Details for: NOSIP

Gene ID: 51070

Symbol: NOSIP

Ensembl ID: ENSG00000142546

Description: nitric oxide synthase interacting protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 233.0512
    Cell Significance Index: -36.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 144.5731
    Cell Significance Index: -36.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.3396
    Cell Significance Index: -44.4200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.2526
    Cell Significance Index: -49.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 97.3006
    Cell Significance Index: -50.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 73.3955
    Cell Significance Index: -49.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 47.0598
    Cell Significance Index: -44.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.2754
    Cell Significance Index: -42.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6813
    Cell Significance Index: -46.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.5012
    Cell Significance Index: -30.8100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.3599
    Cell Significance Index: -31.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.3296
    Cell Significance Index: -18.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.7792
    Cell Significance Index: 261.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1361
    Cell Significance Index: 92.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0713
    Cell Significance Index: 124.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3493
    Cell Significance Index: 35.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2092
    Cell Significance Index: 660.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0013
    Cell Significance Index: 137.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9093
    Cell Significance Index: 58.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8227
    Cell Significance Index: 38.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8065
    Cell Significance Index: 79.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7352
    Cell Significance Index: 132.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6994
    Cell Significance Index: 31.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6825
    Cell Significance Index: 80.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6642
    Cell Significance Index: 23.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6441
    Cell Significance Index: 30.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6258
    Cell Significance Index: 80.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6148
    Cell Significance Index: 75.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5494
    Cell Significance Index: 242.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5470
    Cell Significance Index: 11.4500
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.5184
    Cell Significance Index: 1.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4779
    Cell Significance Index: 25.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4630
    Cell Significance Index: 10.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4533
    Cell Significance Index: 89.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4326
    Cell Significance Index: 11.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4231
    Cell Significance Index: 54.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3559
    Cell Significance Index: 18.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3502
    Cell Significance Index: 66.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3443
    Cell Significance Index: 69.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3430
    Cell Significance Index: 25.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3124
    Cell Significance Index: 53.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2394
    Cell Significance Index: 2.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1957
    Cell Significance Index: 13.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1855
    Cell Significance Index: 167.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1681
    Cell Significance Index: 4.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1583
    Cell Significance Index: 2.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1578
    Cell Significance Index: 1.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1033
    Cell Significance Index: 37.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0736
    Cell Significance Index: 50.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0671
    Cell Significance Index: 0.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0328
    Cell Significance Index: 1.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0166
    Cell Significance Index: 0.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0125
    Cell Significance Index: 0.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0125
    Cell Significance Index: 0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0082
    Cell Significance Index: -15.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0163
    Cell Significance Index: -11.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0196
    Cell Significance Index: -36.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0200
    Cell Significance Index: -15.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0239
    Cell Significance Index: -36.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0285
    Cell Significance Index: -38.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0333
    Cell Significance Index: -3.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0488
    Cell Significance Index: -36.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0490
    Cell Significance Index: -31.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0621
    Cell Significance Index: -28.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0719
    Cell Significance Index: -40.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0855
    Cell Significance Index: -53.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0885
    Cell Significance Index: -3.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1197
    Cell Significance Index: -9.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1282
    Cell Significance Index: -36.8800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2075
    Cell Significance Index: -3.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2266
    Cell Significance Index: -26.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2305
    Cell Significance Index: -14.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2457
    Cell Significance Index: -35.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2470
    Cell Significance Index: -28.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2482
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2576
    Cell Significance Index: -54.2600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2630
    Cell Significance Index: -4.6500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3441
    Cell Significance Index: -3.4500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3842
    Cell Significance Index: -21.5600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4078
    Cell Significance Index: -7.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4196
    Cell Significance Index: -25.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4196
    Cell Significance Index: -10.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4364
    Cell Significance Index: -45.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4522
    Cell Significance Index: -7.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4992
    Cell Significance Index: -39.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5194
    Cell Significance Index: -12.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5560
    Cell Significance Index: -7.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5889
    Cell Significance Index: -39.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6088
    Cell Significance Index: -15.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6268
    Cell Significance Index: -16.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6275
    Cell Significance Index: -38.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6309
    Cell Significance Index: -18.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6527
    Cell Significance Index: -7.7800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6621
    Cell Significance Index: -4.0000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.6675
    Cell Significance Index: -3.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6800
    Cell Significance Index: -19.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6975
    Cell Significance Index: -7.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7109
    Cell Significance Index: -20.9400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7814
    Cell Significance Index: -10.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8215
    Cell Significance Index: -7.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NOSIP is a multifunctional protein that exhibits a range of characteristics, including: 1. **Protein binding**: NOSIP interacts with various proteins, including NOS3, to modulate its activity and localization. 2. **Molecular sequestering**: NOSIP can sequester NOS3, preventing its activation and reducing NO production. 3. **Negative regulation**: NOSIP negatively regulates NOS3 activity, which inhibits NO biosynthesis. 4. **Regulation of nitric oxide biosynthetic process**: NOSIP plays a crucial role in regulating the NO biosynthetic process, influencing cellular responses to NO. 5. **Ubiquitin protein ligase activity**: NOSIP possesses ubiquitin protein ligase activity, which enables it to mark NOS3 for degradation. **Pathways and Functions:** NOSIP is involved in various cellular pathways, including: 1. **Metabolism of nitric oxide**: NOSIP regulates NO production by interacting with NOS3 and modulating its activity. 2. **Molecular sequestering activity**: NOSIP sequesters NOS3, preventing its activation and reducing NO production. 3. **Negative regulation of nitric-oxide synthase activity**: NOSIP negatively regulates NOS3 activity, which inhibits NO biosynthesis. 4. **Nosip mediated enos trafficking**: NOSIP regulates the trafficking of endothelial nitric oxide synthase (eNOS) within cells. 5. **Regulation of nitric oxide biosynthetic process**: NOSIP plays a crucial role in regulating the NO biosynthetic process, influencing cellular responses to NO. **Clinical Significance:** Dysregulation of NOSIP has significant implications for various diseases, including: 1. **Immunological disorders**: NOSIP dysfunction contributes to immunological disorders, such as autoimmune diseases and inflammatory conditions. 2. **Cardiovascular diseases**: NOSIP regulates NO production, which is essential for maintaining cardiovascular health. 3. **Neurological disorders**: NOSIP dysfunction has been implicated in neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Cancer**: NOSIP regulates NO production, which can impact cancer development and progression. In conclusion, NOSIP is a multifunctional protein that plays a crucial role in regulating nitric oxide production and maintaining cellular homeostasis. Its dysregulation has significant implications for various diseases, highlighting the importance of NOSIP in immune regulation and cellular homeostasis. Further research is needed to fully elucidate the role of NOSIP in human health and disease.

Genular Protein ID: 397194866

Symbol: NOSIP_HUMAN

Name: Nitric oxide synthase-interacting protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11149895

Title: NOSIP, a novel modulator of endothelial nitric oxide synthase activity.

PubMed ID: 11149895

DOI: 10.1096/fj.00-0078com

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15548660

Title: Nitric oxide synthase (NOS)-interacting protein interacts with neuronal NOS and regulates its distribution and activity.

PubMed ID: 15548660

DOI: 10.1523/jneurosci.2265-04.2004

PubMed ID: 16135813

Title: Cell cycle-regulated inactivation of endothelial NO synthase through NOSIP-dependent targeting to the cytoskeleton.

PubMed ID: 16135813

DOI: 10.1128/mcb.25.18.8251-8258.2005

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 301
  • Mass: 33172
  • Checksum: FB77D6E31511C884
  • Sequence:
  • MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 
    DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGTRREEQK ELQRAASQDH VRGFLEKESA 
    IVSRPLNPFT AKALSGTSPD DVQPGPSVGP PSKDKDKVLP SFWIPSLTPE AKATKLEKPS 
    RTVTCPMSGK PLRMSDLTPV HFTPLDSSVD RVGLITRSER YVCAVTRDSL SNATPCAVLR 
    PSGAVVTLEC VEKLIRKDMV DPVTGDKLTD RDIIVLQRGG TGFAGSGVKL QAEKSRPVMQ 
    A

Genular Protein ID: 2890121548

Symbol: A0A075B6F9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 304
  • Mass: 33431
  • Checksum: 918126FDC655775B
  • Sequence:
  • MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 
    DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGTRREEQK ELQRAASQDH VRGFLEKESA 
    IVSRPLNPFT AKALSGTSPG DSDDVQPGPS VGPPSKDKDK VLPSFWIPSL TPEAKATKLE 
    KPSRTVTCPM SGKPLRMSDL TPVHFTPLDS SVDRVGLITR SERYVCAVTR DSLSNATPCA 
    VLRPSGAVVT LECVEKLIRK DMVDPVTGDK LTDRDIIVLQ RGGTGFAGSG VKLQAEKSRP 
    VMQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.