Details for: PAIP2

Gene ID: 51247

Symbol: PAIP2

Ensembl ID: ENSG00000120727

Description: poly(A) binding protein interacting protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 444.6295
    Cell Significance Index: -69.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 232.4918
    Cell Significance Index: -58.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 198.8602
    Cell Significance Index: -81.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 174.6792
    Cell Significance Index: -82.4700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 158.9762
    Cell Significance Index: -81.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 123.2895
    Cell Significance Index: -82.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.4945
    Cell Significance Index: -75.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.2516
    Cell Significance Index: -83.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.5049
    Cell Significance Index: -62.9800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.1649
    Cell Significance Index: -51.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.9398
    Cell Significance Index: 259.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.7243
    Cell Significance Index: 175.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.7212
    Cell Significance Index: 71.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.1919
    Cell Significance Index: 16.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1253
    Cell Significance Index: 261.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9144
    Cell Significance Index: 345.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8278
    Cell Significance Index: 215.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8271
    Cell Significance Index: 85.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7583
    Cell Significance Index: 241.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6711
    Cell Significance Index: 58.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5899
    Cell Significance Index: 318.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5118
    Cell Significance Index: 825.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4009
    Cell Significance Index: 84.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3874
    Cell Significance Index: 39.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2143
    Cell Significance Index: 240.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2122
    Cell Significance Index: 56.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1801
    Cell Significance Index: 521.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1748
    Cell Significance Index: 31.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1138
    Cell Significance Index: 142.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1080
    Cell Significance Index: 397.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0510
    Cell Significance Index: 22.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0065
    Cell Significance Index: 29.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0009
    Cell Significance Index: 74.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9728
    Cell Significance Index: 26.4800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8436
    Cell Significance Index: 59.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6815
    Cell Significance Index: 42.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.6029
    Cell Significance Index: 37.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5836
    Cell Significance Index: 32.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5480
    Cell Significance Index: 54.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5448
    Cell Significance Index: 70.3800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5410
    Cell Significance Index: 87.9900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.4251
    Cell Significance Index: 5.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1761
    Cell Significance Index: 7.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1726
    Cell Significance Index: 29.4700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.1132
    Cell Significance Index: 1.4500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0930
    Cell Significance Index: 17.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0762
    Cell Significance Index: 1.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0685
    Cell Significance Index: 1.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0394
    Cell Significance Index: 2.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0349
    Cell Significance Index: 2.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0339
    Cell Significance Index: 63.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0116
    Cell Significance Index: 8.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0096
    Cell Significance Index: -7.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0212
    Cell Significance Index: -32.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0278
    Cell Significance Index: -51.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0338
    Cell Significance Index: -25.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0353
    Cell Significance Index: -47.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0435
    Cell Significance Index: -27.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0489
    Cell Significance Index: -30.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0525
    Cell Significance Index: -0.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0659
    Cell Significance Index: -6.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0754
    Cell Significance Index: -34.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0800
    Cell Significance Index: -45.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0884
    Cell Significance Index: -9.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1708
    Cell Significance Index: -35.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2601
    Cell Significance Index: -74.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2755
    Cell Significance Index: -7.7000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.2931
    Cell Significance Index: -2.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3249
    Cell Significance Index: -47.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3519
    Cell Significance Index: -6.0300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3666
    Cell Significance Index: -9.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3909
    Cell Significance Index: -44.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3976
    Cell Significance Index: -45.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4504
    Cell Significance Index: -10.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4533
    Cell Significance Index: -11.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4774
    Cell Significance Index: -55.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4774
    Cell Significance Index: -16.7800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5078
    Cell Significance Index: -34.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5888
    Cell Significance Index: -12.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5918
    Cell Significance Index: -5.4500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6938
    Cell Significance Index: -54.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.7350
    Cell Significance Index: -7.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7519
    Cell Significance Index: -78.2900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8632
    Cell Significance Index: -23.1300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.8677
    Cell Significance Index: -5.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8790
    Cell Significance Index: -25.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8821
    Cell Significance Index: -19.1100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9199
    Cell Significance Index: -16.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9517
    Cell Significance Index: -30.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9640
    Cell Significance Index: -23.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9839
    Cell Significance Index: -43.5200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0019
    Cell Significance Index: -13.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0832
    Cell Significance Index: -27.0800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.2066
    Cell Significance Index: -7.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.2200
    Cell Significance Index: -13.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.2435
    Cell Significance Index: -47.0900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.2562
    Cell Significance Index: -17.6200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3363
    Cell Significance Index: -39.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3443
    Cell Significance Index: -82.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4126
    Cell Significance Index: -36.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PAIP2 is a conserved protein that interacts with the poly(A) binding protein (PABP), a crucial component of the translational machinery. Its primary function is to regulate mRNA translation by binding to PABP and modulating the translation of specific mRNAs. PAIP2 also exhibits a high degree of specificity in its interactions, allowing it to fine-tune the translation of distinct mRNAs. Furthermore, PAIP2 has been implicated in the regulation of long-term synaptic potentiation, a process critical for learning and memory. **Pathways and Functions** PAIP2 is involved in various cellular pathways, including: 1. **M-decay**: PAIP2 regulates the degradation of maternal mRNAs by maternally stored factors, ensuring the proper establishment of the zygotic genome. 2. **Maternal to Zygotic Transition (mzt)**: PAIP2 plays a critical role in the transition from maternal to zygotic gene expression, influencing the regulation of developmental genes. 3. **Negative Regulation of Translation**: PAIP2 modulates the translation of specific mRNAs, acting as a translational repressor to regulate gene expression. 4. **Regulation of Long-term Synaptic Potentiation**: PAIP2 is involved in the regulation of synaptic plasticity, a process critical for learning and memory. **Clinical Significance** The dysregulation of PAIP2 has been implicated in various diseases, including: 1. **Immune Disorders**: PAIP2 has been shown to play a critical role in regulating immune responses, and its dysregulation may contribute to autoimmune diseases. 2. **Cancer**: PAIP2 has been implicated in the regulation of cancer cell growth and survival, highlighting its potential as a therapeutic target. 3. **Neurodegenerative Diseases**: PAIP2's role in regulating synaptic plasticity and learning and memory may contribute to the development of neurodegenerative diseases such as Alzheimer's and Parkinson's. In conclusion, PAIP2 is a multifunctional gene that plays a critical role in regulating mRNA translation and cellular homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its mechanisms of action and potential therapeutic applications.

Genular Protein ID: 2291615762

Symbol: PAIP2_HUMAN

Name: Polyadenylate-binding protein-interacting protein 2

UniProtKB Accession Codes:

Q9BPZ3 B2RBI1 D3DQC6 Q49A06 Q9H0Y5 Q9P0Q8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11172725

Title: Translational repression by a novel partner of human poly(A) binding protein, Paip2.

PubMed ID: 11172725

DOI: 10.1016/s1097-2765(01)00168-x

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11438674

Title: Dual interactions of the translational repressor Paip2 with poly(A) binding protein.

PubMed ID: 11438674

DOI: 10.1128/mcb.21.15.5200-5213.2001

PubMed ID: 16804161

Title: Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B.

PubMed ID: 16804161

DOI: 10.1261/rna.106506

PubMed ID: 11287632

Title: Structure and function of the C-terminal PABC domain of human poly(A)-binding protein.

PubMed ID: 11287632

DOI: 10.1073/pnas.071024998

Sequence Information:

  • Length: 127
  • Mass: 14984
  • Checksum: CAC27C537E5C6E22
  • Sequence:
    • MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC 
FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISDGS SLEDLVVKSN LNPNAKEFVP 
GVKYGNI

Genular Protein ID: 457733130

Symbol: Q49AE6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q49AE6

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 127
  • Mass: 14970
  • Checksum: CAD6C3189E5C6E22
  • Sequence:
    • MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC 
FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDVVISDGS SLEDLVVKSN LNPNAKEFVP 
GVKYGNI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.