LEF1 | ENSG00000138795 | NCBI 51176

Details for: LEF1

Gene ID: 51176

Symbol: LEF1

Ensembl ID: ENSG00000138795

Description: lymphoid enhancer binding factor 1

Associated with

Beta-catenin independent wnt signaling
(R-HSA-3858494)
Binding of tcf/lef:ctnnb1 to target gene promoters
(R-HSA-4411364)
Ca2+ pathway
(R-HSA-4086398)
Cardiogenesis
(R-HSA-9733709)
Deactivation of the beta-catenin transactivating complex
(R-HSA-3769402)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Developmental biology
(R-HSA-1266738)
Formation of axial mesoderm
(R-HSA-9796292)
Formation of paraxial mesoderm
(R-HSA-9793380)
Formation of the beta-catenin:tcf transactivating complex
(R-HSA-201722)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Germ layer formation at gastrulation
(R-HSA-9754189)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Regulation of mitf-m-dependent genes involved in cell cycle and proliferation
(R-HSA-9825892)
Regulation of mitf-m-dependent genes involved in pigmentation
(R-HSA-9824585)
Repression of wnt target genes
(R-HSA-4641265)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates wnt signaling
(R-HSA-8951430)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-HSA-9856649)
Transcriptional regulation by runx3
(R-HSA-8878159)
Transcriptional regulation by ventx
(R-HSA-8853884)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Anatomical structure regression
(GO:0060033)
Armadillo repeat domain binding
(GO:0070016)
B cell proliferation
(GO:0042100)
Beta-catenin binding
(GO:0008013)
Bmp signaling pathway
(GO:0030509)
Branching involved in blood vessel morphogenesis
(GO:0001569)
C2h2 zinc finger domain binding
(GO:0070742)
Chromatin binding
(GO:0003682)
Dentate gyrus development
(GO:0021542)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Dna binding, bending
(GO:0008301)
Embryonic limb morphogenesis
(GO:0030326)
Epithelial to mesenchymal transition
(GO:0001837)
Forebrain neuroblast division
(GO:0021873)
Forebrain radial glial cell differentiation
(GO:0021861)
Formation of radial glial scaffolds
(GO:0021943)
Gamma-catenin binding
(GO:0045295)
Histone deacetylase binding
(GO:0042826)
Mammary gland development
(GO:0030879)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of interleukin-4 production
(GO:0032713)
Negative regulation of interleukin-5 production
(GO:0032714)
Negative regulation of interleukin-13 production
(GO:0032696)
Negative regulation of striated muscle tissue development
(GO:0045843)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neutrophil differentiation
(GO:0030223)
Nuclear estrogen receptor binding
(GO:0030331)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Osteoblast differentiation
(GO:0001649)
Paraxial mesoderm formation
(GO:0048341)
Positive regulation by host of viral transcription
(GO:0043923)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gamma-delta t cell differentiation
(GO:0045588)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of granulocyte differentiation
(GO:0030854)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of wnt signaling pathway
(GO:0030177)
Protein binding
(GO:0005515)
Regulation of neurogenesis
(GO:0050767)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sensory perception of taste
(GO:0050909)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Somitogenesis
(GO:0001756)
Sprouting angiogenesis
(GO:0002040)
T-helper 1 cell differentiation
(GO:0045063)
T cell receptor v(d)j recombination
(GO:0033153)
Tongue development
(GO:0043586)
Transcription by rna polymerase ii
(GO:0006366)
Transcription corepressor binding
(GO:0001222)
Transcription regulator inhibitor activity
(GO:0140416)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 65.3186
Cell Significance Index: -10.1600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 41.9487
Cell Significance Index: -10.6400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 25.5011
Cell Significance Index: -10.3600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 23.2567
Cell Significance Index: -10.9800
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.6471
Cell Significance Index: -11.1200
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 8.3296
Cell Significance Index: -10.2700
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 4.6296
Cell Significance Index: 46.4200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.1286
Cell Significance Index: -11.0600
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.5062
Cell Significance Index: 93.9500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.2428
Cell Significance Index: -9.9600
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 3.0698
Cell Significance Index: 14.9300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.7568
Cell Significance Index: 177.8600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.7040
Cell Significance Index: -10.6700
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.1295
Cell Significance Index: 6.4900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.3597
Cell Significance Index: 28.4600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0611
Cell Significance Index: 210.5800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.8910
Cell Significance Index: 18.9800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.7095
Cell Significance Index: 8.0600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.6312
Cell Significance Index: 35.4200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6269
Cell Significance Index: 119.3000
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 0.5282
Cell Significance Index: 4.6200
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.4927
Cell Significance Index: 6.3100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4724
Cell Significance Index: 24.6100
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.4260
Cell Significance Index: 9.1100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.4181
Cell Significance Index: 14.5300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3851
Cell Significance Index: 23.1200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.3752
Cell Significance Index: 11.0200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3544
Cell Significance Index: 38.5500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.3421
Cell Significance Index: 35.6200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3299
Cell Significance Index: 53.6600
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.3290
Cell Significance Index: 2.0600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2927
Cell Significance Index: 8.1800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2277
Cell Significance Index: 22.5200
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 0.2156
Cell Significance Index: 1.9400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2135
Cell Significance Index: 192.7700
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.1636
Cell Significance Index: 4.0800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1446
Cell Significance Index: 63.9100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.1430
Cell Significance Index: 20.7800
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1214
Cell Significance Index: 66.3000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1008
Cell Significance Index: 6.9700
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0852
Cell Significance Index: 58.9100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.0731
Cell Significance Index: 9.3700
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.0688
Cell Significance Index: 0.3800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0640
Cell Significance Index: 1.6000
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0633
Cell Significance Index: 1.0600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0615
Cell Significance Index: 115.8800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0175
Cell Significance Index: 7.9600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0102
Cell Significance Index: 0.2200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0040
Cell Significance Index: -0.1400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0066
Cell Significance Index: -12.1200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0077
Cell Significance Index: -0.4700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0079
Cell Significance Index: -1.0800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0079
Cell Significance Index: -12.2000
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0096
Cell Significance Index: -12.9900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0145
Cell Significance Index: -11.0000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0151
Cell Significance Index: -9.6000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0158
Cell Significance Index: -5.6600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0162
Cell Significance Index: -11.9000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0168
Cell Significance Index: -12.4700
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0179
Cell Significance Index: -11.1900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0205
Cell Significance Index: -11.5400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0248
Cell Significance Index: -4.9700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0280
Cell Significance Index: -1.2700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0288
Cell Significance Index: -0.8300
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0301
Cell Significance Index: -0.7700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0311
Cell Significance Index: -8.9500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0374
Cell Significance Index: -6.7400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0505
Cell Significance Index: -5.9600
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0528
Cell Significance Index: -5.3900
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0539
Cell Significance Index: -0.9300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0568
Cell Significance Index: -1.8200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0569
Cell Significance Index: -12.0000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0661
Cell Significance Index: -7.7000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0679
Cell Significance Index: -11.5900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0816
Cell Significance Index: -10.0300
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0838
Cell Significance Index: -10.8300
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0929
Cell Significance Index: -1.3300
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0940
Cell Significance Index: -1.9500
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1040
Cell Significance Index: -11.9200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1053
Cell Significance Index: -2.7700
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1185
Cell Significance Index: -1.0100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1202
Cell Significance Index: -3.5400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1303
Cell Significance Index: -10.0000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1355
Cell Significance Index: -10.1000
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1449
Cell Significance Index: -0.8600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1455
Cell Significance Index: -6.8400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1463
Cell Significance Index: -7.3900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1530
Cell Significance Index: -12.1200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1628
Cell Significance Index: -10.9500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1733
Cell Significance Index: -10.6500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1874
Cell Significance Index: -7.6800
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: -0.1909
Cell Significance Index: -1.4200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1929
Cell Significance Index: -5.1600
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: -0.1935
Cell Significance Index: -1.8600
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2004
Cell Significance Index: -3.0200
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: -0.2086
Cell Significance Index: -1.8000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2247
Cell Significance Index: -11.6700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2270
Cell Significance Index: -11.9200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2440
Cell Significance Index: -10.7900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2640
Cell Significance Index: -12.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **DNA Binding**: LEF1 exhibits specific DNA binding capabilities, allowing it to regulate gene expression by interacting with target gene promoters. 2. **Wnt/β-catenin Pathway Modulation**: LEF1 interacts with β-catenin, a key component of the Wnt signaling pathway, to regulate Wnt target gene expression. 3. **Transcriptional Regulation**: LEF1 acts as a transcriptional activator or repressor, depending on the context, to modulate the expression of target genes. 4. **Cellular Differentiation**: LEF1 is involved in the differentiation of various cell types, including immune cells, neural cells, and muscle cells. 5. **Tissue Development**: LEF1 plays a critical role in the development of various tissues and organs, including the immune system, cardiovascular system, and nervous system. **Pathways and Functions** LEF1 is involved in multiple signaling pathways, including: 1. **Wnt/β-catenin Pathway**: LEF1 interacts with β-catenin to regulate Wnt target gene expression. 2. **β-catenin-independent Wnt Signaling**: LEF1 modulates Wnt signaling through interactions with other proteins, such as β-catenin and TCF/LEF transcription factors. 3. **Cardiogenesis**: LEF1 is involved in the development of the cardiovascular system, particularly in the formation of cardiac tissue. 4. **Neurogenesis**: LEF1 plays a role in the development and maintenance of neural tissue. 5. **Immune Cell Development**: LEF1 is involved in the development and differentiation of immune cells, including T cells and B cells. **Clinical Significance** Dysregulation of LEF1 has been implicated in various diseases, including: 1. **Cancer**: LEF1 is overexpressed in certain types of cancer, including leukemia and lymphoma. 2. **Cardiovascular Disease**: LEF1 is involved in the development of cardiovascular disease, particularly in the formation of atherosclerotic plaques. 3. **Neurological Disorders**: LEF1 is implicated in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immune System Disorders**: LEF1 is involved in the development of immune system disorders, including autoimmune diseases and immune deficiency syndromes. In conclusion, LEF1 is a transcription factor that plays a critical role in regulating various cellular processes, including cell proliferation, differentiation, and survival. Its involvement in multiple signaling pathways highlights the complexity of its regulatory functions, and dysregulation of LEF1 has been implicated in various diseases. Further research is needed to fully understand the mechanisms of LEF1 and its role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

T cell-specific transcription factor 1-alpha
Q659G9_HUMAN

Genular Protein ID: 91882950

Symbol: LEF1_HUMAN

Name: T cell-specific transcription factor 1-alpha

UniProtKB Accession Codes:

Q9UJU2 B4DG38 B7Z8E2 E9PDK3 Q3ZCU4 Q9HAZ0

Database IDs:

Citations:

PubMed ID: 2010090

Title: A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.

PubMed ID: 2010090

DOI: 10.1101/gad.5.4.656

PubMed ID: 10756202

Title: The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.

PubMed ID: 10756202

DOI: 10.1093/nar/28.9.1994

PubMed ID: 19653274

Title: Lef-1 isoforms regulate different target genes and reduce cellular adhesion.

PubMed ID: 19653274

DOI: 10.1002/ijc.24802

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9119228

Title: ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function.

PubMed ID: 9119228

DOI: 10.1101/gad.11.5.640

PubMed ID: 9488439

Title: Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse.

PubMed ID: 9488439

DOI: 10.1128/mcb.18.3.1248

PubMed ID: 9751710

Title: Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors.

PubMed ID: 9751710

DOI: 10.1073/pnas.95.20.11590

PubMed ID: 11326276

Title: Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer.

PubMed ID: 11326276

DOI: 10.1038/ng0501-53

PubMed ID: 11266540

Title: All Tcf HMG box transcription factors interact with Groucho-related co-repressors.

PubMed ID: 11266540

DOI: 10.1093/nar/29.7.1410

PubMed ID: 12192039

Title: I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.

PubMed ID: 12192039

DOI: 10.1128/mcb.22.18.6393-6405.2002

PubMed ID: 12556497

Title: Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling.

PubMed ID: 12556497

DOI: 10.1128/mcb.23.4.1379-1389.2003

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 19304756

Title: Dazap2 modulates transcription driven by the Wnt effector TCF-4.

PubMed ID: 19304756

DOI: 10.1093/nar/gkp179

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 399
Mass: 44201
Checksum: D480D440698EEFE3
Sequence:

MPQLSGGGGG GGGDPELCAT DEMIPFKDEG DPQKEKIFAE ISHPEEEGDL ADIKSSLVNE 
SEIIPASNGH EVARQAQTSQ EPYHDKAREH PDDGKHPDGG LYNKGPSYSS YSGYIMMPNM 
NNDPYMSNGS LSPPIPRTSN KVPVVQPSHA VHPLTPLITY SDEHFSPGSH PSHIPSDVNS 
KQGMSRHPPA PDIPTFYPLS PGGVGQITPP LGWQGQPVYP ITGGFRQPYP SSLSVDTSMS 
RFSHHMIPGP PGPHTTGIPH PAIVTPQVKQ EHPHTDSDLM HVKPQHEQRK EQEPKRPHIK 
KPLNAFMLYM KEMRANVVAE CTLKESAAIN QILGRRWHAL SREEQAKYYE LARKERQLHM 
QLYPGWSARD NYGKKKKRKR EKLQESASGT GPRMTAAYI

Genular Protein ID: 257884789

Symbol: Q659G9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q659G9

Database IDs:

Sequence Information:

Length: 69
Mass: 8251
Checksum: CBF29BD0C3287867
Sequence:

QILGRRWHAL SREEQAKYYE LARKERQLHM QLYPGWSARD NYGKKKKRKR EKLQESASGT 
GPRMTAAYI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: LEF1

Associated with

Cells (max top 100)

Other Information

A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer. PubMed ID: 2010090

The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing. PubMed ID: 10756202

Lef-1 isoforms regulate different target genes and reduce cellular adhesion. PubMed ID: 19653274

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. PubMed ID: 9119228

Two members of the Tcf family implicated in Wnt/b-catenin signaling during embryogenesis in the mouse. PubMed ID: 9488439

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. PubMed ID: 9751710

Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer. PubMed ID: 11326276

All Tcf HMG box transcription factors interact with Groucho-related co-repressors. PubMed ID: 11266540

I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. PubMed ID: 12192039

Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. PubMed ID: 12556497

An unappreciated role for RNA surveillance. PubMed ID: 14759258

Dazap2 modulates transcription driven by the Wnt effector TCF-4. PubMed ID: 19304756

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974