Details for: SAR1B

Gene ID: 51128

Symbol: SAR1B

Ensembl ID: ENSG00000152700

Description: secretion associated Ras related GTPase 1B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 268.6678
    Cell Significance Index: -41.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 186.8371
    Cell Significance Index: -47.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 126.5695
    Cell Significance Index: -52.1400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 108.0863
    Cell Significance Index: -51.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 100.4721
    Cell Significance Index: -40.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 94.1318
    Cell Significance Index: -48.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 76.1674
    Cell Significance Index: -51.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.7497
    Cell Significance Index: -40.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.4661
    Cell Significance Index: -48.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.3204
    Cell Significance Index: -43.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7621
    Cell Significance Index: -50.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.6529
    Cell Significance Index: -32.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8153
    Cell Significance Index: 84.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7348
    Cell Significance Index: 15.9800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4599
    Cell Significance Index: 75.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2385
    Cell Significance Index: 223.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1090
    Cell Significance Index: 180.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0498
    Cell Significance Index: 208.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0288
    Cell Significance Index: 71.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0157
    Cell Significance Index: 203.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0079
    Cell Significance Index: 47.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9919
    Cell Significance Index: 21.4900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.9230
    Cell Significance Index: 22.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8902
    Cell Significance Index: 109.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8198
    Cell Significance Index: 21.8900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7999
    Cell Significance Index: 20.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7833
    Cell Significance Index: 20.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7818
    Cell Significance Index: 21.2800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.7586
    Cell Significance Index: 12.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7398
    Cell Significance Index: 404.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6403
    Cell Significance Index: 87.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5027
    Cell Significance Index: 14.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4873
    Cell Significance Index: 36.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4867
    Cell Significance Index: 174.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4825
    Cell Significance Index: 62.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4306
    Cell Significance Index: 46.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4293
    Cell Significance Index: 189.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4154
    Cell Significance Index: 29.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3963
    Cell Significance Index: 6.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3815
    Cell Significance Index: 17.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3460
    Cell Significance Index: 26.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3354
    Cell Significance Index: 57.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2673
    Cell Significance Index: 184.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2531
    Cell Significance Index: 25.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2496
    Cell Significance Index: 15.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2491
    Cell Significance Index: 31.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2376
    Cell Significance Index: 45.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2051
    Cell Significance Index: 24.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1244
    Cell Significance Index: 3.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0472
    Cell Significance Index: 42.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0390
    Cell Significance Index: 24.7600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0243
    Cell Significance Index: 45.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0174
    Cell Significance Index: 0.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0055
    Cell Significance Index: -4.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0109
    Cell Significance Index: -6.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0115
    Cell Significance Index: -8.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0121
    Cell Significance Index: -22.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0126
    Cell Significance Index: -19.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0157
    Cell Significance Index: -7.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0170
    Cell Significance Index: -12.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0190
    Cell Significance Index: -25.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0507
    Cell Significance Index: -5.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0614
    Cell Significance Index: -34.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0701
    Cell Significance Index: -1.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0863
    Cell Significance Index: -5.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0925
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0954
    Cell Significance Index: -20.1000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1214
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1244
    Cell Significance Index: -14.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1317
    Cell Significance Index: -37.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1351
    Cell Significance Index: -15.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1687
    Cell Significance Index: -24.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1826
    Cell Significance Index: -12.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1857
    Cell Significance Index: -21.2000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1936
    Cell Significance Index: -2.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2226
    Cell Significance Index: -4.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2405
    Cell Significance Index: -2.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2613
    Cell Significance Index: -14.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2741
    Cell Significance Index: -3.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2818
    Cell Significance Index: -17.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3000
    Cell Significance Index: -5.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4076
    Cell Significance Index: -18.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4511
    Cell Significance Index: -46.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4848
    Cell Significance Index: -18.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5011
    Cell Significance Index: -26.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5101
    Cell Significance Index: -40.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5294
    Cell Significance Index: -32.4600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5305
    Cell Significance Index: -7.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5579
    Cell Significance Index: -9.5600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5735
    Cell Significance Index: -15.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6346
    Cell Significance Index: -11.7300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6521
    Cell Significance Index: -3.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7272
    Cell Significance Index: -25.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.7453
    Cell Significance Index: -38.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7615
    Cell Significance Index: -15.9400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7908
    Cell Significance Index: -11.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8043
    Cell Significance Index: -25.7600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8072
    Cell Significance Index: -18.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8312
    Cell Significance Index: -21.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8419
    Cell Significance Index: -22.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SAR1B is a small GTPase that belongs to the Ras superfamily, characterized by its ability to bind and hydrolyze GTP. This GTPase activity enables SAR1B to regulate various cellular processes, including protein transport, lipid metabolism, and membrane trafficking. SAR1B is specifically expressed in multiple cell types, including hematopoietic cells, epithelial cells, and smooth muscle cells, suggesting its importance in diverse cellular functions. **Pathways and Functions:** SAR1B is involved in multiple signaling pathways, including: 1. **Adaptive Immune System:** SAR1B regulates the adaptive immune response by interacting with various immune cells, such as T cells and dendritic cells, to modulate antigen presentation and immune responses. 2. **Antigen Presentation:** SAR1B plays a crucial role in the folding, assembly, and peptide loading of class I MHC molecules, which is essential for the presentation of antigens to CD8+ T cells. 3. **Lipid Metabolism:** SAR1B regulates lipid metabolism by interacting with proteins involved in cholesterol biosynthesis and lipid transport. 4. **Membrane Trafficking:** SAR1B is involved in the regulation of membrane trafficking, including the transport of proteins and lipids within the cell. **Clinical Significance:** SAR1B's involvement in immune function and cellular regulation has significant implications for various diseases, including: 1. **Infectious Diseases:** SAR1B's role in regulating immune responses makes it a potential target for the treatment of infectious diseases, such as COVID-19. 2. **Autoimmune Diseases:** Dysregulation of SAR1B's signaling pathways may contribute to the development of autoimmune diseases, such as multiple sclerosis. 3. **Cancer:** SAR1B's involvement in lipid metabolism and membrane trafficking makes it a potential target for the treatment of cancer. 4. **Metabolic Disorders:** SAR1B's regulation of lipid metabolism may contribute to the development of metabolic disorders, such as obesity and type 2 diabetes. In conclusion, SAR1B is a multifunctional gene that plays a crucial role in regulating immune function, lipid metabolism, and membrane trafficking. Its dysregulation has significant implications for various diseases, highlighting the need for further research into the molecular mechanisms underlying SAR1B's functions and its potential as a therapeutic target.

Genular Protein ID: 1823261874

Symbol: SAR1B_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9Y6B6 D3DQA4 Q567T4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 29 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 28 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 3 Rhea 2 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23433038

Title: Silencing of mammalian Sar1 isoforms reveals COPII-independent protein sorting and transport.

PubMed ID: 23433038

DOI: 10.1111/tra.12060

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32358066

Title: Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.

PubMed ID: 32358066

DOI: 10.1074/jbc.ra120.012964

PubMed ID: 33186557

Title: Receptor-mediated ER export of lipoproteins controls lipid homeostasis in mice and humans.

PubMed ID: 33186557

DOI: 10.1016/j.cmet.2020.10.020

PubMed ID: 34290409

Title: SAR1B senses leucine levels to regulate mTORC1 signalling.

PubMed ID: 34290409

DOI: 10.1038/s41586-021-03768-w

PubMed ID: 36369712

Title: The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.

PubMed ID: 36369712

DOI: 10.1002/prot.26445

PubMed ID: 12692552

Title: Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders.

PubMed ID: 12692552

DOI: 10.1038/ng1145

PubMed ID: 17309654

Title: SIL1 and SARA2 mutations in Marinesco-Sjogren and chylomicron retention diseases.

PubMed ID: 17309654

DOI: 10.1111/j.1399-0004.2007.00759.x

PubMed ID: 19274794

Title: Novel missense mutations of SAR1B gene in an infant with chylomicron retention disease.

PubMed ID: 19274794

DOI: 10.1097/mpg.0b013e318183188f

Sequence Information:

  • Length: 198
  • Mass: 22410
  • Checksum: 3F567683D7F509E6
  • Sequence:
    • MSFIFDWIYS GFSSVLQFLG LYKKTGKLVF LGLDNAGKTT LLHMLKDDRL GQHVPTLHPT 
SEELTIAGMT FTTFDLGGHV QARRVWKNYL PAINGIVFLV DCADHERLLE SKEELDSLMT 
DETIANVPIL ILGNKIDRPE AISEERLREM FGLYGQTTGK GSISLKELNA RPLEVFMCSV 
LKRQGYGEGF RWMAQYID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.