Details for: CDC40

Gene ID: 51362

Symbol: CDC40

Ensembl ID: ENSG00000168438

Description: cell division cycle 40

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 257.9314
    Cell Significance Index: -40.1200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.9850
    Cell Significance Index: -38.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 101.0754
    Cell Significance Index: -47.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 96.2445
    Cell Significance Index: -39.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 86.6277
    Cell Significance Index: -44.5600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 71.1750
    Cell Significance Index: -47.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.3357
    Cell Significance Index: -39.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 36.4652
    Cell Significance Index: -44.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.3946
    Cell Significance Index: -41.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.9194
    Cell Significance Index: -36.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.6952
    Cell Significance Index: -46.1500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 10.9239
    Cell Significance Index: 180.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.1559
    Cell Significance Index: -17.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.0040
    Cell Significance Index: 88.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8319
    Cell Significance Index: 367.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6323
    Cell Significance Index: 61.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5752
    Cell Significance Index: 171.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5033
    Cell Significance Index: 20.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9563
    Cell Significance Index: 61.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.9237
    Cell Significance Index: 7.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9047
    Cell Significance Index: 124.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8072
    Cell Significance Index: 145.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7835
    Cell Significance Index: 52.6800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.6869
    Cell Significance Index: 5.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6820
    Cell Significance Index: 83.8600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6177
    Cell Significance Index: 15.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6128
    Cell Significance Index: 423.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6008
    Cell Significance Index: 119.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5712
    Cell Significance Index: 311.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5388
    Cell Significance Index: 63.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5341
    Cell Significance Index: 33.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5119
    Cell Significance Index: 23.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5108
    Cell Significance Index: 225.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5105
    Cell Significance Index: 183.1200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4377
    Cell Significance Index: 12.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4192
    Cell Significance Index: 41.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4102
    Cell Significance Index: 21.3700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4026
    Cell Significance Index: 27.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3448
    Cell Significance Index: 44.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3406
    Cell Significance Index: 7.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3342
    Cell Significance Index: 20.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3224
    Cell Significance Index: 14.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2284
    Cell Significance Index: 6.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1969
    Cell Significance Index: 10.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1832
    Cell Significance Index: 14.0600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1762
    Cell Significance Index: 2.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1725
    Cell Significance Index: 8.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1458
    Cell Significance Index: 10.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1440
    Cell Significance Index: 16.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1272
    Cell Significance Index: 24.2000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0924
    Cell Significance Index: 4.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0670
    Cell Significance Index: 3.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0599
    Cell Significance Index: 92.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0582
    Cell Significance Index: 9.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0535
    Cell Significance Index: 100.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0314
    Cell Significance Index: 42.6700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0311
    Cell Significance Index: 14.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0129
    Cell Significance Index: 9.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0074
    Cell Significance Index: 13.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0017
    Cell Significance Index: 0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0053
    Cell Significance Index: -3.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0120
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0210
    Cell Significance Index: -15.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0297
    Cell Significance Index: -18.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0302
    Cell Significance Index: -1.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0303
    Cell Significance Index: -22.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0485
    Cell Significance Index: -27.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0649
    Cell Significance Index: -1.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0900
    Cell Significance Index: -9.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1125
    Cell Significance Index: -23.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1324
    Cell Significance Index: -38.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1328
    Cell Significance Index: -15.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1338
    Cell Significance Index: -21.7600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1713
    Cell Significance Index: -22.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1760
    Cell Significance Index: -25.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1936
    Cell Significance Index: -5.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1947
    Cell Significance Index: -5.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2102
    Cell Significance Index: -5.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2280
    Cell Significance Index: -3.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2426
    Cell Significance Index: -6.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2487
    Cell Significance Index: -18.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2659
    Cell Significance Index: -5.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2938
    Cell Significance Index: -10.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3113
    Cell Significance Index: -8.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3589
    Cell Significance Index: -37.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3627
    Cell Significance Index: -3.3400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3711
    Cell Significance Index: -42.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3991
    Cell Significance Index: -31.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4032
    Cell Significance Index: -10.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4161
    Cell Significance Index: -11.1500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5368
    Cell Significance Index: -12.8800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5899
    Cell Significance Index: -18.9000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6189
    Cell Significance Index: -13.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6384
    Cell Significance Index: -10.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6712
    Cell Significance Index: -14.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6865
    Cell Significance Index: -42.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6956
    Cell Significance Index: -17.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7111
    Cell Significance Index: -35.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7751
    Cell Significance Index: -22.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8503
    Cell Significance Index: -27.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CDC40 is a member of the pre-mRNA processing factor family, which is essential for the efficient processing of pre-mRNA into mature mRNA. The gene encodes a protein called PRP17, which is a key component of the splicing machinery. PRP17 is involved in the recognition and binding of introns to the spliceosome, a complex that catalyzes the removal of introns and the joining of exons. CDC40 is also involved in the regulation of gene expression, particularly in the context of alternative splicing and RNA polymerase II transcription. **Pathways and Functions** CDC40 is involved in several key pathways, including: 1. **Splicing**: CDC40 plays a critical role in the recognition and binding of introns to the spliceosome, which is responsible for the removal of introns and the joining of exons. 2. **Gene Expression**: CDC40 is involved in the regulation of gene expression, particularly in the context of alternative splicing and RNA polymerase II transcription. 3. **RNA Polymerase II Transcription**: CDC40 is involved in the regulation of RNA polymerase II transcription, which is the primary mechanism of gene expression in eukaryotic cells. 4. **Metabolism of RNA**: CDC40 is involved in the metabolism of RNA, particularly in the context of pre-mRNA processing and maturation. **Clinical Significance** Dysregulation of CDC40 has been implicated in various diseases, including: 1. **Cancer**: CDC40 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. 2. **Immune Disorders**: CDC40 has been implicated in various immune disorders, including autoimmune diseases and immunodeficiency disorders. 3. **Neurological Disorders**: CDC40 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, CDC40 is a critical regulator of splicing and gene expression, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which CDC40 regulates gene expression and to develop therapeutic strategies for the treatment of diseases associated with CDC40 dysregulation. **References** 1. [Insert references to relevant studies and reviews] Note: This article is a summary of the CDC40 gene and its functions, and is intended to provide an overview of the current understanding of this gene. Further research is needed to fully understand the mechanisms by which CDC40 regulates gene expression and to develop therapeutic strategies for the treatment of diseases associated with CDC40 dysregulation.

Genular Protein ID: 2005225011

Symbol: PRP17_HUMAN

Name: Pre-mRNA-processing factor 17

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9524131

Title: Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing.

PubMed ID: 9524131

DOI: 10.1093/emboj/17.7.2095

PubMed ID: 9830021

Title: Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p.

PubMed ID: 9830021

DOI: 10.1074/jbc.273.49.32771

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9769104

Title: Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control.

PubMed ID: 9769104

DOI: 10.1017/s1355838298980712

PubMed ID: 9303539

Title: Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module.

PubMed ID: 9303539

DOI: 10.1101/gad.11.17.2239

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33220177

Title: Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.

PubMed ID: 33220177

DOI: 10.1016/j.neuron.2020.10.035

PubMed ID: 28502770

Title: An Atomic Structure of the Human Spliceosome.

PubMed ID: 28502770

DOI: 10.1016/j.cell.2017.04.033

PubMed ID: 28076346

Title: Cryo-EM structure of a human spliceosome activated for step 2 of splicing.

PubMed ID: 28076346

DOI: 10.1038/nature21079

PubMed ID: 29361316

Title: Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.

PubMed ID: 29361316

DOI: 10.1016/j.cell.2018.01.010

PubMed ID: 29360106

Title: Structure of the human activated spliceosome in three conformational states.

PubMed ID: 29360106

DOI: 10.1038/cr.2018.14

PubMed ID: 29301961

Title: Structure of a human catalytic step I spliceosome.

PubMed ID: 29301961

DOI: 10.1126/science.aar6401

PubMed ID: 30705154

Title: A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.

PubMed ID: 30705154

DOI: 10.1126/science.aaw5569

Sequence Information:

  • Length: 579
  • Mass: 65521
  • Checksum: 1DE2BAA6F03FF16D
  • Sequence:
  • MSAAIAALAA SYGSGSGSES DSDSESSRCP LPAADSLMHL TKSPSSKPSL AVAVDSAPEV 
    AVKEDLETGV HLDPAVKEVQ YNPTYETMFA PEFGPENPFR TQQMAAPRNM LSGYAEPAHI 
    NDFMFEQQRR TFATYGYALD PSLDNHQVSA KYIGSVEEAE KNQGLTVFET GQKKTEKRKK 
    FKENDASNID GFLGPWAKYV DEKDVAKPSE EEQKELDEIT AKRQKKGKQE EEKPGEEKTI 
    LHVKEMYDYQ GRSYLHIPQD VGVNLRSTMP PEKCYLPKKQ IHVWSGHTKG VSAVRLFPLS 
    GHLLLSCSMD CKIKLWEVYG ERRCLRTFIG HSKAVRDICF NTAGTQFLSA AYDRYLKLWD 
    TETGQCISRF TNRKVPYCVK FNPDEDKQNL FVAGMSDKKI VQWDIRSGEI VQEYDRHLGA 
    VNTIVFVDEN RRFVSTSDDK SLRVWEWDIP VDFKYIAEPS MHSMPAVTLS PNGKWLACQS 
    MDNQILIFGA QNRFRLNKKK IFKGHMVAGY ACQVDFSPDM SYVISGDGNG KLNIWDWKTT 
    KLYSRFKAHD KVCIGAVWHP HETSKVITCG WDGLIKLWD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.