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 1038
  • Mass: 117665
  • Checksum: 1BF9B291F8523359
  • Sequence:
    • MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL SGTSSNYVEE 
MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS RGSLAAVAHA QSLVEAQPNV 
DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL GILDADLDSS VPADIISSTD KLDLAVFKER 
LRMLTVGGFY GLDESDLDKV FHLPTTTFIG GQESALPLRE IIRRLEMAYC QHIGVEFMFI 
NDLEQCQWIR QKFETPGIMQ FTNEEKRTLL ARLVRSTRFE EFLQRKWSSE KRFGLEGCEV 
LIPALKTIID KSSENGVDYV IMGMPHRGRL NVLANVIRKE LEQIFCQFDS KLEAADEGSG 
DVKYHLGMYH RRINRVTDRN ITLSLVANPS HLEAADPVVM GKTKAEQFYC GDTEGKKVMS 
ILLHGDAAFA GQGIVYETFH LSDLPSYTTH GTVHVVVNNQ IGFTTDPRMA RSSPYPTDVA 
RVVNAPIFHV NSDDPEAVMY VCKVAAEWRS TFHKDVVVDL VCYRRNGHNE MDEPMFTQPL 
MYKQIRKQKP VLQKYAELLV SQGVVNQPEY EEEISKYDKI CEEAFARSKD EKILHIKHWL 
DSPWPGFFTL DGQPRSMSCP STGLTEDILT HIGNVASSVP VENFTIHGGL SRILKTRGEM 
VKNRTVDWAL AEYMAFGSLL KEGIHIRLSG QDVERGTFSH RHHVLHDQNV DKRTCIPMNH 
LWPNQAPYTV CNSSLSEYGV LGFELGFAMA SPNALVLWEA QFGDFHNTAQ CIIDQFICPG 
QAKWVRQNGI VLLLPHGMEG MGPEHSSARP ERFLQMCNDD PDVLPDLKEA NFDINQLYDC 
NWVVVNCSTP GNFFHVLRRQ ILLPFRKPLI IFTPKSLLRH PEARSSFDEM LPGTHFQRVI 
PEDGPAAQNP ENVKRLLFCT GKVYYDLTRE RKARDMVGQV AITRIEQLSP FPFDLLLKEV 
QKYPNAELAW CQEEHKNQGY YDYVKPRLRT TISRAKPVWY AGRDPAAAPA TGNKKTHLTE 
LQRLLDTAFD LDVFKNFS

Genular Protein ID: 388618281

Symbol: B4E3E9_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E3E9

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 3 InterPro 6 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 2 Rhea 4 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 818
  • Mass: 92840
  • Checksum: DD846E3E57885C3D
  • Sequence:
    • MLIWTPPCPL TLSHPQTNLG SMAWMSLTST RSSTCPPPLS SGDRNQHFLC GRSSVGWRFE 
EFLQRKWSSE KRFGLEGCEV LIPALKTIID KSSENGVDYV IMGMPHRGRL NVLANVIRKE 
LEQIFCQFDS KLEAADEGSG DVKYHLGMYH RRINRVTDRN ITLSLVANPS HLEAADPVVM 
GKTKAEQFYC GDTEGKKVMS ILLHGDAAFA GQGIVYETFH LSDLPSYTTH GTVHVVVNNQ 
IGFTTDPRMA RSSPYPTDVA RVVNAPIFHV NSDDPEAVMY VCKVAAEWRS TFHKDVVVDL 
VCYRRNGHNE MDEPMFTQPL MYKQIRKQKP VLQKYAELLV SQGVVNQPEY EEEISKYDKI 
CEEAFARSKD EKILHIKHWL DSPWPGFFTL DGQPRSMSCP STGLTEDILT HIGNVASSVP 
VENFTIHGGL SRILKTRGEM VKNRTVDWAL AEYMAFGSLL KEGIHIRLSG QDVERGTFSH 
RHHVLHDQNV DKRTCIPMNH LWPNQAPYTV CNSSLSEYGV LGFELGFAMA SPNALVLWEA 
QFGDFHNTAQ CIIDQFICPG QAKWVRQNGI VLLLPHGMEG MGPEHSSARP ERFLQMCNDD 
PDVLPDLKEA NFDINQLYDC NWVVVNCSTP GNFFHVLRRQ ILLPFRKPLI IFTPKSLLRH 
PEARSSFDEM LPGTHFQRVI PEDGPAAQNP ENVKRLLFCT GKVYYDLTRE RKARDMVGQV 
AITRIEQLSP FPFDLLLKEV QKYPNAELAW CQEEHKNQGY YDYVKPRLRT TISRAKPVWY 
AGRDPAAAPA TGNKKTHLTE LQRLLDTAFD LDVFKNFS

Genular Protein ID: 1809773869

Symbol: A0A140VJQ5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJQ5

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 2 ExpressionAtlas 1 GO 7 Gene3D 2 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 4 RefSeq 1 Rhea 4 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 427
  • Mass: 48180
  • Checksum: 11C89C89F2C6308E
  • Sequence:
    • MFHLRTCAAK LRPLTASQTV KTFSQNRPAA ARTFQQIRCY SAPVAAEPFL SGTSSNYVEE 
MYCAWLENPK SVHKSWDIFF RNTNAGAPPG TAYQSPLPLS RGSLAAVAHA QSLVEAQPNV 
DKLVEDHLAV QSLIRAYQIR GHHVAQLDPL GILDADLDSS VPADIISSTD KLGFYGLDES 
DLDKVFHLPT TTFIGGQESA LPLREIIRRL EMAYCQHIGV EFMFINDLEQ CQWIRQKFET 
PGIMQFTNEE KRTLLARLVR STRFEEFLQR KWSSEKRFGL EGCEVLIPAL KTIIDKSSEN 
GVDYVIMGMP HRGRLNVLAN VIRKELEQIF CQFDSKLEAA DEGSGDVKYH LGMYHRRINR 
VTDRNITLSL VANPSHLEAA DPVVMGKTKA EQFYCGDTEG KKVRPRERRA RQIVKAPCSS 
MEFRSPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.