Details for: APIP

Gene ID: 51074

Symbol: APIP

Ensembl ID: ENSG00000149089

Description: APAF1 interacting protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 197.8846
    Cell Significance Index: -30.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 114.4915
    Cell Significance Index: -29.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 78.0094
    Cell Significance Index: -36.8300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.6848
    Cell Significance Index: -31.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 68.6839
    Cell Significance Index: -35.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 54.9013
    Cell Significance Index: -36.8400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.3388
    Cell Significance Index: -31.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.6385
    Cell Significance Index: -35.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.6430
    Cell Significance Index: -31.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.1902
    Cell Significance Index: -36.2700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.3088
    Cell Significance Index: -25.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3322
    Cell Significance Index: -11.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.4338
    Cell Significance Index: 283.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2220
    Cell Significance Index: 103.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8280
    Cell Significance Index: 109.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8006
    Cell Significance Index: 160.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7224
    Cell Significance Index: 40.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6912
    Cell Significance Index: 6.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6705
    Cell Significance Index: 79.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6568
    Cell Significance Index: 34.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5586
    Cell Significance Index: 100.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5478
    Cell Significance Index: 14.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5388
    Cell Significance Index: 37.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5330
    Cell Significance Index: 291.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5326
    Cell Significance Index: 191.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4806
    Cell Significance Index: 95.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4565
    Cell Significance Index: 56.1300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4523
    Cell Significance Index: 21.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4359
    Cell Significance Index: 70.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4054
    Cell Significance Index: 55.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3588
    Cell Significance Index: 35.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2973
    Cell Significance Index: 6.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2902
    Cell Significance Index: 18.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2898
    Cell Significance Index: 18.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2732
    Cell Significance Index: 7.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2579
    Cell Significance Index: 49.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2079
    Cell Significance Index: 12.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2035
    Cell Significance Index: 26.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1935
    Cell Significance Index: 13.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1809
    Cell Significance Index: 13.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1713
    Cell Significance Index: 75.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1559
    Cell Significance Index: 4.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1492
    Cell Significance Index: 19.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1420
    Cell Significance Index: 98.2300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.1181
    Cell Significance Index: 0.9100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0594
    Cell Significance Index: 111.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0566
    Cell Significance Index: 1.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0549
    Cell Significance Index: 4.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0477
    Cell Significance Index: 73.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0446
    Cell Significance Index: 82.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0309
    Cell Significance Index: 19.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0196
    Cell Significance Index: 26.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0095
    Cell Significance Index: 6.9600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0023
    Cell Significance Index: -1.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0033
    Cell Significance Index: -1.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0082
    Cell Significance Index: -0.2100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0294
    Cell Significance Index: -21.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0311
    Cell Significance Index: -1.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0354
    Cell Significance Index: -3.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0415
    Cell Significance Index: -1.1600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0571
    Cell Significance Index: -32.2100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0583
    Cell Significance Index: -1.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0632
    Cell Significance Index: -2.8700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0637
    Cell Significance Index: -39.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0771
    Cell Significance Index: -13.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0851
    Cell Significance Index: -1.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0870
    Cell Significance Index: -6.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0940
    Cell Significance Index: -1.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1038
    Cell Significance Index: -29.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1129
    Cell Significance Index: -3.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1177
    Cell Significance Index: -17.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1394
    Cell Significance Index: -3.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1545
    Cell Significance Index: -3.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1770
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1837
    Cell Significance Index: -38.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1870
    Cell Significance Index: -21.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1971
    Cell Significance Index: -8.7200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2188
    Cell Significance Index: -3.7500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2471
    Cell Significance Index: -5.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2632
    Cell Significance Index: -9.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2858
    Cell Significance Index: -29.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2902
    Cell Significance Index: -22.9800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2908
    Cell Significance Index: -7.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3232
    Cell Significance Index: -16.9700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3782
    Cell Significance Index: -5.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4537
    Cell Significance Index: -10.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4542
    Cell Significance Index: -13.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4810
    Cell Significance Index: -4.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5124
    Cell Significance Index: -6.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.5364
    Cell Significance Index: -18.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5768
    Cell Significance Index: -16.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5849
    Cell Significance Index: -10.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5910
    Cell Significance Index: -36.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6034
    Cell Significance Index: -6.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6101
    Cell Significance Index: -17.4900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6460
    Cell Significance Index: -13.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6988
    Cell Significance Index: -22.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7105
    Cell Significance Index: -22.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7265
    Cell Significance Index: -14.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Apoptosis regulation:** APIP interacts with APAF1, a key component of the apoptosome, and regulates the intrinsic pathway of apoptosis. This interaction is crucial for the activation of caspase-9, a central enzyme in the apoptotic process. 2. **Protein interactions:** APIP binds to other proteins, including MTNB_HUMAN (MTNB), which suggests a potential role in protein homotetramerization and regulation of the ERK1/2 cascade. 3. **Metabolic functions:** APIP is involved in the methionine salvage pathway, which is essential for maintaining cellular methionine levels. It also interacts with enzymes involved in sulfur amino acid metabolism, highlighting its importance in regulating cellular metabolism. 4. **Cell type specificity:** APIP is expressed in various cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells, suggesting its involvement in different physiological processes. **Pathways and Functions:** 1. **Apoptosis pathways:** APIP regulates the intrinsic pathway of apoptosis, which involves the activation of caspase-9 and the formation of the apoptosome. 2. **Methionine salvage pathway:** APIP interacts with enzymes involved in the methionine salvage pathway, which is essential for maintaining cellular methionine levels. 3. **Sulfur amino acid metabolism:** APIP's interactions with enzymes involved in sulfur amino acid metabolism highlight its importance in regulating cellular metabolism. 4. **Protein interactions:** APIP binds to other proteins, including MTNB_HUMAN, which suggests a potential role in protein homotetramerization and regulation of the ERK1/2 cascade. **Clinical Significance:** 1. **Apoptosis-related diseases:** APIP's involvement in apoptosis pathways suggests its potential as a therapeutic target for diseases characterized by excessive cell death, such as cancer and neurodegenerative disorders. 2. **Metabolic disorders:** APIP's role in the methionine salvage pathway and sulfur amino acid metabolism highlights its importance in maintaining cellular homeostasis, which is relevant to metabolic disorders such as homocystinuria and methionine deficiency. 3. **Immunological disorders:** APIP's expression in hematopoietic cells and its interactions with other proteins suggest its potential involvement in immunological disorders, such as autoimmune diseases and cancer. In conclusion, the APAF1 interacting protein (APIP) is a multifunctional protein that plays a critical role in regulating apoptosis, cellular metabolism, and protein interactions. Its expression in various cell types and its involvement in different physiological processes make it an attractive target for therapeutic interventions in diseases characterized by excessive cell death and metabolic disorders.

Genular Protein ID: 4277924244

Symbol: MTNB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96GX9 A8K9D3 Q6PJX6 Q8WVU2 Q96HK2 Q9Y318

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 7 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15262985

Title: Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein.

PubMed ID: 15262985

DOI: 10.1074/jbc.m405747200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23285211

Title: Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway.

PubMed ID: 23285211

DOI: 10.1371/journal.pone.0052877

PubMed ID: 22837397

Title: Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.

PubMed ID: 22837397

DOI: 10.1073/pnas.1206701109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24367089

Title: Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme.

PubMed ID: 24367089

DOI: 10.1073/pnas.1308768111

Sequence Information:

  • Length: 242
  • Mass: 27125
  • Checksum: 9B8D5D1435D6775A
  • Sequence:
    • MSGCDAREGD CCSRRCGAQD KEHPRYLIPE LCKQFYHLGW VTGTGGGISL KHGDEIYIAP 
SGVQKERIQP EDMFVCDINE KDISGPSPSK KLKKSQCTPL FMNAYTMRGA GAVIHTHSKA 
AVMATLLFPG REFKITHQEM IKGIKKCTSG GYYRYDDMLV VPIIENTPEE KDLKDRMAHA 
MNEYPDSCAV LVRRHGVYVW GETWEKAKTM CECYDYLFDI AVSMKKVGLD PSQLPVGENG 
IV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.