Details for: PDGFB

Gene ID: 5155

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PDGFB

Ensembl ID: ENSG00000100311

Description: platelet derived growth factor subunit B

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

  • Constitutive signaling by aberrant pi3k in cancer
    (R-HSA-2219530)
  • Disease
    (R-HSA-1643685)
  • Diseases of signal transduction by growth factor receptors and second messengers
    (R-HSA-5663202)
  • Downstream signal transduction
    (R-HSA-186763)
  • Extracellular matrix organization
    (R-HSA-1474244)
  • Hemostasis
    (R-HSA-109582)
  • Intracellular signaling by second messengers
    (R-HSA-9006925)
  • Mapk1/mapk3 signaling
    (R-HSA-5684996)
  • Mapk family signaling cascades
    (R-HSA-5683057)
  • Negative regulation of the pi3k/akt network
    (R-HSA-199418)
  • Non-integrin membrane-ecm interactions
    (R-HSA-3000171)
  • Pi3k/akt signaling in cancer
    (R-HSA-2219528)
  • Pi5p, pp2a and ier3 regulate pi3k/akt signaling
    (R-HSA-6811558)
  • Pip3 activates akt signaling
    (R-HSA-1257604)
  • Platelet activation, signaling and aggregation
    (R-HSA-76002)
  • Platelet degranulation
    (R-HSA-114608)
  • Raf/map kinase cascade
    (R-HSA-5673001)
  • Response to elevated platelet cytosolic ca2+
    (R-HSA-76005)
  • Signaling by pdgf
    (R-HSA-186797)
  • Signaling by receptor tyrosine kinases
    (R-HSA-9006934)
  • Signal transduction
    (R-HSA-162582)
  • Angiogenesis
    (GO:0001525)
  • Basolateral plasma membrane
    (GO:0016323)
  • Cell chemotaxis
    (GO:0060326)
  • Cell surface
    (GO:0009986)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to mycophenolic acid
    (GO:0071506)
  • Cellular response to platelet-derived growth factor stimulus
    (GO:0036120)
  • Chemoattractant activity
    (GO:0042056)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Collagen binding
    (GO:0005518)
  • Cytoplasm
    (GO:0005737)
  • Embryonic placenta development
    (GO:0001892)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Gene expression
    (GO:0010467)
  • Golgi lumen
    (GO:0005796)
  • Golgi membrane
    (GO:0000139)
  • Growth factor activity
    (GO:0008083)
  • Heart development
    (GO:0007507)
  • Hemopoiesis
    (GO:0030097)
  • Identical protein binding
    (GO:0042802)
  • Interleukin-18-mediated signaling pathway
    (GO:0035655)
  • Intracellular signal transduction
    (GO:0035556)
  • Metanephric glomerular mesangial cell development
    (GO:0072255)
  • Monocyte chemotaxis
    (GO:0002548)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of mirna transcription
    (GO:1902894)
  • Negative regulation of phosphatidylinositol biosynthetic process
    (GO:0010512)
  • Negative regulation of platelet activation
    (GO:0010544)
  • Negative regulation of vascular associated smooth muscle cell differentiation
    (GO:1905064)
  • Paracrine signaling
    (GO:0038001)
  • Peptidyl-tyrosine phosphorylation
    (GO:0018108)
  • Platelet-derived growth factor binding
    (GO:0048407)
  • Platelet-derived growth factor complex
    (GO:1990265)
  • Platelet-derived growth factor receptor binding
    (GO:0005161)
  • Platelet-derived growth factor receptor signaling pathway
    (GO:0048008)
  • Platelet alpha granule lumen
    (GO:0031093)
  • Positive chemotaxis
    (GO:0050918)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of calcium ion import
    (GO:0090280)
  • Positive regulation of cell-substrate adhesion
    (GO:0010811)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemotaxis
    (GO:0050921)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of dna biosynthetic process
    (GO:2000573)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glomerular filtration
    (GO:0003104)
  • Positive regulation of glomerular mesangial cell proliferation
    (GO:0072126)
  • Positive regulation of hyaluronan biosynthetic process
    (GO:1900127)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of map kinase activity
    (GO:0043406)
  • Positive regulation of metanephric mesenchymal cell migration
    (GO:2000591)
  • Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
    (GO:0035793)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein autophosphorylation
    (GO:0031954)
  • Positive regulation of reactive oxygen species metabolic process
    (GO:2000379)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of vascular associated smooth muscle cell dedifferentiation
    (GO:1905176)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein phosphorylation
    (GO:0006468)
  • Reactive oxygen species metabolic process
    (GO:0072593)
  • Response to wounding
    (GO:0009611)
  • Superoxide-generating nadph oxidase activator activity
    (GO:0016176)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • endothelial cell of placenta CL0009092
    CSI 8.44
    rCSI 41.59%
    PRS 90.25
  • renal interstitial pericyte CL1001318
    CSI 7.56
    rCSI 20.83%
    PRS 79.75
  • neural progenitor cell CL0011020
    CSI 6.91
    rCSI 30.39%
    PRS 72.75
  • enteroglial cell CL4040002
    CSI 6.72
    rCSI 35.34%
    PRS 85.01
  • type EC enteroendocrine cell CL0000577
    CSI 5.15
    rCSI 18.3%
    PRS 86.74
  • lung macrophage CL1001603
    CSI 4.82
    rCSI 10.76%
    PRS 90.35
  • endothelial cell of vascular tree CL0002139
    CSI 4.52
    rCSI 24.7%
    PRS 80.31
  • cerebral cortex endothelial cell CL1001602
    CSI 4.23
    rCSI 7.32%
    PRS 76.49
  • pulmonary capillary endothelial cell CL4028001
    CSI 3.84
    rCSI 7.33%
    PRS 91.91
  • Schwann cell CL0002573
    CSI 3.75
    rCSI 10.66%
    PRS 79.94
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 3.69
    rCSI 4.45%
    PRS 90.67
  • blood vessel endothelial cell CL0000071
    CSI 3
    rCSI 6.22%
    PRS 81.17
  • cardiac endothelial cell CL0010008
    CSI 2.41
    rCSI 9.74%
    PRS 84.27
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 2.33
    rCSI 3.31%
    PRS 81.32
  • alternatively activated macrophage CL0000890
    CSI 2.3
    rCSI 2.89%
    PRS 91.84
  • extravillous trophoblast CL0008036
    CSI 2.3
    rCSI 2.85%
    PRS 82.29
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 2.28
    rCSI 5.94%
    PRS 85.15
  • lung microvascular endothelial cell CL2000016
    CSI 2.27
    rCSI 43.86%
    PRS 89.99
  • pancreatic stellate cell CL0002410
    CSI 2.2
    rCSI 12.82%
    PRS 86.98
  • vein endothelial cell of respiratory system CL4033008
    CSI 2.1
    rCSI 14.4%
    PRS 89.1
  • myoepithelial cell CL0000185
    CSI 1.98
    rCSI 5.01%
    PRS 87.99
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.95
    rCSI 3.12%
    PRS 87.21
  • mononuclear phagocyte CL0000113
    CSI 1.93
    rCSI 4.26%
    PRS 87.3
  • cardiac neuron CL0010022
    CSI 1.87
    rCSI 5.97%
    PRS 82
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 1.84
    rCSI 4.76%
    PRS 80.13
  • microcirculation associated smooth muscle cell CL0008035
    CSI 1.81
    rCSI 5.25%
    PRS 83.2
  • lung endothelial cell CL1001567
    CSI 1.7
    rCSI 3.96%
    PRS 92.41
  • myeloid dendritic cell CL0000782
    CSI 1.66
    rCSI 2.41%
    PRS 94.29
  • tissue-resident macrophage CL0000864
    CSI 1.31
    rCSI 6.15%
    PRS 93.27
  • colon macrophage CL0009038
    CSI 1.16
    rCSI 5.37%
    PRS 93.68

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary The [PDGFB](/details-gene/5155) gene encodes the platelet-derived growth factor B chain, a potent mitogenic and chemotactic growth factor. As a secreted protein, it functions as a disulfide-linked homodimer (PDGF-BB) or as a heterodimer with the PDGF A chain (PDGF-AB). [PDGFB](/details-gene/5155) plays a crucial role in the development and proliferation of cells of mesenchymal origin, including fibroblasts, smooth muscle cells, and glial cells. Its discovery was linked to the v-sis oncogene of the simian sarcoma virus, establishing it as a proto-oncogene [Link](https://pubmed.ncbi.nlm.nih.gov/6306471/). The **Overall** expression profile highlights its significance in vascular biology, with top expression in various endothelial cell types, such as `[endothelial cell of placenta](/details-cell/CL0009092)`, and in pericytes like the `[renal interstitial pericyte](/details-cell/CL1001318)`. Clinically, chromosomal translocations involving this gene are associated with dermatofibrosarcoma protuberans ([190040](https://omim.org/entry/190040)), and mutations have been linked to primary familial brain calcification ([213600](https://omim.org/entry/213600)). ## Cellular Roles and Expression Landscape The expression landscape of [PDGFB](/details-gene/5155) underscores its central role in vasculogenesis, tissue repair, and development. **Overall**, the gene shows the highest significance in cells integral to the vascular system and its support structures. It is a defining marker for `[endothelial cell of placenta](/details-cell/CL0009092)` (CSI: 8.44), `[endothelial cell of vascular tree](/details-cell/CL0002139)` (CSI: 4.52), `[cerebral cortex endothelial cell](/details-cell/CL1001602)` (CSI: 4.23), and `[pulmonary capillary endothelial cell](/details-cell/CL4028001)` (CSI: 3.84). This pattern is consistent with early findings that cultured endothelial cells express the PDGFB chain [Link](https://doi.org/10.1038/316748a0). Beyond the endothelium, [PDGFB](/details-gene/5155) is highly significant in perivascular cells, such as the `[renal interstitial pericyte](/details-cell/CL1001318)` (CSI: 7.56), which is essential for vessel stabilization. Its expression in `[neural progenitor cell](/details-cell/CL0011020)` (CSI: 6.91) and `[Schwann cell](/details-cell/CL0002573)` (CSI: 3.75) suggests a paracrine role in nervous system development and maintenance. Furthermore, its notable significance in immune cells like `[lung macrophage](/details-cell/CL1001603)` (CSI: 4.82) and `[alternatively activated macrophage](/details-cell/CL0000890)` (CSI: 2.30) points towards a function in inflammation, wound healing, and tissue remodeling. The expression data collectively portrays [PDGFB](/details-gene/5155) as a key signaling molecule mediating communication between endothelial, mesenchymal, neural, and immune cell populations. ## Pathways and Molecular Function [PDGFB](/details-gene/5155) functions primarily as a `[Growth factor activity](/details-go/GO:0008083)` that initiates intracellular signaling by binding to and inducing the dimerization and autophosphorylation of platelet-derived growth factor receptors (PDGFRs). This molecular function, `[Platelet-derived growth factor receptor binding](/details-go/GO:0005161)`, is the first step in the canonical `[Platelet-derived growth factor receptor signaling pathway](/details-go/GO:0048008)`. This pathway activates multiple downstream cascades, most notably the `[PI3K/AKT signaling in cancer](/details-reactome/R-HSA-2219528)` and `[MAPK family signaling cascades](/details-reactome/R-HSA-5683057)`. These signaling events translate into potent biological processes, including the `[Positive regulation of cell population proliferation](/details-go/GO:0008284)`, `[Positive regulation of cell migration](/details-go/GO:0030335)`, and `[Angiogenesis](/details-go/GO:0001525)`. As a secreted protein found in the `[Extracellular space](/details-go/GO:0005615)`, [PDGFB](/details-gene/5155) is also a key component of the `[Response to wounding](/details-go/GO:0009611)`. It is stored in platelet alpha granules (`[Platelet alpha granule lumen](/details-go/GO:0031093)`) and released upon platelet activation, a critical step in `[Hemostasis](/details-reactome/R-HSA-109582)` and tissue repair. Its `[Chemoattractant activity](/details-go/GO:0042056)` is vital for recruiting fibroblasts, smooth muscle cells, and inflammatory cells like monocytes (`[Monocyte chemotaxis](/details-go/GO:0002548)`) to sites of injury. The oncogenic potential of [PDGFB](/details-gene/5155) stems from its ability to drive uncontrolled cell proliferation, as highlighted by its involvement in pathways such as `[Constitutive signaling by aberrant PI3K in cancer](/details-reactome/R-HSA-2219530)`. ## Research Directions The expression and functional data for [PDGFB](/details-gene/5155) suggest it is a master regulator of cell proliferation and migration in vascular and mesenchymal contexts. Its established role as a proto-oncogene and its involvement in fibrotic diseases present clear avenues for further investigation. **Proposed Hypotheses:** 1. Given its high significance in both `[cerebral cortex endothelial cell](/details-cell/CL1001602)` and `[neural progenitor cell](/details-cell/CL0011020)`, endothelial-derived [PDGFB](/details-gene/5155) may function as a critical paracrine signal that regulates the neurovascular niche, promoting neural progenitor cell survival and differentiation during development or in response to injury. 2. The high significance of [PDGFB](/details-gene/5155) in `[lung macrophage](/details-cell/CL1001603)` and its potent mitogenic effect on fibroblasts suggest that macrophage-secreted PDGFB is a primary driver of pulmonary fibrosis. In this model, chronic inflammation leads to sustained [PDGFB](/details-gene/5155) release from macrophages, which in turn drives the recruitment and activation of myofibroblasts, leading to excessive matrix deposition. **Experimental Approach:** To test the second hypothesis, a conditional knockout mouse model could be employed. Mice with a myeloid-specific deletion of `Pdgfb` (e.g., *Lyz2-Cre;Pdgfbfl/fl*) would be subjected to a bleomycin-induced lung fibrosis model. The extent of fibrosis would be compared between knockout and wild-type control mice. Key endpoints would include quantitative histology for collagen deposition (e.g., Masson's trichrome staining), assessment of myofibroblast populations via immunohistochemistry for alpha-smooth muscle actin, and analysis of lung function. A significant reduction in fibrosis in the knockout mice would confirm that macrophage-derived PDGFB is a critical pathogenic mediator. **Therapeutic Potential:** [PDGFB](/details-gene/5155) and its signaling pathway represent a well-established therapeutic target. Given its role as an extracellular growth factor that drives pathological cell proliferation, **inhibition** is the primary therapeutic strategy. Tyrosine kinase inhibitors that target PDGFRs (e.g., imatinib, sunitinib) are already in clinical use for cancers driven by aberrant PDGF signaling, such as dermatofibrosarcoma protuberans and certain gastrointestinal stromal tumors. Its role in fibrosis suggests that targeting the PDGFB/PDGFR axis could also be a viable anti-fibrotic strategy in diseases of the lung, liver, and kidney. The major challenge is balancing therapeutic efficacy with on-target side effects, as this pathway is essential for normal physiological processes like wound healing and vascular homeostasis.

Genular Protein ID: 1671928721

Symbol: PDGFB_HUMAN

Name: Platelet-derived growth factor subunit B

UniProtKB Accession Codes:

P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 8 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 26 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 74 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 8 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6740330

Title: Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor.

PubMed ID: 6740330

DOI: 10.1126/science.6740330

PubMed ID: 4033772

Title: Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis.

PubMed ID: 4033772

DOI: 10.1038/316748a0

PubMed ID: 2991848

Title: Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor.

PubMed ID: 2991848

DOI: 10.1093/nar/13.14.5007

PubMed ID: 3472769

Title: Oncogenic potential of the human platelet-derived growth factor transcriptional unit.

PubMed ID: 3472769

DOI: 10.1101/sqb.1986.051.01.109

PubMed ID: 3517869

Title: Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit.

PubMed ID: 3517869

DOI: 10.1073/pnas.83.8.2392

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7659502

Title: A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein.

PubMed ID: 7659502

DOI: 10.1093/nar/23.15.2815

PubMed ID: 8988177

Title: Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma.

PubMed ID: 8988177

DOI: 10.1038/ng0197-95

PubMed ID: 6327048

Title: Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor.

PubMed ID: 6327048

DOI: 10.1016/0092-8674(84)90307-6

PubMed ID: 3456904

Title: The human osteosarcoma cell line U-2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF-B chain.

PubMed ID: 3456904

DOI: 10.1016/0014-5793(86)80433-1

PubMed ID: 6306471

Title: Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.

PubMed ID: 6306471

DOI: 10.1038/304035a0

PubMed ID: 6844921

Title: Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequence.

PubMed ID: 6844921

DOI: 10.1126/science.6844921

PubMed ID: 6329745

Title: The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.

PubMed ID: 6329745

DOI: 10.1002/j.1460-2075.1984.tb01908.x

PubMed ID: 1661670

Title: Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation.

PubMed ID: 1661670

DOI: 10.1002/j.1460-2075.1991.tb04988.x

PubMed ID: 1317862

Title: Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF.

PubMed ID: 1317862

DOI: 10.1016/s0021-9258(19)49905-5

PubMed ID: 11331882

Title: PDGF D, a novel protease-activated growth factor.

PubMed ID: 11331882

DOI: 10.1038/35074593

PubMed ID: 12660034

Title: Dermatofibrosarcoma protuberans of breast.

PubMed ID: 12660034

DOI: 10.1016/s0165-4608(02)00844-0

PubMed ID: 15053742

Title: The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

PubMed ID: 15053742

DOI: 10.1042/bj20040149

PubMed ID: 16393139

Title: Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members.

PubMed ID: 16393139

DOI: 10.1042/bj20051364

PubMed ID: 26599395

Title: Functional characterization of germline mutations in PDGFB and PDGFRB in primary familial brain calcification.

PubMed ID: 26599395

DOI: 10.1371/journal.pone.0143407

PubMed ID: 34530889

Title: KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state.

PubMed ID: 34530889

DOI: 10.1186/s13045-021-01147-6

PubMed ID: 18483217

Title: Role of platelet-derived growth factors in physiology and medicine.

PubMed ID: 18483217

DOI: 10.1101/gad.1653708

PubMed ID: 1396586

Title: Crystal structure of human platelet-derived growth factor BB.

PubMed ID: 1396586

DOI: 10.1002/j.1460-2075.1992.tb05485.x

PubMed ID: 20534510

Title: Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.

PubMed ID: 20534510

DOI: 10.1073/pnas.1000806107

PubMed ID: 23913003

Title: Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice.

PubMed ID: 23913003

DOI: 10.1038/ng.2723

Sequence Information:

  • Length: 241
  • Mass: 27283
  • Checksum: 9F9A3474CE203C0B
  • Sequence:
    • MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG DPGEEDGAEL 
DLNMTRSHSG GELESLARGR RSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV 
WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC 
ETVAAARPVT RSPGGSQEQR AKTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG 
A