Details for: CDC40
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 257.9314
Cell Significance Index: -40.1200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 151.9850
Cell Significance Index: -38.5500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 101.0754
Cell Significance Index: -47.7200 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 96.2445
Cell Significance Index: -39.1000 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 86.6277
Cell Significance Index: -44.5600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 71.1750
Cell Significance Index: -47.7600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 41.3357
Cell Significance Index: -39.4700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 36.4652
Cell Significance Index: -44.9600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 15.3946
Cell Significance Index: -41.2400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 11.9194
Cell Significance Index: -36.6100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 11.6952
Cell Significance Index: -46.1500 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 10.9239
Cell Significance Index: 180.0100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.1559
Cell Significance Index: -17.8500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.0040
Cell Significance Index: 88.6400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8319
Cell Significance Index: 367.4800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.6323
Cell Significance Index: 61.8100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.5752
Cell Significance Index: 171.3400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.5033
Cell Significance Index: 20.5100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.9563
Cell Significance Index: 61.7000 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.9237
Cell Significance Index: 7.1200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9047
Cell Significance Index: 124.2400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8072
Cell Significance Index: 145.5200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7835
Cell Significance Index: 52.6800 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.6869
Cell Significance Index: 5.7700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6820
Cell Significance Index: 83.8600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.6177
Cell Significance Index: 15.4400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6128
Cell Significance Index: 423.8400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6008
Cell Significance Index: 119.2300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5712
Cell Significance Index: 311.9300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5388
Cell Significance Index: 63.5400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5341
Cell Significance Index: 33.6700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5119
Cell Significance Index: 23.8700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.5108
Cell Significance Index: 225.8500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5105
Cell Significance Index: 183.1200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.4377
Cell Significance Index: 12.4900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4192
Cell Significance Index: 41.4700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4102
Cell Significance Index: 21.3700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4026
Cell Significance Index: 27.8500 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3448
Cell Significance Index: 44.2000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3406
Cell Significance Index: 7.3800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.3342
Cell Significance Index: 20.5400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3224
Cell Significance Index: 14.6100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2284
Cell Significance Index: 6.5800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1969
Cell Significance Index: 10.2300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1832
Cell Significance Index: 14.0600 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1762
Cell Significance Index: 2.1000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1725
Cell Significance Index: 8.1100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1458
Cell Significance Index: 10.3200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.1440
Cell Significance Index: 16.5000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1272
Cell Significance Index: 24.2000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0924
Cell Significance Index: 4.8500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.0670
Cell Significance Index: 3.7600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0599
Cell Significance Index: 92.2800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0582
Cell Significance Index: 9.9300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0535
Cell Significance Index: 100.7800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0314
Cell Significance Index: 42.6700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0311
Cell Significance Index: 14.1100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0129
Cell Significance Index: 9.4600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0074
Cell Significance Index: 13.6900 - Cell Name: peg cell (CL4033014)
Fold Change: 0.0017
Cell Significance Index: 0.0400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0053
Cell Significance Index: -3.3700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0120
Cell Significance Index: -0.3200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0210
Cell Significance Index: -15.5500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0297
Cell Significance Index: -18.5800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0302
Cell Significance Index: -1.0600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0303
Cell Significance Index: -22.9000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0485
Cell Significance Index: -27.3400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0649
Cell Significance Index: -1.2000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0900
Cell Significance Index: -9.2000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1125
Cell Significance Index: -23.6900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1324
Cell Significance Index: -38.1100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1328
Cell Significance Index: -15.4800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1338
Cell Significance Index: -21.7600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1713
Cell Significance Index: -22.1300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1760
Cell Significance Index: -25.5800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1936
Cell Significance Index: -5.6900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1947
Cell Significance Index: -5.4400 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2102
Cell Significance Index: -5.7200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2280
Cell Significance Index: -3.8200 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2426
Cell Significance Index: -6.4900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2487
Cell Significance Index: -18.5400 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2659
Cell Significance Index: -5.1900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2938
Cell Significance Index: -10.2100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3113
Cell Significance Index: -8.1900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3589
Cell Significance Index: -37.3700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.3627
Cell Significance Index: -3.3400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3711
Cell Significance Index: -42.3600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3991
Cell Significance Index: -31.6100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4032
Cell Significance Index: -10.3000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4161
Cell Significance Index: -11.1500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.5368
Cell Significance Index: -12.8800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5899
Cell Significance Index: -18.9000 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.6189
Cell Significance Index: -13.2300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.6384
Cell Significance Index: -10.9400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.6712
Cell Significance Index: -14.0500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6865
Cell Significance Index: -42.0900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6956
Cell Significance Index: -17.8800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.7111
Cell Significance Index: -35.9400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7751
Cell Significance Index: -22.2200 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.8503
Cell Significance Index: -27.0800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2005225011
Symbol: PRP17_HUMAN
Name: Pre-mRNA-processing factor 17
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9524131
Title: Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing.
PubMed ID: 9524131
PubMed ID: 9830021
Title: Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p.
PubMed ID: 9830021
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9769104
Title: Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control.
PubMed ID: 9769104
PubMed ID: 9303539
Title: Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.
PubMed ID: 9303539
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 33220177
Title: Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.
PubMed ID: 33220177
PubMed ID: 28502770
Title: An Atomic Structure of the Human Spliceosome.
PubMed ID: 28502770
PubMed ID: 28076346
Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
PubMed ID: 28076346
DOI: 10.1038/nature21079
PubMed ID: 29361316
Title: Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.
PubMed ID: 29361316
PubMed ID: 29360106
Title: Structure of the human activated spliceosome in three conformational states.
PubMed ID: 29360106
DOI: 10.1038/cr.2018.14
PubMed ID: 29301961
Title: Structure of a human catalytic step I spliceosome.
PubMed ID: 29301961
PubMed ID: 30705154
Title: A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.
PubMed ID: 30705154
Sequence Information:
- Length: 579
- Mass: 65521
- Checksum: 1DE2BAA6F03FF16D
- Sequence:
MSAAIAALAA SYGSGSGSES DSDSESSRCP LPAADSLMHL TKSPSSKPSL AVAVDSAPEV AVKEDLETGV HLDPAVKEVQ YNPTYETMFA PEFGPENPFR TQQMAAPRNM LSGYAEPAHI NDFMFEQQRR TFATYGYALD PSLDNHQVSA KYIGSVEEAE KNQGLTVFET GQKKTEKRKK FKENDASNID GFLGPWAKYV DEKDVAKPSE EEQKELDEIT AKRQKKGKQE EEKPGEEKTI LHVKEMYDYQ GRSYLHIPQD VGVNLRSTMP PEKCYLPKKQ IHVWSGHTKG VSAVRLFPLS GHLLLSCSMD CKIKLWEVYG ERRCLRTFIG HSKAVRDICF NTAGTQFLSA AYDRYLKLWD TETGQCISRF TNRKVPYCVK FNPDEDKQNL FVAGMSDKKI VQWDIRSGEI VQEYDRHLGA VNTIVFVDEN RRFVSTSDDK SLRVWEWDIP VDFKYIAEPS MHSMPAVTLS PNGKWLACQS MDNQILIFGA QNRFRLNKKK IFKGHMVAGY ACQVDFSPDM SYVISGDGNG KLNIWDWKTT KLYSRFKAHD KVCIGAVWHP HETSKVITCG WDGLIKLWD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.