Details for: JKAMP

Gene ID: 51528

Symbol: JKAMP

Ensembl ID: ENSG00000050130

Description: JNK1/MAPK8 associated membrane protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 214.5357
    Cell Significance Index: -33.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 129.8871
    Cell Significance Index: -32.9500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 95.8374
    Cell Significance Index: -39.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 81.3348
    Cell Significance Index: -38.4000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 77.4263
    Cell Significance Index: -31.4600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 69.7823
    Cell Significance Index: -35.9000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 57.3454
    Cell Significance Index: -38.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.0403
    Cell Significance Index: -31.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.6280
    Cell Significance Index: -36.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7102
    Cell Significance Index: -31.3700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.5082
    Cell Significance Index: -37.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.6641
    Cell Significance Index: -23.5400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1083
    Cell Significance Index: -11.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.5449
    Cell Significance Index: 176.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0923
    Cell Significance Index: 243.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.0334
    Cell Significance Index: 330.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8869
    Cell Significance Index: 177.9100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7336
    Cell Significance Index: 400.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6558
    Cell Significance Index: 41.3300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6394
    Cell Significance Index: 29.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5821
    Cell Significance Index: 74.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5719
    Cell Significance Index: 78.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5222
    Cell Significance Index: 94.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5118
    Cell Significance Index: 26.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4927
    Cell Significance Index: 97.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4799
    Cell Significance Index: 433.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4651
    Cell Significance Index: 26.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4277
    Cell Significance Index: 189.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4204
    Cell Significance Index: 51.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3967
    Cell Significance Index: 11.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3921
    Cell Significance Index: 140.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3672
    Cell Significance Index: 25.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3258
    Cell Significance Index: 11.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3258
    Cell Significance Index: 62.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3245
    Cell Significance Index: 9.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3217
    Cell Significance Index: 16.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2866
    Cell Significance Index: 6.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2652
    Cell Significance Index: 183.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2613
    Cell Significance Index: 6.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2379
    Cell Significance Index: 4.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2235
    Cell Significance Index: 10.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2047
    Cell Significance Index: 15.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1523
    Cell Significance Index: 7.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1243
    Cell Significance Index: 7.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1203
    Cell Significance Index: 3.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1151
    Cell Significance Index: 3.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1136
    Cell Significance Index: 1.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0940
    Cell Significance Index: 1.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0910
    Cell Significance Index: 15.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0776
    Cell Significance Index: 9.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0297
    Cell Significance Index: 1.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0124
    Cell Significance Index: 23.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0007
    Cell Significance Index: 0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0026
    Cell Significance Index: -0.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0030
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0035
    Cell Significance Index: -2.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0075
    Cell Significance Index: -11.4800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0082
    Cell Significance Index: -0.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0119
    Cell Significance Index: -8.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0148
    Cell Significance Index: -1.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0158
    Cell Significance Index: -0.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0185
    Cell Significance Index: -1.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0187
    Cell Significance Index: -8.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0200
    Cell Significance Index: -12.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0207
    Cell Significance Index: -28.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0210
    Cell Significance Index: -11.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0247
    Cell Significance Index: -18.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0267
    Cell Significance Index: -1.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0347
    Cell Significance Index: -3.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0366
    Cell Significance Index: -0.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0416
    Cell Significance Index: -5.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0457
    Cell Significance Index: -2.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0541
    Cell Significance Index: -7.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0746
    Cell Significance Index: -15.7100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0774
    Cell Significance Index: -0.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0984
    Cell Significance Index: -28.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1644
    Cell Significance Index: -18.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1733
    Cell Significance Index: -11.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2023
    Cell Significance Index: -6.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2227
    Cell Significance Index: -4.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2448
    Cell Significance Index: -6.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3266
    Cell Significance Index: -17.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3359
    Cell Significance Index: -38.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3458
    Cell Significance Index: -36.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3506
    Cell Significance Index: -8.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3723
    Cell Significance Index: -9.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4172
    Cell Significance Index: -33.0400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4228
    Cell Significance Index: -10.8000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4608
    Cell Significance Index: -5.0100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4960
    Cell Significance Index: -9.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5095
    Cell Significance Index: -31.2400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.5371
    Cell Significance Index: -3.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5439
    Cell Significance Index: -15.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5622
    Cell Significance Index: -8.3000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5945
    Cell Significance Index: -5.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6559
    Cell Significance Index: -15.7300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6850
    Cell Significance Index: -12.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7007
    Cell Significance Index: -22.3200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7141
    Cell Significance Index: -10.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** JKAMP exhibits several distinct characteristics that set it apart from other genes: 1. **Expression Pattern**: JKAMP is expressed in a wide range of cell types, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, embryonic stem cells, and various epithelial and immune cells. This broad expression pattern suggests a multifaceted role in cellular regulation. 2. **JNK1/MAPK8 Association**: JKAMP's association with the JNK1/MAPK8 pathway is a critical aspect of its function. The JNK1/MAPK8 pathway is involved in stress response, cell proliferation, and differentiation, and JKAMP's involvement in this pathway may modulate these processes. 3. **Cellular Localization**: JKAMP's localization to the cell membrane is noteworthy, as this may influence its interactions with other proteins and signaling molecules. **Pathways and Functions** JKAMP's involvement in various cellular pathways highlights its potential functions: 1. **Endoplasmic Reticulum Membrane Pathway**: JKAMP's association with the endoplasmic reticulum membrane may regulate protein folding, quality control, and trafficking. 2. **Erad Pathway**: JKAMP's involvement in the ERAD pathway, which is responsible for the degradation of misfolded proteins, may contribute to cellular stress response and homeostasis. 3. **Protein Binding**: JKAMP's ability to bind various proteins, including those involved in the JNK1/MAPK8 pathway, may modulate signaling cascades and cellular processes. 4. **Response to Unfolded Protein**: JKAMP's expression in cells that respond to unfolded proteins suggests a role in maintaining protein homeostasis and responding to cellular stress. 5. **Ubiquitin Protein Ligase Binding**: JKAMP's interaction with ubiquitin protein ligases may regulate protein degradation and modification, further highlighting its role in cellular processes. **Clinical Significance** The clinical significance of JKAMP is an area of ongoing research, and its implications are multifaceted: 1. **Immune Function**: JKAMP's expression in immune cells, including CD8-alpha-beta-positive, alpha-beta intraepithelial T cells, suggests a potential role in immune regulation and function. 2. **Cancer**: JKAMP's involvement in the JNK1/MAPK8 pathway, which is often dysregulated in cancer, may contribute to tumorigenesis and cancer progression. 3. **Neurological Disorders**: JKAMP's expression in ciliated cells of the bronchus and its association with the ERAD pathway may be relevant to neurological disorders, such as neurodegenerative diseases. 4. **Stem Cell Biology**: JKAMP's expression in embryonic stem cells and hematopoietic oligopotent progenitor cells highlights its potential role in maintaining stem cell pluripotency and differentiation. In conclusion, JKAMP is a gene that warrants further investigation due to its unique expression patterns, functional implications, and potential clinical significance. Further research is necessary to elucidate the precise mechanisms by which JKAMP regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 1645255428

Symbol: JKAMP_HUMAN

Name: JNK1/MAPK8-associated membrane protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12800201

Title: Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.

PubMed ID: 12800201

DOI: 10.1002/ijc.11208

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18784250

Title: JAMP optimizes ERAD to protect cells from unfolded proteins.

PubMed ID: 18784250

DOI: 10.1091/mbc.e08-08-0839

Sequence Information:

  • Length: 311
  • Mass: 35239
  • Checksum: F294B4CAFDDCECE4
  • Sequence:
  • MAVDIQPACL GLYCGKTLLF KNGSTEIYGE CGVCPRGQRT NAQKYCQPCT ESPELYDWLY 
    LGFMAMLPLV LHWFFIEWYS GKKSSSALFQ HITALFECSM AAIITLLVSD PVGVLYIRSC 
    RVLMLSDWYT MLYNPSPDYV TTVHCTHEAV YPLYTIVFIY YAFCLVLMML LRPLLVKKIA 
    CGLGKSDRFK SIYAALYFFP ILTVLQAVGG GLLYYAFPYI ILVLSLVTLA VYMSASEIEN 
    CYDLLVRKKR LIVLFSHWLL HAYGIISISR VDKLEQDLPL LALVPTPALF YLFTAKFTEP 
    SRILSEGANG H

Genular Protein ID: 3935325839

Symbol: B3KPC2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 325
  • Mass: 36721
  • Checksum: 4A88BA2B0E866817
  • Sequence:
  • MKGEIQQSLG AWVLLTVDIQ PACLGLYCGK TLLFKNGSTE IYGECGVCPR GQRTNAQKYC 
    QPCTESPELY DWLYLGFMAM LPLVLHWFFI EWYSGKKSSS ALFQHITALF ECSMAAIITL 
    LVSDPVGVLY IRSCRVLMLS DWYTMLYNPS PDYVTTVHCT HEAVYPLYTI VFIYYAFCLV 
    LMMLLRPLLV KKIACGLGKS DRFKSIYAAL YFFPILTVLQ AVGGGLLYYA FPYIILVLSL 
    VTLAVYMSAS EIENCYDLLV RKKRLIVLFS HWLLHAYGII SISRVDKLGQ DLPLLALVPT 
    PALFYLFTAK FTEPSRILSE GANGH

Genular Protein ID: 807483188

Symbol: G3V2M4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 325
  • Mass: 36793
  • Checksum: 4A88BA2B0DD05D77
  • Sequence:
  • MKGEIQQSLG AWVLLTVDIQ PACLGLYCGK TLLFKNGSTE IYGECGVCPR GQRTNAQKYC 
    QPCTESPELY DWLYLGFMAM LPLVLHWFFI EWYSGKKSSS ALFQHITALF ECSMAAIITL 
    LVSDPVGVLY IRSCRVLMLS DWYTMLYNPS PDYVTTVHCT HEAVYPLYTI VFIYYAFCLV 
    LMMLLRPLLV KKIACGLGKS DRFKSIYAAL YFFPILTVLQ AVGGGLLYYA FPYIILVLSL 
    VTLAVYMSAS EIENCYDLLV RKKRLIVLFS HWLLHAYGII SISRVDKLEQ DLPLLALVPT 
    PALFYLFTAK FTEPSRILSE GANGH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.