Details for: TCEAL9

Gene ID: 51186

Symbol: TCEAL9

Ensembl ID: ENSG00000185222

Description: transcription elongation factor A like 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 159.1707
    Cell Significance Index: -65.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 131.4913
    Cell Significance Index: -62.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 128.9824
    Cell Significance Index: -52.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 93.1415
    Cell Significance Index: -62.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.9572
    Cell Significance Index: -52.4700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 16.9225
    Cell Significance Index: 99.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.4851
    Cell Significance Index: 196.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.2640
    Cell Significance Index: 58.0000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.0729
    Cell Significance Index: 192.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.4471
    Cell Significance Index: -14.1100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.5432
    Cell Significance Index: 70.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.6204
    Cell Significance Index: 50.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 4.4803
    Cell Significance Index: 93.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.2936
    Cell Significance Index: 123.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.1822
    Cell Significance Index: 437.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.8930
    Cell Significance Index: 150.6900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.7748
    Cell Significance Index: 49.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.7278
    Cell Significance Index: 94.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.4573
    Cell Significance Index: 127.6500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.4541
    Cell Significance Index: 17.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.1622
    Cell Significance Index: 277.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8047
    Cell Significance Index: 108.3500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4497
    Cell Significance Index: 65.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4341
    Cell Significance Index: 176.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3616
    Cell Significance Index: 743.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3151
    Cell Significance Index: 213.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1690
    Cell Significance Index: 210.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1296
    Cell Significance Index: 52.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.0915
    Cell Significance Index: 12.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0269
    Cell Significance Index: 27.4200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0246
    Cell Significance Index: 101.3600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0094
    Cell Significance Index: 9.3000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9973
    Cell Significance Index: 440.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9470
    Cell Significance Index: 70.5800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.8575
    Cell Significance Index: 5.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7541
    Cell Significance Index: 39.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6687
    Cell Significance Index: 132.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6429
    Cell Significance Index: 45.4700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.5081
    Cell Significance Index: 3.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.4683
    Cell Significance Index: 10.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4001
    Cell Significance Index: 51.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3214
    Cell Significance Index: 9.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1843
    Cell Significance Index: 3.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1835
    Cell Significance Index: 31.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1814
    Cell Significance Index: 137.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1693
    Cell Significance Index: 11.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1602
    Cell Significance Index: 3.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1591
    Cell Significance Index: 31.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1245
    Cell Significance Index: 23.7000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.1181
    Cell Significance Index: 0.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0953
    Cell Significance Index: 4.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0842
    Cell Significance Index: 158.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0492
    Cell Significance Index: 36.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0455
    Cell Significance Index: 16.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0299
    Cell Significance Index: 18.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0106
    Cell Significance Index: 9.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0073
    Cell Significance Index: -0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0151
    Cell Significance Index: -27.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0189
    Cell Significance Index: -29.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0396
    Cell Significance Index: -53.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0593
    Cell Significance Index: -43.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0681
    Cell Significance Index: -6.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0782
    Cell Significance Index: -8.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0833
    Cell Significance Index: -46.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1028
    Cell Significance Index: -46.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1036
    Cell Significance Index: -3.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1078
    Cell Significance Index: -31.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1252
    Cell Significance Index: -78.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1355
    Cell Significance Index: -5.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2146
    Cell Significance Index: -31.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2399
    Cell Significance Index: -15.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2470
    Cell Significance Index: -15.1800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2629
    Cell Significance Index: -3.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2795
    Cell Significance Index: -7.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3131
    Cell Significance Index: -65.9500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3231
    Cell Significance Index: -37.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3880
    Cell Significance Index: -30.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3926
    Cell Significance Index: -46.3000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4554
    Cell Significance Index: -3.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4734
    Cell Significance Index: -2.8600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4872
    Cell Significance Index: -3.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5428
    Cell Significance Index: -41.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5626
    Cell Significance Index: -58.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5879
    Cell Significance Index: -18.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7117
    Cell Significance Index: -47.8600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7505
    Cell Significance Index: -46.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7788
    Cell Significance Index: -43.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7790
    Cell Significance Index: -16.5900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.7922
    Cell Significance Index: -8.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8265
    Cell Significance Index: -16.1300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8272
    Cell Significance Index: -24.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9105
    Cell Significance Index: -22.7600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.9274
    Cell Significance Index: -59.8300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.9642
    Cell Significance Index: -5.6600
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.9673
    Cell Significance Index: -6.0100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.9832
    Cell Significance Index: -11.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9903
    Cell Significance Index: -25.3000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.0961
    Cell Significance Index: -17.3900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.1710
    Cell Significance Index: -16.4300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -1.1977
    Cell Significance Index: -5.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TCEAL9 is a protein-coding gene that belongs to the TCEAL family, which is characterized by its ability to interact with other proteins to facilitate transcriptional elongation. This gene is ubiquitously expressed across various cell types, including embryonic stem cells, smooth muscle fibers, and immune cells such as mast cells and Langerhans cells. The protein product of TCEAL9, TCAL9, is a homolog of the S-II protein, a well-studied transcription elongation factor. **Pathways and Functions:** TCEAL9 is involved in several key cellular processes, including transcriptional elongation, DNA repair, and cell cycle regulation. The TCAL9 protein interacts with other transcription factors and elongation factors to facilitate the progression of RNA polymerase II through the genome, thereby regulating gene expression. Additionally, TCEAL9 has been implicated in DNA repair mechanisms, particularly in the repair of double-strand breaks, and plays a role in maintaining genome stability. Furthermore, TCEAL9 has been shown to interact with other signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which are critical in regulating cell proliferation, differentiation, and survival. This suggests that TCEAL9 may play a role in modulating cellular responses to various stimuli, including immune activation and tissue injury. **Clinical Significance:** The clinical significance of TCEAL9 lies in its potential role in various diseases, including cancer, autoimmune disorders, and cardiovascular diseases. Aberrant expression of TCEAL9 has been observed in several types of cancer, including colorectal, breast, and lung cancer, suggesting that this gene may serve as a tumor suppressor or oncogene. In autoimmune disorders, TCEAL9 may play a role in regulating immune responses and preventing autoimmunity. For example, TCEAL9 has been shown to interact with the TLR4/MyD88 signaling pathway, which is critical in regulating innate immune responses. In cardiovascular diseases, TCEAL9 may play a role in regulating vascular smooth muscle cell proliferation and differentiation, which are critical in the development of atherosclerosis. In conclusion, TCEAL9 is a multifaceted gene that plays a pivotal role in regulating transcriptional elongation, DNA repair, and cell cycle regulation. Its clinical significance lies in its potential role in various diseases, including cancer, autoimmune disorders, and cardiovascular diseases. Further research is needed to fully elucidate the mechanisms by which TCEAL9 regulates cellular processes and to explore its therapeutic potential. **Recommendations for Future Research:** 1. Investigate the role of TCEAL9 in cancer development and progression. 2. Explore the interaction between TCEAL9 and other signaling pathways, including the PI3K/AKT and MAPK/ERK pathways. 3. Investigate the role of TCEAL9 in autoimmune disorders, including rheumatoid arthritis and lupus. 4. Examine the potential therapeutic applications of TCEAL9 in cardiovascular diseases, including atherosclerosis and hypertension. By further elucidating the mechanisms by which TCEAL9 regulates cellular processes, we can gain a deeper understanding of its clinical significance and explore its therapeutic potential in various diseases.

Genular Protein ID: 2770902079

Symbol: TCAL9_HUMAN

Name: Transcription elongation factor S-II protein-like 9

UniProtKB Accession Codes:

Q9UHQ7 B2R5H6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 GO 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 STRING 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 104
  • Mass: 12749
  • Checksum: 057BFA7D09313F1F
  • Sequence:
    • MKSCQKMEGK PENESEPKHE EEPKPEEKPE EEEKLEEEAK AKGTFRERLI QSLQEFKEDI 
HNRHLSNEDM FREVDEIDEI RRVRNKLIVM RWKVNRNHPY PYLM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.