Details for: MRPS7

Gene ID: 51081

Symbol: MRPS7

Ensembl ID: ENSG00000125445

Description: mitochondrial ribosomal protein S7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 209.6496
    Cell Significance Index: -32.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 125.4123
    Cell Significance Index: -31.8100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 96.4564
    Cell Significance Index: -39.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 86.9266
    Cell Significance Index: -41.0400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.0373
    Cell Significance Index: -41.1700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 61.3393
    Cell Significance Index: -41.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.0912
    Cell Significance Index: -40.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8590
    Cell Significance Index: -42.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.4478
    Cell Significance Index: -32.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7523
    Cell Significance Index: -26.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.5314
    Cell Significance Index: 64.6700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.9846
    Cell Significance Index: 16.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3610
    Cell Significance Index: 70.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3502
    Cell Significance Index: 10.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3424
    Cell Significance Index: 84.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2918
    Cell Significance Index: 60.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1929
    Cell Significance Index: 215.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1761
    Cell Significance Index: 10.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1366
    Cell Significance Index: 139.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0965
    Cell Significance Index: 178.3400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.0370
    Cell Significance Index: 15.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.0321
    Cell Significance Index: 27.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.9857
    Cell Significance Index: 11.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9801
    Cell Significance Index: 535.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9691
    Cell Significance Index: 50.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9681
    Cell Significance Index: 26.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9408
    Cell Significance Index: 70.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8993
    Cell Significance Index: 106.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8947
    Cell Significance Index: 40.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8416
    Cell Significance Index: 58.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8305
    Cell Significance Index: 24.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8193
    Cell Significance Index: 112.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8104
    Cell Significance Index: 38.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7905
    Cell Significance Index: 55.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7011
    Cell Significance Index: 309.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.6570
    Cell Significance Index: 84.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6543
    Cell Significance Index: 22.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6416
    Cell Significance Index: 63.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5462
    Cell Significance Index: 493.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5346
    Cell Significance Index: 12.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5091
    Cell Significance Index: 65.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5070
    Cell Significance Index: 5.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4902
    Cell Significance Index: 10.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4615
    Cell Significance Index: 91.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4108
    Cell Significance Index: 10.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3908
    Cell Significance Index: 25.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3183
    Cell Significance Index: 60.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3063
    Cell Significance Index: 3.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2664
    Cell Significance Index: 53.4400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2265
    Cell Significance Index: 4.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1461
    Cell Significance Index: 4.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0907
    Cell Significance Index: 32.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0599
    Cell Significance Index: 43.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0527
    Cell Significance Index: 39.8600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0334
    Cell Significance Index: 0.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0073
    Cell Significance Index: -13.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0094
    Cell Significance Index: -0.2000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0200
    Cell Significance Index: -0.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0212
    Cell Significance Index: -2.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0227
    Cell Significance Index: -41.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0269
    Cell Significance Index: -41.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0367
    Cell Significance Index: -23.2900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0368
    Cell Significance Index: -50.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0453
    Cell Significance Index: -33.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0481
    Cell Significance Index: -8.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0661
    Cell Significance Index: -30.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0662
    Cell Significance Index: -37.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0802
    Cell Significance Index: -50.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0814
    Cell Significance Index: -23.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1178
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1743
    Cell Significance Index: -19.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1880
    Cell Significance Index: -14.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2027
    Cell Significance Index: -23.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2163
    Cell Significance Index: -31.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2178
    Cell Significance Index: -16.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2332
    Cell Significance Index: -49.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2774
    Cell Significance Index: -17.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2937
    Cell Significance Index: -7.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3121
    Cell Significance Index: -5.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3488
    Cell Significance Index: -8.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3752
    Cell Significance Index: -6.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3753
    Cell Significance Index: -5.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4055
    Cell Significance Index: -42.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.4299
    Cell Significance Index: -12.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4619
    Cell Significance Index: -25.9200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4631
    Cell Significance Index: -8.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4685
    Cell Significance Index: -4.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4741
    Cell Significance Index: -13.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4749
    Cell Significance Index: -31.9300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4795
    Cell Significance Index: -3.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4896
    Cell Significance Index: -14.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4896
    Cell Significance Index: -6.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5095
    Cell Significance Index: -31.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8371
    Cell Significance Index: -14.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9005
    Cell Significance Index: -39.8300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9286
    Cell Significance Index: -13.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9386
    Cell Significance Index: -34.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9708
    Cell Significance Index: -34.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0568
    Cell Significance Index: -34.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0642
    Cell Significance Index: -40.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MRPS7 is a mitochondrial ribosomal protein with a molecular weight of approximately 28 kDa. It is encoded by the MRPS7 gene, which is located on chromosome 17q21.2. This gene is highly conserved across species, suggesting its essential role in mitochondrial function. The protein is composed of 128 amino acids and contains a characteristic ribosomal binding domain, which facilitates its interaction with ribosomal RNA (rRNA) and other ribosomal proteins. MRPS7 is highly expressed in cells undergoing rapid proliferation, such as hematopoietic stem cells and embryonic stem cells. Its expression is also observed in smooth muscle fibers of the ileum and peripheral blood mononuclear cells. The protein's expression profile suggests its involvement in cellular differentiation, proliferation, and survival. **Pathways and Functions** MRPS7 is involved in several key pathways, including: 1. **Mitochondrial Translation**: MRPS7 is a critical component of the mitochondrial ribosomal small subunit, which is responsible for the translation of mRNAs within the mitochondria. The protein plays a central role in the assembly and function of the mitochondrial ribosomal subunit, ensuring the accurate translation of mitochondrial mRNAs. 2. **Mitochondrial Translation Initiation**: MRPS7 participates in the initiation of mitochondrial translation by interacting with ribosomal RNA and other ribosomal proteins. This interaction is essential for the recognition of the start codon and the recruitment of the ribosome to the mRNA. 3. **Mitochondrial Translation Termination**: MRPS7 also plays a role in the termination of mitochondrial translation, ensuring the accurate termination of protein synthesis. **Clinical Significance** Mutations in the MRPS7 gene have been associated with certain diseases, including: 1. **Mitochondrial Myopathies**: Mutations in MRPS7 have been linked to mitochondrial myopathies, which are characterized by muscle weakness, fatigue, and other systemic symptoms. 2. **Neuropathies**: MRPS7 mutations have also been associated with neuropathies, which are characterized by nerve damage and sensory dysfunction. 3. **Cancer**: MRPS7 expression has been observed in various types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. In conclusion, MRPS7 is a critical component of the mitochondrial ribosomal subunit, playing a pivotal role in the translation of mRNAs within the mitochondria. Its expression profile and involvement in key pathways suggest its importance in cellular homeostasis and development. Further research is needed to fully understand the clinical significance of MRPS7 and its role in human disease.

Genular Protein ID: 3285045976

Symbol: RT07_HUMAN

Name: 28S ribosomal protein S7, mitochondrial

UniProtKB Accession Codes:

Q9Y2R9 B2R9N5 Q53GD6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 41 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 42 PDBsum 42 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10581179

Title: Identification of a mammalian mitochondrial homolog of ribosomal protein S7.

PubMed ID: 10581179

DOI: 10.1006/bbrc.1999.1785

PubMed ID: 11279123

Title: The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present.

PubMed ID: 11279123

DOI: 10.1074/jbc.m100727200

PubMed ID: 11402041

Title: Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit.

PubMed ID: 11402041

DOI: 10.1074/jbc.m103236200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25556185

Title: Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia.

PubMed ID: 25556185

DOI: 10.1093/hmg/ddu747

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

Sequence Information:

  • Length: 242
  • Mass: 28134
  • Checksum: 945BC3E948B41CCA
  • Sequence:
    • MAAPAVKVAR GWSGLALGVR RAVLQLPGLT QVRWSRYSPE FKDPLIDKEY YRKPVEELTE 
EEKYVRELKK TQLIKAAPAG KTSSVFEDPV ISKFTNMMMI GGNKVLARSL MIQTLEAVKR 
KQFEKYHAAS AEEQATIERN PYTIFHQALK NCEPMIGLVP ILKGGRFYQV PVPLPDRRRR 
FLAMKWMITE CRDKKHQRTL MPEKLSHKLL EAFHNQGPVI KRKHDLHKMA EANRALAHYR 
WW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.