Details for: BET1L

Gene ID: 51272

Symbol: BET1L

Ensembl ID: ENSG00000177951

Description: Bet1 golgi vesicular membrane trafficking protein like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 113.7290
    Cell Significance Index: -17.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.2598
    Cell Significance Index: -17.0600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.0981
    Cell Significance Index: -18.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.1424
    Cell Significance Index: -18.4800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.0330
    Cell Significance Index: -18.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8537
    Cell Significance Index: -18.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7795
    Cell Significance Index: -18.8600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7279
    Cell Significance Index: -11.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6679
    Cell Significance Index: 194.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0151
    Cell Significance Index: 110.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7491
    Cell Significance Index: 10.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7254
    Cell Significance Index: 19.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7186
    Cell Significance Index: 116.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6141
    Cell Significance Index: 28.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5782
    Cell Significance Index: 522.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5424
    Cell Significance Index: 37.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5103
    Cell Significance Index: 50.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4062
    Cell Significance Index: 10.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3591
    Cell Significance Index: 103.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3411
    Cell Significance Index: 7.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3072
    Cell Significance Index: 42.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3061
    Cell Significance Index: 15.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2850
    Cell Significance Index: 8.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2565
    Cell Significance Index: 6.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2510
    Cell Significance Index: 49.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2489
    Cell Significance Index: 44.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2451
    Cell Significance Index: 11.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2409
    Cell Significance Index: 131.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2292
    Cell Significance Index: 28.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1736
    Cell Significance Index: 34.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1701
    Cell Significance Index: 21.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1417
    Cell Significance Index: 16.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1356
    Cell Significance Index: 59.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1335
    Cell Significance Index: 9.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1333
    Cell Significance Index: 2.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1302
    Cell Significance Index: 3.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1298
    Cell Significance Index: 8.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1015
    Cell Significance Index: 36.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0998
    Cell Significance Index: 2.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0951
    Cell Significance Index: 16.2400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0932
    Cell Significance Index: 17.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0917
    Cell Significance Index: 4.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0756
    Cell Significance Index: 4.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0614
    Cell Significance Index: 7.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0314
    Cell Significance Index: 2.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0312
    Cell Significance Index: 0.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0090
    Cell Significance Index: 17.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0050
    Cell Significance Index: 3.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0091
    Cell Significance Index: -5.7600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0094
    Cell Significance Index: -0.1200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0108
    Cell Significance Index: -14.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0116
    Cell Significance Index: -1.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0178
    Cell Significance Index: -8.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0202
    Cell Significance Index: -14.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0262
    Cell Significance Index: -3.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0278
    Cell Significance Index: -15.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0306
    Cell Significance Index: -19.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0324
    Cell Significance Index: -4.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0364
    Cell Significance Index: -2.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0424
    Cell Significance Index: -1.4900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0576
    Cell Significance Index: -0.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0579
    Cell Significance Index: -1.6600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0639
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0942
    Cell Significance Index: -19.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1456
    Cell Significance Index: -9.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1602
    Cell Significance Index: -8.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1677
    Cell Significance Index: -17.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1708
    Cell Significance Index: -10.5000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1731
    Cell Significance Index: -2.4800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1796
    Cell Significance Index: -10.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1899
    Cell Significance Index: -15.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1921
    Cell Significance Index: -5.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1955
    Cell Significance Index: -2.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2047
    Cell Significance Index: -12.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2104
    Cell Significance Index: -2.3900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2381
    Cell Significance Index: -4.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2390
    Cell Significance Index: -10.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2495
    Cell Significance Index: -7.9900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2568
    Cell Significance Index: -1.7400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2607
    Cell Significance Index: -9.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2662
    Cell Significance Index: -6.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2710
    Cell Significance Index: -6.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2728
    Cell Significance Index: -5.8100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2744
    Cell Significance Index: -10.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3105
    Cell Significance Index: -15.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3342
    Cell Significance Index: -3.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3399
    Cell Significance Index: -3.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3411
    Cell Significance Index: -9.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3614
    Cell Significance Index: -9.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3714
    Cell Significance Index: -3.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3738
    Cell Significance Index: -3.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3838
    Cell Significance Index: -7.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4128
    Cell Significance Index: -14.4600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.4237
    Cell Significance Index: -6.0200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4321
    Cell Significance Index: -6.3800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4342
    Cell Significance Index: -12.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4393
    Cell Significance Index: -16.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BET1L is a member of the BET1-like protein family, which is characterized by its ability to interact with the Golgi apparatus and regulate membrane trafficking. The gene is significantly expressed in various cell types, including hematopoietic cells, embryonic stem cells, and smooth muscle fibers. BET1L is involved in several cellular processes, including asparagine n-linked glycosylation, copi-mediated anterograde transport, and regulation of retrograde vesicle-mediated transport. **Pathways and Functions:** BET1L is involved in various cellular pathways, including: 1. **Asparagine n-linked glycosylation**: BET1L regulates the proper glycosylation of proteins, which is essential for their function and stability. 2. **Copi-mediated anterograde transport**: BET1L interacts with the COPI complex to facilitate the transport of proteins from the endoplasmic reticulum to the Golgi apparatus. 3. **Regulation of retrograde vesicle-mediated transport**: BET1L regulates the transport of proteins from the Golgi apparatus to the endoplasmic reticulum, ensuring proper protein degradation and recycling. 4. **Protein binding and transport**: BET1L interacts with various proteins, including SNAP receptors and snare complexes, to regulate protein transport and modification. **Clinical Significance:** Dysregulation of BET1L has been implicated in various immune-related disorders, including: 1. **Immunodeficiency disorders**: Mutations in the BET1L gene have been associated with immunodeficiency disorders, such as severe combined immunodeficiency (SCID) and X-linked agammaglobulinemia. 2. **Autoimmune diseases**: Abnormal expression of BET1L has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: BET1L has been implicated in cancer development and progression, particularly in hematological malignancies. In conclusion, BET1L plays a critical role in regulating membrane trafficking and protein modification in immune cells. Dysregulation of BET1L has been implicated in various immune-related disorders, highlighting the importance of this gene in maintaining immune homeostasis. Further research is needed to fully understand the mechanisms of BET1L and its role in human disease.

Genular Protein ID: 1649208512

Symbol: BET1L_HUMAN

Name: BET1-like protein

UniProtKB Accession Codes:

Q9NYM9 B3KMY0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 34711829

Title: Congenital disorder of glycosylation caused by starting site-specific variant in syntaxin-5.

PubMed ID: 34711829

DOI: 10.1038/s41467-021-26534-y

Sequence Information:

  • Length: 111
  • Mass: 12388
  • Checksum: 76E2C5099EC7EE5E
  • Sequence:
    • MADWARAQSP GAVEEILDRE NKRMADSLAS KVTRLKSLAL DIDRDAEDQN RYLDGMDSDF 
TSMTSLLTGS VKRFSTMARS GQDNRKLLCG MAVGLIVAFF ILSYFLSRAR T

Genular Protein ID: 2846043658

Symbol: A0A0C4DH16_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0C4DH16

Database IDs:

ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PROSITE 2 PeptideAtlas 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1 VEuPathDB 1 iPTMnet 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 102
  • Mass: 11138
  • Checksum: 13A9E26CFA21547D
  • Sequence:
    • MADWARAQSP GAVEEILDRE NKRMADSLAS KVTRLKSLAL DIDRDAEDQN RYLDGMVRAH 
GVRVSVPCPS TTCCRACSVS FSTGAGGWSN HHFCVILLGF LP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.