Details for: HDDC2

Gene ID: 51020

Symbol: HDDC2

Ensembl ID: ENSG00000111906

Description: HD domain containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 260.6637
    Cell Significance Index: -40.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.2884
    Cell Significance Index: -34.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 102.3251
    Cell Significance Index: -48.3100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 102.0639
    Cell Significance Index: -42.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 96.9337
    Cell Significance Index: -39.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.3275
    Cell Significance Index: -44.9200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 72.4268
    Cell Significance Index: -48.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.6185
    Cell Significance Index: -39.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.8204
    Cell Significance Index: -44.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7233
    Cell Significance Index: -31.4100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4672
    Cell Significance Index: -45.2500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5390
    Cell Significance Index: -32.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1586
    Cell Significance Index: -11.2900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4611
    Cell Significance Index: 2222.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3568
    Cell Significance Index: 141.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0763
    Cell Significance Index: 56.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0645
    Cell Significance Index: 335.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.0526
    Cell Significance Index: 28.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9269
    Cell Significance Index: 101.1700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.8911
    Cell Significance Index: 43.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8848
    Cell Significance Index: 87.8800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.4595
    Cell Significance Index: 11.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3978
    Cell Significance Index: 36.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2156
    Cell Significance Index: 13.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0501
    Cell Significance Index: 67.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0214
    Cell Significance Index: 21.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0167
    Cell Significance Index: 139.6200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9419
    Cell Significance Index: 7.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9070
    Cell Significance Index: 495.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8277
    Cell Significance Index: 38.9000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8200
    Cell Significance Index: 105.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8146
    Cell Significance Index: 360.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7378
    Cell Significance Index: 87.0100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7001
    Cell Significance Index: 49.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6887
    Cell Significance Index: 84.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6836
    Cell Significance Index: 88.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5877
    Cell Significance Index: 105.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4636
    Cell Significance Index: 24.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4570
    Cell Significance Index: 15.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4234
    Cell Significance Index: 84.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4068
    Cell Significance Index: 18.4400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3824
    Cell Significance Index: 9.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3673
    Cell Significance Index: 27.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3425
    Cell Significance Index: 7.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3424
    Cell Significance Index: 58.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3364
    Cell Significance Index: 64.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3038
    Cell Significance Index: 210.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2746
    Cell Significance Index: 27.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2222
    Cell Significance Index: 409.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2004
    Cell Significance Index: 377.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1967
    Cell Significance Index: 8.7000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1740
    Cell Significance Index: 62.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1592
    Cell Significance Index: 4.4500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1396
    Cell Significance Index: 15.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1374
    Cell Significance Index: 27.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1194
    Cell Significance Index: 4.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0846
    Cell Significance Index: 62.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0831
    Cell Significance Index: 2.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0615
    Cell Significance Index: 46.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0490
    Cell Significance Index: 0.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0422
    Cell Significance Index: 3.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0339
    Cell Significance Index: 52.1200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0176
    Cell Significance Index: 0.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0168
    Cell Significance Index: 0.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0076
    Cell Significance Index: 4.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0066
    Cell Significance Index: -8.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0137
    Cell Significance Index: -10.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0275
    Cell Significance Index: -17.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0394
    Cell Significance Index: -4.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0419
    Cell Significance Index: -1.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0426
    Cell Significance Index: -0.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0432
    Cell Significance Index: -19.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0574
    Cell Significance Index: -32.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0923
    Cell Significance Index: -26.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1017
    Cell Significance Index: -21.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1091
    Cell Significance Index: -12.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1266
    Cell Significance Index: -18.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1516
    Cell Significance Index: -17.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1781
    Cell Significance Index: -14.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2178
    Cell Significance Index: -13.3900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2272
    Cell Significance Index: -2.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2287
    Cell Significance Index: -15.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2398
    Cell Significance Index: -24.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2400
    Cell Significance Index: -6.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2748
    Cell Significance Index: -8.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2939
    Cell Significance Index: -33.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3260
    Cell Significance Index: -8.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3297
    Cell Significance Index: -20.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4619
    Cell Significance Index: -24.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4823
    Cell Significance Index: -27.0700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5602
    Cell Significance Index: -8.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.6298
    Cell Significance Index: -5.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6439
    Cell Significance Index: -16.5500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7378
    Cell Significance Index: -15.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7841
    Cell Significance Index: -48.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8023
    Cell Significance Index: -8.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8606
    Cell Significance Index: -23.0200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.8631
    Cell Significance Index: -7.2500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.8725
    Cell Significance Index: -27.6000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8887
    Cell Significance Index: -32.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Domain Structure:** The protein encoded by HDDC2 possesses a characteristic HD domain, which is a common structural motif found in various proteins involved in protein-protein interactions and metal ion binding. 2. **Expression Patterns:** HDDC2 is significantly expressed in hematopoietic cells, epithelial cells, and immune cells, indicating its potential role in maintaining cellular homeostasis and immune function. 3. **Cellular Localization:** The expression of HDDC2 has been observed in various cell types, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and smooth muscle fibers of the ileum, suggesting its involvement in multiple cellular processes. **Pathways and Functions:** 1. **5'-Deoxynucleotidase Activity:** HDDC2 has been implicated in 5'-deoxynucleotidase activity, a process that is essential for the degradation of nucleotides and the maintenance of cellular homeostasis. 2. **Metal Ion Binding:** The HD domain of HDDC2 has been shown to bind metal ions, which may play a role in regulating protein-protein interactions and cellular signaling pathways. 3. **Protein Binding:** HDDC2 has been shown to interact with other proteins, including those involved in immune responses, suggesting its potential role in modulating immune function. **Clinical Significance:** 1. **Immunological Disorders:** Alterations in HDDC2 expression or function may contribute to the development of immunological disorders, such as autoimmune diseases or immunodeficiency syndromes. 2. **Cancer:** The expression of HDDC2 has been observed in various types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. 3. **Neurological Disorders:** HDDC2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, suggesting its potential role in neurodegenerative processes. In conclusion, HDDC2 is a gene with a diverse tissue distribution and expression patterns, and its involvement in various cellular processes, including protein-protein interactions, metal ion binding, and 5'-deoxynucleotidase activity, suggests its potential role in maintaining cellular homeostasis and immune function. Further research is necessary to elucidate the functional significance of HDDC2 in various diseases and disorders.

Genular Protein ID: 2506462728

Symbol: HDDC2_HUMAN

Name: HD domain-containing protein 2

UniProtKB Accession Codes:

Q7Z4H3 Q5TDQ4 Q6NZ49 Q9BTT2 Q9BV31 Q9Y3D1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 14 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15188496

Title: Cloning and identification of NS5ATP2 gene and its spliced variant transactivated by hepatitis C virus non-structural protein 5A.

PubMed ID: 15188496

DOI: 10.3748/wjg.v10.i12.1735

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 204
  • Mass: 23390
  • Checksum: E59D03224F8D6A16
  • Sequence:
    • MASVSSATFS GHGARSLLQF LRLVGQLKRV PRTGWVYRNV QRPESVSDHM YRMAVMAMVI 
KDDRLNKDRC VRLALVHDMA ECIVGDIAPA DNIPKEEKHR REEEAMKQIT QLLPEDLRKE 
LYELWEEYET QSSAEAKFVK QLDQCEMILQ ASEYEDLEHK PGRLQDFYDS TAGKFNHPEI 
VQLVSELEAE RSTNIAAAAS EPHS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.