Details for: MRPS16

Gene ID: 51021

Symbol: MRPS16

Ensembl ID: ENSG00000182180

Description: mitochondrial ribosomal protein S16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 198.8489
    Cell Significance Index: -30.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.0180
    Cell Significance Index: -31.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 89.0341
    Cell Significance Index: -42.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.3483
    Cell Significance Index: -41.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 62.5240
    Cell Significance Index: -41.9600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.3937
    Cell Significance Index: -39.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.3000
    Cell Significance Index: -32.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.6866
    Cell Significance Index: -42.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9985
    Cell Significance Index: -30.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.1930
    Cell Significance Index: 488.6500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.1822
    Cell Significance Index: 289.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.4997
    Cell Significance Index: 2257.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8259
    Cell Significance Index: 296.9600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4203
    Cell Significance Index: 73.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4051
    Cell Significance Index: 65.5100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2892
    Cell Significance Index: 35.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2487
    Cell Significance Index: 28.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0848
    Cell Significance Index: 133.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0799
    Cell Significance Index: 194.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.0608
    Cell Significance Index: 125.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9966
    Cell Significance Index: 544.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9761
    Cell Significance Index: 69.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8068
    Cell Significance Index: 60.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7940
    Cell Significance Index: 51.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7936
    Cell Significance Index: 159.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7559
    Cell Significance Index: 103.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7393
    Cell Significance Index: 34.7500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7254
    Cell Significance Index: 6.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7246
    Cell Significance Index: 320.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5966
    Cell Significance Index: 17.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5830
    Cell Significance Index: 12.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5700
    Cell Significance Index: 15.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5634
    Cell Significance Index: 6.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5512
    Cell Significance Index: 109.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4984
    Cell Significance Index: 64.3900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4101
    Cell Significance Index: 3.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4027
    Cell Significance Index: 10.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3891
    Cell Significance Index: 139.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3875
    Cell Significance Index: 49.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3774
    Cell Significance Index: 64.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2704
    Cell Significance Index: 9.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2543
    Cell Significance Index: 48.4000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2428
    Cell Significance Index: 15.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2371
    Cell Significance Index: 148.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2212
    Cell Significance Index: 4.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1791
    Cell Significance Index: 8.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1742
    Cell Significance Index: 5.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1648
    Cell Significance Index: 12.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1024
    Cell Significance Index: 10.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0678
    Cell Significance Index: 4.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0664
    Cell Significance Index: 50.2800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0580
    Cell Significance Index: 0.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0403
    Cell Significance Index: 29.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0125
    Cell Significance Index: 0.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0040
    Cell Significance Index: 7.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0036
    Cell Significance Index: 0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0067
    Cell Significance Index: -10.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0153
    Cell Significance Index: -28.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0154
    Cell Significance Index: -9.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0224
    Cell Significance Index: -30.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0279
    Cell Significance Index: -2.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0324
    Cell Significance Index: -22.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0415
    Cell Significance Index: -23.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0566
    Cell Significance Index: -25.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0870
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0923
    Cell Significance Index: -19.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0995
    Cell Significance Index: -11.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1072
    Cell Significance Index: -30.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1693
    Cell Significance Index: -9.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1732
    Cell Significance Index: -25.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1816
    Cell Significance Index: -1.4500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1922
    Cell Significance Index: -5.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2028
    Cell Significance Index: -5.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2315
    Cell Significance Index: -1.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2667
    Cell Significance Index: -21.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2832
    Cell Significance Index: -19.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3512
    Cell Significance Index: -40.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3622
    Cell Significance Index: -16.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3712
    Cell Significance Index: -6.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3878
    Cell Significance Index: -40.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4017
    Cell Significance Index: -5.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4172
    Cell Significance Index: -15.8000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4469
    Cell Significance Index: -7.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4547
    Cell Significance Index: -5.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4854
    Cell Significance Index: -13.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5226
    Cell Significance Index: -5.4100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5353
    Cell Significance Index: -6.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5454
    Cell Significance Index: -14.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5568
    Cell Significance Index: -8.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5573
    Cell Significance Index: -13.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6099
    Cell Significance Index: -37.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.6534
    Cell Significance Index: -9.7900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.7854
    Cell Significance Index: -13.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8230
    Cell Significance Index: -24.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8377
    Cell Significance Index: -17.8400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8777
    Cell Significance Index: -32.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8836
    Cell Significance Index: -28.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8881
    Cell Significance Index: -18.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8890
    Cell Significance Index: -25.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of mitochondrial ribosome**: MRPS16 is a 16S ribosomal protein, which is a component of the mitochondrial small subunit ribosome. It plays a crucial role in the translation of mitochondrial mRNAs into proteins. 2. **Mitochondrial translation**: MRPS16 is involved in the translation of mitochondrial mRNAs, which are essential for the synthesis of mitochondrial proteins, including those involved in energy production and cellular metabolism. 3. **Wide tissue distribution**: MRPS16 is expressed in various cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells, highlighting its importance in different cellular processes. 4. **Protein binding**: MRPS16 interacts with other mitochondrial proteins, including ribosomal RNA and other ribosomal proteins, to facilitate translation. **Pathways and Functions:** 1. **Mitochondrial translation elongation**: MRPS16 is involved in the elongation phase of mitochondrial translation, where it interacts with other ribosomal proteins to facilitate the movement of the ribosome along the mRNA. 2. **Mitochondrial translation initiation**: MRPS16 plays a role in the initiation phase of mitochondrial translation, where it interacts with other mitochondrial proteins to position the ribosome correctly on the mRNA. 3. **Mitochondrial translation termination**: MRPS16 is involved in the termination phase of mitochondrial translation, where it interacts with other ribosomal proteins to release the completed protein from the ribosome. 4. **Mitochondrial inner membrane**: MRPS16 is localized to the mitochondrial inner membrane, where it interacts with other mitochondrial proteins to facilitate translation. **Clinical Significance:** Abnormalities in MRPS16 expression have been linked to various diseases, including: 1. **Mitochondrial myopathies**: MRPS16 mutations have been identified in patients with mitochondrial myopathies, a group of disorders characterized by muscle weakness and fatigue. 2. **Neurodegenerative diseases**: MRPS16 mutations have also been linked to neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Cancer**: MRPS16 expression has been altered in various types of cancer, including leukemia and breast cancer. In conclusion, MRPS16 is a critical component of the mitochondrial translation machinery, and its expression and function have significant implications for cellular metabolism and disease. Further research is needed to fully understand the role of MRPS16 in human disease and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 2364907213

Symbol: RT16_HUMAN

Name: 28S ribosomal protein S16, mitochondrial

UniProtKB Accession Codes:

Q9Y3D3 B4E032 Q96Q60

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 41 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 11402041

Title: Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit.

PubMed ID: 11402041

DOI: 10.1074/jbc.m103236200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 11279123

Title: The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.

PubMed ID: 11279123

DOI: 10.1074/jbc.m100727200

PubMed ID: 15505824

Title: Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutation.

PubMed ID: 15505824

DOI: 10.1002/ana.20282

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

Sequence Information:

  • Length: 137
  • Mass: 15345
  • Checksum: C12B14B1B357F8D6
  • Sequence:
    • MVHLTTLLCK AYRGGHLTIR LALGGCTNRP FYRIVAAHNK CPRDGRFVEQ LGSYDPLPNS 
HGEKLVALNL DRIRHWIGCG AHLSKPMEKL LGLAGFFPLH PMMITNAERL RRKRAREVLL 
ASQKTDAEAT DTEATET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.