Details for: MRPS18C

Gene ID: 51023

Symbol: MRPS18C

Ensembl ID: ENSG00000163319

Description: mitochondrial ribosomal protein S18C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 208.4924
    Cell Significance Index: -32.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 127.2653
    Cell Significance Index: -32.2800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 101.2993
    Cell Significance Index: -41.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 96.8816
    Cell Significance Index: -45.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.9953
    Cell Significance Index: -37.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.3033
    Cell Significance Index: -42.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.2168
    Cell Significance Index: -45.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 39.8537
    Cell Significance Index: -38.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.1107
    Cell Significance Index: -43.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.9090
    Cell Significance Index: -31.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6572
    Cell Significance Index: -46.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.5059
    Cell Significance Index: -35.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 5.1875
    Cell Significance Index: 358.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.5656
    Cell Significance Index: 29.9500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 2.8195
    Cell Significance Index: 17.0400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.5111
    Cell Significance Index: 26.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5419
    Cell Significance Index: 41.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.5222
    Cell Significance Index: 70.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2369
    Cell Significance Index: 145.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.1734
    Cell Significance Index: 82.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1117
    Cell Significance Index: 200.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1075
    Cell Significance Index: 489.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0700
    Cell Significance Index: 50.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0149
    Cell Significance Index: 139.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0002
    Cell Significance Index: 64.5300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9841
    Cell Significance Index: 22.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.9746
    Cell Significance Index: 26.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9445
    Cell Significance Index: 116.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9096
    Cell Significance Index: 496.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.8507
    Cell Significance Index: 22.3700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.7685
    Cell Significance Index: 8.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7331
    Cell Significance Index: 21.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7080
    Cell Significance Index: 36.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6793
    Cell Significance Index: 87.0800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4832
    Cell Significance Index: 4.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4431
    Cell Significance Index: 57.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4412
    Cell Significance Index: 32.8800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4371
    Cell Significance Index: 3.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4184
    Cell Significance Index: 21.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4099
    Cell Significance Index: 11.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4060
    Cell Significance Index: 81.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3685
    Cell Significance Index: 73.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3505
    Cell Significance Index: 9.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3335
    Cell Significance Index: 11.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2834
    Cell Significance Index: 17.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2685
    Cell Significance Index: 5.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2351
    Cell Significance Index: 4.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2096
    Cell Significance Index: 39.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1845
    Cell Significance Index: 66.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0762
    Cell Significance Index: 7.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0525
    Cell Significance Index: 38.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0400
    Cell Significance Index: 30.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0219
    Cell Significance Index: 0.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0053
    Cell Significance Index: -10.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0172
    Cell Significance Index: -31.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0190
    Cell Significance Index: -29.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0268
    Cell Significance Index: -36.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0338
    Cell Significance Index: -3.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0339
    Cell Significance Index: -1.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0384
    Cell Significance Index: -24.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0393
    Cell Significance Index: -29.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0396
    Cell Significance Index: -6.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0674
    Cell Significance Index: -30.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0713
    Cell Significance Index: -40.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0801
    Cell Significance Index: -50.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0918
    Cell Significance Index: -26.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0918
    Cell Significance Index: -5.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1703
    Cell Significance Index: -24.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2101
    Cell Significance Index: -24.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2144
    Cell Significance Index: -24.5600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2325
    Cell Significance Index: -5.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2377
    Cell Significance Index: -50.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2422
    Cell Significance Index: -19.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2472
    Cell Significance Index: -11.2100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2827
    Cell Significance Index: -3.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2864
    Cell Significance Index: -6.2100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3053
    Cell Significance Index: -5.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3062
    Cell Significance Index: -33.3100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3103
    Cell Significance Index: -16.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3227
    Cell Significance Index: -24.7700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3234
    Cell Significance Index: -18.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3921
    Cell Significance Index: -6.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4098
    Cell Significance Index: -27.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4315
    Cell Significance Index: -44.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4565
    Cell Significance Index: -7.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5599
    Cell Significance Index: -8.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.5675
    Cell Significance Index: -6.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5739
    Cell Significance Index: -7.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6525
    Cell Significance Index: -17.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7094
    Cell Significance Index: -31.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7177
    Cell Significance Index: -7.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7317
    Cell Significance Index: -44.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7832
    Cell Significance Index: -23.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8316
    Cell Significance Index: -31.4900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9436
    Cell Significance Index: -34.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9506
    Cell Significance Index: -20.2500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9706
    Cell Significance Index: -12.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0617
    Cell Significance Index: -37.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0776
    Cell Significance Index: -35.2800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.1114
    Cell Significance Index: -19.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: MRPS18C is specifically localized to the mitochondrial inner membrane, where it interacts with other mitochondrial ribosomal proteins to form the small ribosomal subunit. 2. **Role in protein synthesis**: As a constituent of the small ribosomal subunit, MRPS18C is involved in the translation of mRNAs into proteins within the mitochondria. 3. **High expression levels**: MRPS18C is significantly expressed in various cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells. 4. **Evolutionary conservation**: The MRPS18C gene has been conserved across species, suggesting its essential role in mitochondrial function. **Pathways and Functions:** 1. **Mitochondrial translation**: MRPS18C is involved in the translation of mRNAs into proteins within the mitochondria, which is essential for maintaining cellular energy homeostasis. 2. **Mitochondrial inner membrane**: MRPS18C is localized to the mitochondrial inner membrane, where it interacts with other mitochondrial ribosomal proteins to form the small ribosomal subunit. 3. **Mitochondrial translation elongation**: MRPS18C is involved in the elongation phase of mitochondrial translation, where it helps to assemble the growing peptide chain. 4. **Mitochondrial translation initiation**: MRPS18C is also involved in the initiation phase of mitochondrial translation, where it helps to recruit the small ribosomal subunit to the mRNA. **Clinical Significance:** 1. **Mitochondrial disorders**: Mutations in the MRPS18C gene have been associated with various mitochondrial disorders, including myopathies, encephalopathies, and lactic acidosis. 2. **Neurodegenerative diseases**: Alterations in MRPS18C expression have been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer**: MRPS18C has been identified as a potential tumor suppressor gene, and its expression has been found to be altered in various types of cancer. 4. **Hematological disorders**: MRPS18C is significantly expressed in hematopoietic cells, and alterations in its expression have been linked to hematological disorders, such as anemia and leukemia. In conclusion, MRPS18C is a critical component of the mitochondrial ribosome, playing a pivotal role in regulating mitochondrial protein synthesis. Its widespread expression in various cell types highlights its essential role in maintaining cellular energy homeostasis. Further research is needed to fully elucidate the clinical significance of MRPS18C and its potential as a therapeutic target for various diseases.

Genular Protein ID: 1692080912

Symbol: RT18C_HUMAN

Name: 28S ribosomal protein S18-1, mitochondrial

UniProtKB Accession Codes:

Q9Y3D5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 EMDB 41 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11279123

Title: The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.

PubMed ID: 11279123

DOI: 10.1074/jbc.m100727200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27023846

Title: Structure and function of the mitochondrial ribosome.

PubMed ID: 27023846

DOI: 10.1146/annurev-biochem-060815-014343

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

Sequence Information:

  • Length: 142
  • Mass: 15850
  • Checksum: 375E0F8558492E63
  • Sequence:
    • MAAVVAVCGG LGRKKLTHLV TAAVSLTHPG THTVLWRRGC SQQVSSNEDL PISMENPYKE 
PLKKCILCGK HVDYKNVQLL SQFVSPFTGC IYGRHITGLC GKKQKEITKA IKRAQIMGFM 
PVTYKDPAYL KDPKVCNIRY RE

Genular Protein ID: 1482994797

Symbol: D6RCM2_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RCM2

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 5 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 114
  • Mass: 12592
  • Checksum: 45C5CEE11452EDC9
  • Sequence:
    • MAAVVAVCGG LGRKKLTHLV TAAVSLTHPG THTVLWRRGC SQQVSSNEDL LLSQFVSPFT 
GCIYGRHITG LCGKKQKEIT KAIKRAQIMG FMPVTYKDPA YLKDPKVCNI RYRE

Genular Protein ID: 3093864135

Symbol: D6RE70_HUMAN

Name: N/A

UniProtKB Accession Codes:

D6RE70

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 HOGENOM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Proteomes 2 RefSeq 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 68
  • Mass: 7454
  • Checksum: EF514AEA7AD79AA6
  • Sequence:
    • MAAVVAVCGG LGRKKLTHLV TAAVSLTHPG THTVLWRRGC SQQVSSNEDL VFVGRNRKKS 
QKQLRELK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.