Details for: PBDC1

Gene ID: 51260

Symbol: PBDC1

Ensembl ID: ENSG00000102390

Description: polysaccharide biosynthesis domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 165.8039
    Cell Significance Index: -25.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 87.9581
    Cell Significance Index: -22.3100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 81.4424
    Cell Significance Index: -33.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 61.7212
    Cell Significance Index: -29.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 59.3220
    Cell Significance Index: -24.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 53.7632
    Cell Significance Index: -27.6600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 43.6498
    Cell Significance Index: -29.2900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.6090
    Cell Significance Index: -24.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.1662
    Cell Significance Index: -27.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.8616
    Cell Significance Index: -21.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.1155
    Cell Significance Index: -21.8600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.0881
    Cell Significance Index: -27.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.8686
    Cell Significance Index: 267.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4359
    Cell Significance Index: 240.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9376
    Cell Significance Index: 52.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2661
    Cell Significance Index: 65.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1245
    Cell Significance Index: 10.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9484
    Cell Significance Index: 856.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8932
    Cell Significance Index: 57.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.8262
    Cell Significance Index: 6.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8070
    Cell Significance Index: 50.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7796
    Cell Significance Index: 16.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7553
    Cell Significance Index: 136.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7018
    Cell Significance Index: 383.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6977
    Cell Significance Index: 308.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6615
    Cell Significance Index: 81.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6579
    Cell Significance Index: 29.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6454
    Cell Significance Index: 48.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6424
    Cell Significance Index: 88.2300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5954
    Cell Significance Index: 13.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5853
    Cell Significance Index: 16.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5595
    Cell Significance Index: 16.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5578
    Cell Significance Index: 39.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5528
    Cell Significance Index: 6.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5476
    Cell Significance Index: 14.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4733
    Cell Significance Index: 11.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4596
    Cell Significance Index: 21.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4459
    Cell Significance Index: 20.9600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3967
    Cell Significance Index: 51.2500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3732
    Cell Significance Index: 2.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3613
    Cell Significance Index: 58.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3445
    Cell Significance Index: 11.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3144
    Cell Significance Index: 6.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3141
    Cell Significance Index: 16.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2945
    Cell Significance Index: 34.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2734
    Cell Significance Index: 35.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1752
    Cell Significance Index: 5.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1532
    Cell Significance Index: 29.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1064
    Cell Significance Index: 21.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0934
    Cell Significance Index: 1.4000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0652
    Cell Significance Index: 1.8700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0451
    Cell Significance Index: 7.7000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0286
    Cell Significance Index: 0.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0156
    Cell Significance Index: 11.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0039
    Cell Significance Index: 2.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0019
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0030
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0035
    Cell Significance Index: -2.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0059
    Cell Significance Index: -1.1800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0104
    Cell Significance Index: -19.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0186
    Cell Significance Index: -34.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0191
    Cell Significance Index: -1.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0204
    Cell Significance Index: -31.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0260
    Cell Significance Index: -35.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0267
    Cell Significance Index: -15.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0282
    Cell Significance Index: -3.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0324
    Cell Significance Index: -11.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0351
    Cell Significance Index: -22.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0518
    Cell Significance Index: -10.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0576
    Cell Significance Index: -26.1400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0713
    Cell Significance Index: -0.8500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0837
    Cell Significance Index: -1.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0876
    Cell Significance Index: -10.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1024
    Cell Significance Index: -29.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1213
    Cell Significance Index: -17.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1297
    Cell Significance Index: -6.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1306
    Cell Significance Index: -3.6500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1343
    Cell Significance Index: -1.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1588
    Cell Significance Index: -9.7600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1644
    Cell Significance Index: -4.2000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1753
    Cell Significance Index: -2.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1774
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1792
    Cell Significance Index: -20.4500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2155
    Cell Significance Index: -2.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2516
    Cell Significance Index: -2.7400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2559
    Cell Significance Index: -4.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2580
    Cell Significance Index: -20.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2709
    Cell Significance Index: -28.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2768
    Cell Significance Index: -3.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2770
    Cell Significance Index: -7.4100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3321
    Cell Significance Index: -2.1700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3453
    Cell Significance Index: -10.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3468
    Cell Significance Index: -19.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3641
    Cell Significance Index: -27.9400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3755
    Cell Significance Index: -25.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4107
    Cell Significance Index: -25.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4623
    Cell Significance Index: -8.1700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5164
    Cell Significance Index: -3.1200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6102
    Cell Significance Index: -22.4000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6459
    Cell Significance Index: -9.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PBDC1 is a gene with a unique combination of characteristics that set it apart from other genes. Its primary function appears to be related to polysaccharide biosynthesis, a process crucial for the development and maintenance of the immune system. The gene's expression in a wide range of cell types, including hematopoietic cells, stem cells, and epithelial cells, suggests a multifaceted role in cellular processes. Additionally, the gene's involvement in protein binding and cell signaling pathways further underscores its importance in immunological research. **Pathways and Functions:** The PBDC1 gene is involved in several key pathways, including: 1. **Polysaccharide biosynthesis:** The gene's primary function appears to be related to the synthesis of polysaccharides, which are essential components of the immune system. Polysaccharides play a crucial role in the development of immune cells, the activation of immune responses, and the maintenance of tissue homeostasis. 2. **Protein binding:** The gene's protein product, PBDC1, interacts with various proteins, influencing cellular signaling pathways and immune responses. This interaction is essential for the proper functioning of immune cells and the maintenance of immune homeostasis. 3. **Cell signaling:** PBDC1 is involved in cell signaling pathways, including the regulation of immune responses and the development of immune cells. The gene's protein product interacts with signaling molecules, influencing the activation and proliferation of immune cells. **Clinical Significance:** The PBDC1 gene has significant implications for immunological research and clinical applications. Its involvement in polysaccharide biosynthesis, protein binding, and cell signaling pathways makes it a potential target for the development of novel immunotherapies and treatments for immune-related disorders. Additionally, the gene's expression in various cell types suggests a potential role in the development of cancer and other diseases, warranting further investigation into its clinical significance. In conclusion, the PBDC1 gene is a gene of interest in immunological research, with a unique combination of characteristics that set it apart from other genes. Its involvement in polysaccharide biosynthesis, protein binding, and cell signaling pathways makes it a potential target for the development of novel immunotherapies and treatments for immune-related disorders. Further research is necessary to fully elucidate the role of PBDC1 in the immune system and its clinical significance.

Genular Protein ID: 4056787538

Symbol: PBDC1_HUMAN

Name: Protein PBDC1

UniProtKB Accession Codes:

Q9BVG4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 233
  • Mass: 26057
  • Checksum: 31FD39EC70B9A9C7
  • Sequence:
    • MAATSGTDEP VSGELVSVAH ALSLPAESYG NDPDIEMAWA MRAMQHAEVY YKLISSVDPQ 
FLKLTKVDDQ IYSEFRKNFE TLRIDVLDPE ELKSESAKEK WRPFCLKFNG IVEDFNYGTL 
LRLDCSQGYT EENTIFAPRI QFFAIEIARN REGYNKAVYI SVQDKEGEKG VNNGGEKRAD 
SGEEENTKNG GEKGADSGEE KEEGINREDK TDKGGEKGKE ADKEINKSGE KAM

Genular Protein ID: 795546193

Symbol: A6NDF3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A6NDF3

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 IntAct 1 InterPro 2 MINT 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 232
  • Mass: 26644
  • Checksum: 1BFC6EDCCF79B661
  • Sequence:
    • MAATSGTDEP VSGELVSVAH ALSLPAESYG NDPDIEMAWA MRAMQHAEVY YKLISSVDPQ 
FLKLTKVDDQ IYSEFRKNFE TLRIDVLDPE ELKSESAKEP PGYNSLPLKL LGTGKAITKL 
FISVFRTKKE RKESTMEEKK ELTVEKKRTP RMEERKELIV EKKKRKESTE KTKLTKEEKK 
GKKLTKKSTK VVKKLCKVYR EQHSRSYDSI ETTSTTVLLA QTPLVKCKFL YN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.