Details for: ZNF593

Gene ID: 51042

Symbol: ZNF593

Ensembl ID: ENSG00000142684

Description: zinc finger protein 593

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 164.9520
    Cell Significance Index: -25.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.6751
    Cell Significance Index: -20.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.9219
    Cell Significance Index: -30.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.4389
    Cell Significance Index: -26.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.8862
    Cell Significance Index: -29.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 57.2917
    Cell Significance Index: -29.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 44.2459
    Cell Significance Index: -29.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.1804
    Cell Significance Index: -26.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.4742
    Cell Significance Index: -25.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4518
    Cell Significance Index: -29.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9776
    Cell Significance Index: -18.3600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.0411
    Cell Significance Index: 24.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.8931
    Cell Significance Index: 150.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.6521
    Cell Significance Index: 36.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4500
    Cell Significance Index: 182.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.2350
    Cell Significance Index: 134.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1474
    Cell Significance Index: 58.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0675
    Cell Significance Index: 267.1000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.7572
    Cell Significance Index: 14.0300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5777
    Cell Significance Index: 36.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3805
    Cell Significance Index: 39.7800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3695
    Cell Significance Index: 40.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.2920
    Cell Significance Index: 34.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.2834
    Cell Significance Index: 36.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.2492
    Cell Significance Index: 88.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2489
    Cell Significance Index: 682.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.2113
    Cell Significance Index: 56.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1966
    Cell Significance Index: 55.7900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0800
    Cell Significance Index: 9.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9216
    Cell Significance Index: 113.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8795
    Cell Significance Index: 39.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8760
    Cell Significance Index: 157.9200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8508
    Cell Significance Index: 15.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8196
    Cell Significance Index: 362.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.7671
    Cell Significance Index: 20.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.7384
    Cell Significance Index: 47.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7034
    Cell Significance Index: 10.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6075
    Cell Significance Index: 83.4200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.5750
    Cell Significance Index: 1.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5671
    Cell Significance Index: 66.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4885
    Cell Significance Index: 5.5500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4310
    Cell Significance Index: 3.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4300
    Cell Significance Index: 9.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3371
    Cell Significance Index: 54.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3348
    Cell Significance Index: 8.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3330
    Cell Significance Index: 3.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3316
    Cell Significance Index: 63.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3057
    Cell Significance Index: 30.2500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2800
    Cell Significance Index: 1.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2360
    Cell Significance Index: 3.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1830
    Cell Significance Index: 52.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1796
    Cell Significance Index: 6.3100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1774
    Cell Significance Index: 0.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1491
    Cell Significance Index: 19.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1209
    Cell Significance Index: 24.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0977
    Cell Significance Index: 6.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0848
    Cell Significance Index: 64.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0813
    Cell Significance Index: 13.8800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.0745
    Cell Significance Index: 0.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0508
    Cell Significance Index: 1.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0333
    Cell Significance Index: 30.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0233
    Cell Significance Index: 0.6500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0226
    Cell Significance Index: 0.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0170
    Cell Significance Index: 0.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0107
    Cell Significance Index: 7.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0075
    Cell Significance Index: -0.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0178
    Cell Significance Index: -32.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0185
    Cell Significance Index: -3.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0202
    Cell Significance Index: -0.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0212
    Cell Significance Index: -32.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0235
    Cell Significance Index: -0.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0264
    Cell Significance Index: -35.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0280
    Cell Significance Index: -10.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0287
    Cell Significance Index: -21.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0366
    Cell Significance Index: -0.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0367
    Cell Significance Index: -23.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0415
    Cell Significance Index: -23.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0635
    Cell Significance Index: -28.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0650
    Cell Significance Index: -2.2600
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0703
    Cell Significance Index: -0.4300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0808
    Cell Significance Index: -0.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1008
    Cell Significance Index: -11.5500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1251
    Cell Significance Index: -1.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1352
    Cell Significance Index: -15.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1506
    Cell Significance Index: -31.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1672
    Cell Significance Index: -8.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1747
    Cell Significance Index: -25.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2285
    Cell Significance Index: -4.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2381
    Cell Significance Index: -2.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2385
    Cell Significance Index: -18.8900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2576
    Cell Significance Index: -1.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2790
    Cell Significance Index: -29.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3199
    Cell Significance Index: -16.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3233
    Cell Significance Index: -19.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3310
    Cell Significance Index: -2.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3512
    Cell Significance Index: -26.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3791
    Cell Significance Index: -23.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3825
    Cell Significance Index: -7.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4140
    Cell Significance Index: -27.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZN593 is a member of the zinc finger protein family, characterized by its unique DNA-binding motif, which enables it to regulate gene expression by interacting with specific DNA sequences. This protein exhibits a high degree of tissue specificity, with significant expression observed in hematopoietic cells, stem cells, and epithelial cells. Its expression is also notable in immune cells, such as CD8-alpha-beta-positive, alpha-beta intraepithelial T cells, and peripheral blood mononuclear cells. The protein's ability to bind zinc ions further underscores its role in maintaining protein structure and function. **Pathways and Functions:** ZN593 is involved in several critical cellular pathways, including: 1. **Negative regulation of RNA polymerase II**: ZN593 acts as a repressor of RNA polymerase II, a key enzyme responsible for transcriptional regulation. By inhibiting RNA polymerase II, ZN593 modulates the expression of genes involved in cell differentiation, proliferation, and survival. 2. **Positive regulation of transcription by RNA polymerase II**: Conversely, ZN593 can also act as an activator of RNA polymerase II, leading to the increased expression of genes involved in immune response and cell development. 3. **Preribosome binding**: ZN593 interacts with ribosomal proteins, influencing the assembly and function of ribosomes, which are essential for protein synthesis. 4. **Zinc ion binding**: The protein's ability to bind zinc ions is crucial for maintaining its structure and function, as well as for regulating its interactions with other proteins and DNA sequences. **Clinical Significance:** ZN593's involvement in immune regulation, cell development, and gene expression makes it an attractive target for understanding the pathogenesis of various diseases, including: 1. **Immunodeficiency disorders**: Altered expression or function of ZN593 may contribute to immunodeficiency diseases, such as severe combined immunodeficiency (SCID). 2. **Cancer**: Dysregulation of ZN593's transcriptional regulatory functions may contribute to tumorigenesis and cancer progression. 3. **Neurological disorders**: ZN593's role in brain development and function may be implicated in neurological disorders, such as autism spectrum disorder (ASD). In conclusion, ZNF593 is a complex transcriptional regulator with a multifaceted role in immune regulation, cell development, and gene expression. Further research is necessary to fully elucidate its mechanisms of action and its clinical significance, ultimately shedding light on the intricate relationships between ZN593 and human health and disease.

Genular Protein ID: 2520251094

Symbol: ZN593_HUMAN

Name: Zinc finger protein 593

UniProtKB Accession Codes:

O00488 B2R4S0 Q5T2H7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisProt 1 EMBL 6 EMDB 24 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9115366

Title: A novel genetic system to isolate a dominant negative effector on DNA-binding activity of Oct-2.

PubMed ID: 9115366

DOI: 10.1093/nar/25.10.1984

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 18287285

Title: The solution structure of ZNF593 from Homo sapiens reveals a zinc finger in a predominantly unstructured protein.

PubMed ID: 18287285

DOI: 10.1110/ps.073290408

PubMed ID: 32669547

Title: Structural snapshots of human pre-60S ribosomal particles before and after nuclear export.

PubMed ID: 32669547

DOI: 10.1038/s41467-020-17237-x

Sequence Information:

  • Length: 134
  • Mass: 15199
  • Checksum: 883BCE4F72459818
  • Sequence:
    • MGRSRRTGAH RAHSLARQMK AKRRRPDLDE IHRELRPQGS ARPQPDPNAE FDPDLPGGGL 
HRCLACARYF IDSTNLKTHF RSKDHKKRLK QLSVEPYSQE EAERAAGMGS YVPPRRLAVP 
TEVSTEVPEM DTST

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.