Details for: ECSIT

Gene ID: 51295

Symbol: ECSIT

Ensembl ID: ENSG00000130159

Description: ECSIT signaling integrator

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 179.3691
    Cell Significance Index: -27.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 93.7537
    Cell Significance Index: -23.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 73.4317
    Cell Significance Index: -30.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.9061
    Cell Significance Index: -32.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 66.1650
    Cell Significance Index: -26.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.1021
    Cell Significance Index: -31.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 47.8300
    Cell Significance Index: -32.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.4998
    Cell Significance Index: -27.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.6603
    Cell Significance Index: -30.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.9109
    Cell Significance Index: -26.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0790
    Cell Significance Index: -31.8800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.9185
    Cell Significance Index: -21.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.5378
    Cell Significance Index: -12.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9069
    Cell Significance Index: 114.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7699
    Cell Significance Index: 206.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2823
    Cell Significance Index: 208.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2374
    Cell Significance Index: 33.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1536
    Cell Significance Index: 15.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9082
    Cell Significance Index: 62.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9068
    Cell Significance Index: 41.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8954
    Cell Significance Index: 41.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8062
    Cell Significance Index: 161.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7501
    Cell Significance Index: 57.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6988
    Cell Significance Index: 36.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6374
    Cell Significance Index: 18.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5889
    Cell Significance Index: 30.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5256
    Cell Significance Index: 67.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5244
    Cell Significance Index: 11.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5140
    Cell Significance Index: 184.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5100
    Cell Significance Index: 36.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4763
    Cell Significance Index: 65.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4600
    Cell Significance Index: 203.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3964
    Cell Significance Index: 5.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3723
    Cell Significance Index: 17.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3720
    Cell Significance Index: 203.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3266
    Cell Significance Index: 64.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3121
    Cell Significance Index: 38.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3113
    Cell Significance Index: 215.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3113
    Cell Significance Index: 8.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3098
    Cell Significance Index: 19.5300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3038
    Cell Significance Index: 6.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3024
    Cell Significance Index: 15.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3022
    Cell Significance Index: 38.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3009
    Cell Significance Index: 54.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2913
    Cell Significance Index: 7.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2866
    Cell Significance Index: 33.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2729
    Cell Significance Index: 20.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2691
    Cell Significance Index: 243.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2478
    Cell Significance Index: 47.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2437
    Cell Significance Index: 15.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2060
    Cell Significance Index: 2.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1545
    Cell Significance Index: 4.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1451
    Cell Significance Index: 3.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1250
    Cell Significance Index: 21.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1232
    Cell Significance Index: 12.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0901
    Cell Significance Index: 1.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0659
    Cell Significance Index: 1.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0592
    Cell Significance Index: 2.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0466
    Cell Significance Index: 1.6200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0310
    Cell Significance Index: 0.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0176
    Cell Significance Index: 33.1300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0066
    Cell Significance Index: 12.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0007
    Cell Significance Index: 1.1400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0030
    Cell Significance Index: -2.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0079
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0083
    Cell Significance Index: -11.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0183
    Cell Significance Index: -11.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0188
    Cell Significance Index: -8.5500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0314
    Cell Significance Index: -23.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0383
    Cell Significance Index: -3.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0438
    Cell Significance Index: -24.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0460
    Cell Significance Index: -2.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0551
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0555
    Cell Significance Index: -34.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0729
    Cell Significance Index: -4.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0766
    Cell Significance Index: -4.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0847
    Cell Significance Index: -2.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0952
    Cell Significance Index: -27.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1141
    Cell Significance Index: -1.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1276
    Cell Significance Index: -3.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1448
    Cell Significance Index: -21.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1473
    Cell Significance Index: -16.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1578
    Cell Significance Index: -6.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1594
    Cell Significance Index: -33.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1860
    Cell Significance Index: -4.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1887
    Cell Significance Index: -4.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2752
    Cell Significance Index: -7.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2764
    Cell Significance Index: -28.7800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2788
    Cell Significance Index: -22.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2826
    Cell Significance Index: -10.7000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2897
    Cell Significance Index: -3.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3277
    Cell Significance Index: -8.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3587
    Cell Significance Index: -10.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3761
    Cell Significance Index: -23.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3868
    Cell Significance Index: -11.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4103
    Cell Significance Index: -7.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4234
    Cell Significance Index: -9.2700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.4653
    Cell Significance Index: -3.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Signaling Integrator:** ECSIT acts as a signaling integrator, coordinating the activation of multiple signaling pathways, including the MyD88-dependent cascade. 2. **Mitochondrial Function:** ECSIT regulates the stability of protein complexes and the activity of oxidoreductases, which are essential for energy production in mitochondria. 3. **Immune System:** ECSIT is significantly expressed in immune cells, including macrophages and dendritic cells, where it plays a critical role in the recognition of PAMPs by TLRs. 4. **Cellular Expression:** ECSIT is expressed in various cell types, including pancreatic acinar cells, stem cells, and neurons, highlighting its importance in maintaining tissue homeostasis. **Pathways and Functions:** 1. **MyD88-Dependent Cascade:** ECSIT coordinates the activation of the MyD88-dependent cascade, which is essential for the recognition of PAMPs by TLRs. 2. **Toll-like Receptor Signaling:** ECSIT regulates the activity of TLRs, including TLR2, TLR4, and TLR9, which are essential for the recognition of PAMPs. 3. **Mitochondrial Respiratory Chain Complex I Assembly:** ECSIT regulates the assembly of mitochondrial respiratory chain complex I, which is essential for energy production in mitochondria. 4. **Regulation of Oxidoreductase Activity:** ECSIT regulates the activity of oxidoreductases, which are essential for energy production in mitochondria. **Clinical Significance:** 1. **Immune Deficiency:** Dysregulation of ECSIT has been implicated in various immune deficiency disorders, including chronic inflammatory diseases and autoimmune disorders. 2. **Mitochondrial Dysfunction:** ECSIT dysfunction has been linked to mitochondrial dysfunction, which is a hallmark of various neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Cancer:** ECSIT has been implicated in cancer development and progression, where it regulates the activity of TLRs and the stability of protein complexes. 4. **Neurological Disorders:** ECSIT has been linked to various neurological disorders, including multiple sclerosis and stroke, where it regulates the activity of TLRs and the stability of protein complexes. In conclusion, the ECSIT gene plays a critical role in regulating immune response and mitochondrial function. Its dysregulation has been implicated in various immune deficiency disorders, mitochondrial dysfunction, cancer, and neurological disorders. Further research is necessary to fully understand the mechanisms by which ECSIT regulates immune response and mitochondrial function, and to develop therapeutic strategies to target ECSIT in the treatment of various diseases.

Genular Protein ID: 4266599553

Symbol: ECSIT_HUMAN

Name: Protein SITPEC

UniProtKB Accession Codes:

Q9BQ95 E9PAN9 K7EMM0 Q96HQ7 Q9NYI1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 Ensembl 6 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17344420

Title: Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.

PubMed ID: 17344420

DOI: 10.1101/gad.408407

PubMed ID: 20816094

Title: Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I.

PubMed ID: 20816094

DOI: 10.1016/j.cmet.2010.08.002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21525932

Title: TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.

PubMed ID: 21525932

DOI: 10.1038/nature09973

PubMed ID: 22588174

Title: TRIM59 interacts with ECSIT and negatively regulates NF-kappaB and IRF-3/7-mediated signal pathways.

PubMed ID: 22588174

DOI: 10.1016/j.bbrc.2012.05.028

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25355951

Title: Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-kappaBs in Toll-like receptor 4 signaling.

PubMed ID: 25355951

DOI: 10.1091/mbc.e14-08-1277

PubMed ID: 25228397

Title: ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses.

PubMed ID: 25228397

DOI: 10.1159/000365971

PubMed ID: 31281713

Title: p62 Negatively Regulates TLR4 Signaling via Functional Regulation of the TRAF6-ECSIT Complex.

PubMed ID: 31281713

DOI: 10.4110/in.2019.19.e16

PubMed ID: 31620128

Title: CRBN Is a Negative Regulator of Bactericidal Activity and Autophagy Activation Through Inhibiting the Ubiquitination of ECSIT and BECN1.

PubMed ID: 31620128

DOI: 10.3389/fimmu.2019.02203

PubMed ID: 32320651

Title: Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I.

PubMed ID: 32320651

DOI: 10.1016/j.celrep.2020.107541

PubMed ID: 33753518

Title: TMEM70 and TMEM242 help to assemble the rotor ring of human ATP synthase and interact with assembly factors for complex I.

PubMed ID: 33753518

DOI: 10.1073/pnas.2100558118

Sequence Information:

  • Length: 431
  • Mass: 49148
  • Checksum: 42AFEBFFA6953C80
  • Sequence:
    • MSWVQATLLA RGLCRAWGGT CGAALTGTSI SQVPRRLPRG LHCSAAAHSS EQSLVPSPPE 
PRQRPTKALV PFEDLFGQAP GGERDKASFL QTVQKFAEHS VRKRGHIDFI YLALRKMREY 
GVERDLAVYN QLLNIFPKEV FRPRNIIQRI FVHYPRQQEC GIAVLEQMEN HGVMPNKETE 
FLLIQIFGRK SYPMLKLVRL KLWFPRFMNV NPFPVPRDLP QDPVELAMFG LRHMEPDLSA 
RVTIYQVPLP KDSTGAADPP QPHIVGIQSP DQQAALARHN PARPVFVEGP FSLWLRNKCV 
YYHILRADLL PPEEREVEET PEEWNLYYPM QLDLEYVRSG WDNYEFDINE VEEGPVFAMC 
MAGAHDQATM AKWIQGLQET NPTLAQIPVV FRLAGSTREL QTSSAGLEEP PLPEDHQEED 
DNLQRQQQGQ S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.