Details for: ORC1

Gene ID: 4998

Symbol: ORC1

Ensembl ID: ENSG00000085840

Description: origin recognition complex subunit 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 19.2002
    Cell Significance Index: -4.8700
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 11.3793
    Cell Significance Index: -1.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.9985
    Cell Significance Index: -4.9300
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 1.1858
    Cell Significance Index: 0.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7612
    Cell Significance Index: 75.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4797
    Cell Significance Index: 28.8000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4304
    Cell Significance Index: 46.8100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4180
    Cell Significance Index: 11.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4080
    Cell Significance Index: 66.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3115
    Cell Significance Index: 281.2300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2513
    Cell Significance Index: 47.8300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2214
    Cell Significance Index: 3.1700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2088
    Cell Significance Index: 2.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2083
    Cell Significance Index: 3.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2036
    Cell Significance Index: 40.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1871
    Cell Significance Index: 22.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1574
    Cell Significance Index: 4.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1424
    Cell Significance Index: 3.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1422
    Cell Significance Index: 2.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1064
    Cell Significance Index: 5.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0930
    Cell Significance Index: 2.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0818
    Cell Significance Index: 2.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0732
    Cell Significance Index: 3.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0595
    Cell Significance Index: 3.6500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0490
    Cell Significance Index: 0.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0428
    Cell Significance Index: 0.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0402
    Cell Significance Index: 2.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0375
    Cell Significance Index: 1.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0358
    Cell Significance Index: 4.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0291
    Cell Significance Index: 0.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0270
    Cell Significance Index: 5.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0245
    Cell Significance Index: 0.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0215
    Cell Significance Index: 11.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0180
    Cell Significance Index: 7.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0160
    Cell Significance Index: 0.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0122
    Cell Significance Index: 0.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0108
    Cell Significance Index: 1.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0088
    Cell Significance Index: 0.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0074
    Cell Significance Index: 0.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0051
    Cell Significance Index: 3.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0049
    Cell Significance Index: 1.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0036
    Cell Significance Index: -5.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0044
    Cell Significance Index: -2.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0045
    Cell Significance Index: -0.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0049
    Cell Significance Index: -6.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0078
    Cell Significance Index: -0.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0083
    Cell Significance Index: -1.0200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0084
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0092
    Cell Significance Index: -5.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0103
    Cell Significance Index: -4.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0108
    Cell Significance Index: -0.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0122
    Cell Significance Index: -3.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0124
    Cell Significance Index: -7.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0170
    Cell Significance Index: -1.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0260
    Cell Significance Index: -3.5700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0273
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0274
    Cell Significance Index: -4.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0279
    Cell Significance Index: -0.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0346
    Cell Significance Index: -7.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0349
    Cell Significance Index: -2.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0362
    Cell Significance Index: -4.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0394
    Cell Significance Index: -4.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0406
    Cell Significance Index: -4.6600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0429
    Cell Significance Index: -0.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0436
    Cell Significance Index: -1.1200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0475
    Cell Significance Index: -0.4700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0480
    Cell Significance Index: -5.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0481
    Cell Significance Index: -3.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0513
    Cell Significance Index: -2.3900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0588
    Cell Significance Index: -0.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0612
    Cell Significance Index: -3.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0616
    Cell Significance Index: -4.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0630
    Cell Significance Index: -4.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0676
    Cell Significance Index: -1.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0687
    Cell Significance Index: -0.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0699
    Cell Significance Index: -5.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0708
    Cell Significance Index: -4.7600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0737
    Cell Significance Index: -1.1100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0816
    Cell Significance Index: -1.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0859
    Cell Significance Index: -4.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0898
    Cell Significance Index: -0.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0943
    Cell Significance Index: -4.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0994
    Cell Significance Index: -5.2200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1073
    Cell Significance Index: -3.1500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1083
    Cell Significance Index: -1.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1090
    Cell Significance Index: -3.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1094
    Cell Significance Index: -2.1400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1166
    Cell Significance Index: -1.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1187
    Cell Significance Index: -4.5000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1272
    Cell Significance Index: -5.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1384
    Cell Significance Index: -6.9900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.1403
    Cell Significance Index: -1.5500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1411
    Cell Significance Index: -1.5400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1417
    Cell Significance Index: -1.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ORC1 is a highly conserved protein that belongs to the Origin Recognition Complex, a heteropentameric protein complex that recognizes and binds to the origin of replication. The ORC complex is composed of four subunits, with ORC1 being one of the essential components. ORC1 is characterized by its ability to bind to DNA and its role in regulating the assembly of the pre-replicative complex. The protein exhibits ATP-binding and hydrolysis activity, which is crucial for its function in DNA replication. **Pathways and Functions:** ORC1 is involved in several key pathways that regulate DNA replication and cell cycle progression. These include: 1. **Activation of the pre-replicative complex**: ORC1 plays a critical role in the assembly of the pre-replicative complex, which is essential for the initiation of DNA replication. 2. **Assembly of the ORC complex at the origin of replication**: ORC1 is responsible for binding to the origin of replication, facilitating the recognition and assembly of the pre-replicative complex. 3. **DNA replication initiation**: ORC1 is involved in the initiation of DNA replication, ensuring that the replication process is accurately and efficiently executed. 4. **Cell cycle regulation**: ORC1 is also involved in regulating the cell cycle, particularly during the G1/S transition, ensuring that the cell enters the S phase of the cell cycle for DNA replication. **Clinical Significance:** Dysregulation of ORC1 has been implicated in various diseases, including cancer and genetic disorders. For example, mutations in ORC1 have been associated with inherited disorders such as Fanconi anemia and Bloom syndrome, which are characterized by genomic instability and increased risk of cancer. Additionally, ORC1 has been shown to play a role in the development of certain types of cancer, including breast and lung cancer. Furthermore, ORC1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. Understanding the role of ORC1 in DNA replication and cell cycle regulation is essential for the development of novel therapeutic strategies for these diseases. **Significantly Expressed Cells:** ORC1 is highly expressed in various cell types, including: 1. **Retinal cone cells**: ORC1 is expressed in retinal cone cells, highlighting its role in maintaining retinal homeostasis. 2. **Neural progenitor cells**: ORC1 is expressed in neural progenitor cells, underscoring its importance in neural development and maintenance. 3. **Erythroblasts**: ORC1 is expressed in erythroblasts, suggesting its role in hematopoiesis. 4. **Cerebral cortex GABAergic interneuron**: ORC1 is expressed in cerebral cortex GABAergic interneurons, highlighting its role in regulating neural function. 5. **Forebrain radial glial cell**: ORC1 is expressed in forebrain radial glial cells, underscoring its importance in neural development. In conclusion, ORC1 is a crucial gene that plays a vital role in regulating DNA replication and cell cycle progression. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2785955609

Symbol: ORC1_HUMAN

Name: Origin recognition complex subunit 1

UniProtKB Accession Codes:

Q13415 D3DQ34 Q13471 Q5T0F5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 7 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 5 EMDB 6 Ensembl 2 GO 13 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 8 RefSeq 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7502077

Title: Conserved initiator proteins in eukaryotes.

PubMed ID: 7502077

DOI: 10.1126/science.270.5242.1667

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 9566895

Title: Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase.

PubMed ID: 9566895

DOI: 10.1128/mcb.18.5.2758

PubMed ID: 10438470

Title: Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein.

PubMed ID: 10438470

DOI: 10.1074/jbc.274.33.23027

PubMed ID: 12909627

Title: The ORC1 cycle in human cells: I. cell cycle-regulated oscillation of human ORC1.

PubMed ID: 12909627

DOI: 10.1074/jbc.m307534200

PubMed ID: 12909626

Title: The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle.

PubMed ID: 12909626

DOI: 10.1074/jbc.m307535200

PubMed ID: 17716973

Title: ATP-dependent assembly of the human origin recognition complex.

PubMed ID: 17716973

DOI: 10.1074/jbc.m705905200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22645314

Title: Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.

PubMed ID: 22645314

DOI: 10.1128/mcb.00362-12

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 21358633

Title: Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome.

PubMed ID: 21358633

DOI: 10.1038/ng.776

PubMed ID: 21358632

Title: Mutations in the pre-replication complex cause Meier-Gorlin syndrome.

PubMed ID: 21358632

DOI: 10.1038/ng.775

PubMed ID: 21358631

Title: Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.

PubMed ID: 21358631

DOI: 10.1038/ng.777

PubMed ID: 28112645

Title: Structure of the active form of human origin recognition complex and its ATPase motor module.

PubMed ID: 28112645

DOI: 10.7554/elife.20818

Sequence Information:

  • Length: 861
  • Mass: 97350
  • Checksum: 5C594553F7F808E2
  • Sequence:
    • MAHYPTRLKT RKTYSWVGRP LLDRKLHYQT YREMCVKTEG CSTEIHIQIG QFVLIEGDDD 
ENPYVAKLLE LFEDDSDPPP KKRARVQWFV RFCEVPACKR HLLGRKPGAQ EIFWYDYPAC 
DSNINAETII GLVRVIPLAP KDVVPTNLKN EKTLFVKLSW NEKKFRPLSS ELFAELNKPQ 
ESAAKCQKPV RAKSKSAESP SWTPAEHVAK RIESRHSASK SRQTPTHPLT PRARKRLELG 
NLGNPQMSQQ TSCASLDSPG RIKRKVAFSE ITSPSKRSQP DKLQTLSPAL KAPEKTRETG 
LSYTEDDKKA SPEHRIILRT RIAASKTIDI REERTLTPIS GGQRSSVVPS VILKPENIKK 
RDAKEAKAQN EATSTPHRIR RKSSVLTMNR IRQQLRFLGN SKSDQEEKEI LPAAEISDSS 
SDEEEASTPP LPRRAPRTVS RNLRSSLKSS LHTLTKVPKK SLKPRTPRCA APQIRSRSLA 
AQEPASVLEE ARLRLHVSAV PESLPCREQE FQDIYNFVES KLLDHTGGCM YISGVPGTGK 
TATVHEVIRC LQQAAQANDV PPFQYIEVNG MKLTEPHQVY VQILQKLTGQ KATANHAAEL 
LAKQFCTRGS PQETTVLLVD ELDLLWTHKQ DIMYNLFDWP THKEARLVVL AIANTMDLPE 
RIMMNRVSSR LGLTRMCFQP YTYSQLQQIL RSRLKHLKAF EDDAIQLVAR KVAALSGDAR 
RCLDICRRAT EICEFSQQKP DSPGLVTIAH SMEAVDEMFS SSYITAIKNS SVLEQSFLRA 
ILAEFRRSGL EEATFQQIYS QHVALCRMEG LPYPTMSETM AVCSHLGSCR LLLVEPSRND 
LLLRVRLNVS QDDVLYALKD E

Genular Protein ID: 2959467495

Symbol: B7Z8H0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z8H0

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 3 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SAM 1 SMART 3 SUPFAM 1

Sequence Information:

  • Length: 856
  • Mass: 96750
  • Checksum: 14ED4BB2F35F45A2
  • Sequence:
    • MAHYPTRLKT RKTYSWVGRP LLDRKLHYQT YREMCVKTEG CSTEIHIQIG QFVLIEGDDD 
ENPYVAKLLE LFEDDSDPPP KKRARVQWFV RFCEVPACKR HLLGRKPGAQ EIFWYDYPAC 
DSNINAETII GLVRVIPLAP KDVVPTNLKN EKTLFVKLSW NEKKFRPLSS ELFAELNKPQ 
ESAAKCQKPV RAKSKSAESP SWTPAEHVAK RIESRHSASK SRQTPTHPLT PRARKRLELG 
NLGNPQMSQQ TSCASLDSPG RIKRKVAFSE ITSPSKRSQP DKLQTLSPAL KAPEKTRETG 
LSYTEDDKKA SPEHRIILRT RIAASKTIDI REERTLTPIS GGQRSSVVPS VILKPENIKK 
RDAKEAKAQN EATSTPHRIR RKSSVLTMNR IRQQLRFLGN SKSDQEEKEI LPAAEISDSS 
SDEEEASTPP LPRRAPRTVS RNLRSSLKSS LHTLTKLKPR TPRCAAPQIR SRSLAAQEPA 
SVLEEARLRL HVSAVPESLP CREQEFQDIY NFVESKLLDH TGGCMYISGV PGTGKTATVH 
EVIRCLQQAA QANDVPPFQY IEVNGMKLTE PHQVCVQILQ KLTGQKATAN HAAELLAKQF 
CTRGSPQETT VLLVDELDLL WTHKQDIMYN LFDWPTHKEA RLVVLAIANT MDLPERIMMN 
RVSSRLGLTR MCFQPYTYSQ LQQILRSRLK HLKAFEDDAI QLVARKVAAL SGDARRCLDI 
CRRATEICEF SQQKPDSPGL VTIAHSMEAV DEMFSSSYIT AIKNSSVLEQ SFLRAILAEF 
RRSGLEEATF QQIYSQHVAL CRMEGLPYPT MSETMAVCSH LGSCRLLLVE PSRNDLLLRV 
RLNVSQDDVL YALKDE

Genular Protein ID: 192547614

Symbol: Q96F82_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96F82

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 3 IntAct 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SAM 1 SMART 3 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 861
  • Mass: 97323
  • Checksum: 5FBFC5F1C35B4254
  • Sequence:
    • MAHYPTRLTT RKTYSWVGRP LLDRKLHYQT YREMCVKTEG CSTEIHIQIG QFVLIEGDDD 
ENPYVAKLLE LFEDDSDPPP KKRARVQWFV RFCEVPACKR HLLGRKPGAQ EIFWYDYPAC 
DSNINAETII GLVRVIPLAP KDVVPTNLKN EKTLFVKLSW NEKKFRPLSS ELFAELNKPQ 
ESAAKCQKPV RAKSKSAESP SWTPAEHVAK RIESRHSASK SRQTPTHPLT PRARKRLELG 
NLGNPQMSQQ TSCASLDSPG RIKRKVAFSE ITSPSKRSQP DKLQTLSPAL KAPEKTRETG 
LSYTEDDKKA SPEHRIILRT RIAASKTIDI REERTLTPIS GGQRSSVVPS VILKPENIKK 
RDAKEAKAQN EATSTPHRIR RKSSVLTMNR IRQQLRFLGN SKSDQEEKEI LPAAEISDSS 
SDEEEASTPP LPRRAPRTVS RNLRSSLKSS LHTLTKVPKK SLKPRTPRCA APQIRSRSLA 
AQEPASVLEE ARLRLHVSAV PESLPCREQE FQDIYNFVES KLLDHTGGCM YISGVPGTGK 
TATVHEVIRC LQQAAQANDV PPFQYIEVNG MKLTEPHQVY VQILQKLTGQ KATANHAAEL 
LAKQFCTRGS PQETTVLLVD ELDLLWTHKQ DIMYNLFDWP THKEARLVVL AIANTMDLPE 
RIMMNRVSSR LGLTRMCFQP YTYSQLQQIL RSRLKHLKAF EDDAIQLVAR KVAALSGDAR 
RCLDICRRAT EICEFSQQKP DSPGLVTIAH SMEAVDEMFS SSYITAIKNS SVLEQSFLRA 
ILAEFRRSGL EEATFQQIYS QHVALCRMEG LPYPTMSETM AVCSHLGSCR LLLVEPSRND 
LLLRVRLNVS QDDVLYALKD E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.