ANAPC11 | ENSG00000141552 | NCBI 51529

Details for: ANAPC11

Gene ID: 51529

Symbol: ANAPC11

Ensembl ID: ENSG00000141552

Description: anaphase promoting complex subunit 11

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Cell division
(GO:0051301)
Cullin family protein binding
(GO:0097602)
Cytosol
(GO:0005829)
Mitotic cell cycle
(GO:0000278)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Protein binding
(GO:0005515)
Protein branched polyubiquitination
(GO:0141198)
Protein k11-linked ubiquitination
(GO:0070979)
Protein k48-linked ubiquitination
(GO:0070936)
Protein ubiquitination
(GO:0016567)
Regulation of meiotic cell cycle
(GO:0051445)
Regulation of mitotic cell cycle
(GO:0007346)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin-ubiquitin ligase activity
(GO:0034450)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 358.4167
Cell Significance Index: -55.7500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 266.8708
Cell Significance Index: -67.6900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 197.2095
Cell Significance Index: -81.2400
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 173.7049
Cell Significance Index: -82.0100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 155.3602
Cell Significance Index: -79.9200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 122.7232
Cell Significance Index: -82.3500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 64.3048
Cell Significance Index: -79.2900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 21.2897
Cell Significance Index: -84.0100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.4747
Cell Significance Index: -52.1700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 19.3231
Cell Significance Index: -59.3500
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.7741
Cell Significance Index: -23.5800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.4302
Cell Significance Index: 206.5600
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.2707
Cell Significance Index: 68.4600
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.7010
Cell Significance Index: 1475.0900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.6705
Cell Significance Index: 328.3600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.4865
Cell Significance Index: 448.2300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.3984
Cell Significance Index: 282.8400
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.3373
Cell Significance Index: 25.4100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.2432
Cell Significance Index: 167.1800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.1876
Cell Significance Index: 20.1500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.1714
Cell Significance Index: 298.2000
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.1616
Cell Significance Index: 56.8400
Cell Name: kidney cell (CL1000497)
Fold Change: 2.1567
Cell Significance Index: 17.2200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.1566
Cell Significance Index: 58.7000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.0121
Cell Significance Index: 69.9200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.8899
Cell Significance Index: 88.8300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.8721
Cell Significance Index: 98.2900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.8605
Cell Significance Index: 1679.9100
Cell Name: peg cell (CL4033014)
Fold Change: 1.7880
Cell Significance Index: 41.3100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.6808
Cell Significance Index: 44.8800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.5413
Cell Significance Index: 17.5100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.5374
Cell Significance Index: 679.7100
Cell Name: lactocyte (CL0002325)
Fold Change: 1.4749
Cell Significance Index: 190.5500
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.4631
Cell Significance Index: 103.4800
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.4060
Cell Significance Index: 90.7100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.3833
Cell Significance Index: 71.8600
Cell Name: odontoblast (CL0000060)
Fold Change: 1.3448
Cell Significance Index: 172.3900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.2342
Cell Significance Index: 55.9400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.2088
Cell Significance Index: 35.5000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.0686
Cell Significance Index: 13.6900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.0648
Cell Significance Index: 19.6800
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.9782
Cell Significance Index: 6.0200
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7328
Cell Significance Index: 72.4900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.6560
Cell Significance Index: 130.1900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6109
Cell Significance Index: 13.2400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.4388
Cell Significance Index: 74.9200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2617
Cell Significance Index: 49.8100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2588
Cell Significance Index: 195.8700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2196
Cell Significance Index: 44.0500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1303
Cell Significance Index: 2.1800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1036
Cell Significance Index: 75.9400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0178
Cell Significance Index: 1.1200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0147
Cell Significance Index: -1.5000
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0173
Cell Significance Index: -6.2200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0186
Cell Significance Index: -13.7800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0259
Cell Significance Index: -4.2200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0341
Cell Significance Index: -64.1900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0394
Cell Significance Index: -1.1400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0470
Cell Significance Index: -29.3600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0525
Cell Significance Index: -96.9200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0629
Cell Significance Index: -96.7800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0736
Cell Significance Index: -100.0900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0971
Cell Significance Index: -54.7600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1035
Cell Significance Index: -65.7200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1482
Cell Significance Index: -67.2600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1750
Cell Significance Index: -36.8700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2185
Cell Significance Index: -62.8600
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2369
Cell Significance Index: -6.6200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3067
Cell Significance Index: -35.1400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3426
Cell Significance Index: -39.9300
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3468
Cell Significance Index: -8.8600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.3750
Cell Significance Index: -4.4700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4983
Cell Significance Index: -30.6300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.5099
Cell Significance Index: -74.1200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5117
Cell Significance Index: -40.5300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5209
Cell Significance Index: -16.6900
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5330
Cell Significance Index: -3.2200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.6303
Cell Significance Index: -71.9500
Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.6374
Cell Significance Index: -3.9900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.6914
Cell Significance Index: -10.3600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7696
Cell Significance Index: -10.5000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.7846
Cell Significance Index: -13.8700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.8017
Cell Significance Index: -83.4800
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.8224
Cell Significance Index: -46.1500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8277
Cell Significance Index: -24.3800
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.8393
Cell Significance Index: -17.8800
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.8576
Cell Significance Index: -59.3100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.9224
Cell Significance Index: -26.4400
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.9625
Cell Significance Index: -13.5000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.9669
Cell Significance Index: -74.2000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.9972
Cell Significance Index: -67.0500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.0025
Cell Significance Index: -26.8200
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -1.1636
Cell Significance Index: -7.2300
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.2298
Cell Significance Index: -10.3300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3276
Cell Significance Index: -81.3900
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -1.3780
Cell Significance Index: -14.2700
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -1.4548
Cell Significance Index: -9.4900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.5450
Cell Significance Index: -41.4000
Cell Name: germ cell (CL0000586)
Fold Change: -1.5906
Cell Significance Index: -12.0100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.8881
Cell Significance Index: -83.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Subunit of the Anaphase Promoting Complex**: ANAPC11 is a core component of the APC, a large protein complex that regulates the cell cycle by ubiquitinating and degrading key mitotic proteins. 2. **Ubiquitination and Degradation**: ANAPC11 is involved in the ubiquitination of mitotic proteins, which leads to their degradation and the promotion of the cell cycle. 3. **Regulation of Mitotic Protein Degradation**: ANAPC11 regulates the degradation of key mitotic proteins, including securin, cyclin B, and Nek2A, by interacting with other components of the APC complex. 4. **Cell Cycle Regulation**: ANAPC11 plays a critical role in regulating the transition from metaphase to anaphase, ensuring proper chromosome segregation and cell division. **Pathways and Functions:** 1. **Activation of APC/C and APC/C:cdc20-mediated Degradation**: ANAPC11 activates the APC/C complex, which then interacts with the cdc20 regulatory subunit to degrade key mitotic proteins. 2. **Apc/C:cdh1-mediated Degradation of Cdc20 and Other APC/C:cdh1-Targeted Proteins**: ANAPC11 interacts with the APC/C:cdh1 complex to regulate the degradation of cdc20 and other APC/C:cdh1-targeted proteins. 3. **Cdc20:Phospho-apc/c-mediated Degradation of Cyclin A**: ANAPC11 regulates the degradation of cyclin A by interacting with the cdc20 regulatory subunit and the APC/C complex. 4. **Autodegradation of CDH1 by CDH1:APC/C**: ANAPC11 is involved in the autodegradation of CDH1 by the APC/C complex. **Clinical Significance:** 1. **Cancer**: Aberrations in ANAPC11 have been linked to various types of cancer, including breast, lung, and colon cancer. 2. **Mitotic Cell Cycle Diseases**: ANAPC11 plays a critical role in regulating the mitotic cell cycle, and aberrations in this gene can lead to diseases of the mitotic cell cycle. 3. **Immunological Disorders**: ANAPC11 has been identified as significantly expressed in various immune cells, including T cells and dendritic cells, suggesting a potential role in immunological disorders. 4. **Synthetic Lethality**: ANAPC11 has been identified as a synthetic lethal gene, meaning that its inactivation can be lethal in the absence of other specific mutations. In conclusion, ANAPC11 is a critical regulator of the mitotic cell cycle, and its dysregulation can lead to various diseases, including cancer and immunological disorders. Further research is needed to fully elucidate the role of ANAPC11 in human disease and to develop therapeutic strategies to target this gene in cancer and other diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Anaphase-promoting complex subunit 11

Genular Protein ID: 3135292355

Symbol: APC11_HUMAN

Name: Anaphase-promoting complex subunit 11

UniProtKB Accession Codes:

Q9NYG5 A8MTT2 B7ZW64 Q502X9 Q9BW64 Q9P0R2

Database IDs:

Citations:

PubMed ID: 11573242

Title: Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p.

PubMed ID: 11573242

DOI: 10.1002/jcb.1217

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10922056

Title: The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.

PubMed ID: 10922056

DOI: 10.1073/pnas.97.16.8973

PubMed ID: 11739784

Title: APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.

PubMed ID: 11739784

DOI: 10.1091/mbc.12.12.3839

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 29033132

Title: Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control.

PubMed ID: 29033132

DOI: 10.1016/j.cell.2017.09.040

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

Sequence Information:

Length: 84
Mass: 9841
Checksum: EACBD5A54FDC11AE
Sequence:

MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ CSHCFHMHCI 
LKWLHAQQVQ QHCPMCRQEW KFKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ANAPC11

Associated with

Cells (max top 100)

Other Information

Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p. PubMed ID: 11573242

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. PubMed ID: 10922056

APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. PubMed ID: 11739784

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PubMed ID: 16364912

Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control. PubMed ID: 29033132

Molecular architecture and mechanism of the anaphase-promoting complex. PubMed ID: 25043029

Atomic structure of the APC/C and its mechanism of protein ubiquitination. PubMed ID: 26083744