Details for: ZC2HC1A

Gene ID: 51101

Symbol: ZC2HC1A

Ensembl ID: ENSG00000104427

Description: zinc finger C2HC-type containing 1A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 278.3756
    Cell Significance Index: -43.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 165.5474
    Cell Significance Index: -41.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 95.7646
    Cell Significance Index: -39.4500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 88.5787
    Cell Significance Index: -41.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.9062
    Cell Significance Index: -34.9000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 79.0750
    Cell Significance Index: -40.6800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.4706
    Cell Significance Index: -34.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.1919
    Cell Significance Index: -43.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.9983
    Cell Significance Index: -43.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6562
    Cell Significance Index: -32.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.9549
    Cell Significance Index: -17.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1000
    Cell Significance Index: 421.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.0111
    Cell Significance Index: 123.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9357
    Cell Significance Index: 37.7800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.7165
    Cell Significance Index: 17.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5475
    Cell Significance Index: 86.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.5115
    Cell Significance Index: 36.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2728
    Cell Significance Index: 242.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1375
    Cell Significance Index: 31.7900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0321
    Cell Significance Index: 22.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8425
    Cell Significance Index: 302.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8139
    Cell Significance Index: 30.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7798
    Cell Significance Index: 99.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7595
    Cell Significance Index: 136.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7576
    Cell Significance Index: 33.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.6386
    Cell Significance Index: 42.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6192
    Cell Significance Index: 76.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6134
    Cell Significance Index: 84.2400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6079
    Cell Significance Index: 31.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4811
    Cell Significance Index: 434.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4785
    Cell Significance Index: 55.7600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4664
    Cell Significance Index: 13.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4399
    Cell Significance Index: 304.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4335
    Cell Significance Index: 22.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4251
    Cell Significance Index: 11.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3481
    Cell Significance Index: 190.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3304
    Cell Significance Index: 32.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3056
    Cell Significance Index: 49.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2777
    Cell Significance Index: 122.7600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2551
    Cell Significance Index: 5.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2140
    Cell Significance Index: 42.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1947
    Cell Significance Index: 10.1400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1879
    Cell Significance Index: 3.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1738
    Cell Significance Index: 18.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1030
    Cell Significance Index: 3.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0854
    Cell Significance Index: 6.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0585
    Cell Significance Index: 110.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0512
    Cell Significance Index: 1.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0454
    Cell Significance Index: 83.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0365
    Cell Significance Index: 56.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0025
    Cell Significance Index: 1.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0107
    Cell Significance Index: -6.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0110
    Cell Significance Index: -14.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0255
    Cell Significance Index: -1.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0267
    Cell Significance Index: -19.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0284
    Cell Significance Index: -21.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0291
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0300
    Cell Significance Index: -18.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0362
    Cell Significance Index: -2.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0368
    Cell Significance Index: -1.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0385
    Cell Significance Index: -0.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0467
    Cell Significance Index: -35.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0518
    Cell Significance Index: -29.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0563
    Cell Significance Index: -2.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0576
    Cell Significance Index: -8.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0629
    Cell Significance Index: -1.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0826
    Cell Significance Index: -14.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0905
    Cell Significance Index: -1.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0979
    Cell Significance Index: -10.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1165
    Cell Significance Index: -8.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1226
    Cell Significance Index: -35.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1249
    Cell Significance Index: -26.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2017
    Cell Significance Index: -23.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2061
    Cell Significance Index: -24.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2186
    Cell Significance Index: -15.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2375
    Cell Significance Index: -30.6900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2638
    Cell Significance Index: -3.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2686
    Cell Significance Index: -5.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3324
    Cell Significance Index: -37.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3342
    Cell Significance Index: -34.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3424
    Cell Significance Index: -25.5200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3918
    Cell Significance Index: -5.9500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3992
    Cell Significance Index: -8.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4195
    Cell Significance Index: -25.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4365
    Cell Significance Index: -20.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4422
    Cell Significance Index: -35.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4826
    Cell Significance Index: -11.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4991
    Cell Significance Index: -13.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5021
    Cell Significance Index: -16.4400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5071
    Cell Significance Index: -16.1500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.5174
    Cell Significance Index: -6.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5230
    Cell Significance Index: -11.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5608
    Cell Significance Index: -16.4700
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.6079
    Cell Significance Index: -3.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6113
    Cell Significance Index: -39.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6275
    Cell Significance Index: -15.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7382
    Cell Significance Index: -21.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7487
    Cell Significance Index: -23.9800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.7719
    Cell Significance Index: -11.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7864
    Cell Significance Index: -15.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ZC2HC1A gene exhibits several key characteristics that distinguish it from other genes: 1. **Zinc finger C2HC-type domain**: The gene contains a unique C2HC-type zinc finger domain, which is a characteristic motif found in proteins involved in protein-protein interactions and DNA binding. 2. **Metal ion binding**: The gene's ability to bind metal ions suggests its involvement in redox reactions and oxidative stress regulation. 3. **Significant expression in various cell types**: ZC2HC1A is expressed in a wide range of cell types, including hematopoietic progenitor cells, embryonic stem cells, and immune cells such as T cells and mast cells. 4. **Protein-protein interactions**: The gene's ability to interact with other proteins highlights its potential as a regulator of cellular processes. **Pathways and Functions:** The ZC2HC1A gene is involved in several key pathways and functions: 1. **Immune system development**: The gene plays a role in the development and maturation of immune cells, including T cells and mast cells. 2. **Cellular homeostasis**: ZC2HC1A regulates cellular processes such as redox reactions, oxidative stress, and protein-protein interactions. 3. **Hematopoiesis**: The gene is involved in the regulation of hematopoietic progenitor cells and the development of blood cells. 4. **Stem cell maintenance**: ZC2HC1A is expressed in embryonic stem cells and plays a role in maintaining stem cell homeostasis. **Clinical Significance:** The ZC2HC1A gene's involvement in immune system development and function has significant clinical implications: 1. **Immunodeficiency disorders**: Mutations in the ZC2HC1A gene may contribute to immunodeficiency disorders, such as impaired T cell development and function. 2. **Cancer**: The gene's role in regulating cellular homeostasis and immune response may also contribute to cancer development and progression. 3. **Autoimmune diseases**: ZC2HC1A's involvement in immune system regulation may also contribute to autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Stem cell transplantation**: The gene's role in maintaining stem cell homeostasis may also have implications for stem cell transplantation and regenerative medicine. In conclusion, the ZC2HC1A gene is a novel gene that plays a critical role in regulating cellular homeostasis and immune response. Further research is needed to fully elucidate the gene's function and its clinical significance.

Genular Protein ID: 2312976413

Symbol: ZC21A_HUMAN

Name: Zinc finger C2HC domain-containing protein 1A

UniProtKB Accession Codes:

Q96GY0 Q9Y372

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 9 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 325
  • Mass: 35092
  • Checksum: 8ECAA1FB8B00A8BC
  • Sequence:
    • MEGLEENGGV VQVGELLPCK ICGRTFFPVA LKKHGPICQK TATKKRKTFD SSRQRAEGTD 
IPTVKPLKPR PEPPKKPSNW RRKHEEFIAT IRAAKGLDQA LKEGGKLPPP PPPSYDPDYI 
QCPYCQRRFN ENAADRHINF CKEQAARISN KGKFSTDTKG KPTSRTQVYK PPALKKSNSP 
GTASSGSSRL PQPSGAGKTV VGVPSGKVSS SSSSLGNKLQ TLSPSHKGIA APHAGANVKP 
RNSTPPSLAR NPAPGVLTNK RKTYTESYIA RPDGDCASSL NGGNIKGIEG HSPGNLPKFC 
HECGTKYPVE WAKFCCECGI RRMIL

Genular Protein ID: 4096191895

Symbol: B2R9B8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R9B8

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 325
  • Mass: 35076
  • Checksum: 0CCAA1FB94E0A8A3
  • Sequence:
    • MEGLEENGGV VQVGELLPCK ICGRTFFPVA LKKHGPICQK TATKKRKTFD SSRQRAEGTD 
IPTVKPLKPR PEPPKKPSNW RRKHEEFIAT IRAAKGLDQA LKEGGKLPPP PPPSYDPDYI 
QCPYCQRRFN ENAADRHINF CKEQAARISN KGKFSTDTKG KPTSRTQVYK PPALKKSNSP 
GTASSGSSRL PQPSGAGKTV VGVPSGKVSS SSSSLGNKLQ TLSPSHKGIA APHAGANVKP 
RNSTPPSLAR NPAPGVLTNK RKTYTESYIA RPVGDCASSL NGGNIKGIEG HSPGNLPKFC 
HECGTKYPVE WAKFCCECGI RRMIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.