Details for: NAA20

Gene ID: 51126

Symbol: NAA20

Ensembl ID: ENSG00000173418

Description: N-alpha-acetyltransferase 20, NatB catalytic subunit

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 274.1968
    Cell Significance Index: -42.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 143.8240
    Cell Significance Index: -36.4800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 116.4226
    Cell Significance Index: -47.9600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 113.2121
    Cell Significance Index: -53.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 101.9551
    Cell Significance Index: -41.4200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 93.5874
    Cell Significance Index: -48.1400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 79.8334
    Cell Significance Index: -53.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 43.6138
    Cell Significance Index: -41.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.9957
    Cell Significance Index: -48.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.6826
    Cell Significance Index: -33.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.6202
    Cell Significance Index: -49.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.0762
    Cell Significance Index: -34.0200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.1527
    Cell Significance Index: -22.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.4475
    Cell Significance Index: 66.6200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.1465
    Cell Significance Index: 18.0300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.0038
    Cell Significance Index: 21.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4072
    Cell Significance Index: 104.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.3546
    Cell Significance Index: 95.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3080
    Cell Significance Index: 61.4800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2323
    Cell Significance Index: 169.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1633
    Cell Significance Index: 54.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1623
    Cell Significance Index: 230.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1374
    Cell Significance Index: 621.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1200
    Cell Significance Index: 137.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0546
    Cell Significance Index: 466.2500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.0282
    Cell Significance Index: 8.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9795
    Cell Significance Index: 126.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9270
    Cell Significance Index: 167.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8765
    Cell Significance Index: 45.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8575
    Cell Significance Index: 139.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7551
    Cell Significance Index: 17.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7134
    Cell Significance Index: 20.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6060
    Cell Significance Index: 39.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5928
    Cell Significance Index: 37.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5822
    Cell Significance Index: 30.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5569
    Cell Significance Index: 111.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4872
    Cell Significance Index: 57.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4700
    Cell Significance Index: 60.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4392
    Cell Significance Index: 11.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4190
    Cell Significance Index: 71.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4164
    Cell Significance Index: 12.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4136
    Cell Significance Index: 11.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2834
    Cell Significance Index: 6.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2573
    Cell Significance Index: 177.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2394
    Cell Significance Index: 2.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2366
    Cell Significance Index: 6.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2304
    Cell Significance Index: 43.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2281
    Cell Significance Index: 22.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2202
    Cell Significance Index: 78.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1735
    Cell Significance Index: 6.0300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1655
    Cell Significance Index: 2.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1565
    Cell Significance Index: 4.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0693
    Cell Significance Index: 1.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0390
    Cell Significance Index: 28.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0226
    Cell Significance Index: 0.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0189
    Cell Significance Index: 14.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0095
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0229
    Cell Significance Index: -14.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0242
    Cell Significance Index: -44.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0291
    Cell Significance Index: -2.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0302
    Cell Significance Index: -46.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0356
    Cell Significance Index: -0.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0358
    Cell Significance Index: -0.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0375
    Cell Significance Index: -50.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0396
    Cell Significance Index: -25.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0564
    Cell Significance Index: -31.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0719
    Cell Significance Index: -32.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0747
    Cell Significance Index: -15.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0772
    Cell Significance Index: -0.9200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1007
    Cell Significance Index: -0.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1298
    Cell Significance Index: -37.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1698
    Cell Significance Index: -19.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1824
    Cell Significance Index: -20.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2417
    Cell Significance Index: -35.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2423
    Cell Significance Index: -12.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2600
    Cell Significance Index: -19.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2685
    Cell Significance Index: -31.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2882
    Cell Significance Index: -22.8300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2908
    Cell Significance Index: -7.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2981
    Cell Significance Index: -18.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3006
    Cell Significance Index: -16.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3136
    Cell Significance Index: -11.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3532
    Cell Significance Index: -2.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3631
    Cell Significance Index: -11.6300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3707
    Cell Significance Index: -2.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3843
    Cell Significance Index: -25.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4075
    Cell Significance Index: -5.5600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4250
    Cell Significance Index: -4.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4695
    Cell Significance Index: -48.8900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5586
    Cell Significance Index: -8.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5855
    Cell Significance Index: -12.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5888
    Cell Significance Index: -10.0900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6827
    Cell Significance Index: -41.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7142
    Cell Significance Index: -31.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7246
    Cell Significance Index: -19.4200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8897
    Cell Significance Index: -33.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9049
    Cell Significance Index: -23.2600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9198
    Cell Significance Index: -17.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Catalytic activity**: NAA20 is a catalytic subunit of N-alpha-acetyltransferase 20, which catalyzes the transfer of an acetyl group from acetyl-CoA to the N-terminal amino acids of proteins. 2. **N-terminal acetylation**: NAA20 is involved in the acetylation of N-terminal amino acids, including aspartic acid, glutamic acid, and glutamine, which is a post-translational modification that affects protein function, stability, and localization. 3. **Cellular expression**: NAA20 is expressed in a variety of cell types, including hematopoietic cells, smooth muscle cells, epithelial cells, and immune cells. 4. **Regulation of actin cytoskeleton organization**: NAA20 is involved in the regulation of actin cytoskeleton organization, which is essential for cell migration, division, and signaling. **Pathways and Functions** 1. **N-terminal peptide acetylation**: NAA20 is involved in the acetylation of N-terminal peptide amino acids, which affects protein function, stability, and localization. 2. **Peptide alpha-n-acetyltransferase activity**: NAA20 catalyzes the transfer of an acetyl group from acetyl-CoA to the N-terminal amino acids of proteins. 3. **N-terminal protein amino acid acetylation**: NAA20 is involved in the acetylation of N-terminal protein amino acids, which affects protein function, stability, and localization. 4. **NatB complex**: NAA20 is part of the NatB complex, which is a heterodimeric enzyme complex that catalyzes the acetylation of N-terminal amino acids. **Clinical Significance** 1. **Disease association**: NAA20 has been associated with various diseases, including cancer, where altered acetylation patterns can affect protein function and tumor progression. 2. **Immunological disorders**: NAA20 is involved in the regulation of immune cell function, and alterations in its expression or activity may contribute to immunological disorders, such as autoimmune diseases. 3. **Regulation of actin cytoskeleton organization**: NAA20's involvement in the regulation of actin cytoskeleton organization may have implications for cell migration, division, and signaling, which are essential for various physiological and pathological processes. 4. **Potential therapeutic targets**: NAA20 may serve as a potential therapeutic target for the treatment of diseases associated with altered acetylation patterns, such as cancer and immunological disorders. In conclusion, NAA20 is a gene that encodes a protein involved in the catalytic activity of N-alpha-acetyltransferase 20, which plays a crucial role in the post-translational modification of proteins by acetylating N-terminal amino acids. The expression of NAA20 is observed in various cell types, and its involvement in the regulation of actin cytoskeleton organization and protein binding further highlights its significance in cellular processes. The clinical significance of NAA20 is evident, and its potential as a therapeutic target for the treatment of diseases associated with altered acetylation patterns is an area of ongoing research.

Genular Protein ID: 1286299766

Symbol: NAA20_HUMAN

Name: N-alpha-acetyltransferase 20

UniProtKB Accession Codes:

P61599 A6NHA3 B2R4G4 Q5TFT7 Q9D7H8 Q9H0Y4 Q9NQH6 Q9Y6D2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 20 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 4 EMBL 10 EMDB 3 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 Rhea 12 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18570629

Title: Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression.

PubMed ID: 18570629

DOI: 10.1042/bj20080658

PubMed ID: 19660095

Title: A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates.

PubMed ID: 19660095

DOI: 10.1186/1753-6561-3-s6-s2

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25732826

Title: An organellar nalpha-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

PubMed ID: 25732826

DOI: 10.1016/j.celrep.2015.01.053

PubMed ID: 34230638

Title: Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly.

PubMed ID: 34230638

DOI: 10.1038/s41436-021-01264-0

PubMed ID: 37191084

Title: Novel biallelic variants expand the phenotype of NAA20-related syndrome.

PubMed ID: 37191084

DOI: 10.1111/cge.14359

Sequence Information:

  • Length: 178
  • Mass: 20368
  • Checksum: C5CCEA50CD60E097
  • Sequence:
    • MTTLRAFTCD DLFRFNNINL DPLTETYGIP FYLQYLAHWP EYFIVAEAPG GELMGYIMGK 
AEGSVAREEW HGHVTALSVA PEFRRLGLAA KLMELLEEIS ERKGGFFVDL FVRVSNQVAV 
NMYKQLGYSV YRTVIEYYSA SNGEPDEDAY DMRKALSRDT EKKSIIPLPH PVRPEDIE

Genular Protein ID: 820923995

Symbol: A8MZB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8MZB2

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 20 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 4 EMBL 4 Ensembl 2 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 12 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 166
  • Mass: 18857
  • Checksum: 1940B85AF8DF384A
  • Sequence:
    • MLSQSCNLDP LTETYGIPFY LQYLAHWPEY FIVAEAPGGE LMGYIMGKAE GSVAREEWHG 
HVTALSVAPE FRRLGLAAKL MELLEEISER KGGFFVDLFV RVSNQVAVNM YKQLGYSVYR 
TVIEYYSASN GEPDEDAYDM RKALSRDTEK KSIIPLPHPV RPEDIE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.