Details for: UTP11

Gene ID: 51118

Symbol: UTP11

Ensembl ID: ENSG00000183520

Description: UTP11 small subunit processome component

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 75.1309
    Cell Significance Index: -30.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.2315
    Cell Significance Index: -33.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.6573
    Cell Significance Index: -27.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.0935
    Cell Significance Index: -31.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.5836
    Cell Significance Index: -27.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.7359
    Cell Significance Index: -28.7600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.9776
    Cell Significance Index: -18.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.9843
    Cell Significance Index: -8.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2079
    Cell Significance Index: 359.1000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.6012
    Cell Significance Index: 13.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3743
    Cell Significance Index: 14.9400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.3641
    Cell Significance Index: 22.0100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.3004
    Cell Significance Index: 31.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1832
    Cell Significance Index: 1068.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1569
    Cell Significance Index: 31.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1035
    Cell Significance Index: 120.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8953
    Cell Significance Index: 18.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8315
    Cell Significance Index: 102.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.7866
    Cell Significance Index: 55.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7169
    Cell Significance Index: 316.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6195
    Cell Significance Index: 111.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5827
    Cell Significance Index: 6.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5710
    Cell Significance Index: 7.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5660
    Cell Significance Index: 14.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5628
    Cell Significance Index: 38.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5340
    Cell Significance Index: 27.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5206
    Cell Significance Index: 71.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4893
    Cell Significance Index: 63.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4549
    Cell Significance Index: 21.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3816
    Cell Significance Index: 37.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3556
    Cell Significance Index: 26.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3552
    Cell Significance Index: 193.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2965
    Cell Significance Index: 38.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2768
    Cell Significance Index: 7.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2724
    Cell Significance Index: 14.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2614
    Cell Significance Index: 11.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2263
    Cell Significance Index: 5.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2074
    Cell Significance Index: 35.4200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2065
    Cell Significance Index: 24.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2054
    Cell Significance Index: 41.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1990
    Cell Significance Index: 12.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1832
    Cell Significance Index: 20.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1604
    Cell Significance Index: 2.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1563
    Cell Significance Index: 5.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1481
    Cell Significance Index: 9.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1475
    Cell Significance Index: 29.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1350
    Cell Significance Index: 3.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1171
    Cell Significance Index: 81.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0660
    Cell Significance Index: 2.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0639
    Cell Significance Index: 22.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0628
    Cell Significance Index: 11.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0569
    Cell Significance Index: 2.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0187
    Cell Significance Index: 0.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0075
    Cell Significance Index: 5.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0051
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0096
    Cell Significance Index: -18.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0180
    Cell Significance Index: -8.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0189
    Cell Significance Index: -13.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0192
    Cell Significance Index: -35.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0197
    Cell Significance Index: -0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0223
    Cell Significance Index: -34.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0272
    Cell Significance Index: -1.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0274
    Cell Significance Index: -37.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0357
    Cell Significance Index: -26.4200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0377
    Cell Significance Index: -23.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0417
    Cell Significance Index: -1.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0462
    Cell Significance Index: -4.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0521
    Cell Significance Index: -29.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0651
    Cell Significance Index: -40.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0878
    Cell Significance Index: -25.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1184
    Cell Significance Index: -3.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1289
    Cell Significance Index: -15.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1298
    Cell Significance Index: -2.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1511
    Cell Significance Index: -7.9400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1718
    Cell Significance Index: -7.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1761
    Cell Significance Index: -37.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1864
    Cell Significance Index: -27.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1906
    Cell Significance Index: -14.6300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1961
    Cell Significance Index: -5.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2430
    Cell Significance Index: -6.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2509
    Cell Significance Index: -15.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2811
    Cell Significance Index: -3.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2955
    Cell Significance Index: -30.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3177
    Cell Significance Index: -9.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3178
    Cell Significance Index: -25.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3331
    Cell Significance Index: -18.6900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3647
    Cell Significance Index: -24.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4327
    Cell Significance Index: -3.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4353
    Cell Significance Index: -2.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4471
    Cell Significance Index: -6.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5260
    Cell Significance Index: -5.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5414
    Cell Significance Index: -33.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5523
    Cell Significance Index: -24.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5636
    Cell Significance Index: -16.6000
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.5702
    Cell Significance Index: -3.3500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6133
    Cell Significance Index: -14.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6368
    Cell Significance Index: -11.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6581
    Cell Significance Index: -24.9200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6963
    Cell Significance Index: -25.5600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7701
    Cell Significance Index: -9.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The UTP11 gene has several key characteristics that make it an essential component of RNA processing: 1. **Small subunit processome component**: UTP11 is a component of the processome, a complex structure involved in the processing of small nuclear RNAs (snRNAs). 2. **RNA binding**: UTP11 binds to U3 small nucleolar RNA (snoRNA), a type of RNA involved in RNA processing. 3. **Positive regulation of apoptotic process**: UTP11 has been shown to regulate the apoptotic process, which is essential for the elimination of damaged or unnecessary cells. 4. **Protein binding**: UTP11 binds to various proteins, including other components of the processome, to regulate RNA processing. **Pathways and Functions** The UTP11 gene is involved in several key pathways, including: 1. **RNA processing**: UTP11 is involved in the processing of small nuclear RNAs (snRNAs) in the nucleolus and cytosol. 2. **Ribosomal small subunit biogenesis**: UTP11 is involved in the biogenesis of ribosomal small subunits, which are essential for protein synthesis. 3. **RNA modification**: UTP11 is involved in the modification of RNA molecules, including the addition of nucleotides and the removal of nucleotides. 4. **Apoptotic regulation**: UTP11 regulates the apoptotic process, which is essential for the elimination of damaged or unnecessary cells. **Clinical Significance** The UTP11 gene has significant clinical implications, particularly in the context of immune function and RNA processing disorders. Some potential clinical applications of the UTP11 gene include: 1. **RNA processing disorders**: Mutations in the UTP11 gene may lead to RNA processing disorders, such as muscular dystrophy or other neurodegenerative diseases. 2. **Apoptotic regulation**: Dysregulation of UTP11 may contribute to cancer development, as the protein plays a crucial role in regulating the apoptotic process. 3. **Immune function**: UTP11 is expressed in various immune cells, including T cells and macrophages, suggesting a potential role in immune function and disease. In conclusion, the UTP11 gene is a crucial component of RNA processing and immune function, and its dysregulation may contribute to various diseases, including RNA processing disorders and cancer. Further research is needed to fully understand the role of UTP11 in human health and disease.

Genular Protein ID: 3006378870

Symbol: UTP11_HUMAN

Name: Probable U3 small nucleolar RNA-associated protein 11

UniProtKB Accession Codes:

Q9Y3A2 A8K785 B4DJC6 D3DPT7 Q5VT93 Q9BS98 Q9NS31

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 3 Ensembl 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 253
  • Mass: 30447
  • Checksum: D005AD09E96E7FA4
  • Sequence:
    • MAAAFRKAAK SRQREHRERS QPGFRKHLGL LEKKKDYKLR ADDYRKKQEY LKALRKKALE 
KNPDEFYYKM TRVKLQDGVH IIKETKEEVT PEQLKLMRTQ DVKYIEMKRV AEAKKIERLK 
SELHLLDFQG KQQNKHVFFF DTKKEVEQFD VATHLQTAPE LVDRVFNRPR IETLQKEKVK 
GVTNQTGLKR IAKERQKQYN CLTQRIEREK KLFVIAQKIQ TRKDLMDKTQ KVKVKKETVN 
SPAIYKFQSR RKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.