Details for: ASB3

Gene ID: 51130

Symbol: ASB3

Ensembl ID: ENSG00000115239

Description: ankyrin repeat and SOCS box containing 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 244.5591
    Cell Significance Index: -38.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.2610
    Cell Significance Index: -38.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.8085
    Cell Significance Index: -40.0400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 71.1126
    Cell Significance Index: -28.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.2907
    Cell Significance Index: -38.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.3014
    Cell Significance Index: -28.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.3240
    Cell Significance Index: -53.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.8149
    Cell Significance Index: -38.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1899
    Cell Significance Index: -9.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.8724
    Cell Significance Index: 1030.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5124
    Cell Significance Index: 140.9900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.9864
    Cell Significance Index: 47.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.8034
    Cell Significance Index: 68.2900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.7685
    Cell Significance Index: 21.9400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.7684
    Cell Significance Index: 78.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.7564
    Cell Significance Index: 107.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4333
    Cell Significance Index: 109.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2483
    Cell Significance Index: 863.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1658
    Cell Significance Index: 221.8600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8568
    Cell Significance Index: 43.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8202
    Cell Significance Index: 20.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7029
    Cell Significance Index: 15.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5875
    Cell Significance Index: 58.1200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.5795
    Cell Significance Index: 12.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5385
    Cell Significance Index: 486.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3334
    Cell Significance Index: 627.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3142
    Cell Significance Index: 51.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3128
    Cell Significance Index: 198.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3119
    Cell Significance Index: 480.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2341
    Cell Significance Index: 431.7900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2207
    Cell Significance Index: 24.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1896
    Cell Significance Index: 22.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1818
    Cell Significance Index: 82.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1791
    Cell Significance Index: 22.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1639
    Cell Significance Index: 20.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1474
    Cell Significance Index: 200.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1311
    Cell Significance Index: 23.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1228
    Cell Significance Index: 24.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1010
    Cell Significance Index: 3.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0919
    Cell Significance Index: 5.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0447
    Cell Significance Index: 1.1500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0321
    Cell Significance Index: 0.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0180
    Cell Significance Index: 0.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0109
    Cell Significance Index: 5.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0072
    Cell Significance Index: 0.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0043
    Cell Significance Index: 0.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0100
    Cell Significance Index: -1.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0127
    Cell Significance Index: -1.7500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0132
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0310
    Cell Significance Index: -22.9400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0394
    Cell Significance Index: -0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0416
    Cell Significance Index: -30.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0483
    Cell Significance Index: -21.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0494
    Cell Significance Index: -37.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0634
    Cell Significance Index: -35.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0637
    Cell Significance Index: -7.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0798
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0842
    Cell Significance Index: -52.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1104
    Cell Significance Index: -3.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1178
    Cell Significance Index: -33.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1215
    Cell Significance Index: -5.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1578
    Cell Significance Index: -4.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1630
    Cell Significance Index: -16.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1877
    Cell Significance Index: -39.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2013
    Cell Significance Index: -12.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2421
    Cell Significance Index: -24.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2487
    Cell Significance Index: -16.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2494
    Cell Significance Index: -32.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2540
    Cell Significance Index: -6.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2658
    Cell Significance Index: -45.3900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2749
    Cell Significance Index: -3.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2789
    Cell Significance Index: -14.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3223
    Cell Significance Index: -36.9200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3710
    Cell Significance Index: -2.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3906
    Cell Significance Index: -20.2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3922
    Cell Significance Index: -25.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3992
    Cell Significance Index: -8.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4174
    Cell Significance Index: -25.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4204
    Cell Significance Index: -6.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4284
    Cell Significance Index: -33.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4424
    Cell Significance Index: -32.9700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4604
    Cell Significance Index: -7.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4819
    Cell Significance Index: -15.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4956
    Cell Significance Index: -26.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5053
    Cell Significance Index: -17.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5296
    Cell Significance Index: -3.2000
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6265
    Cell Significance Index: -7.1700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6683
    Cell Significance Index: -31.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6855
    Cell Significance Index: -14.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6900
    Cell Significance Index: -22.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7121
    Cell Significance Index: -50.3600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7592
    Cell Significance Index: -9.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7768
    Cell Significance Index: -24.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8216
    Cell Significance Index: -14.0800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8337
    Cell Significance Index: -24.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8704
    Cell Significance Index: -24.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8784
    Cell Significance Index: -14.7000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.8913
    Cell Significance Index: -9.7100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9126
    Cell Significance Index: -19.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9200
    Cell Significance Index: -26.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ASB3 is a gene that encodes a protein containing ankyrin repeat and SOCS box domains. These domains are essential for protein-protein interactions, regulation of protein activity, and localization to specific cellular compartments. The ASB3 protein is highly expressed in cells involved in the adaptive immune system, such as CD8-positive T cells, alpha-beta regulatory T cells, and hematopoietic oligopotent progenitor cells. The gene is also expressed in other cell types, including smooth muscle fibers, mucosal type mast cells, and ciliated cells. **Pathways and Functions:** ASB3 is involved in several cellular pathways, including: 1. **Adaptive Immune System:** ASB3 plays a crucial role in the adaptive immune system by regulating the function of CD8-positive T cells and alpha-beta regulatory T cells. 2. **Antigen Processing:** ASB3 is involved in the ubiquitination and proteasome degradation of antigens, which is essential for the presentation of antigens to T cells. 3. **Cilium and T-tubule Localization:** ASB3 is localized to the cilium and T-tubule compartments, where it regulates protein activity and localization. 4. **Intracellular Signal Transduction:** ASB3 is involved in the regulation of intracellular signal transduction pathways, including those involved in immune responses. 5. **Protein Modification:** ASB3 is involved in the modification of proteins through ubiquitination and neddylation, which is essential for protein degradation and regulation. **Clinical Significance:** ASB3 has significant implications in various clinical settings, including: 1. **Immunodeficiency Disorders:** ASB3 mutations or dysregulation may contribute to immunodeficiency disorders, such as impaired T cell function and antigen presentation. 2. **Cancer:** ASB3 may play a role in the regulation of protein modification and localization in cancer cells, influencing tumor progression and metastasis. 3. **Neurological Disorders:** ASB3 may be involved in the regulation of protein activity and localization in neurons, influencing neurological disorders such as epilepsy and Parkinson's disease. 4. **Cardiac Muscle Contraction:** ASB3 may play a role in the regulation of cardiac muscle contraction and relaxation, influencing cardiovascular disease. In conclusion, ASB3 is a multifunctional gene that plays a crucial role in various cellular processes, including immune regulation, protein modification, and localization. Further research is necessary to fully understand the significance of ASB3 in clinical settings and its potential as a therapeutic target for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.