Details for: MRPL4

Gene ID: 51073

Symbol: MRPL4

Ensembl ID: ENSG00000105364

Description: mitochondrial ribosomal protein L4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 197.6596
    Cell Significance Index: -30.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 108.1045
    Cell Significance Index: -27.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 81.1801
    Cell Significance Index: -32.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 80.9112
    Cell Significance Index: -38.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 73.3303
    Cell Significance Index: -37.7200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.9728
    Cell Significance Index: -38.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.0775
    Cell Significance Index: -33.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.7132
    Cell Significance Index: -36.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.9842
    Cell Significance Index: -29.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6730
    Cell Significance Index: -38.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.6636
    Cell Significance Index: -26.6100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.2321
    Cell Significance Index: 33.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5590
    Cell Significance Index: 41.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5008
    Cell Significance Index: 106.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4355
    Cell Significance Index: 42.1600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.4078
    Cell Significance Index: 11.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3396
    Cell Significance Index: 183.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2877
    Cell Significance Index: 66.8900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.2258
    Cell Significance Index: 144.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1816
    Cell Significance Index: 55.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1180
    Cell Significance Index: 72.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1169
    Cell Significance Index: 10.2900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0708
    Cell Significance Index: 14.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0590
    Cell Significance Index: 578.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0459
    Cell Significance Index: 462.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0243
    Cell Significance Index: 27.8800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.9631
    Cell Significance Index: 8.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9441
    Cell Significance Index: 170.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9377
    Cell Significance Index: 121.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9006
    Cell Significance Index: 40.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8920
    Cell Significance Index: 41.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8637
    Cell Significance Index: 9.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8452
    Cell Significance Index: 103.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7504
    Cell Significance Index: 9.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7381
    Cell Significance Index: 51.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7119
    Cell Significance Index: 53.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6756
    Cell Significance Index: 109.8900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6705
    Cell Significance Index: 15.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6655
    Cell Significance Index: 17.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6548
    Cell Significance Index: 591.2200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6276
    Cell Significance Index: 21.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5437
    Cell Significance Index: 11.7800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5427
    Cell Significance Index: 11.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4772
    Cell Significance Index: 95.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3786
    Cell Significance Index: 19.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3641
    Cell Significance Index: 130.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3453
    Cell Significance Index: 68.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3066
    Cell Significance Index: 39.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3019
    Cell Significance Index: 3.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2888
    Cell Significance Index: 18.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2147
    Cell Significance Index: 40.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1341
    Cell Significance Index: 13.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1302
    Cell Significance Index: 3.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0836
    Cell Significance Index: 1.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0826
    Cell Significance Index: 57.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0712
    Cell Significance Index: 2.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0305
    Cell Significance Index: 1.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0276
    Cell Significance Index: 20.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0246
    Cell Significance Index: 18.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0097
    Cell Significance Index: -18.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0218
    Cell Significance Index: -40.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0220
    Cell Significance Index: -2.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0264
    Cell Significance Index: -40.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0309
    Cell Significance Index: -19.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0335
    Cell Significance Index: -45.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0378
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0465
    Cell Significance Index: -34.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0555
    Cell Significance Index: -25.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0579
    Cell Significance Index: -9.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0617
    Cell Significance Index: -34.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0721
    Cell Significance Index: -45.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0942
    Cell Significance Index: -7.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1073
    Cell Significance Index: -30.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1284
    Cell Significance Index: -3.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1378
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1667
    Cell Significance Index: -19.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1948
    Cell Significance Index: -22.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1956
    Cell Significance Index: -28.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2020
    Cell Significance Index: -3.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2118
    Cell Significance Index: -44.6100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2966
    Cell Significance Index: -23.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3132
    Cell Significance Index: -19.2500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3412
    Cell Significance Index: -22.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3601
    Cell Significance Index: -37.5000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4094
    Cell Significance Index: -4.8800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4335
    Cell Significance Index: -6.0800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4425
    Cell Significance Index: -6.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4651
    Cell Significance Index: -26.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4680
    Cell Significance Index: -28.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5432
    Cell Significance Index: -16.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5444
    Cell Significance Index: -9.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5777
    Cell Significance Index: -5.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6249
    Cell Significance Index: -27.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6368
    Cell Significance Index: -11.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7316
    Cell Significance Index: -4.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7360
    Cell Significance Index: -27.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7466
    Cell Significance Index: -19.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7549
    Cell Significance Index: -13.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7573
    Cell Significance Index: -11.1800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8178
    Cell Significance Index: -28.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MRPL4 is a mitochondrial ribosomal protein that belongs to the L4 family of ribosomal proteins. It is a small protein, consisting of 39 amino acids, and is encoded by the ENSG00000105364 gene. The protein is highly conserved across different species, suggesting its essential role in the mitochondria. MRPL4 is known to interact with other mitochondrial ribosomal proteins and is involved in the assembly and function of the mitochondrial large ribosomal subunit. **Pathways and Functions** The primary function of MRPL4 is to participate in the translation process within the mitochondria. It is involved in the assembly and function of the mitochondrial large ribosomal subunit, which is responsible for translating mitochondrial mRNAs into proteins. The protein plays a crucial role in the elongation, initiation, and termination phases of translation. MRPL4 is also involved in the regulation of mitochondrial translation, which is essential for maintaining cellular homeostasis and energy production. **Clinical Significance** Dysregulation of MRPL4 has been implicated in various diseases, including mitochondrial disorders and cancer. Mitochondrial disorders are characterized by defects in energy production, leading to impaired cell function and tissue damage. Cancer cells often exhibit altered mitochondrial translation, which can contribute to tumor progression and metastasis. The expression of MRPL4 is also altered in certain types of leukemia and lymphoma, suggesting its potential role as a biomarker for disease diagnosis and prognosis. Furthermore, MRPL4 has been identified as a potential target for therapeutic intervention in mitochondrial disorders. The protein's role in regulating mitochondrial translation makes it an attractive candidate for the development of novel therapeutic strategies aimed at improving mitochondrial function and reducing disease severity. In conclusion, MRPL4 is a critical component of the mitochondrial large ribosomal subunit, playing a vital role in the translation process within the mitochondria. Its expression and function are essential for maintaining cellular homeostasis and energy production, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of MRPL4 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1497914544

Symbol: RM04_HUMAN

Name: 39S ribosomal protein L4, mitochondrial

UniProtKB Accession Codes:

Q9BYD3 A6NNV7 Q9BW07 Q9H4N2 Q9Y317

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 57 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 61 PDBsum 61 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11279069

Title: Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.

PubMed ID: 11279069

DOI: 10.1074/jbc.m100432200

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30215512

Title: MIEF1 microprotein regulates mitochondrial translation.

PubMed ID: 30215512

DOI: 10.1021/acs.biochem.8b00726

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 311
  • Mass: 34919
  • Checksum: 8267C61C42BFCF07
  • Sequence:
    • MLQFVRAGAR AWLRPTGSQG LSSLAEEAAR ATENPEQVAS EGLPEPVLRK VELPVPTHRR 
PVQAWVESLR GFEQERVGLA DLHPDVFATA PRLDILHQVA MWQKNFKRIS YAKTKTRAEV 
RGGGRKPWPQ KGTGRARHGS IRSPLWRGGG VAHGPRGPTS YYYMLPMKVR ALGLKVALTV 
KLAQDDLHIM DSLELPTGDP QYLTELAHYR RWGDSVLLVD LTHEEMPQSI VEATSRLKTF 
NLIPAVGLNV HSMLKHQTLV LTLPTVAFLE DKLLWQDSRY RPLYPFSLPY SDFPRPLPHA 
TQGPAATPYH C

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.