Details for: ORC2

Gene ID: 4999

Symbol: ORC2

Ensembl ID: ENSG00000115942

Description: origin recognition complex subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 193.0628
    Cell Significance Index: -30.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.8102
    Cell Significance Index: -31.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.7398
    Cell Significance Index: -33.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.0327
    Cell Significance Index: -26.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.7457
    Cell Significance Index: -26.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.4486
    Cell Significance Index: -32.6100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.5833
    Cell Significance Index: -31.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1911
    Cell Significance Index: -28.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.9053
    Cell Significance Index: -19.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3818
    Cell Significance Index: -33.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3832
    Cell Significance Index: 472.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7645
    Cell Significance Index: 353.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.7254
    Cell Significance Index: 48.2200
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.7040
    Cell Significance Index: 17.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4052
    Cell Significance Index: 107.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3423
    Cell Significance Index: 1211.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0768
    Cell Significance Index: 386.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9905
    Cell Significance Index: 107.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9827
    Cell Significance Index: 26.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9484
    Cell Significance Index: 110.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9380
    Cell Significance Index: 63.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9341
    Cell Significance Index: 52.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7545
    Cell Significance Index: 122.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7042
    Cell Significance Index: 31.1500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6918
    Cell Significance Index: 8.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6813
    Cell Significance Index: 25.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6489
    Cell Significance Index: 12.6700
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.6106
    Cell Significance Index: 5.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5421
    Cell Significance Index: 15.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4881
    Cell Significance Index: 30.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4804
    Cell Significance Index: 332.2500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4765
    Cell Significance Index: 32.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4472
    Cell Significance Index: 20.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3999
    Cell Significance Index: 49.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.3938
    Cell Significance Index: 9.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3746
    Cell Significance Index: 67.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2645
    Cell Significance Index: 6.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2151
    Cell Significance Index: 404.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2042
    Cell Significance Index: 20.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1985
    Cell Significance Index: 87.7800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1660
    Cell Significance Index: 2.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1535
    Cell Significance Index: 4.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1489
    Cell Significance Index: 94.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1408
    Cell Significance Index: 76.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1289
    Cell Significance Index: 3.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1232
    Cell Significance Index: 189.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1195
    Cell Significance Index: 220.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1170
    Cell Significance Index: 6.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1144
    Cell Significance Index: 1.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1078
    Cell Significance Index: 20.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1022
    Cell Significance Index: 3.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0973
    Cell Significance Index: 2.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0776
    Cell Significance Index: 35.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0722
    Cell Significance Index: 9.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0389
    Cell Significance Index: 52.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0307
    Cell Significance Index: 1.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0092
    Cell Significance Index: 0.4300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0053
    Cell Significance Index: 0.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0052
    Cell Significance Index: 0.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0132
    Cell Significance Index: -1.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0211
    Cell Significance Index: -0.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0259
    Cell Significance Index: -18.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0344
    Cell Significance Index: -25.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0355
    Cell Significance Index: -26.8400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0463
    Cell Significance Index: -0.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0513
    Cell Significance Index: -28.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0576
    Cell Significance Index: -7.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0578
    Cell Significance Index: -9.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0583
    Cell Significance Index: -36.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0600
    Cell Significance Index: -2.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0942
    Cell Significance Index: -27.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0961
    Cell Significance Index: -13.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1034
    Cell Significance Index: -7.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1470
    Cell Significance Index: -9.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1522
    Cell Significance Index: -15.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1676
    Cell Significance Index: -35.3000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1776
    Cell Significance Index: -2.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1777
    Cell Significance Index: -22.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2110
    Cell Significance Index: -21.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2185
    Cell Significance Index: -25.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2215
    Cell Significance Index: -3.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2319
    Cell Significance Index: -12.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2602
    Cell Significance Index: -3.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2616
    Cell Significance Index: -6.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2647
    Cell Significance Index: -5.7400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2754
    Cell Significance Index: -6.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2822
    Cell Significance Index: -21.0300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2840
    Cell Significance Index: -4.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2910
    Cell Significance Index: -7.9200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3482
    Cell Significance Index: -27.5800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3732
    Cell Significance Index: -2.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3929
    Cell Significance Index: -20.6300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4057
    Cell Significance Index: -8.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4324
    Cell Significance Index: -11.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4756
    Cell Significance Index: -7.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4761
    Cell Significance Index: -5.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5236
    Cell Significance Index: -32.1000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5349
    Cell Significance Index: -6.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5439
    Cell Significance Index: -18.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5452
    Cell Significance Index: -17.8500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ORC2 is a highly conserved protein that shares structural and functional similarities with other ORC subunits. It is encoded by the ENSG00000115942 gene and is significantly expressed in various cell types, including pvalb GABAergic cortical interneurons, germ cells, and cardiac myocytes. ORC2 is a multifunctional protein that interacts with multiple partners, including Cdc6, Orc1, and other ORC subunits, to regulate DNA replication and cell cycle progression. **Pathways and Functions:** ORC2 is involved in several critical pathways, including: 1. **DNA Replication Initiation:** ORC2 recognizes and binds to the origin of replication, facilitating the assembly of the pre-replicative complex and the subsequent unwinding of DNA. 2. **Cell Cycle Regulation:** ORC2 regulates cell cycle progression by controlling the assembly of the pre-replicative complex and the subsequent entry into the S phase. 3. **Mitotic Checkpoints:** ORC2 is involved in the regulation of mitotic checkpoints, ensuring accurate chromosome segregation and preventing aneuploidy. 4. **Transcriptional Regulation:** ORC2 can interact with RNA polymerase II to regulate transcription, influencing gene expression and cellular differentiation. **Clinical Significance:** Dysregulation of ORC2 has been implicated in various diseases, including: 1. **Cancer:** Mutations in ORC2 have been associated with several types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** ORC2 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Cardiovascular Diseases:** ORC2 may play a role in the development of cardiovascular diseases, including atherosclerosis and cardiac arrhythmias. In conclusion, ORC2 is a crucial protein that plays a vital role in DNA replication, cell cycle regulation, and transcriptional control. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying ORC2 function.

Genular Protein ID: 3441140308

Symbol: ORC2_HUMAN

Name: Origin recognition complex subunit 2

UniProtKB Accession Codes:

Q13416 Q13204 Q53TX5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 EMDB 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7502077

Title: Conserved initiator proteins in eukaryotes.

PubMed ID: 7502077

DOI: 10.1126/science.270.5242.1667

PubMed ID: 8808289

Title: Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L.

PubMed ID: 8808289

DOI: 10.1006/geno.1996.0018

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11095689

Title: The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.

PubMed ID: 11095689

DOI: 10.1093/nar/28.23.4769

PubMed ID: 12909626

Title: The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle.

PubMed ID: 12909626

DOI: 10.1074/jbc.m307535200

PubMed ID: 17716973

Title: ATP-dependent assembly of the human origin recognition complex.

PubMed ID: 17716973

DOI: 10.1074/jbc.m705905200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22935713

Title: Orc2 protects ORCA from ubiquitin-mediated degradation.

PubMed ID: 22935713

DOI: 10.4161/cc.21870

PubMed ID: 22427655

Title: Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.

PubMed ID: 22427655

DOI: 10.1074/jbc.m111.337980

PubMed ID: 22645314

Title: Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.

PubMed ID: 22645314

DOI: 10.1128/mcb.00362-12

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24989122

Title: A role for DNA polymerase theta in the timing of DNA replication.

PubMed ID: 24989122

DOI: 10.1038/ncomms5285

Sequence Information:

  • Length: 577
  • Mass: 65972
  • Checksum: DF3F9C2CF147DA5F
  • Sequence:
    • MSKPELKEDK MLEVHFVGDD DVLNHILDRE GGAKLKKERA QLLVNPKKII KKPEYDLEED 
DQEVLKDQNY VEIMGRDVQE SLKNGSATGG GNKVYSFQNR KHSEKMAKLA SELAKTPQKS 
VSFSLKNDPE ITINVPQSSK GHSASDKVQP KNNDKSEFLS TAPRSLRKRL IVPRSHSDSE 
SEYSASNSED DEGVAQEHEE DTNAVIFSQK IQAQNRVVSA PVGKETPSKR MKRDKTSDLV 
EEYFEAHSSS KVLTSDRTLQ KLKRAKLDQQ TLRNLLSKVS PSFSAELKQL NQQYEKLFHK 
WMLQLHLGFN IVLYGLGSKR DLLERFRTTM LQDSIHVVIN GFFPGISVKS VLNSITEEVL 
DHMGTFRSIL DQLDWIVNKF KEDSSLELFL LIHNLDSQML RGEKSQQIIG QLSSLHNIYL 
IASIDHLNAP LMWDHAKQSL FNWLWYETTT YSPYTEETSY ENSLLVKQSG SLPLSSLTHV 
LRSLTPNARG IFRLLIKYQL DNQDNPSYIG LSFQDFYQQC REAFLVNSDL TLRAQLTEFR 
DHKLIRTKKG TDGVEYLLIP VDNGTLTDFL EKEEEEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.