Details for: RHCG

Gene ID: 51458

Symbol: RHCG

Ensembl ID: ENSG00000140519

Description: Rh family C glycoprotein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 17.5346
    Cell Significance Index: 67.1400
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 8.5507
    Cell Significance Index: 29.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.6603
    Cell Significance Index: 130.2400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.2519
    Cell Significance Index: 8.3100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9743
    Cell Significance Index: 24.3600
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.8383
    Cell Significance Index: 1.8900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6994
    Cell Significance Index: 6.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3464
    Cell Significance Index: 42.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2675
    Cell Significance Index: 50.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2219
    Cell Significance Index: 63.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2099
    Cell Significance Index: 42.1000
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.1785
    Cell Significance Index: 1.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1737
    Cell Significance Index: 156.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1584
    Cell Significance Index: 298.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1273
    Cell Significance Index: 1.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1265
    Cell Significance Index: 5.9000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1200
    Cell Significance Index: 11.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0642
    Cell Significance Index: 23.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0344
    Cell Significance Index: 5.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0301
    Cell Significance Index: 0.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0074
    Cell Significance Index: -3.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0103
    Cell Significance Index: -19.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0128
    Cell Significance Index: -19.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0130
    Cell Significance Index: -9.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0131
    Cell Significance Index: -8.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0134
    Cell Significance Index: -18.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0147
    Cell Significance Index: -11.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0155
    Cell Significance Index: -1.6900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0162
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0205
    Cell Significance Index: -12.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0229
    Cell Significance Index: -1.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0232
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0236
    Cell Significance Index: -17.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0240
    Cell Significance Index: -13.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0245
    Cell Significance Index: -0.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0266
    Cell Significance Index: -4.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0309
    Cell Significance Index: -17.4300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0314
    Cell Significance Index: -4.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0332
    Cell Significance Index: -15.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0346
    Cell Significance Index: -1.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0486
    Cell Significance Index: -9.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0533
    Cell Significance Index: -5.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0615
    Cell Significance Index: -1.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0661
    Cell Significance Index: -9.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0663
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0665
    Cell Significance Index: -11.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0764
    Cell Significance Index: -16.0900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0844
    Cell Significance Index: -2.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0975
    Cell Significance Index: -6.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1049
    Cell Significance Index: -13.5600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1090
    Cell Significance Index: -1.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1098
    Cell Significance Index: -15.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1144
    Cell Significance Index: -1.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1161
    Cell Significance Index: -6.0300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1237
    Cell Significance Index: -1.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1240
    Cell Significance Index: -12.9100
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: -0.1246
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1328
    Cell Significance Index: -15.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1499
    Cell Significance Index: -11.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1501
    Cell Significance Index: -9.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1503
    Cell Significance Index: -3.2900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1621
    Cell Significance Index: -10.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1932
    Cell Significance Index: -9.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2001
    Cell Significance Index: -12.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2031
    Cell Significance Index: -15.5900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2049
    Cell Significance Index: -3.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2080
    Cell Significance Index: -9.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2302
    Cell Significance Index: -11.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2380
    Cell Significance Index: -6.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2529
    Cell Significance Index: -14.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2532
    Cell Significance Index: -18.8700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2543
    Cell Significance Index: -2.2000
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2545
    Cell Significance Index: -1.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2600
    Cell Significance Index: -9.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2766
    Cell Significance Index: -8.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2788
    Cell Significance Index: -14.6400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2823
    Cell Significance Index: -8.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2891
    Cell Significance Index: -7.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2908
    Cell Significance Index: -9.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2964
    Cell Significance Index: -13.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2972
    Cell Significance Index: -6.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3010
    Cell Significance Index: -11.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3169
    Cell Significance Index: -6.8700
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3353
    Cell Significance Index: -2.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3632
    Cell Significance Index: -18.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3684
    Cell Significance Index: -13.9500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4026
    Cell Significance Index: -11.4900
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.4227
    Cell Significance Index: -4.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4344
    Cell Significance Index: -11.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4361
    Cell Significance Index: -10.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4400
    Cell Significance Index: -11.7900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4449
    Cell Significance Index: -18.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4456
    Cell Significance Index: -11.9200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.4483
    Cell Significance Index: -2.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4518
    Cell Significance Index: -6.4700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4581
    Cell Significance Index: -7.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4678
    Cell Significance Index: -12.3000
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: -0.4748
    Cell Significance Index: -3.7900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4763
    Cell Significance Index: -9.9400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4811
    Cell Significance Index: -12.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RHCG gene exhibits several key characteristics that contribute to its functional significance. These include: - **Amine transport:** RHCG is involved in the transport of amines, such as ammonia, across epithelial cell membranes. - **Ammonium homeostasis:** The gene plays a critical role in maintaining ammonium homeostasis, preventing the accumulation of toxic ammonia levels. - **Transmembrane transport:** RHCG facilitates the transport of small molecules, including metal ions, bile salts, and organic acids, across epithelial cell membranes. - **Regulation of pH:** The gene is involved in regulating pH levels, which is essential for maintaining cellular homeostasis. **Pathways and Functions:** RHCG is implicated in several key pathways and functions, including: - **Amine transport pathways:** RHCG mediates the transport of amines across epithelial cell membranes, facilitating the removal of toxic ammonia levels. - **Ammonium transmembrane transport:** The gene plays a critical role in the transport of ammonium across epithelial cell membranes, maintaining homeostasis and preventing toxicity. - **Regulation of ph:** RHCG is involved in regulating pH levels, which is essential for maintaining cellular homeostasis. - **Homeostatic processes:** The gene is involved in maintaining homeostatic processes, including the regulation of ion and water balance. **Clinical Significance:** The RHCG gene has significant implications for various clinical conditions, including: - **Neonatal metabolic disorders:** Mutations in the RHCG gene have been associated with neonatal metabolic disorders, such as hyperammonemia. - **Kidney disease:** RHCG dysfunction can lead to kidney disease, characterized by impaired ammonium transport and hyperammonemia. - **Neurological disorders:** The gene's role in regulating pH levels and maintaining homeostasis makes it a potential target for the treatment of neurological disorders, such as seizures and epilepsy. - **Cancer:** RHCG expression has been observed in various types of cancer, including colon and breast cancer, suggesting its potential role in tumorigenesis. In conclusion, the RHCG gene plays a critical role in mediating ammonium transport and maintaining homeostasis in various tissues. Its dysfunction can lead to various clinical conditions, highlighting the need for further research into the gene's mechanisms and potential therapeutic applications.

Genular Protein ID: 3168333937

Symbol: RHCG_HUMAN

Name: Ammonium transporter Rh type C

UniProtKB Accession Codes:

Q9UBD6 A8K4D4 Q6X3Y4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 15 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 7 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10852913

Title: Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis.

PubMed ID: 10852913

DOI: 10.1074/jbc.m003353200

PubMed ID: 12204676

Title: RhCG is downregulated in oesophageal squamous cell carcinomas, but expressed in multiple squamous epithelia.

PubMed ID: 12204676

DOI: 10.1016/s0959-8049(02)00190-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11062476

Title: The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast.

PubMed ID: 11062476

DOI: 10.1038/81656

PubMed ID: 14761968

Title: NH3 is involved in the NH4+ transport induced by the functional expression of the human Rh C glycoprotein.

PubMed ID: 14761968

DOI: 10.1074/jbc.m308528200

PubMed ID: 15929723

Title: Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells.

PubMed ID: 15929723

DOI: 10.1042/bj20050657

PubMed ID: 16477434

Title: Structural involvement in substrate recognition of an essential aspartate residue conserved in Mep/Amt and Rh-type ammonium transporters.

PubMed ID: 16477434

DOI: 10.1007/s00294-006-0062-5

PubMed ID: 16580862

Title: Ammonium transport properties of HEK293 cells expressing RhCG mutants: preliminary analysis of structure/function by site-directed mutagenesis.

PubMed ID: 16580862

DOI: 10.1016/j.tracli.2006.02.025

PubMed ID: 24077989

Title: Relative CO(2)/NH(3) permeabilities of human RhAG, RhBG and RhCG.

PubMed ID: 24077989

DOI: 10.1007/s00232-013-9593-0

PubMed ID: 20457942

Title: Function of human Rh based on structure of RhCG at 2.1 A.

PubMed ID: 20457942

DOI: 10.1073/pnas.1003587107

Sequence Information:

  • Length: 479
  • Mass: 53179
  • Checksum: E5D8024D720D4589
  • Sequence:
    • MAWNTNLRWR LPLTCLLLQV IMVILFGVFV RYDFEADAHW WSERTHKNLS DMENEFYYRY 
PSFQDVHVMV FVGFGFLMTF LQRYGFSAVG FNFLLAAFGI QWALLMQGWF HFLQDRYIVV 
GVENLINADF CVASVCVAFG AVLGKVSPIQ LLIMTFFQVT LFAVNEFILL NLLKVKDAGG 
SMTIHTFGAY FGLTVTRILY RRNLEQSKER QNSVYQSDLF AMIGTLFLWM YWPSFNSAIS 
YHGDSQHRAA INTYCSLAAC VLTSVAISSA LHKKGKLDMV HIQNATLAGG VAVGTAAEMM 
LMPYGALIIG FVCGIISTLG FVYLTPFLES RLHIQDTCGI NNLHGIPGII GGIVGAVTAA 
SASLEVYGKE GLVHSFDFQG FNGDWTARTQ GKFQIYGLLV TLAMALMGGI IVGLILRLPF 
WGQPSDENCF EDAVYWEMPE GNSTVYIPED PTFKPSGPSV PSVPMVSPLP MASSVPLVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.