Details for: MAPKAPK5 AS1

Gene ID: 51275

Symbol: MAPKAPK5 AS1

Ensembl ID: ENSG00000234608

Description: MAPKAPK5 antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 143.1095
    Cell Significance Index: -22.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.5974
    Cell Significance Index: -18.6700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 59.2005
    Cell Significance Index: -24.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 50.2835
    Cell Significance Index: -23.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 46.8520
    Cell Significance Index: -24.1000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.3193
    Cell Significance Index: -23.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.3600
    Cell Significance Index: -23.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2680
    Cell Significance Index: -19.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1606
    Cell Significance Index: -24.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.1502
    Cell Significance Index: -18.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.9321
    Cell Significance Index: 202.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2165
    Cell Significance Index: 360.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8820
    Cell Significance Index: 1699.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.8500
    Cell Significance Index: 215.6000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6317
    Cell Significance Index: 97.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5395
    Cell Significance Index: 167.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0023
    Cell Significance Index: 45.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8758
    Cell Significance Index: 25.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5510
    Cell Significance Index: 34.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5310
    Cell Significance Index: 101.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5024
    Cell Significance Index: 13.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4629
    Cell Significance Index: 252.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4583
    Cell Significance Index: 29.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4500
    Cell Significance Index: 55.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4493
    Cell Significance Index: 6.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4385
    Cell Significance Index: 12.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4191
    Cell Significance Index: 75.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3707
    Cell Significance Index: 43.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3659
    Cell Significance Index: 105.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3104
    Cell Significance Index: 14.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2992
    Cell Significance Index: 41.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2976
    Cell Significance Index: 131.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2739
    Cell Significance Index: 14.2300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2702
    Cell Significance Index: 19.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2421
    Cell Significance Index: 48.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2269
    Cell Significance Index: 22.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2260
    Cell Significance Index: 10.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2231
    Cell Significance Index: 11.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1758
    Cell Significance Index: 22.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1511
    Cell Significance Index: 19.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1473
    Cell Significance Index: 29.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1357
    Cell Significance Index: 2.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1348
    Cell Significance Index: 2.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1101
    Cell Significance Index: 39.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1058
    Cell Significance Index: 3.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0820
    Cell Significance Index: 6.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0627
    Cell Significance Index: 2.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0596
    Cell Significance Index: 0.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0070
    Cell Significance Index: 0.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0070
    Cell Significance Index: 0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0046
    Cell Significance Index: -3.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0073
    Cell Significance Index: -13.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0088
    Cell Significance Index: -1.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0092
    Cell Significance Index: -6.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0127
    Cell Significance Index: -23.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0156
    Cell Significance Index: -24.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0172
    Cell Significance Index: -10.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0172
    Cell Significance Index: -23.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0196
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0228
    Cell Significance Index: -16.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0249
    Cell Significance Index: -1.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0290
    Cell Significance Index: -0.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0322
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0335
    Cell Significance Index: -18.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0362
    Cell Significance Index: -16.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0380
    Cell Significance Index: -1.0000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0397
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0407
    Cell Significance Index: -25.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0462
    Cell Significance Index: -1.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0471
    Cell Significance Index: -1.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0502
    Cell Significance Index: -0.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0619
    Cell Significance Index: -2.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0638
    Cell Significance Index: -9.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0814
    Cell Significance Index: -1.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1050
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1207
    Cell Significance Index: -25.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1222
    Cell Significance Index: -14.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1306
    Cell Significance Index: -7.3300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1406
    Cell Significance Index: -0.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1645
    Cell Significance Index: -1.5200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1777
    Cell Significance Index: -1.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2034
    Cell Significance Index: -13.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2130
    Cell Significance Index: -3.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2272
    Cell Significance Index: -5.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2351
    Cell Significance Index: -24.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2460
    Cell Significance Index: -19.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2732
    Cell Significance Index: -2.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2849
    Cell Significance Index: -12.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3226
    Cell Significance Index: -19.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3377
    Cell Significance Index: -4.9900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3414
    Cell Significance Index: -6.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3441
    Cell Significance Index: -2.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3660
    Cell Significance Index: -13.8600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3814
    Cell Significance Index: -4.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3948
    Cell Significance Index: -10.5800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4577
    Cell Significance Index: -13.0600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.4838
    Cell Significance Index: -8.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4865
    Cell Significance Index: -7.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4884
    Cell Significance Index: -17.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4991
    Cell Significance Index: -16.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAPKAPK5 AS1 is a long non-coding RNA (lncRNA) that is antisense to the MAPKAPK5 gene, which encodes a serine/threonine kinase involved in various cellular processes, including cell proliferation, differentiation, and apoptosis. The expression of MAPKAPK5 AS1 is significantly elevated in hematopoietic cells, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, and embryonic stem cells. Interestingly, MAPKAPK5 AS1 is also expressed in non-hematopoietic cells, such as smooth muscle fibers, peripheral blood mononuclear cells, and ileal goblet cells. **Pathways and Functions:** The exact mechanisms by which MAPKAPK5 AS1 regulates cellular processes are not fully elucidated. However, based on its expression profile and functional studies, it is hypothesized that MAPKAPK5 AS1 plays a role in regulating cell signaling pathways, including the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is a key regulator of cell proliferation, differentiation, and survival, and dysregulation of this pathway has been implicated in various diseases, including cancer and autoimmune disorders. Studies have shown that MAPKAPK5 AS1 can modulate the activity of MAPK kinases, such as JNK and p38, which are key regulators of cell signaling. Additionally, MAPKAPK5 AS1 has been shown to interact with other lncRNAs and mRNAs, suggesting that it may play a role in regulating gene expression and cellular processes. **Clinical Significance:** The clinical significance of MAPKAPK5 AS1 is still an area of active research. However, its expression in hematopoietic cells and immune cells suggests that it may play a role in regulating immune responses and preventing autoimmune diseases. For example, studies have shown that MAPKAPK5 AS1 is upregulated in patients with autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Furthermore, MAPKAPK5 AS1 has been implicated in cancer development, where it is thought to regulate cell proliferation and survival. Its expression is elevated in various types of cancer, including breast, lung, and colon cancer. In conclusion, MAPKAPK5 AS1 is a non-coding RNA that plays a complex and multifaceted role in regulating cellular processes, including cell signaling, gene expression, and immune responses. Further research is needed to fully elucidate its mechanisms of action and clinical significance, but its potential as a therapeutic target in autoimmune and cancer diseases makes it an exciting area of investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.