Details for: ADIPOR1

Gene ID: 51094

Symbol: ADIPOR1

Ensembl ID: ENSG00000159346

Description: adiponectin receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 175.8974
    Cell Significance Index: -27.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 128.3495
    Cell Significance Index: -32.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 98.8961
    Cell Significance Index: -40.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.4696
    Cell Significance Index: -39.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.1585
    Cell Significance Index: -34.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.3715
    Cell Significance Index: -38.7700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.4317
    Cell Significance Index: -39.8800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.0411
    Cell Significance Index: -34.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.5003
    Cell Significance Index: -22.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4974
    Cell Significance Index: -30.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4791
    Cell Significance Index: -37.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.7939
    Cell Significance Index: -27.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6880
    Cell Significance Index: -10.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2908
    Cell Significance Index: 106.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0213
    Cell Significance Index: 27.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0056
    Cell Significance Index: 52.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9499
    Cell Significance Index: 59.8700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9122
    Cell Significance Index: 8.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9081
    Cell Significance Index: 42.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8778
    Cell Significance Index: 65.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8317
    Cell Significance Index: 107.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8221
    Cell Significance Index: 133.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8027
    Cell Significance Index: 98.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7762
    Cell Significance Index: 139.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7648
    Cell Significance Index: 14.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6450
    Cell Significance Index: 352.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6255
    Cell Significance Index: 32.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.6180
    Cell Significance Index: 385.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6113
    Cell Significance Index: 31.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5745
    Cell Significance Index: 15.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5714
    Cell Significance Index: 16.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5096
    Cell Significance Index: 102.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5037
    Cell Significance Index: 59.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4828
    Cell Significance Index: 213.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4583
    Cell Significance Index: 413.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4283
    Cell Significance Index: 58.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3866
    Cell Significance Index: 27.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3600
    Cell Significance Index: 61.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3566
    Cell Significance Index: 67.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3227
    Cell Significance Index: 64.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2594
    Cell Significance Index: 6.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2268
    Cell Significance Index: 29.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2168
    Cell Significance Index: 6.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2128
    Cell Significance Index: 4.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2029
    Cell Significance Index: 72.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1676
    Cell Significance Index: 115.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1656
    Cell Significance Index: 16.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1639
    Cell Significance Index: 3.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1576
    Cell Significance Index: 10.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1483
    Cell Significance Index: 3.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0941
    Cell Significance Index: 2.6300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0865
    Cell Significance Index: 0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0732
    Cell Significance Index: 55.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0485
    Cell Significance Index: 1.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0207
    Cell Significance Index: 0.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0020
    Cell Significance Index: 0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0125
    Cell Significance Index: -9.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0127
    Cell Significance Index: -9.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0164
    Cell Significance Index: -30.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0213
    Cell Significance Index: -32.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0273
    Cell Significance Index: -37.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0343
    Cell Significance Index: -21.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0349
    Cell Significance Index: -19.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0370
    Cell Significance Index: -1.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0598
    Cell Significance Index: -27.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0736
    Cell Significance Index: -3.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0778
    Cell Significance Index: -16.3800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0781
    Cell Significance Index: -1.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0832
    Cell Significance Index: -2.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1042
    Cell Significance Index: -15.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1068
    Cell Significance Index: -30.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1092
    Cell Significance Index: -12.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1136
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1152
    Cell Significance Index: -13.2000
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: -0.1177
    Cell Significance Index: -0.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1737
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2039
    Cell Significance Index: -23.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2122
    Cell Significance Index: -2.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2363
    Cell Significance Index: -18.1400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2403
    Cell Significance Index: -2.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2620
    Cell Significance Index: -5.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3304
    Cell Significance Index: -8.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3371
    Cell Significance Index: -22.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3502
    Cell Significance Index: -36.4600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3989
    Cell Significance Index: -2.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4089
    Cell Significance Index: -25.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4176
    Cell Significance Index: -23.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4179
    Cell Significance Index: -33.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4452
    Cell Significance Index: -10.2900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5036
    Cell Significance Index: -8.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5226
    Cell Significance Index: -7.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5503
    Cell Significance Index: -24.3400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6430
    Cell Significance Index: -3.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6438
    Cell Significance Index: -39.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6792
    Cell Significance Index: -25.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6917
    Cell Significance Index: -7.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6960
    Cell Significance Index: -17.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7578
    Cell Significance Index: -22.3200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7642
    Cell Significance Index: -38.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Adiponectin Receptor**: ADIPOR1 is a receptor for adiponectin, a protein hormone involved in regulating glucose and lipid metabolism. 2. **Signaling Pathways**: ADIPOR1 is involved in various signaling pathways, including adipokinetic hormone receptor activity, adiponectin-activated signaling pathway, and hormone-mediated signaling pathway. 3. **Cellular Expression**: ADIPOR1 is expressed in multiple cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells. 4. **Regulatory Functions**: ADIPOR1 regulates glucose and lipid metabolism, energy homeostasis, and immune responses. **Pathways and Functions:** ADIPOR1 is involved in several key pathways, including: 1. **Adiponectin-Activated Signaling Pathway**: ADIPOR1 mediates the signaling effects of adiponectin, a protein hormone involved in regulating glucose and lipid metabolism. 2. **Hormone-Mediated Signaling Pathway**: ADIPOR1 is involved in the signaling pathways of various hormone receptors, including the insulin receptor and leptin receptor. 3. **Glucose Homeostasis**: ADIPOR1 regulates glucose metabolism by modulating the activity of key enzymes involved in glycolysis and gluconeogenesis. 4. **Lipid Metabolism**: ADIPOR1 is involved in regulating lipid metabolism by modulating the activity of key enzymes involved in fatty acid oxidation and lipogenesis. 5. **Immune Responses**: ADIPOR1 regulates immune responses by modulating the activity of key immune cells, including T cells and macrophages. **Clinical Significance:** 1. **Metabolic Disorders**: ADIPOR1 dysfunction has been implicated in various metabolic disorders, including type 2 diabetes and obesity. 2. **Cardiovascular Diseases**: ADIPOR1 has been shown to play a role in regulating cardiovascular disease risk factors, including hypertension and atherosclerosis. 3. **Cancer**: ADIPOR1 has been implicated in the development and progression of certain types of cancer, including colorectal cancer and breast cancer. 4. **Immune-Related Disorders**: ADIPOR1 dysfunction has been associated with various immune-related disorders, including autoimmune diseases and inflammatory disorders. In conclusion, the ADIPOR1 gene plays a crucial role in regulating glucose and lipid metabolism, energy homeostasis, and immune responses. Its dysfunction has been implicated in various metabolic and immune-related disorders, highlighting the importance of ADIPOR1 in maintaining health and preventing disease. Further research is needed to fully elucidate the mechanisms underlying ADIPOR1 function and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3560986737

Symbol: PAQR1_HUMAN

Name: Progestin and adipoQ receptor family member I

UniProtKB Accession Codes:

Q96A54 B3KMB0 Q53HS7 Q53YY6 Q9Y360

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 23 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16044242

Title: PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.

PubMed ID: 16044242

DOI: 10.1007/s00239-004-0375-2

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12802337

Title: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.

PubMed ID: 12802337

DOI: 10.1038/nature01705

PubMed ID: 25855295

Title: Crystal structures of the human adiponectin receptors.

PubMed ID: 25855295

DOI: 10.1038/nature14301

Sequence Information:

  • Length: 375
  • Mass: 42616
  • Checksum: 1CC0300A7D178EB0
  • Sequence:
    • MSSHKGSVVA QGNGAPASNR EADTVELAEL GPLLEEKGKR VIANPPKAEE EQTCPVPQEE 
EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL PDWLKDNDYL LHGHRPPMPS 
FRACFKSIFR IHTETGNIWT HLLGFVLFLF LGILTMLRPN MYFMAPLQEK VVFGMFFLGA 
VLCLSFSWLF HTVYCHSEKV SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS 
IVCVLGISAI IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM 
GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV HFYGVSNLQE 
FRYGLEGGCT DDTLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.