Details for: MRPL2

Gene ID: 51069

Symbol: MRPL2

Ensembl ID: ENSG00000112651

Description: mitochondrial ribosomal protein L2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 106.4642
    Cell Significance Index: -16.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 88.7466
    Cell Significance Index: -22.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 69.2321
    Cell Significance Index: -28.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.0601
    Cell Significance Index: -29.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.5008
    Cell Significance Index: -27.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.2579
    Cell Significance Index: -26.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4439
    Cell Significance Index: -22.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1641
    Cell Significance Index: -28.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.7134
    Cell Significance Index: -20.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.0425
    Cell Significance Index: 210.4100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.3882
    Cell Significance Index: 20.0600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.7653
    Cell Significance Index: 14.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2446
    Cell Significance Index: 202.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0866
    Cell Significance Index: 49.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9325
    Cell Significance Index: 25.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7369
    Cell Significance Index: 34.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6945
    Cell Significance Index: 49.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6866
    Cell Significance Index: 94.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6204
    Cell Significance Index: 39.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6151
    Cell Significance Index: 271.9700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.5920
    Cell Significance Index: 6.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5729
    Cell Significance Index: 29.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5640
    Cell Significance Index: 308.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5536
    Cell Significance Index: 99.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5415
    Cell Significance Index: 14.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5325
    Cell Significance Index: 65.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5173
    Cell Significance Index: 27.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4559
    Cell Significance Index: 58.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4380
    Cell Significance Index: 28.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4014
    Cell Significance Index: 4.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4004
    Cell Significance Index: 47.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3772
    Cell Significance Index: 28.1100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3698
    Cell Significance Index: 4.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3590
    Cell Significance Index: 16.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3497
    Cell Significance Index: 66.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3308
    Cell Significance Index: 32.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3182
    Cell Significance Index: 41.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3005
    Cell Significance Index: 6.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2943
    Cell Significance Index: 6.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2695
    Cell Significance Index: 77.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2502
    Cell Significance Index: 6.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2258
    Cell Significance Index: 44.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1854
    Cell Significance Index: 2.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1759
    Cell Significance Index: 5.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1652
    Cell Significance Index: 33.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1574
    Cell Significance Index: 108.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0850
    Cell Significance Index: 76.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0768
    Cell Significance Index: 1.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0581
    Cell Significance Index: 2.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0528
    Cell Significance Index: 1.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0407
    Cell Significance Index: 29.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0306
    Cell Significance Index: 10.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0066
    Cell Significance Index: 1.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0037
    Cell Significance Index: 2.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0123
    Cell Significance Index: -23.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0176
    Cell Significance Index: -32.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0203
    Cell Significance Index: -2.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0214
    Cell Significance Index: -32.9100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0251
    Cell Significance Index: -34.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0276
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0321
    Cell Significance Index: -23.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0352
    Cell Significance Index: -22.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0417
    Cell Significance Index: -23.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0437
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0529
    Cell Significance Index: -33.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0532
    Cell Significance Index: -1.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0569
    Cell Significance Index: -25.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0841
    Cell Significance Index: -9.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0908
    Cell Significance Index: -1.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1196
    Cell Significance Index: -9.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1227
    Cell Significance Index: -9.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1488
    Cell Significance Index: -31.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1809
    Cell Significance Index: -26.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1819
    Cell Significance Index: -1.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2022
    Cell Significance Index: -2.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2257
    Cell Significance Index: -6.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2423
    Cell Significance Index: -5.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2640
    Cell Significance Index: -5.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2745
    Cell Significance Index: -28.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2799
    Cell Significance Index: -4.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2869
    Cell Significance Index: -2.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3156
    Cell Significance Index: -17.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3166
    Cell Significance Index: -19.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3228
    Cell Significance Index: -8.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3351
    Cell Significance Index: -8.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3672
    Cell Significance Index: -22.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3847
    Cell Significance Index: -25.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3868
    Cell Significance Index: -6.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4333
    Cell Significance Index: -12.4900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4417
    Cell Significance Index: -2.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4763
    Cell Significance Index: -14.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5074
    Cell Significance Index: -25.6400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5285
    Cell Significance Index: -4.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5569
    Cell Significance Index: -24.6400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5919
    Cell Significance Index: -21.7300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5942
    Cell Significance Index: -7.6100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6092
    Cell Significance Index: -11.2600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6163
    Cell Significance Index: -8.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6663
    Cell Significance Index: -25.2300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.7022
    Cell Significance Index: -11.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPL2 is a mitochondrial protein that belongs to the ribosomal protein L2 family. It is encoded by the ENSG00000112651 gene and is expressed in a wide range of cell types, including hematopoietic stem cells, embryonic stem cells, and smooth muscle fibers. The protein consists of 39 amino acids and is characterized by its ability to bind to mitochondrial ribosomal RNA (rRNA) and other ribosomal proteins. MRPL2 has been shown to be essential for the proper assembly and function of the mitochondrial ribosome, which is critical for protein synthesis and mitochondrial energy production. **Pathways and Functions:** MRPL2 is involved in various cellular pathways, including: 1. **Mitochondrial translation**: MRPL2 plays a crucial role in the translation of mitochondrial mRNAs into polypeptides that are essential for mitochondrial function. 2. **Mitochondrial inner membrane**: MRPL2 is localized to the inner membrane of the mitochondrion, where it interacts with other mitochondrial proteins to regulate mitochondrial function. 3. **Metabolism of proteins**: MRPL2 is involved in the regulation of protein synthesis and degradation within the mitochondrion, which is critical for maintaining mitochondrial homeostasis. 4. **Rna binding**: MRPL2 binds to mitochondrial rRNA and other ribosomal proteins, regulating the assembly and function of the mitochondrial ribosome. **Clinical Significance:** Dysregulation of MRPL2 has been implicated in various human diseases, including: 1. **Mitochondrial disorders**: Mutations in the MRPL2 gene have been associated with mitochondrial disorders, such as Leigh syndrome and MELAS syndrome. 2. **Cancer**: MRPL2 has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer. 3. **Neurological disorders**: MRPL2 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immune system disorders**: MRPL2 has been shown to play a role in the regulation of immune responses, and dysregulation of MRPL2 has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. In conclusion, MRPL2 is a critical component of the mitochondrial ribosome, essential for protein synthesis and mitochondrial function. Its dysregulation has been implicated in various human diseases, highlighting the importance of understanding the role of MRPL2 in maintaining mitochondrial homeostasis and regulating cellular processes. Further research is needed to fully elucidate the mechanisms by which MRPL2 regulates mitochondrial function and its implications for human health.

Genular Protein ID: 4082950476

Symbol: RM02_HUMAN

Name: 39S ribosomal protein L2, mitochondrial

UniProtKB Accession Codes:

Q5T653 B2RC56 Q8WUL1 Q96Q56 Q9Y311

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 6 EMDB 23 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11543634

Title: The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.

PubMed ID: 11543634

DOI: 10.1006/geno.2001.6622

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 305
  • Mass: 33301
  • Checksum: AE1D777E2CF9DBCB
  • Sequence:
    • MALCALTRAL RSLNLAPPTV AAPAPSLFPA AQMMNNGLLQ QPSALMLLPC RPVLTSVALN 
ANFVSWKSRT KYTITPVKMR KSGGRDHTGR IRVHGIGGGH KQRYRMIDFL RFRPEETKSG 
PFEEKVIQVR YDPCRSADIA LVAGGSRKRW IIATENMQAG DTILNSNHIG RMAVAAREGD 
AHPLGALPVG TLINNVESEP GRGAQYIRAA GTCGVLLRKV NGTAIIQLPS KRQMQVLETC 
VATVGRVSNV DHNKRVIGKA GRNRWLGKRP NSGRWHRKGG WAGRKIRPLP PMKSYVKLPS 
ASAQS

Genular Protein ID: 1319099381

Symbol: C9IY40_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9IY40

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 2 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 225
  • Mass: 24430
  • Checksum: C486BE0AB6191148
  • Sequence:
    • MALCALTRAL RSLNLAPPTV AAPAPSLFPA AQMMNNGLLQ QPSALMLLPC RPVLTSVALN 
ANFVSWKSRT KYTITPVKMR KSGGRDHTGR IRVHGIGGGH KQRYRMIDFL RFRPEETKSG 
PFEEKVIQVR YDPCRSADIA LVAGGSRKRW IIATENMQAG DTILNSNHIG RMAVAAREGD 
AHPLGALPVG TLINNVESEP GRGAQYIRAA GAGNVRSNSR PSIQR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.