Details for: PDCD2

Gene ID: 5134

Symbol: PDCD2

Ensembl ID: ENSG00000071994

Description: programmed cell death 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 175.7045
    Cell Significance Index: -27.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.2823
    Cell Significance Index: -24.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 72.9341
    Cell Significance Index: -29.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.7610
    Cell Significance Index: -33.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 66.7010
    Cell Significance Index: -34.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.7733
    Cell Significance Index: -34.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 31.4221
    Cell Significance Index: -30.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.2053
    Cell Significance Index: -32.3100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.6149
    Cell Significance Index: -34.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2158
    Cell Significance Index: -19.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.8469
    Cell Significance Index: -21.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.0718
    Cell Significance Index: -11.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.2088
    Cell Significance Index: 359.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1283
    Cell Significance Index: 231.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7366
    Cell Significance Index: 47.2700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4573
    Cell Significance Index: 13.4200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4178
    Cell Significance Index: 91.4700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2440
    Cell Significance Index: 64.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1431
    Cell Significance Index: 140.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.1047
    Cell Significance Index: 76.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0896
    Cell Significance Index: 51.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0892
    Cell Significance Index: 196.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9940
    Cell Significance Index: 22.9700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9790
    Cell Significance Index: 69.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9485
    Cell Significance Index: 130.2600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9112
    Cell Significance Index: 497.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8345
    Cell Significance Index: 38.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7130
    Cell Significance Index: 315.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7125
    Cell Significance Index: 24.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7056
    Cell Significance Index: 91.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6777
    Cell Significance Index: 50.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6711
    Cell Significance Index: 79.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.5114
    Cell Significance Index: 15.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4826
    Cell Significance Index: 12.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.4609
    Cell Significance Index: 47.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4437
    Cell Significance Index: 12.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4251
    Cell Significance Index: 84.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4089
    Cell Significance Index: 69.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3908
    Cell Significance Index: 4.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3631
    Cell Significance Index: 72.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3520
    Cell Significance Index: 9.4000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3255
    Cell Significance Index: 32.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2943
    Cell Significance Index: 18.5500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2838
    Cell Significance Index: 3.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2370
    Cell Significance Index: 4.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2357
    Cell Significance Index: 44.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2094
    Cell Significance Index: 9.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2062
    Cell Significance Index: 26.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1676
    Cell Significance Index: 60.1200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1106
    Cell Significance Index: 0.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0312
    Cell Significance Index: 1.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0143
    Cell Significance Index: 26.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0106
    Cell Significance Index: 8.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0036
    Cell Significance Index: 6.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0003
    Cell Significance Index: 0.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0002
    Cell Significance Index: -0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0026
    Cell Significance Index: -1.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0034
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0065
    Cell Significance Index: -4.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0122
    Cell Significance Index: -0.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0154
    Cell Significance Index: -20.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0205
    Cell Significance Index: -13.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0254
    Cell Significance Index: -0.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0274
    Cell Significance Index: -0.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0312
    Cell Significance Index: -17.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0503
    Cell Significance Index: -22.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0628
    Cell Significance Index: -1.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0671
    Cell Significance Index: -14.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0758
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0808
    Cell Significance Index: -9.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0876
    Cell Significance Index: -12.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0898
    Cell Significance Index: -25.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0991
    Cell Significance Index: -2.7700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1000
    Cell Significance Index: -1.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1116
    Cell Significance Index: -5.8600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1281
    Cell Significance Index: -1.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1356
    Cell Significance Index: -10.4100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1528
    Cell Significance Index: -17.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1669
    Cell Significance Index: -19.4500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1722
    Cell Significance Index: -8.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1784
    Cell Significance Index: -10.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2345
    Cell Significance Index: -3.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2451
    Cell Significance Index: -4.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2549
    Cell Significance Index: -4.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2760
    Cell Significance Index: -3.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3085
    Cell Significance Index: -24.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3100
    Cell Significance Index: -32.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3226
    Cell Significance Index: -21.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3351
    Cell Significance Index: -8.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3600
    Cell Significance Index: -7.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4811
    Cell Significance Index: -14.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4929
    Cell Significance Index: -21.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5385
    Cell Significance Index: -27.2100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5424
    Cell Significance Index: -9.3500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5513
    Cell Significance Index: -13.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5577
    Cell Significance Index: -34.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5594
    Cell Significance Index: -3.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5739
    Cell Significance Index: -7.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5812
    Cell Significance Index: -22.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Apoptotic Regulation:** PDCD2 is a pro-apoptotic gene that promotes the activation of cysteine-type endopeptidase activity, a key enzyme involved in the apoptotic process. 2. **Hematopoietic Relevance:** PDCD2 has been shown to regulate hematopoietic stem cell proliferation and progenitor cell differentiation, highlighting its importance in hematopoiesis. 3. **Cellular Differentiation:** PDCD2 has been implicated in the regulation of cellular differentiation, particularly in the context of primordial germ cell development. 4. **Expression Patterns:** PDCD2 is expressed in various cell types, including pro-T cells, bladder urothelial cells, and primordial germ cells, underscoring its broad functional relevance. **Pathways and Functions:** 1. **Apoptotic Pathway:** PDCD2 is involved in the regulation of the apoptotic process through the activation of cysteine-type endopeptidase activity. 2. **Hematopoietic Pathway:** PDCD2 regulates hematopoietic stem cell proliferation and progenitor cell differentiation, highlighting its importance in hematopoiesis. 3. **Cellular Differentiation Pathway:** PDCD2 has been implicated in the regulation of cellular differentiation, particularly in the context of primordial germ cell development. 4. **DNA Binding and Protein Interaction:** PDCD2 interacts with various DNA-binding proteins and enzymes, highlighting its role in regulating gene expression and cellular processes. **Clinical Significance:** 1. **Cancer Therapeutics:** PDCD2 has been identified as a potential target for cancer therapeutics, as its dysregulation has been implicated in various types of cancer. 2. **Hematological Disorders:** PDCD2 has been implicated in hematological disorders, such as leukemia and lymphoma, highlighting its importance in hematopoiesis. 3. **Neurological Disorders:** PDCD2 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, underscoring its role in cellular differentiation and apoptosis. 4. **Immunological Disorders:** PDCD2 has been implicated in immunological disorders, such as autoimmune diseases, highlighting its role in regulating immune cell function and apoptosis. In conclusion, PDCD2 is a complex gene that plays a pivotal role in regulating apoptosis, hematopoiesis, and cellular differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its mechanisms of action and therapeutic potential.

Genular Protein ID: 2686402000

Symbol: PDCD2_HUMAN

Name: Programmed cell death protein 2

UniProtKB Accession Codes:

Q16342 E9PCU7 F5GYS7 Q58HM9 Q58HN0 Q9UH12

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CORUM 1 CTD 1 ChEBI 8 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 5 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 5 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7606924

Title: Isolation and mapping of a human gene (PDCD2) that is highly homologous to Rp8, a rat gene associated with programmed cell death.

PubMed ID: 7606924

DOI: 10.1159/000134058

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19146857

Title: Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease.

PubMed ID: 19146857

DOI: 10.1016/j.febslet.2008.12.055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 344
  • Mass: 38592
  • Checksum: F3E7BA2C9FBAFD0E
  • Sequence:
    • MAAAGARPVE LGFAESAPAW RLRSEQFPSK VGGRPAWLGA AGLPGPQALA CELCGRPLSF 
LLQVYAPLPG RPDAFHRCIF LFCCREQPCC AGLRVFRNQL PRKNDFYSYE PPSENPPPET 
GESVCLQLKS GAHLCRVCGC LGPKTCSRCH KAYYCSKEHQ TLDWRLGHKQ ACAQPDHLDH 
IIPDHNFLFP EFEIVIETED EIMPEVVEKE DYSEIIGSMG EALEEELDSM AKHESREDKI 
FQKFKTQIAL EPEQILRYGR GIAPIWISGE NIPQEKDIPD CPCGAKRILE FQVMPQLLNY 
LKADRLGKSI DWGILAVFTC AESCSLGTGY TEEFVWKQDV TDTP

Genular Protein ID: 2386039324

Symbol: A0A087WYJ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WYJ3

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 221
  • Mass: 24601
  • Checksum: CE71C662649C0D38
  • Sequence:
    • MAAAGARPVE LGFAESAPAW RLRSEQFPSK VGGRPAWLGA AGLPGPQALA CELCGRPLSF 
LLQVYAPLPG RPDAFHRCIF LFCCREQPCC AGLRVFRNQL PRKNDFYSYE PPSENPPPET 
GESVCLQLKS GAHLCRVCGC LGPKTCSRCH KAYYCSKEHQ TLDWRLGHKQ ACAQPDHLDH 
IIPDHNFLFP EFEIVIETED EIMPEVVEKE DYSEIIGSMG I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.