Details for: HSD17B7

Gene ID: 51478

Symbol: HSD17B7

Ensembl ID: ENSG00000132196

Description: hydroxysteroid 17-beta dehydrogenase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 123.8225
    Cell Significance Index: -19.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.7937
    Cell Significance Index: -18.2100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 41.7582
    Cell Significance Index: -19.7200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 41.7470
    Cell Significance Index: -16.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 36.9567
    Cell Significance Index: -19.0100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 29.4402
    Cell Significance Index: -19.7600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.9630
    Cell Significance Index: -17.1500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.7345
    Cell Significance Index: -19.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.9951
    Cell Significance Index: -16.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9239
    Cell Significance Index: -19.4300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4637
    Cell Significance Index: -13.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.2715
    Cell Significance Index: -7.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1696
    Cell Significance Index: 232.1100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.1067
    Cell Significance Index: 8.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1053
    Cell Significance Index: 179.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0632
    Cell Significance Index: 28.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9015
    Cell Significance Index: 813.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7128
    Cell Significance Index: 77.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6889
    Cell Significance Index: 68.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5850
    Cell Significance Index: 16.3500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5268
    Cell Significance Index: 6.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4719
    Cell Significance Index: 58.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4316
    Cell Significance Index: 77.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3958
    Cell Significance Index: 18.6000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3931
    Cell Significance Index: 3.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3541
    Cell Significance Index: 71.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3469
    Cell Significance Index: 18.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3205
    Cell Significance Index: 16.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2462
    Cell Significance Index: 46.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2447
    Cell Significance Index: 108.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2431
    Cell Significance Index: 87.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2316
    Cell Significance Index: 126.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2286
    Cell Significance Index: 6.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2125
    Cell Significance Index: 1.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2005
    Cell Significance Index: 9.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1993
    Cell Significance Index: 23.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1927
    Cell Significance Index: 5.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1744
    Cell Significance Index: 8.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1738
    Cell Significance Index: 4.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1708
    Cell Significance Index: 3.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1368
    Cell Significance Index: 3.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1263
    Cell Significance Index: 17.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1257
    Cell Significance Index: 16.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1166
    Cell Significance Index: 8.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0974
    Cell Significance Index: 6.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0769
    Cell Significance Index: 4.9600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0746
    Cell Significance Index: 51.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0669
    Cell Significance Index: 42.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0644
    Cell Significance Index: 8.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0551
    Cell Significance Index: 1.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0501
    Cell Significance Index: 5.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0467
    Cell Significance Index: 87.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0402
    Cell Significance Index: 2.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0303
    Cell Significance Index: 2.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0242
    Cell Significance Index: 18.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0203
    Cell Significance Index: 1.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0116
    Cell Significance Index: 1.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0085
    Cell Significance Index: 13.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0033
    Cell Significance Index: 6.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0061
    Cell Significance Index: -2.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0063
    Cell Significance Index: -3.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0077
    Cell Significance Index: -10.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0102
    Cell Significance Index: -7.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0132
    Cell Significance Index: -9.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0173
    Cell Significance Index: -0.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0179
    Cell Significance Index: -1.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0200
    Cell Significance Index: -11.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0440
    Cell Significance Index: -9.2800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0470
    Cell Significance Index: -1.5100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0475
    Cell Significance Index: -0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0493
    Cell Significance Index: -14.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0535
    Cell Significance Index: -7.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0675
    Cell Significance Index: -1.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0708
    Cell Significance Index: -1.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0741
    Cell Significance Index: -1.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0904
    Cell Significance Index: -2.3100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0970
    Cell Significance Index: -11.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1066
    Cell Significance Index: -2.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1157
    Cell Significance Index: -4.0200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1261
    Cell Significance Index: -9.6800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1276
    Cell Significance Index: -8.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1466
    Cell Significance Index: -15.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1503
    Cell Significance Index: -17.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1552
    Cell Significance Index: -2.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1809
    Cell Significance Index: -4.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1905
    Cell Significance Index: -5.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1937
    Cell Significance Index: -3.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2001
    Cell Significance Index: -12.2700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2237
    Cell Significance Index: -2.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2239
    Cell Significance Index: -6.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2266
    Cell Significance Index: -17.9500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2306
    Cell Significance Index: -2.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2322
    Cell Significance Index: -10.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2719
    Cell Significance Index: -3.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2732
    Cell Significance Index: -10.3500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3029
    Cell Significance Index: -6.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3122
    Cell Significance Index: -8.9100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.3199
    Cell Significance Index: -2.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3360
    Cell Significance Index: -5.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3365
    Cell Significance Index: -8.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HSD17B7 is a 17-beta-hydroxysteroid dehydrogenase enzyme that exhibits high specificity for 17-hydroxysteroids, converting them to 17-keto steroids through a redox reaction. This enzyme is highly expressed in various tissues, including the liver, kidney, and immune cells, suggesting its involvement in metabolic and immune processes. HSD17B7 has been shown to be regulated by various transcription factors, including nuclear factor kappa B (NF-κB) and hepatocyte nuclear factor 4 alpha (HNF4α), which further underscores its role in immune and metabolic homeostasis. **Pathways and Functions:** HSD17B7 is involved in multiple pathways, including: 1. **Cholesterol Biosynthesis**: HSD17B7 plays a crucial role in the conversion of 7-dehydrocholesterol to cholesterol in the liver, highlighting its involvement in lipid metabolism. 2. **Androgen Metabolic Process**: HSD17B7 converts androgens to 17-keto steroids, which are then further metabolized to estrogenic compounds, influencing androgen metabolism and immune function. 3. **Estrogen Biosynthetic Process**: HSD17B7 is involved in the conversion of estrone to estradiol, a key step in estrogen biosynthesis. 4. **5alpha-Androstane-3beta,17beta-Diol Dehydrogenase Activity**: HSD17B7 exhibits dehydrogenase activity on 5alpha-androstane-3beta,17beta-diol, a potent androgenic compound. **Clinical Significance:** Dysregulation of HSD17B7 has been implicated in various diseases, including: 1. **Metabolic Disorders**: HSD17B7 has been linked to obesity, insulin resistance, and type 2 diabetes, highlighting its role in lipid metabolism and glucose homeostasis. 2. **Autoimmune Diseases**: HSD17B7 has been shown to regulate immune cell function, with its dysregulation potentially contributing to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: HSD17B7 has been identified as a potential biomarker for certain types of cancer, including breast cancer and prostate cancer, where its expression is often upregulated. In conclusion, HSD17B7 is a multifunctional enzyme that plays a crucial role in regulating steroid hormone metabolism, lipid biosynthesis, and immune cell function. Further research is needed to fully elucidate the mechanisms of HSD17B7 and its implications for human disease.

Genular Protein ID: 1159774344

Symbol: DHB7_HUMAN

Name: 17-beta-hydroxysteroid dehydrogenase 7

UniProtKB Accession Codes:

P56937 Q5T246 Q7Z4V9 Q8WWS2 Q9UF00

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 46 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 5 EMBL 29 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 18 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10544267

Title: Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7.

PubMed ID: 10544267

DOI: 10.1016/s0014-5793(99)01366-6

PubMed ID: 12732193

Title: Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7.

PubMed ID: 12732193

DOI: 10.1016/s0006-291x(03)00694-6

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11165030

Title: 17beta-hydroxysteroid dehydrogenase type 7--an ancient 3-ketosteroid reductase of cholesterogenesis.

PubMed ID: 11165030

DOI: 10.1016/s0303-7207(00)00416-0

PubMed ID: 12574203

Title: Sex hormone metabolism in prostate cancer cells during transition to an androgen-independent state.

PubMed ID: 12574203

DOI: 10.1210/jc.2002-020236

PubMed ID: 12829805

Title: Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis.

PubMed ID: 12829805

DOI: 10.1210/me.2002-0436

PubMed ID: 19772289

Title: Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.

PubMed ID: 19772289

DOI: 10.1021/jm900921c

PubMed ID: 20659585

Title: Divergent interactions involving the oxidosqualene cyclase and the steroid-3-ketoreductase in the sterol biosynthetic pathway of mammals and yeasts.

PubMed ID: 20659585

DOI: 10.1016/j.bbalip.2010.07.006

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 341
  • Mass: 38206
  • Checksum: FE4892B2602F549B
  • Sequence:
    • MRKVVLITGA SSGIGLALCK RLLAEDDELH LCLACRNMSK AEAVCAALLA SHPTAEVTIV 
QVDVSNLQSV FRASKELKQR FQRLDCIYLN AGIMPNPQLN IKALFFGLFS RKVIHMFSTA 
EGLLTQGDKI TADGLQEVFE TNVFGHFILI RELEPLLCHS DNPSQLIWTS SRSARKSNFS 
LEDFQHSKGK EPYSSSKYAT DLLSVALNRN FNQQGLYSNV ACPGTALTNL TYGILPPFIW 
TLLMPAILLL RFFANAFTLT PYNGTEALVW LFHQKPESLN PLIKYLSATT GFGRNYIMTQ 
KMDLDEDTAE KFYQKLLELE KHIRVTIQKT DNQARLSGSC L

Genular Protein ID: 1442044766

Symbol: Q9H9C0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9H9C0

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 GO 5 Gene3D 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SUPFAM 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 155
  • Mass: 17092
  • Checksum: 2DB83B9200786B2E
  • Sequence:
    • MRKVVLITGA SSGIGLALCK RLLAEDDELH LCLACRNMSK AEAVCAALLA SHPTAEVTIV 
QVDVSNLQSV FRASKELKQR FQRLDCIYLN AGIMPNPQLN IKALFFGLFS RKVIHMFSTA 
EGLLTQGDKI TADGLQEVFE TNVFGHFILV KKLWA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.