Details for: PDGFB

Gene ID: 5155

Symbol: PDGFB

Ensembl ID: ENSG00000100311

Description: platelet derived growth factor subunit B

Associated with

  • Constitutive signaling by aberrant pi3k in cancer
    (R-HSA-2219530)
  • Disease
    (R-HSA-1643685)
  • Diseases of signal transduction by growth factor receptors and second messengers
    (R-HSA-5663202)
  • Downstream signal transduction
    (R-HSA-186763)
  • Extracellular matrix organization
    (R-HSA-1474244)
  • Hemostasis
    (R-HSA-109582)
  • Intracellular signaling by second messengers
    (R-HSA-9006925)
  • Mapk1/mapk3 signaling
    (R-HSA-5684996)
  • Mapk family signaling cascades
    (R-HSA-5683057)
  • Negative regulation of the pi3k/akt network
    (R-HSA-199418)
  • Non-integrin membrane-ecm interactions
    (R-HSA-3000171)
  • Pi3k/akt signaling in cancer
    (R-HSA-2219528)
  • Pi5p, pp2a and ier3 regulate pi3k/akt signaling
    (R-HSA-6811558)
  • Pip3 activates akt signaling
    (R-HSA-1257604)
  • Platelet activation, signaling and aggregation
    (R-HSA-76002)
  • Platelet degranulation
    (R-HSA-114608)
  • Raf/map kinase cascade
    (R-HSA-5673001)
  • Response to elevated platelet cytosolic ca2+
    (R-HSA-76005)
  • Signaling by pdgf
    (R-HSA-186797)
  • Signaling by receptor tyrosine kinases
    (R-HSA-9006934)
  • Signal transduction
    (R-HSA-162582)
  • Angiogenesis
    (GO:0001525)
  • Cell chemotaxis
    (GO:0060326)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to mycophenolic acid
    (GO:0071506)
  • Cellular response to platelet-derived growth factor stimulus
    (GO:0036120)
  • Chemoattractant activity
    (GO:0042056)
  • Collagen binding
    (GO:0005518)
  • Embryonic placenta development
    (GO:0001892)
  • Gene expression
    (GO:0010467)
  • Growth factor activity
    (GO:0008083)
  • Heart development
    (GO:0007507)
  • Hemopoiesis
    (GO:0030097)
  • Identical protein binding
    (GO:0042802)
  • Interleukin-18-mediated signaling pathway
    (GO:0035655)
  • Intracellular signal transduction
    (GO:0035556)
  • Metanephric glomerular mesangial cell development
    (GO:0072255)
  • Monocyte chemotaxis
    (GO:0002548)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of mirna transcription
    (GO:1902894)
  • Negative regulation of phosphatidylinositol biosynthetic process
    (GO:0010512)
  • Negative regulation of platelet activation
    (GO:0010544)
  • Negative regulation of vascular associated smooth muscle cell differentiation
    (GO:1905064)
  • Paracrine signaling
    (GO:0038001)
  • Peptidyl-tyrosine phosphorylation
    (GO:0018108)
  • Platelet-derived growth factor binding
    (GO:0048407)
  • Platelet-derived growth factor receptor binding
    (GO:0005161)
  • Platelet-derived growth factor receptor signaling pathway
    (GO:0048008)
  • Positive chemotaxis
    (GO:0050918)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of calcium ion import
    (GO:0090280)
  • Positive regulation of cell-substrate adhesion
    (GO:0010811)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemotaxis
    (GO:0050921)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of dna biosynthetic process
    (GO:2000573)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glomerular filtration
    (GO:0003104)
  • Positive regulation of glomerular mesangial cell proliferation
    (GO:0072126)
  • Positive regulation of hyaluronan biosynthetic process
    (GO:1900127)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of map kinase activity
    (GO:0043406)
  • Positive regulation of metanephric mesenchymal cell migration
    (GO:2000591)
  • Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
    (GO:0035793)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein autophosphorylation
    (GO:0031954)
  • Positive regulation of reactive oxygen species metabolic process
    (GO:2000379)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of vascular associated smooth muscle cell dedifferentiation
    (GO:1905176)
  • Positive regulation of vascular associated smooth muscle cell migration
    (GO:1904754)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein phosphorylation
    (GO:0006468)
  • Reactive oxygen species metabolic process
    (GO:0072593)
  • Response to wounding
    (GO:0009611)
  • Superoxide-generating nadph oxidase activator activity
    (GO:0016176)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 77.6623
    Cell Significance Index: -12.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 25.6242
    Cell Significance Index: -10.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.9244
    Cell Significance Index: -10.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.7390
    Cell Significance Index: -12.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.9041
    Cell Significance Index: 203.3600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0613
    Cell Significance Index: -12.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.7577
    Cell Significance Index: 25.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6855
    Cell Significance Index: 130.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4633
    Cell Significance Index: 45.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4247
    Cell Significance Index: 383.5100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.4140
    Cell Significance Index: 3.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2966
    Cell Significance Index: 7.9400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2656
    Cell Significance Index: 1.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2153
    Cell Significance Index: 35.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1777
    Cell Significance Index: 63.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1419
    Cell Significance Index: 15.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1386
    Cell Significance Index: 27.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0860
    Cell Significance Index: 17.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0778
    Cell Significance Index: 34.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0517
    Cell Significance Index: 3.5800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0497
    Cell Significance Index: 0.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0396
    Cell Significance Index: 21.6200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0343
    Cell Significance Index: 0.5300
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.0084
    Cell Significance Index: 0.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0079
    Cell Significance Index: 14.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0068
    Cell Significance Index: 4.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0016
    Cell Significance Index: -0.0500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0050
    Cell Significance Index: -3.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0052
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0057
    Cell Significance Index: -10.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0058
    Cell Significance Index: -0.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0073
    Cell Significance Index: -0.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0073
    Cell Significance Index: -11.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0101
    Cell Significance Index: -13.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0112
    Cell Significance Index: -6.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0152
    Cell Significance Index: -11.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0157
    Cell Significance Index: -11.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0163
    Cell Significance Index: -10.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0196
    Cell Significance Index: -5.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0226
    Cell Significance Index: -10.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0229
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0267
    Cell Significance Index: -5.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0273
    Cell Significance Index: -4.6700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0384
    Cell Significance Index: -0.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0391
    Cell Significance Index: -1.7300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0469
    Cell Significance Index: -4.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0531
    Cell Significance Index: -6.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0577
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0579
    Cell Significance Index: -6.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0613
    Cell Significance Index: -2.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0630
    Cell Significance Index: -3.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0704
    Cell Significance Index: -10.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0715
    Cell Significance Index: -8.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0730
    Cell Significance Index: -10.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0740
    Cell Significance Index: -5.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0761
    Cell Significance Index: -9.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0771
    Cell Significance Index: -8.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0779
    Cell Significance Index: -10.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0826
    Cell Significance Index: -2.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0861
    Cell Significance Index: -3.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0892
    Cell Significance Index: -4.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0905
    Cell Significance Index: -1.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1000
    Cell Significance Index: -7.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1066
    Cell Significance Index: -7.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1101
    Cell Significance Index: -12.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1149
    Cell Significance Index: -11.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1461
    Cell Significance Index: -11.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1611
    Cell Significance Index: -9.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1910
    Cell Significance Index: -12.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1922
    Cell Significance Index: -12.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1942
    Cell Significance Index: -10.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2067
    Cell Significance Index: -11.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2170
    Cell Significance Index: -3.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2209
    Cell Significance Index: -2.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2237
    Cell Significance Index: -4.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2324
    Cell Significance Index: -12.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2388
    Cell Significance Index: -8.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2481
    Cell Significance Index: -7.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2655
    Cell Significance Index: -3.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2682
    Cell Significance Index: -8.7800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2846
    Cell Significance Index: -9.0700
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.2900
    Cell Significance Index: -3.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3037
    Cell Significance Index: -11.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3078
    Cell Significance Index: -5.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3133
    Cell Significance Index: -15.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3210
    Cell Significance Index: -8.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3283
    Cell Significance Index: -9.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3360
    Cell Significance Index: -11.6800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3370
    Cell Significance Index: -14.6600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.3393
    Cell Significance Index: -4.0100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3430
    Cell Significance Index: -4.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3435
    Cell Significance Index: -8.8300
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.3466
    Cell Significance Index: -2.1700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.3472
    Cell Significance Index: -3.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3612
    Cell Significance Index: -6.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3689
    Cell Significance Index: -9.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Expression:** PDGFB is highly expressed in endothelial cells, immune cells, and smooth muscle cells, indicating its involvement in vascular development, immune responses, and tissue repair. 2. **Protein Structure:** PDGFB is a 22-kDa protein that forms homodimers or heterodimers with other PDGF subunits, enabling it to interact with specific receptors on target cells. 3. **Receptor Binding:** PDGFB binds to the PDGF receptor alpha (PDGFRα) and beta (PDGFRβ) subunits, triggering signaling cascades that regulate various cellular responses. 4. **Signaling Pathways:** PDGFB activates multiple signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway, mitogen-activated protein kinase (MAPK) pathway, and receptor tyrosine kinase (RTK) pathway. **Pathways and Functions:** 1. **Cell Proliferation and Differentiation:** PDGFB promotes cell proliferation and differentiation by activating the PI3K/Akt pathway, which regulates cell cycle progression and apoptosis. 2. **Vascular Development:** PDGFB plays a crucial role in vascular development, particularly in endothelial cell migration, proliferation, and differentiation. 3. **Immune Responses:** PDGFB is involved in immune responses, including the regulation of immune cell proliferation, differentiation, and function. 4. **Tissue Repair:** PDGFB promotes tissue repair by regulating the proliferation and differentiation of smooth muscle cells and fibroblasts. 5. **Cancer:** PDGFB is overexpressed in various cancers, including breast, lung, and colon cancer, where it contributes to tumor growth, metastasis, and resistance to therapy. **Clinical Significance:** 1. **Cancer Therapy:** Targeting PDGFB with specific inhibitors or antibodies may provide a novel therapeutic strategy for cancer treatment. 2. **Cardiovascular Diseases:** PDGFB dysregulation is implicated in cardiovascular diseases, including atherosclerosis, restenosis, and cardiac hypertrophy. 3. **Inflammatory Disorders:** PDGFB plays a role in inflammatory disorders, including rheumatoid arthritis and asthma, where it regulates immune cell function and tissue repair. 4. **Vascular Development:** Understanding PDGFB's role in vascular development may lead to the development of novel therapies for cardiovascular diseases. In conclusion, the PDGFB gene is a crucial regulator of various cellular processes, including cell proliferation, differentiation, migration, and survival. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular diseases, and inflammatory disorders. Further research is needed to fully understand the mechanisms of PDGFB's action and to explore its therapeutic potential.

Genular Protein ID: 1671928721

Symbol: PDGFB_HUMAN

Name: Platelet-derived growth factor subunit B

UniProtKB Accession Codes:

P01127 G3XAG8 P78431 Q15354 Q6FHE7 Q9UF23

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 8 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 26 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 74 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 4 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 8 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6740330

Title: Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor.

PubMed ID: 6740330

DOI: 10.1126/science.6740330

PubMed ID: 4033772

Title: Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis.

PubMed ID: 4033772

DOI: 10.1038/316748a0

PubMed ID: 2991848

Title: Nucleotide sequence of transforming human c-sis cDNA clones with homology to platelet-derived growth factor.

PubMed ID: 2991848

DOI: 10.1093/nar/13.14.5007

PubMed ID: 3472769

Title: Oncogenic potential of the human platelet-derived growth factor transcriptional unit.

PubMed ID: 3472769

DOI: 10.1101/sqb.1986.051.01.109

PubMed ID: 3517869

Title: Structure and sequence of the human c-sis/platelet-derived growth factor 2 (SIS/PDGF2) transcriptional unit.

PubMed ID: 3517869

DOI: 10.1073/pnas.83.8.2392

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7659502

Title: A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein.

PubMed ID: 7659502

DOI: 10.1093/nar/23.15.2815

PubMed ID: 8988177

Title: Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma.

PubMed ID: 8988177

DOI: 10.1038/ng0197-95

PubMed ID: 6327048

Title: Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor.

PubMed ID: 6327048

DOI: 10.1016/0092-8674(84)90307-6

PubMed ID: 3456904

Title: The human osteosarcoma cell line U-2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF-B chain.

PubMed ID: 3456904

DOI: 10.1016/0014-5793(86)80433-1

PubMed ID: 6306471

Title: Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus.

PubMed ID: 6306471

DOI: 10.1038/304035a0

PubMed ID: 6844921

Title: Human platelet-derived growth factor (PDGF): amino-terminal amino acid sequence.

PubMed ID: 6844921

DOI: 10.1126/science.6844921

PubMed ID: 6329745

Title: The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.

PubMed ID: 6329745

DOI: 10.1002/j.1460-2075.1984.tb01908.x

PubMed ID: 1661670

Title: Two PDGF-B chain residues, arginine 27 and isoleucine 30, mediate receptor binding and activation.

PubMed ID: 1661670

DOI: 10.1002/j.1460-2075.1991.tb04988.x

PubMed ID: 1317862

Title: Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF.

PubMed ID: 1317862

DOI: 10.1016/s0021-9258(19)49905-5

PubMed ID: 11331882

Title: PDGF D, a novel protease-activated growth factor.

PubMed ID: 11331882

DOI: 10.1038/35074593

PubMed ID: 12660034

Title: Dermatofibrosarcoma protuberans of breast.

PubMed ID: 12660034

DOI: 10.1016/s0165-4608(02)00844-0

PubMed ID: 15053742

Title: The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

PubMed ID: 15053742

DOI: 10.1042/bj20040149

PubMed ID: 16393139

Title: Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members.

PubMed ID: 16393139

DOI: 10.1042/bj20051364

PubMed ID: 26599395

Title: Functional characterization of germline mutations in PDGFB and PDGFRB in primary familial brain calcification.

PubMed ID: 26599395

DOI: 10.1371/journal.pone.0143407

PubMed ID: 34530889

Title: KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state.

PubMed ID: 34530889

DOI: 10.1186/s13045-021-01147-6

PubMed ID: 18483217

Title: Role of platelet-derived growth factors in physiology and medicine.

PubMed ID: 18483217

DOI: 10.1101/gad.1653708

PubMed ID: 1396586

Title: Crystal structure of human platelet-derived growth factor BB.

PubMed ID: 1396586

DOI: 10.1002/j.1460-2075.1992.tb05485.x

PubMed ID: 20534510

Title: Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex.

PubMed ID: 20534510

DOI: 10.1073/pnas.1000806107

PubMed ID: 23913003

Title: Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice.

PubMed ID: 23913003

DOI: 10.1038/ng.2723

Sequence Information:

  • Length: 241
  • Mass: 27283
  • Checksum: 9F9A3474CE203C0B
  • Sequence:
    • MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG DPGEEDGAEL 
DLNMTRSHSG GELESLARGR RSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV 
WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC 
ETVAAARPVT RSPGGSQEQR AKTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG 
A

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.