Details for: IGF2 AS

Gene ID: 51214

Symbol: IGF2 AS

Ensembl ID: ENSG00000099869

Description: IGF2 antisense RNA

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 9.0303
    Cell Significance Index: -3.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0106
    Cell Significance Index: 53.8800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.2611
    Cell Significance Index: 13.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1367
    Cell Significance Index: 39.5000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.1365
    Cell Significance Index: 14.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.6941
    Cell Significance Index: 18.2500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.6386
    Cell Significance Index: 10.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4822
    Cell Significance Index: 56.2000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4541
    Cell Significance Index: 5.0800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4106
    Cell Significance Index: 6.0600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3459
    Cell Significance Index: 4.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3449
    Cell Significance Index: 7.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2033
    Cell Significance Index: 40.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1735
    Cell Significance Index: 5.1100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0888
    Cell Significance Index: 1.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0679
    Cell Significance Index: 1.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0530
    Cell Significance Index: 0.3200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0448
    Cell Significance Index: 0.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0077
    Cell Significance Index: 0.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0027
    Cell Significance Index: 0.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0009
    Cell Significance Index: 0.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0023
    Cell Significance Index: -1.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0025
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0048
    Cell Significance Index: -3.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0065
    Cell Significance Index: -4.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0092
    Cell Significance Index: -4.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0096
    Cell Significance Index: -3.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0103
    Cell Significance Index: -2.9700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0118
    Cell Significance Index: -0.4800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0141
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0185
    Cell Significance Index: -2.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0189
    Cell Significance Index: -3.7900
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0209
    Cell Significance Index: -0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0210
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0226
    Cell Significance Index: -4.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0235
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0242
    Cell Significance Index: -4.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0284
    Cell Significance Index: -4.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0317
    Cell Significance Index: -3.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0324
    Cell Significance Index: -4.1900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0351
    Cell Significance Index: -0.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0352
    Cell Significance Index: -3.6700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0375
    Cell Significance Index: -0.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0494
    Cell Significance Index: -3.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0515
    Cell Significance Index: -2.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0517
    Cell Significance Index: -2.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0650
    Cell Significance Index: -0.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0656
    Cell Significance Index: -4.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0703
    Cell Significance Index: -1.1200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.0740
    Cell Significance Index: -0.3600
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.0775
    Cell Significance Index: -0.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0806
    Cell Significance Index: -1.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0852
    Cell Significance Index: -4.0100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0877
    Cell Significance Index: -2.3500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0904
    Cell Significance Index: -1.4900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0937
    Cell Significance Index: -1.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1092
    Cell Significance Index: -1.6900
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1124
    Cell Significance Index: -1.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1144
    Cell Significance Index: -3.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1145
    Cell Significance Index: -2.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1229
    Cell Significance Index: -2.4300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1245
    Cell Significance Index: -1.2000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1273
    Cell Significance Index: -0.7800
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.1288
    Cell Significance Index: -1.6500
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1374
    Cell Significance Index: -1.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1420
    Cell Significance Index: -3.5400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1444
    Cell Significance Index: -3.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1466
    Cell Significance Index: -3.5500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1584
    Cell Significance Index: -2.2700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1598
    Cell Significance Index: -3.9900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1660
    Cell Significance Index: -4.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1666
    Cell Significance Index: -3.6000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1667
    Cell Significance Index: -2.4200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1700
    Cell Significance Index: -2.4200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1711
    Cell Significance Index: -0.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1728
    Cell Significance Index: -2.9100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1735
    Cell Significance Index: -4.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1779
    Cell Significance Index: -4.1100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1783
    Cell Significance Index: -2.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1798
    Cell Significance Index: -3.5100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1800
    Cell Significance Index: -3.5200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1801
    Cell Significance Index: -2.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1818
    Cell Significance Index: -3.9800
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.1826
    Cell Significance Index: -2.1700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1871
    Cell Significance Index: -3.7300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1886
    Cell Significance Index: -2.8700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1901
    Cell Significance Index: -3.8200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1936
    Cell Significance Index: -3.9400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2046
    Cell Significance Index: -3.2900
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.2078
    Cell Significance Index: -2.4100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2102
    Cell Significance Index: -2.1800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.2140
    Cell Significance Index: -2.3700
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2154
    Cell Significance Index: -2.9300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2164
    Cell Significance Index: -2.0600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2208
    Cell Significance Index: -3.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Antisense orientation**: IGF2 AS is transcribed from the opposite strand of the IGF2 gene, indicating a potential regulatory role in modulating IGF2 expression. 2. **Diverse expression patterns**: IGF2 AS is significantly expressed in various cell types, including embryonic stem cells, cortical cells of the adrenal gland, skeletal muscle myoblasts, and mesonephric nephron tubule epithelial cells. 3. **Cell-type specific expression**: IGF2 AS expression is highly regulated, with significant fluctuations observed across different developmental stages and tissue types. **Pathways and Functions** 1. **IGF2 regulation**: IGF2 AS may play a regulatory role in modulating IGF2 expression, potentially influencing cell growth, differentiation, and survival. 2. **Cell signaling pathways**: IGF2 AS may interact with various cell signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, to modulate cellular responses to growth factors and hormones. 3. **Epigenetic regulation**: IGF2 AS may also interact with epigenetic regulators, such as histone modifications and DNA methylation, to influence gene expression and chromatin structure. **Clinical Significance** 1. **Cancer association**: IGF2 AS has been implicated in various types of cancer, including hepatocellular carcinoma, colorectal cancer, and breast cancer, suggesting its potential role as a tumor suppressor or oncogene. 2. **Developmental disorders**: Altered IGF2 AS expression has been linked to developmental disorders, such as Wilms tumor and congenital adrenal hyperplasia, highlighting its potential role in embryonic development and tissue patterning. 3. **Therapeutic targets**: IGF2 AS may serve as a potential therapeutic target for the treatment of various diseases, including cancer and developmental disorders, by modulating IGF2 expression and signaling pathways. In conclusion, IGF2 AS is a complex gene with diverse expression patterns and regulatory functions. Further research is needed to fully elucidate its role in modulating IGF2 expression and its potential clinical significance in various diseases. As an expert immunologist, I believe that IGF2 AS has the potential to serve as a valuable tool for understanding the complex interplay between gene expression, cell signaling, and disease pathogenesis.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.