Details for: ING4

Gene ID: 51147

Symbol: ING4

Ensembl ID: ENSG00000111653

Description: inhibitor of growth family member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 177.8904
    Cell Significance Index: -27.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.4349
    Cell Significance Index: -21.6700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 72.9462
    Cell Significance Index: -30.0500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.1282
    Cell Significance Index: -28.8600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.0636
    Cell Significance Index: -24.0000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.7146
    Cell Significance Index: -27.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.2843
    Cell Significance Index: -24.1400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.3403
    Cell Significance Index: -28.7800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4663
    Cell Significance Index: -22.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.4733
    Cell Significance Index: -29.4900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.4725
    Cell Significance Index: -19.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.3185
    Cell Significance Index: -11.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2496
    Cell Significance Index: 75.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1936
    Cell Significance Index: 9.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0823
    Cell Significance Index: 37.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9551
    Cell Significance Index: 61.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.9178
    Cell Significance Index: 106.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7215
    Cell Significance Index: 144.7300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7114
    Cell Significance Index: 49.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7036
    Cell Significance Index: 9.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6430
    Cell Significance Index: 127.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5789
    Cell Significance Index: 35.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5612
    Cell Significance Index: 77.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4967
    Cell Significance Index: 13.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4836
    Cell Significance Index: 25.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4474
    Cell Significance Index: 44.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4437
    Cell Significance Index: 23.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4382
    Cell Significance Index: 78.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4121
    Cell Significance Index: 225.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3894
    Cell Significance Index: 351.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3845
    Cell Significance Index: 10.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3792
    Cell Significance Index: 11.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3776
    Cell Significance Index: 46.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3636
    Cell Significance Index: 7.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3487
    Cell Significance Index: 125.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3131
    Cell Significance Index: 138.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2973
    Cell Significance Index: 18.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2656
    Cell Significance Index: 5.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2479
    Cell Significance Index: 3.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2351
    Cell Significance Index: 10.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2340
    Cell Significance Index: 44.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2320
    Cell Significance Index: 160.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2204
    Cell Significance Index: 28.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2100
    Cell Significance Index: 24.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1536
    Cell Significance Index: 7.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1438
    Cell Significance Index: 8.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1377
    Cell Significance Index: 10.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1299
    Cell Significance Index: 21.1300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1105
    Cell Significance Index: 2.6500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1097
    Cell Significance Index: 3.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0285
    Cell Significance Index: 53.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0256
    Cell Significance Index: 3.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0222
    Cell Significance Index: 0.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0209
    Cell Significance Index: 0.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0181
    Cell Significance Index: 0.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0179
    Cell Significance Index: 0.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0144
    Cell Significance Index: 1.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0099
    Cell Significance Index: 6.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0080
    Cell Significance Index: 10.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0047
    Cell Significance Index: 8.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0042
    Cell Significance Index: 6.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0021
    Cell Significance Index: -0.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0114
    Cell Significance Index: -0.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0177
    Cell Significance Index: -12.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0229
    Cell Significance Index: -10.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0264
    Cell Significance Index: -20.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0362
    Cell Significance Index: -5.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0368
    Cell Significance Index: -27.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0395
    Cell Significance Index: -4.0300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0462
    Cell Significance Index: -1.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0484
    Cell Significance Index: -27.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0522
    Cell Significance Index: -32.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0637
    Cell Significance Index: -1.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0795
    Cell Significance Index: -3.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0801
    Cell Significance Index: -23.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0844
    Cell Significance Index: -14.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0956
    Cell Significance Index: -6.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1202
    Cell Significance Index: -8.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1458
    Cell Significance Index: -5.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1545
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1555
    Cell Significance Index: -32.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1599
    Cell Significance Index: -18.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1728
    Cell Significance Index: -2.0600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2591
    Cell Significance Index: -26.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2812
    Cell Significance Index: -17.2400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2852
    Cell Significance Index: -3.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2961
    Cell Significance Index: -23.4500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2965
    Cell Significance Index: -3.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2994
    Cell Significance Index: -8.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3155
    Cell Significance Index: -9.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3193
    Cell Significance Index: -8.6900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3407
    Cell Significance Index: -5.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4012
    Cell Significance Index: -7.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4238
    Cell Significance Index: -11.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4882
    Cell Significance Index: -12.5500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4988
    Cell Significance Index: -10.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5228
    Cell Significance Index: -16.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5249
    Cell Significance Index: -14.9800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5310
    Cell Significance Index: -4.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5376
    Cell Significance Index: -17.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ING4 is a member of the inhibitor of growth family, which is characterized by its ability to regulate cellular growth and proliferation. The protein's unique structure, comprising three N-terminal domains and a C-terminal phosphoesterase domain, allows it to interact with various transcription factors and chromatin-modifying enzymes. ING4's expression is tightly regulated, with its levels often inversely correlated with cell proliferation and tumorigenesis. **Pathways and Functions:** ING4's involvement in multiple signaling pathways underscores its importance in regulating cellular homeostasis. Notably, ING4 is: 1. **Negative regulator of DNA replication-dependent chromatin disassembly**: ING4 interacts with chromatin-modifying enzymes to maintain chromatin structure and prevent excessive DNA replication, thereby preventing genomic instability. 2. **Inhibitor of cell proliferation**: ING4's expression is downregulated in proliferating cells, suggesting its role in suppressing cell growth and promoting differentiation. 3. **Regulator of DNA damage response**: ING4 interacts with p53 and other transcription factors to modulate the cellular response to DNA damage, ensuring the integrity of the genome. 4. **Histone acetyltransferase activity**: ING4's ability to acetylate histones regulates chromatin structure and transcriptional activity, further highlighting its role in gene expression and cellular differentiation. **Clinical Significance:** ING4's dysregulation has been implicated in various human diseases, including: 1. **Cancer**: ING4's loss of expression is observed in many types of cancer, including leukemia, lymphoma, and solid tumors, suggesting its potential as a tumor suppressor. 2. **Autoimmune diseases**: ING4's expression is altered in autoimmune diseases, such as rheumatoid arthritis and lupus, indicating its role in regulating immune responses. 3. **Neurological disorders**: ING4's dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, highlighting its potential as a therapeutic target. In conclusion, ING4's intricate mechanisms of action underscore its critical role in regulating gene expression, cell cycle, and DNA damage response. Further research on ING4's functions and dysregulation in human disease will provide valuable insights into the development of novel therapeutic strategies for various cancers and autoimmune diseases.

Genular Protein ID: 1832301831

Symbol: ING4_HUMAN

Name: Inhibitor of growth protein 4

UniProtKB Accession Codes:

Q9UNL4 A4KYM4 A4KYM6 D3DUR8 Q0EF62 Q0EF63 Q4VBQ6 Q96E15 Q9H3J0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 2 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 15 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12750254

Title: p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity.

PubMed ID: 12750254

PubMed ID: 16973615

Title: Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility.

PubMed ID: 16973615

DOI: 10.1074/jbc.m606296200

PubMed ID: 17325660

Title: Detection of novel mRNA splice variants of human ING4 tumor suppressor gene.

PubMed ID: 17325660

DOI: 10.1038/sj.onc.1210335

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15251430

Title: ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells.

PubMed ID: 15251430

DOI: 10.1016/j.febslet.2004.06.010

PubMed ID: 15029197

Title: The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.

PubMed ID: 15029197

DOI: 10.1038/nature02329

PubMed ID: 15528276

Title: A screen for genes that suppress loss of contact inhibition: Identification of ING4 as a candidate tumor suppressor gene in human cancer.

PubMed ID: 15528276

DOI: 10.1073/pnas.0407158101

PubMed ID: 15882981

Title: Nuclear localization signal of ING4 plays a key role in its binding to p53.

PubMed ID: 15882981

DOI: 10.1016/j.bbrc.2005.04.023

PubMed ID: 15897452

Title: The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

PubMed ID: 15897452

DOI: 10.1073/pnas.0502716102

PubMed ID: 16387653

Title: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

PubMed ID: 16387653

DOI: 10.1016/j.molcel.2005.12.007

PubMed ID: 16728974

Title: ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.

PubMed ID: 16728974

DOI: 10.1038/nature04835

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21454715

Title: Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53.

PubMed ID: 21454715

DOI: 10.1074/jbc.m111.230961

PubMed ID: 18381289

Title: Molecular basis of histone H3K4me3 recognition by ING4.

PubMed ID: 18381289

DOI: 10.1074/jbc.m710020200

PubMed ID: 19187765

Title: ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation.

PubMed ID: 19187765

DOI: 10.1016/j.molcel.2008.12.016

PubMed ID: 22334692

Title: Crystal structure of inhibitor of growth 4 (ING4) dimerization domain reveals functional organization of ING family of chromatin-binding proteins.

PubMed ID: 22334692

DOI: 10.1074/jbc.m111.330001

Sequence Information:

  • Length: 249
  • Mass: 28530
  • Checksum: CE3FD9CC9F0CE949
  • Sequence:
    • MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARSLSSEE 
KLALLKQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 
YDSSSSKGKK KGRTQKEKKA ARARSKGKNS DEEAPKTAQK KLKLVRTSPE YGMPSVTFGS 
VHPSDVLDMP VDPNEPTYCL CHQVSYGEMI GCDNPDCSIE WFHFACVGLT TKPRGKWFCP 
RCSQERKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.