ANAPC11 | ENSG00000141552 | NCBI 51529

Details for: ANAPC11

Associated with

Aberrant regulation of mitotic cell cycle due to rb1 defects
(R-HSA-9687139)
Aberrant regulation of mitotic exit in cancer due to rb1 defects
(R-HSA-9687136)
Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of cyclin b
(R-HSA-174048)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc/c:cdc20 mediated degradation of securin
(R-HSA-174154)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-HSA-174178)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Assembly of the pre-replicative complex
(R-HSA-68867)
Autodegradation of cdh1 by cdh1:apc/c
(R-HSA-174084)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cdk-mediated phosphorylation and removal of cdc6
(R-HSA-69017)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Conversion from apc/c:cdc20 to apc/c:cdh1 in late anaphase
(R-HSA-176407)
Disease
(R-HSA-1643685)
Diseases of mitotic cell cycle
(R-HSA-9675126)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Phosphorylation of the apc/c
(R-HSA-176412)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Rna polymerase ii transcription
(R-HSA-73857)
Senescence-associated secretory phenotype (sasp)
(R-HSA-2559582)
Separation of sister chromatids
(R-HSA-2467813)
S phase
(R-HSA-69242)
Switching of origins to a post-replicative state
(R-HSA-69052)
Synthesis of dna
(R-HSA-69239)
Transcriptional regulation by ventx
(R-HSA-8853884)
Anaphase-promoting complex
(GO:0005680)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Cell division
(GO:0051301)
Cullin family protein binding
(GO:0097602)
Cytosol
(GO:0005829)
Mitotic cell cycle
(GO:0000278)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Protein binding
(GO:0005515)
Protein branched polyubiquitination
(GO:0141198)
Protein k11-linked ubiquitination
(GO:0070979)
Protein k48-linked ubiquitination
(GO:0070936)
Protein ubiquitination
(GO:0016567)
Regulation of meiotic cell cycle
(GO:0051445)
Regulation of mitotic cell cycle
(GO:0007346)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin-ubiquitin ligase activity
(GO:0034450)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

granulocyte monocyte progenitor cell CL0000557

CSI 72.91

rCSI 63.13%

PRS 10.79
epithelial cell of lung CL0000082

CSI 67.26

rCSI 55.76%

PRS 9.17
fallopian tube secretory epithelial cell CL4030006

CSI 66.31

rCSI 63.84%

PRS 10
stem cell CL0000034

CSI 59.75

rCSI 57.61%

PRS 6.41
common myeloid progenitor CL0000049

CSI 58.88

rCSI 47.61%

PRS 9.56
transit amplifying cell of colon CL0009011

CSI 53.49

rCSI 62.82%

PRS 11.5
multi-ciliated epithelial cell CL0005012

CSI 51.69

rCSI 51.58%

PRS 8.3
intestinal epithelial cell CL0002563

CSI 48.9

rCSI 51.11%

PRS 10.22
keratinocyte CL0000312

CSI 48.47

rCSI 40.63%

PRS 11.58
plasmablast CL0000980

CSI 47.89

rCSI 37.67%

PRS 11.49
ciliated epithelial cell CL0000067

CSI 47.56

rCSI 41.83%

PRS 7.01
extravillous trophoblast CL0008036

CSI 46.8

rCSI 57.89%

PRS 8.49
promyelocyte CL0000836

CSI 45.89

rCSI 66.19%

PRS 13.54
placental villous trophoblast CL2000060

CSI 45.7

rCSI 70.61%

PRS 9.06
common dendritic progenitor CL0001029

CSI 44.89

rCSI 56.34%

PRS 12.36
promonocyte CL0000559

CSI 44.46

rCSI 76.17%

PRS 13
megakaryocyte-erythroid progenitor cell CL0000050

CSI 43.16

rCSI 38.98%

PRS 8.56
peripheral nervous system neuron CL2000032

CSI 42.47

rCSI 57.87%

PRS 8.66
colon epithelial cell CL0011108

CSI 40.6

rCSI 42.53%

PRS 9
mesodermal cell CL0000222

CSI 39.32

rCSI 47.19%

PRS 9.57
intestine goblet cell CL0019031

CSI 36.63

rCSI 32.52%

PRS 9.68
fraction A pre-pro B cell CL0002045

CSI 34.23

rCSI 39.18%

PRS 19.96
enteric smooth muscle cell CL0002504

CSI 33.89

rCSI 48.36%

PRS 10.93
myeloid leukocyte CL0000766

CSI 32.86

rCSI 30.31%

PRS 9.84
mucous neck cell CL0000651

CSI 31.67

rCSI 45.65%

PRS 15.62
retinal cone cell CL0000573

CSI 29.43

rCSI 47.37%

PRS 7.41
hepatocyte CL0000182

CSI 27.44

rCSI 49.11%

PRS 9.07
pancreatic A cell CL0000171

CSI 27.37

rCSI 28.67%

PRS 10.31
tracheal goblet cell CL1000329

CSI 25.25

rCSI 55.12%

PRS 19.66
large pre-B-II cell CL0000957

CSI 25.21

rCSI 71.98%

PRS 16.97
neural crest cell CL0011012

CSI 24.18

rCSI 19.11%

PRS 6.66
mucus secreting cell CL0000319

CSI 24.12

rCSI 38.31%

PRS 12.56
M cell of gut CL0000682

CSI 23.48

rCSI 24.95%

PRS 17.27
enteroendocrine cell CL0000164

CSI 23.17

rCSI 31.66%

PRS 10.69
elicited macrophage CL0000861

CSI 22.97

rCSI 21.09%

PRS 11.07
kidney epithelial cell CL0002518

CSI 22.66

rCSI 43.26%

PRS 23.15
microcirculation associated smooth muscle cell CL0008035

CSI 22.56

rCSI 65.31%

PRS 10.95
transit amplifying cell CL0009010

CSI 21.46

rCSI 32.82%

PRS 15.74
epithelial cell CL0000066

CSI 21.26

rCSI 32.67%

PRS 13.87
pancreatic D cell CL0000173

CSI 20.95

rCSI 20.6%

PRS 10.52
forebrain radial glial cell CL0013000

CSI 20.51

rCSI 65.8%

PRS 14.35
foveolar cell of stomach CL0002179

CSI 20.09

rCSI 42.76%

PRS 15.63
retinal pigment epithelial cell CL0002586

CSI 20.01

rCSI 39.73%

PRS 10.4
hematopoietic stem cell CL0000037

CSI 19.65

rCSI 13.06%

PRS 11.56
early lymphoid progenitor CL0000936

CSI 19.16

rCSI 16.83%

PRS 10.87
cardiac muscle cell CL0000746

CSI 18.28

rCSI 26.24%

PRS 7.7
lung secretory cell CL1000272

CSI 18.16

rCSI 44.96%

PRS 8.94
acinar cell CL0000622

CSI 17.49

rCSI 25.65%

PRS 12.74
plasmacytoid dendritic cell, human CL0001058

CSI 16.58

rCSI 11.57%

PRS 10.2
colon goblet cell CL0009039

CSI 16.21

rCSI 38.54%

PRS 14.53
retina horizontal cell CL0000745

CSI 15.98

rCSI 24.36%

PRS 9.06
interstitial cell of Cajal CL0002088

CSI 15.8

rCSI 20.12%

PRS 11.24
type B pancreatic cell CL0000169

CSI 15.61

rCSI 34.55%

PRS 8.98
muscle cell CL0000187

CSI 15.61

rCSI 32.05%

PRS 22.98
pancreatic ductal cell CL0002079

CSI 14.87

rCSI 28.91%

PRS 9.86
deuterosomal cell CL4033044

CSI 14.79

rCSI 49.99%

PRS 16.53
club cell CL0000158

CSI 14.49

rCSI 21.22%

PRS 11.34
enterocyte CL0000584

CSI 13.9

rCSI 22.42%

PRS 15.51
primitive red blood cell CL0002355

CSI 13.81

rCSI 74.52%

PRS 18.32
melanocyte CL0000148

CSI 13.74

rCSI 10.18%

PRS 8.72
mammary gland epithelial cell CL0002327

CSI 13.54

rCSI 47.49%

PRS 17.57
pancreatic PP cell CL0002275

CSI 12.65

rCSI 50.34%

PRS 17.06
respiratory suprabasal cell CL4033048

CSI 12.04

rCSI 15.44%

PRS 11.16
type EC enteroendocrine cell CL0000577

CSI 11.74

rCSI 41.67%

PRS 15.88
goblet cell CL0000160

CSI 11.56

rCSI 10.92%

PRS 10.1
pancreatic stellate cell CL0002410

CSI 11.4

rCSI 66.31%

PRS 14.55
progenitor cell CL0011026

CSI 11.06

rCSI 23.53%

PRS 17.62
nasal mucosa goblet cell CL0002480

CSI 11.02

rCSI 12.78%

PRS 14.35
neuroblast (sensu Vertebrata) CL0000031

CSI 10.8

rCSI 13.86%

PRS 9.43
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 10.73

rCSI 8.05%

PRS 28.15
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 10.6

rCSI 12.25%

PRS 8.58
tracheobronchial serous cell CL0019001

CSI 10.47

rCSI 45.22%

PRS 18.78
mesenchymal cell CL0008019

CSI 10.33

rCSI 26.23%

PRS 9.84
epithelial cell of lower respiratory tract CL0002632

CSI 10.26

rCSI 7.95%

PRS 9.25
pro-B cell CL0000826

CSI 10.18

rCSI 8.43%

PRS 9.69
double negative thymocyte CL0002489

CSI 10.07

rCSI 7%

PRS 11.33
pulmonary alveolar type 2 cell CL0002063

CSI 9.92

rCSI 15.39%

PRS 14.93
cerebral cortex GABAergic interneuron CL0010011

CSI 9.9

rCSI 29.21%

PRS 12.11
Cajal-Retzius cell CL0000695

CSI 9.69

rCSI 75.91%

PRS 21.64
colonocyte CL1000347

CSI 9.68

rCSI 13.87%

PRS 13.27
myofibroblast cell CL0000186

CSI 9.58

rCSI 13.27%

PRS 13.95
radial glial cell CL0000681

CSI 9.55

rCSI 13.27%

PRS 10.01
pancreatic epsilon cell CL0005019

CSI 9.15

rCSI 42.64%

PRS 23.52
double-positive, alpha-beta thymocyte CL0000809

CSI 9.06

rCSI 9.23%

PRS 13.8
respiratory hillock cell CL4030023

CSI 9.02

rCSI 16.09%

PRS 16.53
pancreatic acinar cell CL0002064

CSI 8.84

rCSI 11.75%

PRS 10.55
CD14-low, CD16-positive monocyte CL0002396

CSI 8.69

rCSI 6.69%

PRS 8.74
respiratory epithelial cell CL0002368

CSI 8.68

rCSI 53.59%

PRS 31.7
syncytiotrophoblast cell CL0000525

CSI 8.58

rCSI 24.71%

PRS 19.14
renal alpha-intercalated cell CL0005011

CSI 8.47

rCSI 11.32%

PRS 12.9
transit amplifying cell of small intestine CL0009012

CSI 8.37

rCSI 36.73%

PRS 18.11
adventitial cell CL0002503

CSI 8.03

rCSI 19.17%

PRS 15.31
plasma cell CL0000786

CSI 7.99

rCSI 10.48%

PRS 44.42
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 7.95

rCSI 5.58%

PRS 26.47
luminal cell of prostate epithelium CL0002340

CSI 7.93

rCSI 42.65%

PRS 17.5
precursor B cell CL0000817

CSI 7.51

rCSI 6.58%

PRS 12.92
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 7.51

rCSI 9.43%

PRS 44.88
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 7.47

rCSI 14.89%

PRS 16.19
endothelial cell of placenta CL0009092

CSI 7.27

rCSI 35.83%

PRS 13.16
ionocyte CL0005006

CSI 7.22

rCSI 7.74%

PRS 8.9

effector memory CD8-positive, alpha-beta T cell CL0000913

CSI -17.2

rCSI -15.7%

PRS 14.8%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI -11.0

rCSI -10.8%

PRS 15.3%
alveolar type 1 fibroblast cell CL4028004

CSI -9.4

rCSI -10.3%

PRS 11.2%
activated CD8-positive, alpha-beta T cell, human CL0001049

CSI -5.5

rCSI -9.5%

PRS 19.9%
pulmonary capillary endothelial cell CL4028001

CSI -4.5

rCSI -8.5%

PRS 15.5%
astrocyte of the cerebral cortex CL0002605

CSI -4.3

rCSI -9.7%

PRS 6.0%
effector CD4-positive, alpha-beta T cell CL0001044

CSI -3.8

rCSI -10.9%

PRS 14.0%
late pro-B cell CL0002048

CSI -2.9

rCSI -7.2%

PRS 29.9%
brush cell of tracheobronchial tree CL0002075

CSI -2.8

rCSI -8.4%

PRS 15.1%
group 3 innate lymphoid cell CL0001071

CSI -2.6

rCSI -1.9%

PRS 10.0%
neural cell CL0002319

CSI -2.3

rCSI -8.5%

PRS 16.2%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI -2.2

rCSI -2.7%

PRS 16.8%
Schwann cell CL0002573

CSI -1.8

rCSI -5.2%

PRS 12.0%
IgA plasma cell CL0000987

CSI -1.8

rCSI -1.8%

PRS 18.2%
exhausted T cell CL0011025

CSI -1.6

rCSI -27.2%

PRS 40.1%
platelet CL0000233

CSI -1.1

rCSI -4.6%

PRS 22.8%
cord blood hematopoietic stem cell CL2000095

CSI -0.6

rCSI -12.1%

PRS 61.6%
retinal blood vessel endothelial cell CL0002585

CSI -0.6

rCSI -1.0%

PRS 10.6%
brush cell CL0002204

CSI -0.4

rCSI -0.7%

PRS 26.5%
helper T cell CL0000912

CSI 0.0

rCSI 0.1%

PRS 13.8%
L6b glutamatergic cortical neuron CL4023038

CSI 0.1

rCSI 0.2%

PRS 6.1%
prostate gland microvascular endothelial cell CL2000059

CSI 0.1

rCSI 2.1%

PRS 34.4%
kidney connecting tubule epithelial cell CL1000768

CSI 0.2

rCSI 0.5%

PRS 7.5%
collagen secreting cell CL0000667

CSI 0.2

rCSI 1.1%

PRS 37.8%
keratocyte CL0002363

CSI 0.2

rCSI 0.5%

PRS 14.7%
sncg GABAergic cortical interneuron CL4023015

CSI 0.2

rCSI 0.4%

PRS 6.4%
cytotoxic T cell CL0000910

CSI 0.2

rCSI 1.3%

PRS 14.4%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.4

rCSI 0.6%

PRS 5.7%
T-helper 1 cell CL0000545

CSI 0.4

rCSI 0.6%

PRS 27.0%
cerebral cortex pyramidal neuron CL4023111

CSI 0.4

rCSI 2.2%

PRS 29.1%
colon macrophage CL0009038

CSI 0.4

rCSI 1.8%

PRS 20.6%
renal principal cell CL0005009

CSI 0.4

rCSI 1.0%

PRS 13.4%
vasa recta ascending limb cell CL1001131

CSI 0.4

rCSI 1.9%

PRS 37.8%
chondrocyte CL0000138

CSI 0.4

rCSI 0.7%

PRS 8.4%
follicular dendritic cell CL0000442

CSI 0.5

rCSI 7.5%

PRS 51.3%
lung pericyte CL0009089

CSI 0.5

rCSI 1.3%

PRS 11.6%
kidney loop of Henle epithelial cell CL1000909

CSI 0.5

rCSI 10.9%

PRS 61.8%
macroglial cell CL0000126

CSI 0.5

rCSI 1.4%

PRS 14.7%
lung microvascular endothelial cell CL2000016

CSI 0.5

rCSI 10.2%

PRS 32.0%
renal intercalated cell CL0005010

CSI 0.5

rCSI 4.8%

PRS 64.7%
blood vessel smooth muscle cell CL0019018

CSI 0.6

rCSI 4.5%

PRS 10.1%
uterine smooth muscle cell CL0002601

CSI 0.6

rCSI 3.7%

PRS 56.5%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.6

rCSI 0.7%

PRS 13.4%
myelocyte CL0002193

CSI 0.6

rCSI 3.8%

PRS 31.7%
IgM plasma cell CL0000986

CSI 0.6

rCSI 2.6%

PRS 46.1%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 0.6

rCSI 0.9%

PRS 9.1%
Bergmann glial cell CL0000644

CSI 0.6

rCSI 0.9%

PRS 10.1%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.6

rCSI 1.1%

PRS 5.7%
renal beta-intercalated cell CL0002201

CSI 0.7

rCSI 1.5%

PRS 11.9%
basophil mast progenitor cell CL0002028

CSI 0.7

rCSI 3.5%

PRS 35.7%
cholangiocyte CL1000488

CSI 0.7

rCSI 4.2%

PRS 16.2%
sst GABAergic cortical interneuron CL4023017

CSI 0.7

rCSI 1.0%

PRS 6.0%
T-helper 17 cell CL0000899

CSI 0.8

rCSI 0.6%

PRS 17.0%
cerebellar granule cell CL0001031

CSI 0.8

rCSI 1.1%

PRS 9.2%
class switched memory B cell CL0000972

CSI 0.8

rCSI 0.6%

PRS 16.3%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.8

rCSI 1.9%

PRS 5.6%
T follicular helper cell CL0002038

CSI 0.8

rCSI 0.6%

PRS 15.8%
antibody secreting cell CL0000946

CSI 0.8

rCSI 3.7%

PRS 40.1%
small intestine goblet cell CL1000495

CSI 0.9

rCSI 1.9%

PRS 13.0%
podocyte CL0000653

CSI 0.9

rCSI 3.8%

PRS 9.6%
mesenchymal lymphangioblast CL0005021

CSI 0.9

rCSI 23.2%

PRS 46.8%
Merkel cell CL0000242

CSI 0.9

rCSI 20.8%

PRS 60.4%
vasa recta descending limb cell CL1001285

CSI 0.9

rCSI 7.2%

PRS 40.5%
basophil CL0000767

CSI 0.9

rCSI 1.9%

PRS 20.3%
serous secreting cell CL0000313

CSI 1.0

rCSI 4.8%

PRS 41.7%
myeloid dendritic cell, human CL0001057

CSI 1.0

rCSI 5.8%

PRS 30.8%
small pre-B-II cell CL0000954

CSI 1.1

rCSI 1.0%

PRS 20.4%
rod bipolar cell CL0000751

CSI 1.1

rCSI 1.9%

PRS 8.1%
parietal cell CL0000162

CSI 1.1

rCSI 9.4%

PRS 51.8%
paneth cell CL0000510

CSI 1.1

rCSI 1.6%

PRS 15.3%
epithelial cell of urethra CL1000296

CSI 1.1

rCSI 28.4%

PRS 32.3%
forebrain neuroblast CL1000042

CSI 1.1

rCSI 12.3%

PRS 76.1%
regular atrial cardiac myocyte CL0002129

CSI 1.1

rCSI 3.7%

PRS 10.8%
natural T-regulatory cell CL0000903

CSI 1.3

rCSI 2.4%

PRS 26.9%
megakaryocyte progenitor cell CL0000553

CSI 1.3

rCSI 23.5%

PRS 27.7%
cell of skeletal muscle CL0000188

CSI 1.3

rCSI 14.1%

PRS 52.1%
intermediate monocyte CL0002393

CSI 1.3

rCSI 2.0%

PRS 9.5%
enterocyte of epithelium of small intestine CL1000334

CSI 1.3

rCSI 20.7%

PRS 24.2%
squamous epithelial cell CL0000076

CSI 1.4

rCSI 3.3%

PRS 12.5%
primordial germ cell CL0000670

CSI 1.4

rCSI 7.1%

PRS 54.8%
vein endothelial cell of respiratory system CL4033008

CSI 1.4

rCSI 9.8%

PRS 19.0%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.4

rCSI 2.0%

PRS 20.3%
professional antigen presenting cell CL0000145

CSI 1.4

rCSI 5.0%

PRS 38.3%
enterocyte of epithelium of large intestine CL0002071

CSI 1.4

rCSI 7.6%

PRS 17.9%
tendon cell CL0000388

CSI 1.5

rCSI 3.8%

PRS 27.6%
osteoblast CL0000062

CSI 1.5

rCSI 37.6%

PRS 66.1%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 1.6

rCSI 9.5%

PRS 21.9%
intraepithelial lymphocyte CL0002496

CSI 1.6

rCSI 4.4%

PRS 41.2%
metallothionein-positive alveolar macrophage CL4033042

CSI 1.7

rCSI 17.9%

PRS 40.1%
hair follicular keratinocyte CL2000092

CSI 1.7

rCSI 28.9%

PRS 39.2%
activated CD4-positive, alpha-beta T cell, human CL0001043

CSI 1.7

rCSI 4.0%

PRS 54.1%
adipocyte CL0000136

CSI 1.7

rCSI 2.2%

PRS 10.2%
glial cell CL0000125

CSI 1.7

rCSI 6.6%

PRS 10.1%
innate lymphoid cell CL0001065

CSI 1.7

rCSI 3.6%

PRS 15.1%
fibroblast CL0000057

CSI 1.8

rCSI 5.0%

PRS 52.4%
enteroendocrine cell of small intestine CL0009006

CSI 1.8

rCSI 3.9%

PRS 14.8%
group 2 innate lymphoid cell CL0001069

CSI 1.8

rCSI 9.7%

PRS 33.1%
dendritic cell, human CL0001056

CSI 1.9

rCSI 2.8%

PRS 11.3%
ON-bipolar cell CL0000749

CSI 1.9

rCSI 2.8%

PRS 11.9%
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.0

rCSI 3.1%

PRS 23.8%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [ANAPC11](/details-gene/51529) is a protein-coding gene located on chromosome 17q25.3 that encodes Anaphase-Promoting Complex Subunit 11. This protein is a critical component of the Anaphase-Promoting Complex/Cyclosome (APC/C), a large E3 ubiquitin ligase that plays an essential role in regulating cell cycle progression. Specifically, [ANAPC11](/details-gene/51529) contains a RING-H2 finger domain that is central to the catalytic activity of the APC/C, enabling the ubiquitination and subsequent proteasomal degradation of key cell cycle proteins to ensure the orderly transition through mitosis, particularly from metaphase to anaphase ([Link](https://doi.org/10.1073/pnas.97.16.8973), [Link](https://doi.org/10.1091/mbc.12.12.3839)). Reflecting its fundamental role in cell division, its expression is most significant in highly proliferative cell populations, including progenitor cells like the [granulocyte monocyte progenitor cell](/details-cell/CL0000557) and various rapidly renewing epithelial tissues. ## Cellular Roles and Expression Landscape The expression profile of [ANAPC11](/details-gene/51529) underscores its function as a core component of the cell division machinery. **Overall**, the gene shows the highest significance in cell populations characterized by high rates of proliferation and differentiation. These include hematopoietic progenitors such as [granulocyte monocyte progenitor cell](/details-cell/CL0000557), [common myeloid progenitor](/details-cell/CL0000049), and undifferentiated [stem cell](/details-cell/CL0000034). Furthermore, [ANAPC11](/details-gene/51529) is highly expressed in rapidly renewing epithelial tissues, as evidenced by its high CSI scores in [epithelial cell of lung](/details-cell/CL0000082), [fallopian tube secretory epithelial cell](/details-cell/CL4030006), [transit amplifying cell of colon](/details-cell/CL0009011), and [keratinocyte](/details-cell/CL0000312). This pattern suggests a crucial role in maintaining tissue homeostasis in organs that require constant cell turnover. Conversely, [ANAPC11](/details-gene/51529) shows low to negative significance in terminally differentiated and quiescent cell types. Its expression is notably low in various mature lymphocyte populations, including [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) and [CD4-positive, CD25-positive, alpha-beta regulatory T cell](/details-cell/CL0000792). Similarly, it is a significant anti-marker for structural and neural cells like the [alveolar type 1 fibroblast cell](/details-cell/CL4028004), [astrocyte of the cerebral cortex](/details-cell/CL0002605), and [Schwann cell](/details-cell/CL0002573). This dichotomy highlights its specialized function in active cell cycle progression rather than in the maintenance of differentiated cellular states. ## Pathways and Molecular Function Functionally, [ANAPC11](/details-gene/51529) is integral to the process of protein ubiquitination. As a core subunit of the [anaphase-promoting complex](/details-go/GO0005680), it exhibits [ubiquitin protein ligase activity](/details-go/GO0061630) that is essential for the [anaphase-promoting complex-dependent catabolic process](/details-go/GO0031145) ([Link](https://doi.org/10.1016/j.cell.2008.04.012)). This activity drives the degradation of target proteins, which is a key regulatory step for progression through the [mitotic cell cycle](/details-go/GO0000278). The Reactome pathway annotations further detail its central role. [ANAPC11](/details-gene/51529) is a key player in the overarching [Cell cycle](/details-reactome/R-HSA-1640170) pathway, with specific involvement in [M phase](/details-reactome/R-HSA-68886) events such as the [separation of sister chromatids](/details-reactome/R-HSA-2467813). It is directly implicated in the [Apc/c:cdc20 mediated degradation of securin](/details-reactome/R-HSA-174154) and the [Apc/c:cdc20 mediated degradation of cyclin b](/details-reactome/R-HSA-174048), two critical events that trigger the onset of anaphase. The gene's involvement is also noted in pathways related to disease, including [diseases of mitotic cell cycle](/details-reactome/R-HSA-9675126), highlighting that its dysregulation can have pathological consequences. Its function is also connected to the [immune system](/details-reactome/R-HSA-168256) through pathways like [class i mhc mediated antigen processing & presentation](/details-reactome/R-HSA-983169), where ubiquitination is required for generating peptides for antigen display. ## Research Directions Given that [ANAPC11](/details-gene/51529) is an essential regulator of the cell cycle, its dysregulation is a plausible driver of diseases characterized by aberrant cell proliferation, most notably cancer. The high expression in rapidly dividing progenitor and epithelial cells suggests that these tissues may be particularly vulnerable to alterations in [ANAPC11](/details-gene/51529) function. Based on its known function and expression pattern, several testable hypotheses can be proposed: 1. **Hypothesis 1:** Overexpression of [ANAPC11](/details-gene/51529) in epithelial cells, such as those of the lung or colon, accelerates the degradation of cell cycle checkpoints proteins, leading to chromosomal instability and promoting the initial stages of tumorigenesis. 2. **Hypothesis 2:** In hematopoietic malignancies, aberrant splicing or gain-of-function mutations in [ANAPC11](/details-gene/51529) may alter APC/C substrate specificity, leading to the inappropriate degradation of tumor suppressors and driving leukemic proliferation in progenitor cell populations. To test the first hypothesis regarding the role of [ANAPC11](/details-gene/51529) in promoting tumorigenesis, a key experiment could be designed. Lentiviral vectors could be used to induce stable overexpression of [ANAPC11](/details-gene/51529) in a non-transformed human colon epithelial cell line (e.g., NCM460). The consequences could be assessed by measuring rates of aneuploidy via flow cytometry or metaphase spreads, monitoring for accelerated G1/S transition, and performing soft agar assays to test for the acquisition of anchorage-independent growth, a hallmark of cellular transformation. From a therapeutic perspective, [ANAPC11](/details-gene/51529), as the catalytic core of the APC/C, represents a compelling target for anti-cancer therapies. Its function is critical for cell division, making cancer cells, which are defined by their rapid proliferation, potentially more sensitive to its disruption than quiescent normal cells. Therefore, the development of small molecule inhibitors that specifically target the RING-H2 domain of [ANAPC11](/details-gene/51529) could be a viable strategy for **inhibition**. Such a drug would be expected to induce mitotic arrest and apoptosis in cancer cells. However, its essential role in normal progenitor cells and high-turnover tissues poses a significant risk for on-target toxicity (e.g., myelosuppression, mucositis), suggesting that the therapeutic window may be narrow.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Anaphase-promoting complex subunit 11

Genular Protein ID: 3135292355

Symbol: APC11_HUMAN

Name: Anaphase-promoting complex subunit 11

UniProtKB Accession Codes:

Q9NYG5 A8MTT2 B7ZW64 Q502X9 Q9BW64 Q9P0R2

Database IDs:

Citations:

PubMed ID: 11573242

Title: Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p.

PubMed ID: 11573242

DOI: 10.1002/jcb.1217

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10922056

Title: The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.

PubMed ID: 10922056

DOI: 10.1073/pnas.97.16.8973

PubMed ID: 11739784

Title: APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.

PubMed ID: 11739784

DOI: 10.1091/mbc.12.12.3839

PubMed ID: 18485873

Title: Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.

PubMed ID: 18485873

DOI: 10.1016/j.cell.2008.04.012

PubMed ID: 16364912

Title: Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

PubMed ID: 16364912

DOI: 10.1016/j.molcel.2005.11.008

PubMed ID: 29033132

Title: Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control.

PubMed ID: 29033132

DOI: 10.1016/j.cell.2017.09.040

PubMed ID: 25043029

Title: Molecular architecture and mechanism of the anaphase-promoting complex.

PubMed ID: 25043029

DOI: 10.1038/nature13543

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

Sequence Information:

Length: 84
Mass: 9841
Checksum: EACBD5A54FDC11AE
Sequence:

MKVKIKCWNG VATWLWVAND ENCGICRMAF NGCCPDCKVP GDDCPLVWGQ CSHCFHMHCI 
LKWLHAQQVQ QHCPMCRQEW KFKE

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Ascending colon UBERON0001156
	Basal cell carcinoma MONDO0020804
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	\|— Brain Healthy UBERON0000955_PATO0000461
	Breast UBERON0000310
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	\|— Cerebellum Healthy UBERON0002037_PATO0000461
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	\|— Colonic epithelium Healthy UBERON0000397_PATO0000461
	Colorectal cancer MONDO0005575
	Colorectum UBERON0012652
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dental pulp UBERON0001754
	Dorsolateral prefrontal cortex UBERON0009834
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Lamina propria of small intestine UBERON0001238
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neuroblastoma MONDO0005072
	Nonpapillary renal cell carcinoma MONDO0007763
	Ovary UBERON0000992
	\|— Ovary Healthy UBERON0000992_PATO0000461
	Parkinson disease MONDO0005180
	Placenta UBERON0001987
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prostate gland UBERON0002367
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Sigmoid colon UBERON0001159
	\|— Sigmoid colon Healthy UBERON0001159_PATO0000461
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Stomach UBERON0000945
	\|— Stomach Healthy UBERON0000945_PATO0000461
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952

Details for: ANAPC11

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p. PubMed ID: 11573242

Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. PubMed ID: 11042152

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. PubMed ID: 10922056

APC2 cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. PubMed ID: 11739784

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. PubMed ID: 18485873

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. PubMed ID: 16364912

Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control. PubMed ID: 29033132

Molecular architecture and mechanism of the anaphase-promoting complex. PubMed ID: 25043029

Atomic structure of the APC/C and its mechanism of protein ubiquitination. PubMed ID: 26083744